| CASK, APBA1, and STXBP1 collaborate during insulin secretion. | CASK, APBA1, and STXBP1 collaborate during insulin secretion.
Zhang K, Wang T, Liu X, Yuan Q, Xiao T, Yuan X, Zhang Y, Yuan L, Wang Y. | 08/14/2021 |
| Structural Basis for the High-Affinity Interaction between CASK and Mint1. | Structural Basis for the High-Affinity Interaction between CASK and Mint1.
Wu X, Cai Q, Chen Y, Zhu S, Mi J, Wang J, Zhang M. | 05/1/2021 |
| induction of beta cell insulin-secretion defects by fatty acids is mediated, at least in part, by FOXO1 via downregulation of Cask expression | Forkhead box O1 mediates defects in palmitate-induced insulin granule exocytosis by downregulation of calcium/calmodulin-dependent serine protein kinase expression in INS-1 cells.
Wang Y, Lin H, Hao N, Zhu Z, Wang D, Li Y, Chen H, Zhu Y, Han X. | 03/12/2016 |
| Data suggest that Y-P30 can control the nuclear localization of Calcium/calmodulin-dependent serine kinase (CASK) in a syndecan (SDC) -2 and -3 -dependent manner. | Binding of Y-P30 to syndecan 2/3 regulates the nuclear localization of CASK.
Landgraf P, Mikhaylova M, Macharadze T, Borutzki C, Zenclussen AC, Wahle P, Kreutz MR., Free PMC Article | 12/6/2014 |
| The findings suggest that CASK and the truncated prestin splice isoform contribute to confinement of prestin to the basolateral region of the plasma membrane. | Generation of somatic electromechanical force by outer hair cells may be influenced by prestin-CASK interaction at the basal junction with the Deiter's cell.
Cimerman J, Waldhaus J, Harasztosi C, Duncker SV, Dettling J, Heidrych P, Bress A, Gampe-Braig C, Frank G, Gummer AW, Oliver D, Knipper M, Zimmermann U. | 11/29/2014 |
| Our study suggests that the stimulation of beta-cell insulin secretion by Ex-4 is mediated, at least in part, by CASK via a novel signaling mechanism. | Calcium/calmodulin-dependent serine protein kinase is involved in exendin-4-induced insulin secretion in INS-1 cells.
Zhu ZQ, Wang D, Xiang D, Yuan YX, Wang Y. | 02/8/2014 |
| Depletion of liprin-alpha2 resulted in reduced turnover of RIM1 and CASK at presynaptic terminals, suggesting that liprin-alpha2 promotes dynamic scaffolding for molecular complexes that facilitate synaptic vesicle release. | Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.
Spangler SA, Schmitz SK, Kevenaar JT, de Graaff E, de Wit H, Demmers J, Toonen RF, Hoogenraad CC., Free PMC Article | 08/31/2013 |
| Post-translational modifications to CASK are major regulatory steps leading to its proteasomal degradation. | Post-translational modification of CASK leads to its proteasome-dependent degradation.
Sun Q, Kelly GM. | 03/1/2010 |
| Our data demonstrate that the retention and trafficking of NMDARs in this endoplasmic reticulum subcompartment requires both CASK and SAP97. | SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway.
Jeyifous O, Waites CL, Specht CG, Fujisawa S, Schubert M, Lin EI, Marshall J, Aoki C, de Silva T, Montgomery JM, Garner CC, Green WN., Free PMC Article | 01/21/2010 |
| The Tbr-1-CASK-CINAP complex regulates expression of NR2b;a Thr-to-Ala point mutation in CASK affects NR2b promoter activity. | CASK point mutation regulates protein-protein interactions and NR2b promoter activity.
Huang TN, Hsueh YP. | 01/21/2010 |
| Data show that Cask is present in the olfactory cilia. | Scaffolding proteins in highly purified rat olfactory cilia membranes.
Saavedra MV, Smalla KH, Thomas U, Sandoval S, Olavarria K, Castillo K, Delgado MG, Delgado R, Gundelfinger ED, Bacigalupo J, Wyneken U. | 01/21/2010 |
| The function of calcium/calmodulin-dependent serine protein kinase (CASK), a MAGUK protein, in dendritic spine formation by RNA interference, is analyzed. | SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis.
Chao HW, Hong CJ, Huang TN, Lin YL, Hsueh YP., Free PMC Article | 01/21/2010 |
| CASK and Dlg may act as a scaffold for organizing receptors and channels at the postsynaptic membrane of the neuromuscular junction. | CASK and Dlg form a PDZ protein complex at the mammalian neuromuscular junction.
Sanford JL, Mays TA, Rafael-Fortney JA. | 01/21/2010 |
| a complex composed of SAP97, CASK, Veli, and Mint1 associates with Kir2 channels via the C-terminal PDZ-binding motif. SAP97, Veli-1, or Veli-3 binds directly to the Kir2.2 C terminus and recruits CASK | A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.
Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA. | 01/21/2010 |
| analysis of the nucleotide binding domain of CASK | Functional analysis of the nucleotide binding domain of membrane-associated guanylate kinases.
Olsen O, Bredt DS. | 01/21/2010 |
| In conclusion, our study suggests that the CASK protein complex not only functions as a scaffold but also recruits signaling molecules and may contribute to signal transduction. | CASK associates with glutamate receptor interacting protein and signaling molecules.
Hong CJ, Hsueh YP. | 01/21/2010 |
| plasma membrane Ca2+ pump 4b/CI binds to Ca2+/calmodulin-dependent membrane-associated kinase CASK | Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK.
Schuh K, Uldrijan S, Gambaryan S, Roethlein N, Neyses L. | 01/21/2010 |
| interacts with CIP98; co-localizes with CIP98 along the dendritic processes of neurons | CIP98, a novel PDZ domain protein, is expressed in the central nervous system and interacts with calmodulin-dependent serine kinase.
Yap CC, Liang F, Yamazaki Y, Muto Y, Kishida H, Hayashida T, Hashikawa T, Yano R. | 01/21/2010 |