| Antidepressants Differentially Regulate Intracellular Signaling from alpha1-Adrenergic Receptor Subtypes In Vitro. | Antidepressants Differentially Regulate Intracellular Signaling from α1-Adrenergic Receptor Subtypes In Vitro.
Chmielarz P, Kuśmierczyk J, Rafa-Zabłocka K, Chorązka K, Kowalska M, Satała G, Nalepa I., Free PMC Article | 07/3/2021 |
| These results suggest that alpha-blockade reduces the urethral resistance associated with detrusor-sphincter dyssynergia, thus improving voiding efficiency in SCI rats. | α1D-Adrenoceptor blockade increases voiding efficiency by improving external urethral sphincter activity in rats with spinal cord injury.
Ishida H, Yamauchi H, Ito H, Akino H, Yokoyama O. | 07/1/2017 |
| effects of female sexual hormones on the expression and function of alpha1A- and alpha1D-adrenoceptor subtypes in the late-pregnant rat myometrium | The effects of female sexual hormones on the expression and function of α1A- and α1D-adrenoceptor subtypes in the late-pregnant rat myometrium.
Bóta J, Hajagos-Tóth J, Ducza E, Samavati R, Borsodi A, Benyhe S, Gáspár R. | 09/24/2016 |
| Within 2 weeks of a burn, Adra1 expression increased in the re-forming epidermis, in dense bands of spindle-shaped cells in the upper dermis and on nerve fibres in the deep dermis. Adra1 expression in the upper dermis decreased contralateral to the burn. | Up-regulation of cutaneous α1-adrenoceptors after a burn.
Drummond PD, Dawson LF, Finch PM, Drummond ES, Wood FM, Fear MW. | 06/28/2016 |
| NA promotes HSC-T6 cell activation, proliferation and secretion of ECM in vitro via activation of Galpha-coupled alpha1B-AR and alpha1D-AR and the PKC-PI3K-AKT signaling pathway. | Selective α1B- and α1D-adrenoceptor antagonists suppress noradrenaline-induced activation, proliferation and ECM secretion of rat hepatic stellate cells in vitro.
Liu TT, Ding TL, Ma Y, Wei W., Free PMC Article | 07/4/2015 |
| Data suggest Adra1d expression is up-regulated in diabetic kidney; PPAR (peroxisome proliferator-activated receptor) activation (via PPAR alpha or gamma agonists as hypoglycemic agents) suppresses renal expression of Adra1d in diabetic nephropathy. | Altered expression profile of renal α(1D)-adrenergic receptor in diabetes and its modulation by PPAR agonists.
Zhao X, Zhang Y, Leander M, Li L, Wang G, Emmett N., Free PMC Article | 11/8/2014 |
| The alpha(1D)-adrenergic receptor is involved in methamphetamine-induced hyperthermia and neurotoxicity. | Involvement of the α(1D)-adrenergic receptor in methamphetamine-induced hyperthermia and neurotoxicity in rats.
Kikuchi-Utsumi K, Ishizaka M, Matsumura N, Watabe M, Aoyama K, Sasakawa N, Nakaki T. | 03/8/2014 |
| The effect of Ang II on a1B-AR mRNA seems to be influenced by the absence of a1D-AR in aortic smooth muscle cells. | Angiotensin II modifies the expression of α(1)-adrenoceptors in aorta smooth muscle cells of α(1D)-adrenoceptor knockout mice.
Lázaro-Suárez ML, Gómez-Zamudio JH, Delgado-Buenrostro NL, Tanoue A, Tsujimoto G, Villalobos-Molina R. | 01/21/2012 |
| activation of alpha(1D)-AR releases ATP, which induces P2X(7) receptors to increase [Ca(2+)](i) but not to stimulate protein secretion in lacrimal glands | Interaction of alpha1D-adrenergic and P2X(7) receptors in the rat lacrimal gland and the effect on intracellular [Ca2+] and protein secretion.
Dartt DA, Hodges RR., Free PMC Article | 10/1/2011 |
| pressor nerve responses in the pithed rat involve both alpha(1A) and alpha(1D)-adrenoceptor | Vasopressor nerve responses in the pithed rat, previously identified as α2-adrenoceptor mediated, may be α1D-adrenoceptor mediated.
Docherty JR. | 07/30/2011 |
| AT(1)R and alpha1D -adrenoceptor may form heterodimers, and may play a role in preeclampsia. | Angiotensin-II type 1 receptor (AT1R) and alpha-1D adrenoceptor form a heterodimer during pregnancy-induced hypertension.
González-Hernández Mde L, Godínez-Hernández D, Bobadilla-Lugo RA, López-Sánchez P. | 02/26/2011 |
| physical and psychological stressors resulted in a rapid upregulation of alpha(1d) ADR mRNA in the dentate gyrus | Stress rapidly increases alpha 1d adrenergic receptor mRNA in the rat dentate gyrus.
