| CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer. | CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer.
Aiyappa-Maudsley R, Storr SJ, Rakha EA, Green AR, Ellis IO, Martin SG., Free PMC Article | 10/15/2022 |
| CYP2S1 rs338599 polymorphism confers reduced risk to anti-tuberculosis drug-induced liver injury and may be a novel marker for its risk prediction. | CYP2S1 rs338599 polymorphism confers reduced risk to anti-tuberculosis drug-induced liver injury and may be a novel marker for its risk prediction.
Wang L, Wang H, Qi Y., Free PMC Article | 06/11/2022 |
| Knockdown CYP2S1 inhibits lung cancer cells proliferation and migration. | Knockdown CYP2S1 inhibits lung cancer cells proliferation and migration.
Guo H, Zeng B, Wang L, Ge C, Zuo X, Li Y, Ding W, Deng L, Zhang J, Qian X, Song X, Zhang P. | 03/5/2022 |
| CYP2S1 might regulate proliferation and immune response of keratinocyte in psoriasis. | CYP2S1 might regulate proliferation and immune response of keratinocyte in psoriasis.
Sheng Y, Wen L, Zheng X, Li M, Wang D, Chen S, Li R, Tang L, Zhou F., Free PMC Article | 01/15/2022 |
| CYP2S1 is a synthetic lethal target in BRAF(V600E)-driven thyroid cancers. | CYP2S1 is a synthetic lethal target in BRAF(V600E)-driven thyroid cancers.
Li Y, Su X, Feng C, Liu S, Guan H, Sun Y, He N, Ji M, Hou P., Free PMC Article | 10/16/2021 |
| Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia. | Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia.
Cabrera-Cano A, Dávila-Borja VM, Juárez-Méndez S, Marcial-Quino J, Gómez-Manzo S, Castillo-Rodríguez RA. | 07/10/2021 |
| PPARalpha plays an important role in the migration activity, and the expression of CYP2S1 and CYP1B1 in chrysin-treated HCT116 cells. | PPARα plays an important role in the migration activity, and the expression of CYP2S1 and CYP1B1 in chrysin-treated HCT116 cells.
Khor CY, Khoo BY. | 02/13/2021 |
| There were 21 genetic variants identified in CYP2S1 in three Chinese populations: Han, Tibetan and Uighur. | Genetic polymorphisms of CYP2S1, CYP2J2 and CYP2R1 genes in three Chinese populations: Han, Tibetan and Uighur.
Kang X, Shi H, Zhang L, Wang Y, Zhang T, Han M, Chen C, Wang H. | 09/7/2019 |
| Biotransformation of (+)-fenchone by Salmonella typhimurium OY1002/2A6 expressing human CYP2A6 and NADPH-P450 reductase. | Biotransformation of (+)-fenchone by Salmonella typhimurium OY1002/2A6 expressing human CYP2A6 and NADPH-P450 reductase.
Nakahashi H, Yagi N, Miyazawa M. | 04/22/2019 |
| These results suggest that oxaliplatin exerts its inhibitory effects in human CRC cells via upregulation of CYP2S1 expression in a p53-dependent manner. | Upregulation of CYP2S1 by oxaliplatin is associated with p53 status in colorectal cancer cell lines.
Yang C, Zhou Q, Li M, Tong X, Sun J, Qing Y, Sun L, Yang X, Hu X, Jiang J, Yan X, He L, Wan C., Free PMC Article | 06/2/2018 |
| CYP2S1 regulates colorectal cancer growth through associated with prostaglandin E2-mediated activation of beta-catenin signaling. | CYP2S1 depletion enhances colorectal cell proliferation is associated with PGE2-mediated activation of β-catenin signaling.
Yang C, Li C, Li M, Tong X, Hu X, Yang X, Yan X, He L, Wan C. | 04/25/2015 |
| The P450 2S1 may be involved in the reductive detoxication of several of the activated products of carcinogenic aromatic amines and heterocyclic aromatic amines. | Reduction of aromatic and heterocyclic aromatic N-hydroxylamines by human cytochrome P450 2S1.
Wang K, Guengerich FP., Free PMC Article | 01/3/2015 |
| found that CYP inhibition and siRNA-mediated downregulation of CYP2S1 increased macrophage phagocytosis | Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques.
