| This study demonstrates the involvement of ADAM10 and PI3K/Akt signaling in mediating RLX-induced Notch-1 activation. | Relaxin induces up-regulation of ADAM10 metalloprotease in RXFP1-expressing cells by PI3K/AKT signaling.
Boccalini G, Sassoli C, Bani D, Nistri S. | 04/27/2019 |
| Relaxin-1 mRNA in the hearts of diabetic rats was significantly increased and that relaxin-3 mRNA expression at different time points was decreased. In addition, significant down-regulation of the mRNA expression of RXFP1 and RXFP3 was observed at 4 weeks after Streptozocin. | Alterations of relaxin and its receptor system components in experimental diabetic cardiomyopathy rats.
Zhang X, Pan L, Yang K, Fu Y, Liu Y, Chen W, Ma X, Yin X. | 06/9/2018 |
| Results suggest that changes in relaxin family peptides (RXFP3, RXFP1) may contribute to the significant sex differences observed in the hippocampus and amygdala as a function of aging | Sex- and age-specific differences in relaxin family peptide receptor expression within the hippocampus and amygdala in rats.
Meadows KL, Byrnes EM. | 12/26/2015 |
| Data indicate that knee passive range of motion (ROM), relaxin receptor isoforms Rxfp1 and Rxfp2 expression were significantly reduced following treatment with testosterone, and androgen antagonist flutamide antagonized the testosterone effect. | Testosterone reduces knee passive range of motion and expression of relaxin receptor isoforms via 5α-dihydrotestosterone and androgen receptor binding.
Dehghan F, Muniandy S, Yusof A, Salleh N., Free PMC Article | 02/14/2015 |
| RXFP1 & RXFP2 up-regulation by progesterone and estrogen could provide the basis for the reported increase in knee laxity while down-regulation of these receptor isoforms by testosterone could explain low incidence of non-contact knee injury in male. | Sex-steroid regulation of relaxin receptor isoforms (RXFP1 & RXFP2) expression in the patellar tendon and lateral collateral ligament of female WKY rats.
Dehghan F, Muniandy S, Yusof A, Salleh N., Free PMC Article | 09/20/2014 |
| RXFP1 was predominantly localized to the tunica media vascular smooth muscle cells in the uterine artery. Highest expression of Rxfp1 in the uterine artery occurred in estrus and early pregnancy. | Relaxin mediates uterine artery compliance during pregnancy and increases uterine blood flow.
Vodstrcil LA, Tare M, Novak J, Dragomir N, Ramirez RJ, Wlodek ME, Conrad KP, Parry LJ., Free PMC Article | 12/22/2012 |
| H3 relaxin exerts antifibrotic actions via RXFP1 receptor | H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor.
Hossain MA, Man BC, Zhao C, Xu Q, Du XJ, Wade JD, Samuel CS. | 04/9/2011 |
| investigation of expression of RXFP1 in uterine tissues before, during, and after pregnancy; fetal-placental unit appears involved in regulation of expression of RXFP1; down-regulation of RXFP1 expression occurs in late gestation | Decreased expression of the rat myometrial relaxin receptor (RXFP1) in late pregnancy is partially mediated by the presence of the conceptus.
Vodstrcil LA, Shynlova O, Verlander JW, Wlodek ME, Parry LJ. | 03/5/2011 |
| investigation of expression of RXFP1 in myometrium during gestation; the down-regulation of RXFP1 expression that occurs in late gestation correlates well with progesterone withdrawal | Progesterone withdrawal, and not increased circulating relaxin, mediates the decrease in myometrial relaxin receptor (RXFP1) expression in late gestation in rats.
Vodstrcil LA, Shynlova O, Westcott K, Laker R, Simpson E, Wlodek ME, Parry LJ. | 03/5/2011 |
| Uncovered is a pre-assembled, constitutively active G-protein-coupled receptor signalosome, that couples the relaxin receptor, relaxin family peptide receptor 1 (RXFP1), to cAMP following receptor stimulation with sub-picomolar concentrations of peptide. | Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex.
Halls ML, Cooper DM., Free PMC Article | 09/27/2010 |
| G-protein coupled receptor RXFP1, previously known as LGR7, is widely distributed throughout the male rat reproductive tract and may be important in regulation of spermatogenesis. | Relaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat.
Filonzi M, Cardoso LC, Pimenta MT, Queiróz DB, Avellar MC, Porto CS, Lazari MF., Free PMC Article | 01/21/2010 |
| Lgr7 and Lgr8 are upregulated in response to a reduction in uteroplacental blood flow in rats. | Effects of uteroplacental restriction on the relaxin-family receptors, Lgr7 and Lgr8, in the uterus of late pregnant rats.
Vodstrcil LA, Wlodek ME, Parry LJ. | 01/21/2010 |
| derivatives of LGR7 relaxin receptor have a dose dependent affect on the enyzymatic activity of relaxin-sensitive adenylate cyclase | Peptide derivatives of the LGR7 relaxin receptor control the functional activity of relaxin-sensitive adenylate cyclase.
Shpakov AO, Gur'yanov IA, Kuznetsova LA, Plesneva SA, Shpakova EA, Vlasov GP, Pertseva MN. | 01/21/2010 |
| mouse and rat LGR7 are the relaxin receptors in these species | Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7.
Scott DJ, Layfield S, Riesewijk A, Morita H, Tregear GW, Bathgate RA. | 01/21/2010 |
| Leucine-rich-repeat-containing G-protein-coupled receptor-7 mRNA was expressed by neurons in several brain regions, including the olfactory bulb, cerebral cortex, thalamus, hippocampus, hypothalamus, midbrain, pons and medulla. | Comparative localization of leucine-rich repeat-containing G-protein-coupled receptor-7 (RXFP1) mRNA and [33P]-relaxin binding sites in rat brain: restricted somatic co-expression a clue to relaxin action?
Ma S, Shen PJ, Burazin TC, Tregear GW, Gundlach AL. | 01/21/2010 |
| High densities of LGR7 mRNA hybridization were detected in deep layers of neocortex, hypothalamic paraventricular and supraoptic nuclei and within hippocampal subiculum and CA3, the basolateral amygdala and subfornical organ | Localization of LGR7 (relaxin receptor) mRNA and protein in rat forebrain: correlation with relaxin binding site distribution.
Burazin TC, Johnson KJ, Ma S, Bathgate RA, Tregear GW, Gundlach AL. | 01/21/2010 |
| both LGR7 and LGR8 are expressed in activated hepatic stellate cells and cirrhotic liver | Relaxin receptor expression in hepatic stellate cells and in cirrhotic rat liver tissue.
Bennett RG, Mahan KJ, Gentry-Nielsen MJ, Tuma DJ. | 01/21/2010 |
| LGR7-Truncate is potentially an endogenous regulator of LGR7 signaling | LGR7-truncate is a splice variant of the relaxin receptor LGR7 and is a relaxin antagonist in vitro.
Scott DJ, Tregear GW, Bathgate RA. | 01/21/2010 |
| Mouse and rat LGR7 were able to bind to and be activated by relaxin ligands | Characterization of the mouse and rat relaxin receptors.
Scott DJ, Layfield S, Riesewijk A, Morita H, Tregear GW, Bathgate RA. | 01/21/2010 |