| Immediate inhibition of spinal secretory phospholipase A2 prevents the pain and elevated spinal neuronal hyperexcitability and neuroimmune regulatory genes that develop with nerve root compression. | Immediate inhibition of spinal secretory phospholipase A2 prevents the pain and elevated spinal neuronal hyperexcitability and neuroimmune regulatory genes that develop with nerve root compression.
Quindlen-Hotek JC, Kartha S, Winkelstein BA., Free PMC Article | 10/23/2021 |
| The present study was designed to determine the relationship between phenformin coupling AMP-activated protein kinase (AMPK) function and the molecular mechanism by which the sPLA2 IIA expression was modulated in vascular smooth muscle cells. | AMPK Signaling Involvement for the Repression of the IL-1β-Induced Group IIA Secretory Phospholipase A2 Expression in VSMCs.
El Hadri K, Denoyelle C, Ravaux L, Viollet B, Foretz M, Friguet B, Rouis M, Raymondjean M., Free PMC Article | 04/23/2016 |
| a novel inverse recruitment mechanism in which liganded TRbeta recruits corepressors to inhibit PLA2g2a expression. | Nuclear corepressors mediate the repression of phospholipase A2 group IIa gene transcription by thyroid hormone.
Sharma P, Thakran S, Deng X, Elam MB, Park EA., Free PMC Article | 08/31/2013 |
| Secreted PLA2-IIA regulates the permeability of microvascular endothelial cells during brain inflammation. | Regulatory effects of the JAK3/STAT1 pathway on the release of secreted phospholipase A₂-IIA in microvascular endothelial cells of the injured brain.
Wang G, Qian P, Xu Z, Zhang J, Wang Y, Cheng S, Cai W, Qian G, Wang C, Decoster MA., Free PMC Article | 01/26/2013 |
| Data show changes in cell morphology and upregulation of ERK1/2, iNOS and sPLA-IIA expression in astrocytes and microglia on exposure to lipopolysaccharides and cytokines. | Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA₂-IIA expression in astrocytes and microglia.
Sheng W, Zong Y, Mohammad A, Ajit D, Cui J, Han D, Hamilton JL, Simonyi A, Sun AY, Gu Z, Hong JS, Weisman GA, Sun GY., Free PMC Article | 03/31/2012 |
| cPLA(2)alpha-mediated induction of PPAR-beta/delta is a novel intracellular signalling pathway in spontaneous and TGF-beta induced activation of hepatic stellate cells. | Involvement of cytosolic phospholipase A2 alpha signalling pathway in spontaneous and transforming growth factor-beta-induced activation of rat hepatic stellate cells.
Zhao L, Gandhi CR, Gao ZH. | 03/24/2012 |
| The expression of sPLA(2)-IIA in the dorsal horn and spinal trigeminal nucleus is consistent with previous results which showed an important role of CNS sPLA(2) in nociceptive transmission. | Expression profile of multiple secretory phospholipase A(2) isoforms in the rat CNS: enriched expression of sPLA(2)-IIA in brainstem and spinal cord.
Ma MT, Nevalainen TJ, Yeo JF, Ong WY. | 07/5/2010 |
| calcium-independent phospholipase A2beta has a role in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals | Role of calcium-independent phospholipase A2beta in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals.
Xie Z, Gong MC, Su W, Xie D, Turk J, Guo Z., Free PMC Article | 04/19/2010 |
| During atherogenesis, SAA can amplify the involvement of smooth muscle cells in vascular inflammation and that this can lead to deposition of sPLA(2) and subsequent local changes in lipid homeostasis. | Secretory phospholipase A2, group IIA is a novel serum amyloid A target gene: activation of smooth muscle cell expression by an interleukin-1 receptor-independent mechanism.
Sullivan CP, Seidl SE, Rich CB, Raymondjean M, Schreiber BM., Free PMC Article | 02/1/2010 |
| sPLA(2)-IIA may be an important mediator of oligodendrocyte death and a novel target for therapeutic intervention following spinal cord injury | Differential expression of sPLA2 following spinal cord injury and a functional role for sPLA2-IIA in mediating oligodendrocyte death.
Titsworth WL, Cheng X, Ke Y, Deng L, Burckardt KA, Pendleton C, Liu NK, Shao H, Cao QL, Xu XM., Free PMC Article | 01/21/2010 |
| sPLA2-derived oxidative products contribute to significant neurovascular damage, and treatment with sPLA2 inhibitor DEDA ameliorates secondary injury by reducing exacerbations from lipoxidative stress. | Reduction of lipoxidative load by secretory phospholipase A2 inhibition protects against neurovascular injury following experimental stroke in rat.
Hoda MN, Singh I, Singh AK, Khan M., Free PMC Article | 01/21/2010 |
| Reactive oxygen species from NADPH oxidase iare involved in cytokine induction of sPLA2-IIA in astrocytes. Botanical antioxidants may be protective agents for inhibition of inflammatory responses in these cells. | Involvement of oxidative pathways in cytokine-induced secretory phospholipase A2-IIA in astrocytes.