Frömel T, Kohlstedt K, Popp R, Yin X, Awwad K, Barbosa-Sicard E, Thomas AC, Lieberz R, Mayr M, Fleming I. | 08/10/2013 |
| The reduction in CYP2S1 expression doubled intracellular PGE(2) levels. | Cytochrome P450 2S1 depletion enhances cell proliferation and migration in bronchial epithelial cells, in part, through modulation of prostaglandin E(2) synthesis.
Madanayake TW, Fidler TP, Fresquez TM, Bajaj N, Rowland AM., Free PMC Article | 06/15/2013 |
| Data suggest that CYP2S1 is induced in a keratinocyte cell line by exposure to all-trans retinoic acid and ultraviolet B radiation. | Characterization of a human keratinocyte HaCaT cell line model to study the regulation of CYP2S1.
McNeilly AD, Woods JA, Ibbotson SH, Wolf CR, Smith G. | 05/19/2012 |
| No association has been found between the CYP2J2 (rs890293, -76G > T) or CYP2S1 (rs34971233, 13106C > T, P466L and rs338583, 13255A > G) gene polymorphisms and respiratory diseases. | [Polymorphic markers of the CYP1B1 (4326C > G), CYP2F1 (c.14_15insC), CYP2J2 (-76G > T), and CYP2S1 (13106C > T and 13255A > G) genes and genetic predisposition to chronic respiratory diseases induced by smoking and occupational factors].
Akhmadishina LA, Korytina GF, Victorova TV. | 02/11/2012 |
| P450 2S1 can be reduced by NADPH-P450 reductase and suggest normal mixed-function oxidase roles of P450 2S1 to be revealed. | Cytochrome P450 2S1 is reduced by NADPH-cytochrome P450 reductase.
Xiao Y, Shinkyo R, Guengerich FP., Free PMC Article | 09/17/2011 |
| Review compares the expression of CYP2S1 mRNA and protein in humans, mice and rats, and critically examines evidence pertaining to CYP2S1 regulation and its catalytic activity. | Characterization and expression of extrahepatic CYP2S1.
Deb S, Bandiera SM. | 01/21/2010 |
| CYP2S1 contributes to the metabolism of environmental carcinogens via a nicotinamide adenine dinucleotide phosphate (NADPH)- independent activity. | Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli.
Bui PH, Hankinson O., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Saito A, Kawamoto M, Kamatani N. | 04/29/2009 |
| Observational study of genotype prevalence. (HuGE Navigator) | See all PubMed (2) articlesThree novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals.
Hanzawa Y, Sasaki T, Hiratsuka M, Ishikawa M, Mizugaki M, Hanzawa Y, Sasaki T, Hiratsuka M, Ishikawa M, Mizugaki M. Identification of genetic polymorphisms of CYP2S1 in a Finnish Caucasian population.
Saarikoski ST, Suitiala T, Holmila R, Impivaara O, Järvisalo J, Hirvonen A, Husgafvel-Pursiainen K. | 03/13/2008 |
| The presence of a CYP2A-related protein and testosterone metabolism in stellate cell cultures suggest that stellate cells express specific functional isoforms of CYP of which a major form is CYP2S1 | Expression of CYP2S1 in human hepatic stellate cells.
Marek CJ, Tucker SJ, Koruth M, Wallace K, Wright MC. | 01/21/2010 |
| identified the following three novel single nucleotide polymorphisms (SNPs): 4612G>A (Glu147Glu) in exon 3, 5478C>T (Leu230Leu) and 5479T>G (Leu230Arg, CYP2S1*5A) in exon 5 in Japanese individuals | Three novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals.
Hanzawa Y, Sasaki T, Hiratsuka M, Ishikawa M, Mizugaki M, Hanzawa Y, Sasaki T, Hiratsuka M, Ishikawa M, Mizugaki M. | 01/21/2010 |
| identify a novel regulatory cassette that mediates changes in Cyp2s1 expression | A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia.
Rivera SP, Wang F, Saarikoski ST, Taylor RT, Chapman B, Zhang R, Hankinson O. | 01/21/2010 |
| 12 genetic variations, which included the two novel nonsynonymous mutations CYP2S1 S61N (0.3%) and CYP2S1 L230R (0.8%), were identified in 50 Korean subjects | CYP2S1 gene polymorphisms in a Korean population.
Jang YJ, Cha EY, Kim WY, Park SW, Shon JH, Lee SS, Shin JG. | 01/21/2010 |