| Pax2 overexpression by kidney tubule cells alters the expression of complement system proteins to induce epithelial-mesenchymal transition. | Screening of genes involved in epithelial-mesenchymal transition and differential expression of complement-related genes induced by PAX2 in renal tubules.
Wang XL, Hou L, Zhao CG, Tang Y, Zhang B, Zhao JY, Wu YB., Free PMC Article | 06/1/2019 |
| PAX2 directly increased expression of ADAM10, the presence of which contributed to EMT in renal tubular epithelia and hence plays an important role in renal fibrosis. | PAX2 may induce ADAM10 expression in renal tubular epithelial cells and contribute to epithelial-to-mesenchymal transition.
Hou L, Du Y, Zhao C, Wu Y., Free PMC Article | 12/22/2018 |
| Persistent Pax2 expression may be required to maintain a GABAergic phenotype. | Pax2 is persistently expressed by GABAergic neurons throughout the adult rat dorsal horn.
Larsson M. | 11/18/2017 |
| Activin A regulates tubular cell growth and differentiation by modulating the expression of Pax-2 during regeneration. | Involvement of Pax-2 in the action of activin A on tubular cell regeneration.
Maeshima A, Maeshima K, Nojima Y, Kojima I. | 11/12/2015 |
| Those findings suggest that mature TECs can trans-differentiate into progenitor-like cells by "atavistic transition", which may participate in the recovery of tissue structure and Pax2 may play a pivotal role in this process. | Cell atavistic transition: Paired box 2 re-expression occurs in mature tubular epithelial cells during acute kidney injury and is regulated by Angiotensin II.
Jiang Y, Jiang T, Ouyang J, Zhou Q, Liang Y, Cui Y, Chen P, Huang B., Free PMC Article | 06/20/2015 |
| There might be a potential signaling pathway between PAX2 and CD2AP in RIF disease. Further research is needed to determine the association in RIF disease. | The potential signal pathway between PAX2 and CD2AP in the renal interstitial fibrosis disease.
Xu HL, Ou C, Rong L, Zhou TB. | 04/4/2015 |
| PAX2 induces renal tubular mesenchymal transition in vitro. | Paired box 2 induces epithelial-mesenchymal transition in normal renal tubular epithelial cells of rats.
Li L, Wu Y, Yang Y. | 11/16/2013 |
| ATRA increases the number of glomerular epithelial transition cells in experimental proteinuric glomerular diseases. Thus, ATRA may provide a useful pharmacologic approach to decipher the | Retinoids augment the expression of podocyte proteins by glomerular parietal epithelial cells in experimental glomerular disease.
Zhang J, Pippin JW, Vaughan MR, Krofft RD, Taniguchi Y, Romagnani P, Nelson PJ, Liu ZH, Shankland SJ., Free PMC Article | 07/13/2013 |
| The re-expression of WT1 and Pax2 in the tubular epithelial cells plays important roles in the promotion of epithelial-mesenchymal transition. | WT1 and Pax2 re-expression is required for epithelial-mesenchymal transition in 5/6 nephrectomized rats and cultured kidney tubular epithelial cells.
Huang B, Pi L, Chen C, Yuan F, Zhou Q, Teng J, Jiang T. | 09/29/2012 |
| In rats with obstructive nephropathy, embryonic development gene PAX2 is re-expressed in the renal tubules, which may participate in the pathogenesis of renal tubular damage and renal interstitial fibrosis. | PAX2 re-expression in renal tubular epithelial cells and correlation with renal interstitial fibrosis of rats with obstructive nephropathy.
Li L, Wu Y, Zhang W. | 09/13/2010 |
| Ang II stimulates Pax-2 gene expression in proximal tubule cells via AT2R and the JAK2/signal transducers and activators of transcription (STAT) signaling transduction pathway | Angiotensin II stimulates Pax-2 in rat kidney proximal tubular cells: impact on proliferation and apoptosis.
Zhang SL, Guo J, Moini B, Ingelfinger JR. | 01/21/2010 |