| HAP1 interacts with 14-3-3 to regulate epileptic seizure via GABAAR-mediated inhibitory synaptic transmission in pentylenetetrazole rat model. | HAP1 interacts with 14-3-3 to regulate epileptic seizure via GABA(A)R-mediated inhibitory synaptic transmission in pentylenetetrazole rat model.
Wen Y, Zhang G, Liu L, Zhang P, Lin L, Mei R, Zhang F, Chen Y, Li R. | 08/20/2022 |
| Immunohistochemical relationships of huntingtin-associated protein 1 with enteroendocrine cells in the pyloric mucosa of the rat stomach. | Immunohistochemical relationships of huntingtin-associated protein 1 with enteroendocrine cells in the pyloric mucosa of the rat stomach.
Yanai A, Islam MN, Hayashi-Okada M, Jahan MR, Tarif AMM, Nozaki K, Masumoto KH, Shinoda K. | 09/4/2021 |
| A key role for HAP1 protein was determined in the down-regulation Of GABA A receptor neurotransmission during cerebral ischemia. | Downregulation of GABA(A) Receptor Recycling Mediated by HAP1 Contributes to Neuronal Death in In Vitro Brain Ischemia.
Mele M, Aspromonte MC, Duarte CB. | 02/10/2018 |
| Study demonstrated that HAP1 is abundantly expressed in spinal neurons of the somatosensory, viscerosensory, and autonomic regions but absent in somatomotor neurons, suggesting that the spinal motoneurons are, due to lack of putative HAP1 protectivity, more vulnerable to stresses in neurodegenerative diseases than other HAP1-expressing neurons probably involved in spinal sensory and autonomic functions. | Immunohistochemical analysis of huntingtin-associated protein 1 in adult rat spinal cord and its regional relationship with androgen receptor.
Islam MN, Takeshita Y, Yanai A, Imagawa A, Jahan MR, Wroblewski G, Nemoto J, Fujinaga R, Shinoda K. | 11/11/2017 |
| results provide real-time evidence in living cells that HAP1 may help regulate transport of insulin-containing secretory granules along cortical actin filaments | HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic β cells.
Wang Z, Peng T, Wu H, He J, Li H. | 03/26/2016 |
| sortilin stabilizes the proBDNF.HAP1 complex | Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing.
Yang M, Lim Y, Li X, Zhong JH, Zhou XF., Free PMC Article | 07/2/2011 |
| Data suggest that HAP1-KIF5-dependent GABA(A)R trafficking is a fundamental mechanism controlling the strength of synaptic inhibition in the brain. | Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.
Twelvetrees AE, Yuen EY, Arancibia-Carcamo IL, MacAskill AF, Rostaing P, Lumb MJ, Humbert S, Triller A, Saudou F, Yan Z, Kittler JT., Free PMC Article | 03/29/2010 |
| HAP1 is selectively expressed in beta-cells of rat pancreatic islets, suggesting the involvement of HAP1 in the regulation of cellular trafficking and secretion of insulin. | Selective expression of Huntingtin-associated protein 1 in {beta}-cells of the rat pancreatic islets.
Liao M, Chen X, Han J, Yang S, Peng T, Li H., Free PMC Article | 03/15/2010 |
| HAP1-induced/immunoreactive inclusions correspond to the human placental antigen complex X-P-immunoreactive stigmoid bodies previously identified in the brain | Anti-human placental antigen complex X-P2 (hPAX-P2) anti-serum recognizes C-terminus of huntingtin-associated protein 1A common to 1B as a determinant marker for the stigmoid body.
Fujinaga R, Yanai A, Nakatsuka H, Yoshida K, Takeshita Y, Uozumi K, Zhao C, Hirata K, Kokubu K, Nagano M, Shinoda K. | 01/21/2010 |
| HAP1 trafficking is critical for the stability of TrkA and neurite function, both of which can be attenuated by mutant huntingtin. | Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth.
Rong J, McGuire JR, Fang ZH, Sheng G, Shin JY, Li SH, Li XJ., Free PMC Article | 01/21/2010 |
| HAP1 interacts with Androgen Receptor through its ligand-binding domain in a polyQ-length-dependent manner and suppresses SBMA-mutant-AR-induced apoptosis. | Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis.
Takeshita Y, Fujinaga R, Zhao C, Yanai A, Shinoda K. | 01/21/2010 |
| chromosome 10 mapping by radiation hybrid mapping and FISH | Assignment of the huntingtin (Hdh) gene, the huntingtin associated protein (Hap1) gene, and the huntingtin interacting protein (Hip1) gene to rat chromosomes 14, 10, and 12 by radiation hybrid mapping and fluorescent in situ hybridization.
Zimdahl H, Gösele C, Lütjens G, Grützner F, Kreitler T, Voss K, Wanker E, Knoblauch M. | 01/21/2010 |
| interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking | Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking.
Li Y, Chin LS, Levey AI, Li L. | 01/21/2010 |
| phosphorylation-dependent interaction of HAP1A with 14-3-3 regulates HAP1 function by influencing its association with kinesin light chain and trafficking in neuronal processes. | 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking.
Rong J, Li S, Sheng G, Wu M, Coblitz B, Li M, Fu H, Li XJ. | 01/21/2010 |
| Huntingtin-associated protein-1 interacts with kinesin light chain and has a role in intracellular trafficking in neurons | Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons.
McGuire JR, Rong J, Li SH, Li XJ. | 01/21/2010 |