| Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high-salt diet. | Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high-salt diet.
Dunaway LS, Cook AK, Kellum CE, Edell C, Botta D, Molina PA, Sedaka RS, d'Uscio LV, Katusic ZS, Pollock DM, Inscho EW, Pollock JS., | 08/20/2024 |
| Silencing EIF3A ameliorates pulmonary arterial hypertension through HDAC1 and PTEN/PI3K/AKT pathway in vitro and in vivo. | Silencing EIF3A ameliorates pulmonary arterial hypertension through HDAC1 and PTEN/PI3K/AKT pathway in vitro and in vivo.
Yang HT, Wang G, Zhu PC, Xiao ZY. | 08/11/2023 |
| HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits FGF21 expression in metabolic syndrome-related liver injury. | HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits FGF21 expression in metabolic syndrome-related liver injury.
Chen Y, Cai K, Du Y, Liu Z, Gong Y. | 02/11/2023 |
| [(11)C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease. | [(11)C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease.
Pascoal TA, Chamoun M, Lax E, Wey HY, Shin M, Ng KP, Kang MS, Mathotaarachchi S, Benedet AL, Therriault J, Lussier FZ, Schroeder FA, DuBois JM, Hightower BG, Gilbert TM, Zürcher NR, Wang C, Hopewell R, Chakravarty M, Savard M, Thomas E, Mohaddes S, Farzin S, Salaciak A, Tullo S, Cuello AC, Soucy JP, Massarweh G, Hwang H, Kobayashi E, Hyman BT, Dickerson BC, Guiot MC, Szyf M, Gauthier S, Hooker JM, Rosa-Neto P., Free PMC Article | 07/30/2022 |
| Activation-induced chromatin reorganization in neurons depends on HDAC1 activity. | Activation-induced chromatin reorganization in neurons depends on HDAC1 activity.
Grabowska A, Sas-Nowosielska H, Wojtas B, Holm-Kaczmarek D, Januszewicz E, Yushkevich Y, Czaban I, Trzaskoma P, Krawczyk K, Gielniewski B, Martin-Gonzalez A, Filipkowski RK, Olszynski KH, Bernas T, Szczepankiewicz AA, Sliwinska MA, Kanhema T, Bramham CR, Bokota G, Plewczynski D, Wilczynski GM, Magalska A. | 03/5/2022 |
| Bilateral histone deacetylase 1 and 2 activity and enrichment at unique genes following induction of long-term potentiation in vivo. | Bilateral histone deacetylase 1 and 2 activity and enrichment at unique genes following induction of long-term potentiation in vivo.
Kyrke-Smith M, Logan B, Abraham WC, Williams JM. | 02/26/2022 |
| HDAC1 deregulation promotes neuronal loss and deficit of motor function in stroke pathogenesis. | HDAC1 deregulation promotes neuronal loss and deficit of motor function in stroke pathogenesis.
Chen JS, Wang HK, Hsu CY, Su YT, Chen JS, Liang CL, Hsieh PC, Wu CC, Kwan AL., Free PMC Article | 11/13/2021 |
| HDAC1 Expression, Histone Deacetylation, and Protective Role of Sodium Valproate in the Rat Dorsal Root Ganglia After Sciatic Nerve Transection. | HDAC1 Expression, Histone Deacetylation, and Protective Role of Sodium Valproate in the Rat Dorsal Root Ganglia After Sciatic Nerve Transection.
Dzreyan VA, Rodkin SV, Pitinova MA, Uzdensky AB. | 08/7/2021 |
| Inhibition of Histone Deacetylase 1 Prevents the Decrease in Titin (Connectin) Content and Development of Atrophy in Rat m. soleus after 3-Day Hindlimb Unloading. | Inhibition of Histone Deacetylase 1 Prevents the Decrease in Titin (Connectin) Content and Development of Atrophy in Rat m. soleus after 3-Day Hindlimb Unloading.
Ulanova AD, Gritsyna YV, Bobylev AG, Yakupova EI, Zhalimov VK, Belova SP, Mochalova EP, Nemirovskaya TL, Shenkman BS, Vikhlyantsev IM. | 07/10/2021 |
| MiR-449 improves cardiac function by regulating HDAC1 and cTnI. | MiR-449 improves cardiac function by regulating HDAC1 and cTnI.
Yang B, Zhao H, Dong R. | 07/3/2021 |
| HDAC1-mediated deacetylation of LSD1 regulates vascular calcification by promoting autophagy in chronic renal failure. | HDAC1-mediated deacetylation of LSD1 regulates vascular calcification by promoting autophagy in chronic renal failure.
Zhou J, Zhou H, Liu C, Huang L, Lu D, Gao C., Free PMC Article | 05/15/2021 |
| Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling. | Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling.
Zhang Y, Wang S, Zhang L, Zhou F, Zhu K, Zhu Q, Liu Q, Liu Y, Jiang L, Ning G, Bi Y, Zhou L, Wang X., Free PMC Article | 05/8/2021 |
| Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts. | Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts.
Deng M, Yang S, Ji Y, Lu Y, Qiu M, Sheng Y, Sun W, Kong X., Free PMC Article | 05/1/2021 |
| Atrogin-1/MAFbx mRNA expression is regulated by histone deacetylase 1 in rat soleus muscle under hindlimb unloading. | Atrogin-1/MAFbx mRNA expression is regulated by histone deacetylase 1 in rat soleus muscle under hindlimb unloading.
