| This work confirms a new biological role of MAP1B in the regulation of sodium channel localization | The MAP1B Binding Domain of Na(v)1.6 Is Required for Stable Expression at the Axon Initial Segment.
Solé L, Wagnon JL, Akin EJ, Meisler MH, Tamkun MM., Free PMC Article | 06/13/2020 |
| MAP1B restricts the access of AMPARs to dendritic spines and the postsynaptic membrane, contributing to downregulating synaptic transmission | MAP1B Light Chain Modulates Synaptic Transmission via AMPA Receptor Intracellular Trapping.
Palenzuela R, Gutiérrez Y, Draffin JE, Lario A, Benoist M, Esteban JA., Free PMC Article | 10/28/2017 |
| MAP1B interacts with a guanine exchange factor, termed Tiam1, which specifically activates Rac1. a novel function of MAP1B related with the control of small GTPases | The light chain 1 subunit of the microtubule-associated protein 1B (MAP1B) is responsible for Tiam1 binding and Rac1 activation in neuronal cells.
Henríquez DR, Bodaleo FJ, Montenegro-Venegas C, González-Billault C., Free PMC Article | 06/29/2013 |
| Overexpression of MAP1B 1-126 induced both neurite extension and neuronal death, suggesting that MAP1B 1-126 could be involved in neuronal degeneration and aberrant sprouting. | MAP1B 1-126 interacts with tubulin isoforms and induces neurite outgrowth and neuronal death of cultured cortical neurons.
Gomi F, Uchida Y. | 09/15/2012 |
| MAP1B enhances microtubule assembly rates and axon extension rates in developing neurons by binding to dynamic microtubules. | MAP1B enhances microtubule assembly rates and axon extension rates in developing neurons.
Tymanskyj SR, Scales TM, Gordon-Weeks PR. | 06/9/2012 |
| We suggest a role for Stau2 in the generation and regulation of Map1b mRNA containing granules that are required for mGluR-long-term depression | Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons.
Lebeau G, Miller LC, Tartas M, McAdam R, Laplante I, Badeaux F, DesGroseillers L, Sossin WS, Lacaille JC. | 08/6/2011 |
| Results provide marker proteins Gap-43 and newly identified candidate neuronal growth-associated proteins MAP1B, CRMP5, crmp5 and catenins. | Identification of functional marker proteins in the mammalian growth cone.
Nozumi M, Togano T, Takahashi-Niki K, Lu J, Honda A, Taoka M, Shinkawa T, Koga H, Takeuchi K, Isobe T, Igarashi M., Free PMC Article | 01/21/2010 |
| Data report that Bcl11A downregulates axon branching, and that the expression of DCC and MAP1b, two molecules involved in direction and branching of axon outgrowth, is controlled by Bcl11A-L. | Bcl11A/CTIP1 regulates expression of DCC and MAP1b in control of axon branching and dendrite outgrowth.
Kuo TY, Hong CJ, Hsueh YP. | 01/21/2010 |
| Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons. | Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons.
Scales TM, Lin S, Kraus M, Goold RG, Gordon-Weeks PR., Free PMC Article | 01/21/2010 |
| The light chain (LC1) of microtubule-associated protein 1B (MAP1B)-5-HT(3A) receptor interaction contributes to a mechanism that regulates receptor desensitization kinetics. | Modulation of 5-HT3 receptor desensitization by the light chain of microtubule-associated protein 1B expressed in HEK 293 cells.
Sun H, Hu XQ, Emerit MB, Schoenebeck JC, Kimmel CE, Peoples RW, Miko A, Zhang L., Free PMC Article | 01/21/2010 |
| These results reveal an S-nitrosylation-dependent signal-transduction pathway that is involved in regulation of the axonal cytoskeleton and identify MAP1B as a major component of this pathway. | S-nitrosylation of microtubule-associated protein 1B mediates nitric-oxide-induced axon retraction.
Stroissnigg H, Trancíková A, Descovich L, Fuhrmann J, Kutschera W, Kostan J, Meixner A, Nothias F, Propst F. | 01/21/2010 |
| MAP1B was also detected as a biotinylated transmembrane protein which increased with synaptogenesis, indicating a role in neurites maturation. | Changes in the subcellular distribution of microtubule-associated protein 1B during synaptogenesis of cultured rat cortical neurons.
Kitamura C, Shirai K, Inoue M, Tashiro T. | 01/21/2010 |
| GSK-3beta phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons | Glycogen synthase kinase-3beta phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons.
Trivedi N, Marsh P, Goold RG, Wood-Kaczmar A, Gordon-Weeks PR. | 01/21/2010 |
| Thus, NGF drives increased neurite growth rates partly by coupling the MAPK pathway to the activation of GSK3beta and thereby phosphorylation of MAP1B. | The MAP kinase pathway is upstream of the activation of GSK3beta that enables it to phosphorylate MAP1B and contributes to the stimulation of axon growth.
Goold RG, Gordon-Weeks PR. | 01/21/2010 |
| Transcriptional regulation of MAP1B appears to be a common mechanism in both neurons and oligodendroglia. In addition, we found posttranscriptional regulation of MAP1B mRNA by the selective RNA-binding protein QKI in oligodendroglia. | QKI binds MAP1B mRNA and enhances MAP1B expression during oligodendrocyte development.
Zhao L, Ku L, Chen Y, Xia M, LoPresti P, Feng Y., Free PMC Article | 01/21/2010 |
| These results suggest that beta-amyloid does not induce deleterious full-length MAP1B directly, but overexpression of full-length MAP1B might act as an effector of cell death in neurodegenerative disorders related to cytoskeletal abnormalities. | Overexpression of full-length but not N-terminal truncated isoform of microtubule-associated protein (MAP) 1B accelerates apoptosis of cultured cortical neurons.
Uchida Y. | 01/21/2010 |
| MAP1B is rapidly expessed in axons associated with plasticity of myelinated fibers. | Phosphorylated MAP1B is induced in central sprouting of primary afferents in response to peripheral injury but not in response to rhizotomy.
Soares S, von Boxberg Y, Lombard MC, Ravaille-Veron M, Fischer I, Eyer J, Nothias F. | 01/21/2010 |
| The recovery of the plasticity-associated protein MAP1B following stroke is delayed in both 3- and 20-month-old rats and becomes prominent between days 14 and 28. | Accelerated accumulation of N- and C-terminal beta APP fragments and delayed recovery of microtubule-associated protein 1B expression following stroke in aged rats.
Badan I, Dinca I, Buchhold B, Suofu Y, Walker L, Gratz M, Platt D, Kessler CH, Popa-Wagner A. | 01/21/2010 |
| MAP1B immunoreactivities are widely distributed in the cerebral cortex and are observed in the postsynaptic area, but not in presynaptic terminals, suggesting important roles for MAP1B in synaptic functions. | Localization of microtubule-associated protein (MAP) 1B in the postsynaptic densities of the rat cerebral cortex.
Kawakami S, Muramoto K, Ichikawa M, Kuroda Y. | 01/21/2010 |