| Determining Structural Changes for Ligand Recognition between Human and Rat Phosphorylated BACE1 in Silico and Its Phosphorylation by GSK3beta at Thr252 by in Vitro Studies. | Determining Structural Changes for Ligand Recognition between Human and Rat Phosphorylated BACE1 in Silico and Its Phosphorylation by GSK3β at Thr252 by in Vitro Studies.
Velazquez Toledano J, Bello M, Correa Basurto J, Guerrero González I, Pacheco-Yépez J, Rosales Hernández MC. | 02/13/2024 |
| miR-29c-3p Attenuates beta-Amyloid-Induced Neurotoxicity in Alzheimer's Disease Through Regulating beta-Site Amyloid Precursor Protein-Cleaving Enzyme 1. | miR-29c-3p Attenuates beta-Amyloid-Induced Neurotoxicity in Alzheimer's Disease Through Regulating beta-Site Amyloid Precursor Protein-Cleaving Enzyme 1.
Wang X, Li M, Hu Y., Free PMC Article | 01/27/2024 |
| MicroRNA-132-3p alleviates neuron apoptosis and impairments of learning and memory abilities in Alzheimer's disease by downregulation of HNRNPU stabilized BACE1. | MicroRNA-132-3p alleviates neuron apoptosis and impairments of learning and memory abilities in Alzheimer's disease by downregulation of HNRNPU stabilized BACE1.
Qu J, Xiong X, Hujie G, Ren J, Yan L, Ma L., Free PMC Article | 07/9/2022 |
| Effect of Global Brain Ischemia on Amyloid Precursor Protein Metabolism and Expression of Amyloid-Degrading Enzymes in Rat Cortex: Role in Pathogenesis of Alzheimer's Disease. | Effect of Global Brain Ischemia on Amyloid Precursor Protein Metabolism and Expression of Amyloid-Degrading Enzymes in Rat Cortex: Role in Pathogenesis of Alzheimer's Disease.
Babusikova E, Dobrota D, Turner AJ, Nalivaeva NN. | 07/17/2021 |
| Downregulation of lncRNA BACE1-AS improves dopamine-dependent oxidative stress in rats with Parkinson's disease by upregulating microRNA-34b-5p and downregulating BACE1. | Downregulation of lncRNA BACE1-AS improves dopamine-dependent oxidative stress in rats with Parkinson's disease by upregulating microRNA-34b-5p and downregulating BACE1.
Li Y, Fang J, Zhou Z, Zhou Q, Sun S, Jin Z, Xi Z, Wei J., Free PMC Article | 07/17/2021 |
| Effect of memantine on expression of Bace1-as and Bace1 genes in STZ-induced Alzheimeric rats. | Effect of memantine on expression of Bace1-as and Bace1 genes in STZ-induced Alzheimeric rats.
Azadfar P, Noormohammadi Z, Noroozian M, Eidi A, Mortazavi P. | 06/26/2021 |
| Nogo66 promotes betaamyloid protein secretion via NgR/ROCKdependent BACE1 activation. | Nogo‑66 promotes β‑amyloid protein secretion via NgR/ROCK‑dependent BACE1 activation.
Xie QQ, Feng X, Huang YΥ, Fang N, Yi H, Wang ZJ, Cao QΥ, Lou GF, Pan JP, Hu Y, Li FC, Zheng Q, Xiao F., Free PMC Article | 05/8/2021 |
| that NEAT1 worked as a regulating factor to promote the development of AD via modulating miR-124/BACE1 axis | The long-non-coding RNA NEAT1 is a novel target for Alzheimer's disease progression via miR-124/BACE1 axis.
Zhao MY, Wang GQ, Wang NN, Yu QY, Liu RL, Shi WQ. | 07/13/2019 |
| Study utilizing glutamate excitotoxicity model in rat cortical primary cell cultures suggests for the first time a more direct action of BACE1 on the hyperphosphorylation state of tau (implemented in Alzheimer's disease pathogenesis) that is mediated through cPLA2 and desaturases SCD1 and FADS6 modulation during glutamate excitotoxicity. | cPLA2 and desaturases underlie the tau hyperphosphorylation offset induced by BACE knock-down in neuronal primary cultures.