Jensen MD, Sheng W, Simonyi A, Johnson GS, Sun AY, Sun GY., Free PMC Article | 01/21/2010 |
| Simvastatin may reduce the process of atherosclerosis by decreasing the expression level of sPLA2 IIa in myocardium and aorta. | Simvastatin inhibits sPLA2 IIa expression in aorta and myocardium.
Wei-hua L, Chang-qing S, Qiang X, Rong W, Kai-min L. | 01/21/2010 |
| On Chr 5, Pla2g2a is subject to a syntenic control while expression of the Tp53 (Chr 10) and Pmai1/Noxa (Chr 18) genes appears to be controlled by several mammary cancer resistance QTLs. | Contrasting epistatic interactions between rat quantitative trait loci controlling mammary cancer development.
Piessevaux G, Lella V, Rivière M, Stieber D, Drèze P, Szpirer J, Szpirer C. | 01/21/2010 |
| The regulation of sPLA2-IIA gene transcription by PPARalpha/RXR and PPARgamma/RXR heterodimers requires an interaction with a PPAR response element (PPRE) of the sPLA2-IIA promoter. | Inhibition of interleukin-1beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: cooperation between PPARbeta and the proto-oncogene BCL-6.
Ravaux L, Denoyelle C, Monne C, Limon I, Raymondjean M, El Hadri K., Free PMC Article | 01/21/2010 |
| a novel regulatory role of iPLA(2)gamma in stimulus-coupled sPLA(2)-IIA expression. | A novel role of group VIB calcium-independent phospholipase A2 (iPLA2gamma) in the inducible expression of group IIA secretory PLA2 in rat fibroblastic cells.
Kuwata H, Fujimoto C, Yoda E, Shimbara S, Nakatani Y, Hara S, Murakami M, Kudo I. | 01/21/2010 |
| During pleurisy resolution there is a switch to a sequential induction of first sPLA2 (types IIa and V) that mediates the release of PAF and lipoxin A4. | A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation.
Gilroy DW, Newson J, Sawmynaden P, Willoughby DA, Croxtall JD. | 01/21/2010 |
| It was shown that exposure of cultured astrocytes to oxygen glucose deprivation (0.5-24h) causes an increase in cPLA(2) and sPLA(2) expression and activity. | Activation of cPLA2 and sPLA2 in astrocytes exposed to simulated ischemia in vitro.
Gabryel B, Chalimoniuk M, Stolecka A, Langfort J. | 01/21/2010 |
| These results indicate that phospholipase A(2)-IIA is coexpressed with SNAP-25 in mature taste receptor cells that possess exocytotic machinery. | Group IIA phospholipase A(2) is coexpressed with SNAP-25 in mature taste receptor cells of rat circumvallate papillae.
Oike H, Matsumoto I, Abe K. | 01/21/2010 |
| We investigated temporal and spatial expression of sPLA2-IIA mRNA and immunoreactivity in transient focal cerebral ischemia, demonstrating an up-regulation of the inflammatory sPLA2-IIA in reactive astrocytes in response to cerebral ischemia-reperfusion. | Induction of secretory phospholipase A2 in reactive astrocytes in response to transient focal cerebral ischemia in the rat brain.
Lin TN, Wang Q, Simonyi A, Chen JJ, Cheung WM, He YY, Xu J, Sun AY, Hsu CY, Sun GY. | 01/21/2010 |
| new autocrine and paracrine pathways activating sPLA2-IIA gene expression in rat and human vascular smooth muscle cells | Autocrine and paracrine transcriptional regulation of type IIA secretory phospholipase A2 gene in vascular smooth muscle cells.
Jaulmes A, Janvier B, Andreani M, Raymondjean M. | 01/21/2010 |
| tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression is potentiated in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation | Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation.
Beck S, Lambeau G, Scholz-Pedretti K, Gelb MH, Janssen MJ, Edwards SH, Wilton DC, Pfeilschifter J, Kaszkin M. | 01/21/2010 |
| Transcriptional activation of the group IIA secretory phospholipase A2 gene in vascular smooth muscle. | Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells.
Antonio V, Janvier B, Brouillet A, Andreani M, Raymondjean M., Free PMC Article | 01/21/2010 |
| cytosolic and group IIA secreted phospholipases A(2) work together to liberate arachidonate from phospholipids in response to cytokines | Intracellular actions of group IIA secreted phospholipase A2 and group IVA cytosolic phospholipase A2 contribute to arachidonic acid release and prostaglandin production in rat gastric mucosal cells and transfected human embryonic kidney cells.
Ni Z, Okeley NM, Smart BP, Gelb MH., Free PMC Article | 01/21/2010 |
| A calcium-independent, type IIA secretory phospholipase A2 newly isolated from liver mitochondria, most apparent in media of high ionic strength, initiates the removal of poorly functioning mitochondria by processes involving autolysis. | Pore formation and uncoupling initiate a Ca2+-independent degradation of mitochondrial phospholipids.
Broekemeier KM, Iben JR, LeVan EG, Crouser ED, Pfeiffer DR. | 01/21/2010 |