Mochalova EP, Belova SP, Mirzoev TM, Shenkman BS, Nemirovskaya TL., Free PMC Article | 11/21/2020 |
| Expression of Histone Deacetylases HDAC1 and HDAC2 and Their Role in Apoptosis in the Penumbra Induced by Photothrombotic Stroke. | Expression of Histone Deacetylases HDAC1 and HDAC2 and Their Role in Apoptosis in the Penumbra Induced by Photothrombotic Stroke.
Demyanenko SV, Dzreyan VA, Neginskaya MA, Uzdensky AB. | 10/10/2020 |
| In CeM, the main output of the fear circuitry, the level of HDAC1 was down-regulated following conditioning and up-regulated following extinction as opposed to which HDAC2 was down-regulated in CeM following conditioning but not following extinction. | Regulation of HDAC1 and HDAC2 during consolidation and extinction of fear memory.
Siddiqui SA, Singh S, Ugale R, Ranjan V, Kanojia R, Saha S, Tripathy S, Kumar S, Mehrotra S, Modi DR, Prakash A. | 07/25/2020 |
| HDAC1 was increased in RSC96 Schwann cells stimulated with high glucose. Inhibition of HDAC1 by small hairpin RNA vector enhanced LC3-II/LC3-I under these conditions. Blocking STAT3 phosphorylation by chemical inhibitor AG490 induced HDAC1 down-regulation followed by increases in Atg3 and LC3-II/LC3-I. | STAT3 phosphorylation mediates high glucose-impaired cell autophagy in an HDAC1-dependent and -independent manner in Schwann cells of diabetic peripheral neuropathy.
Du W, Wang N, Li F, Jia K, An J, Liu Y, Wang Y, Zhu L, Zhao S, Hao J. | 05/30/2020 |
| These findings suggest that HDAC2, but not HDAC1, is involved in neuropathic pain through regulation of Kv1.2 expression. | HDAC2, but not HDAC1, regulates Kv1.2 expression to mediate neuropathic pain in CCI rats.
Li Z, Guo Y, Ren X, Rong L, Huang M, Cao J, Zang W. | 01/11/2020 |
| HDAC1 is present within the mitochondria of cardiac myocytes, and mitochondrial HDAC1 contributes significantly to ischemia reperfusion (I/R) injury within the first hour of reperfusion. | HDAC1 localizes to the mitochondria of cardiac myocytes and contributes to early cardiac reperfusion injury.
Herr DJ, Baarine M, Aune SE, Li X, Ball LE, Lemasters JJ, Beeson CC, Chou JC, Menick DR., Free PMC Article | 06/29/2019 |
| Female rats treated with the LSD1 inhibitor failed to show any measure of mate guarding, whereas females treated with vehicle displayed mate guarding behavior. Demethylase inhibitor treatment also blocked the ability of familiar male cues to activate oxytocin and vasopressin neurons, whereas vehicle-treated females showed this enhanced activation. | Inhibition of lysine-specific demethylase enzyme disrupts sexually conditioned mate guarding in the female rat.
Holley A, Joulakian L, Wenzel K, Roorda S Jr, Gonzalez B, Sparks L, Pfaus JG. | 06/15/2019 |
| HDAC1 expression increases pancreatic Beta-cell proliferation in primary islets. | HDAC1 overexpression enhances β-cell proliferation by down-regulating Cdkn1b/p27.
Draney C, Austin MC, Leifer AH, Smith CJ, Kener KB, Aitken TJ, Hess KH, Haines AC, Lett E, Hernandez-Carretero A, Fueger PT, Arlotto M, Tessem JS. | 06/1/2019 |
| HDAC1 inhibition protects against hypoxia-induced swelling in H9c2 cardiomyocytes through enhancing cell stiffness. Overall, HDAC1 is a potential therapeutic target for myocardial edema. | Histone Deacetylase 1 Inhibition Protects Against Hypoxia-Induced Swelling in H9c2 Cardiomyocytes Through Regulating Cell Stiffness.
Li Y, Zhang Z, Zhou X, Li R, Cheng Y, Shang B, Han Y, Liu B, Xie X. | 03/9/2019 |
| p75NTR intracellular domain as a retrograde degenerative signal and reveal p150(Glued) deacetylation as a unique mechanism regulating axonal transport | Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150(Glued) Deacetylation by Axonal HDAC1.
Pathak A, Stanley EM, Hickman FE, Wallace N, Brewer B, Li D, Gluska S, Perlson E, Fuhrmann S, Akassoglou K, Bronfman F, Casaccia P, Burnette DT, Carter BD., Free PMC Article | 08/25/2018 |
| Findings support the hypothesis that the epigenetic factors HDAC1 and DAXX are part of a complex network of genes that contribute to the synaptic regulation of GAD67 and GAD65 and help to promote the functional integrity of GABAergic interneurons located within stratum oriens-CA3/2 of the hippocampus | Epigenetic Regulation of Glutamic Acid Decarboxylase 67 in a Hippocampal Circuit.
Subburaju S, Coleman AJ, Cunningham MG, Ruzicka WB, Benes FM., Free PMC Article | 06/23/2018 |
| Co-regulation of H3K9ac by HDAC1 and HDAC3 is important development of the pathophysiology of a schizophrenia-like phenotype. | HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals.
Večeřa J, Bártová E, Krejčí J, Legartová S, Komůrková D, Rudá-Kučerová J, Štark T, Dražanová E, Kašpárek T, Šulcová A, Dekker FJ, Szymanski W, Seiser C, Weitzer G, Mechoulam R, Micale V, Kozubek S., Free PMC Article | 10/28/2017 |