Campeau S, Nyhuis TJ, Kryskow EM, Masini CV, Babb JA, Sasse SK, Greenwood BN, Fleshner M, Day HE., Free PMC Article | 11/27/2010 |
| the expression, cellular localization and coupling to membrane signalling (inositol phosphate accumulation) of alpha(1)-adrenoceptor subtypes in a native tissue | Alpha1-adrenoceptors in the rat cerebral cortex: new insights into the characterization of alpha1L- and alpha1D-adrenoceptors.
Segura V, Flacco N, Oliver E, Barettino D, D'Ocon P, Ivorra MD. | 10/30/2010 |
| Inhibition of Adra1d leads to an increase in myoblast death in conditions that are generally associated with myoblast survival. | C2 skeletal myoblast survival, death, proliferation and differentiation: regulation by Adra1d.
Saini A, Al-Shanti N, Stewart C. | 04/12/2010 |
| There was a functional coexistence of alpha(1A)- and alpha(1D)-adrenoceptors in the renal vasculature of spontaneously hypertensive rats irrespective of the presence of diabetic nephropathy. | Functional subtypes of renal alpha1-adrenoceptor in spontaneously hypertensive rats with streptozotocin-induced experimental diabetic nephropathy.
Khan MA, Sattar MA, Abdullah NA, Abdulla MH, Salman IM, Kazi RN, Swarup KR, Rathore HA, Basri F, Hussain NM, Dewa A, Johns EJ. | 02/8/2010 |
| Irrespective of dietary sodium content, in Wistar-Kyoto rats, alpha(1A)- and alpha(1D)-subtypes are the major alpha(1)-adrenoceptors in renal cortical vasculature. Alpha(1B)-adrenoceptors appear also to be involved in high dietary sodium rats. | Influence of high dietary sodium intake on the functional subtypes of alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats.
Kazi RN, Munavvar AS, Abdullah NA, Khan AH, Johns EJ. | 01/21/2010 |
| influence of adrenergic activity on bladder contractility increases with aging is due to overexpression of the AR1D | Increased alpha1D adrenergic receptor activity and protein expression in the urinary bladder of aged rats.
Dmitrieva N, Zhang G, Nagabukuro H. | 01/21/2010 |
| RT-PCR studies indicated differential distribution of all ADRA1A-related splice variants as well as ADRA1B and ADRA1D mRNAs, in tissues from rhesus and human male reproductive tract. | Cloning, expression and immunolocalization of alpha1-adrenoceptor in different tissues from rhesus monkey and human male reproductive tract.
Patrão MT, Queiróz DB, Grossman G, Petrusz P, Lázari Mde F, Avellar MC. | 01/21/2010 |
| These findings suggest alpha(1A)- and alpha(1D)-adrenoceptors mediated the renal vasoconstrictor responses in spontaneously hypertensive rats (SHR) and RFSHR (hypertension combined with renal failure) | Influence of combined hypertension and renal failure on functional alpha(1)-adrenoceptor subtypes in the rat kidney.
Hye Khan MA, Sattar MA, Abdullah NA, Johns EJ., Free PMC Article | 01/21/2010 |
| Adrenergically induced renal vasoconstriction is mediated predominantly by alpha1A- and alpha1D-adrenoceptors in rats irrespective of underlying diabetes. | Alpha1A- and alpha1D-adrenoceptors are the major functional subtypes of renal alpha1-adrenoceptors in streptozotocin-induced diabetic and normal Sprague-Dawley rats.
Armenia, Sattar MA, Abdullah NA, Khan MA, Johns EJ. | 01/21/2010 |
| Alpha(1)-adrenergic agonists activate the alpha(1D)-AR adrenergic receptors to stimulate protein secretion and the ectodomain shedding of epidermal growth factor (EGF) to transactivate the EGF receptor. | Effects of alpha1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells.
Chen L, Hodges RR, Funaki C, Zoukhri D, Gaivin RJ, Perez DM, Dartt DA., Free PMC Article | 01/21/2010 |
| This study suggests that: (i) alpha(1A) and alpha(1D)-adrenoceptor subtypes mediate vasoconstriction of perfused rat kidney. Ageing significantly decreases alpha1-adrenoceptor-mediated vasoconstriction of rat kidney. | Vascular alpha1-adrenoceptors in isolated perfused rat kidney: influence of ageing.
Awe SO, Adeagbo AS. | 01/21/2010 |
| cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors | Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors.
Hague C, Uberti MA, Chen Z, Hall RA, Minneman KP. | 01/21/2010 |
| three subpopulations of alpha1-adrenoceptor binding sites exist in the rat lung (alpha1A, alpha1B and alpha1D) | Identification of all alpha1-adrenoceptor subtypes in rat lung.
Nováková M, Myslivecek J. | 01/21/2010 |