Villamil-Ortiz JG, Cardona-Gómez GP. | 12/22/2018 |
| Beta-site APP cleaving enzyme 1 knockout (Bace1-/-) mice and rats differed in body weight, spontaneous locomotor activity, and prepulse inhibition of startle. | BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats.
Weber M, Wu T, Meilandt WJ, Dominguez SL, Solanoy HO, Maloney JA, Ngu H, Baca M, Kung C, Lima L, Earr TK, Fleck D, Shields SD, Forrest WF, Foreman O, Warming S, Watts RJ, Scearce-Levie K., Free PMC Article | 12/1/2018 |
| miR-9 plays an important role in regulating the process of dementia induced by occlusion of the bilateral common carotid artery in rats by increasing BACE1 expression via downregulation of CREB. | MiR-9 Regulates the Expression of BACE1 in Dementia Induced by Chronic Brain Hypoperfusion in Rats.
Xie H, Zhao Y, Zhou Y, Liu L, Liu Y, Wang D, Zhang S, Yang M. | 11/11/2017 |
| beta-site APP cleaving enzyme 1 (BACE1) is essential for amyloid beta protein production. We discovered that A673V mutation shifted the BACE1 cleavage site from the Glu(11) to the Asp(1) site, resulting in much higher C99 level and C99/C89 ratio. | BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis.
Zhang S, Wang Z, Cai F, Zhang M, Wu Y, Zhang J, Song W., Free PMC Article | 08/19/2017 |
| as an endogenous regulator of BACE1 protein, miR-124 may play a role in Alzheimer's disease onset induced by Chronic cerebral hypoperfusion. | miR-124 Regulates the Expression of BACE1 in the Hippocampus Under Chronic Cerebral Hypoperfusion.
Zhang X, Huang X, Fang C, Li Q, Cui J, Sun J, Li L. | 07/1/2017 |
| data indicate that Egr-1 promotes Abeta synthesis via transcriptional activation of BACE-1 and suggest that Egr-1 plays role in activation of BACE-1 and acceleration of Abeta synthesis in AD brain. | Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain.
Qin X, Wang Y, Paudel HK., Free PMC Article | 05/27/2017 |
| This study demonstrated that the downregulation of BACE1 in Rat Medial Temporal Lobe Cortex Following Transient Global Brain ischemia. | Discrepancy in Expression of β-Secretase and Amyloid-β Protein Precursor in Alzheimer-Related Genes in the Rat Medial Temporal Lobe Cortex Following Transient Global Brain Ischemia.
Pluta R, Kocki J, Ułamek-Kozioł M, Petniak A, Gil-Kulik P, Januszewski S, Bogucki J, Jabłoński M, Brzozowska J, Furmaga-Jabłońska W, Bogucka-Kocka A, Czuczwar SJ. | 12/31/2016 |
| Lipid alterations induced by oxygen and glucose deprivation enhance beta-secretase 1 activity. | Ischemic conditions and ß-secretase activation: The impact of membrane cholesterol enrichment as triggering factor in rat brain endothelial cells.
Brambillaa A, Lonati E, Milani C, Rizzo AM, Farina F, Botto L, Masserini M, Palestini P, Bulbarelli A. | 09/24/2016 |
| Abeta oligomers induce BACE1 elevation via a post-translational mechanism involving its altered subcellular distribution in neurons. | Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons.
Mamada N, Tanokashira D, Hosaka A, Kametani F, Tamaoka A, Araki W., Free PMC Article | 07/16/2016 |
| Quantitative reverse-transcriptase PCR assay demonstrated that the expression of APP, beta- and gamma-secretase, and PSEN1 that contribute to Abeta peptide generation was dysregulated during 30 days in postischemic hippocampal CA1 area | Dysregulation of Amyloid-β Protein Precursor, β-Secretase, Presenilin 1 and 2 Genes in the Rat Selectively Vulnerable CA1 Subfield of Hippocampus Following Transient Global Brain Ischemia.
Kocki J, Ułamek-Kozioł M, Bogucka-Kocka A, Januszewski S, Jabłoński M, Gil-Kulik P, Brzozowska J, Petniak A, Furmaga-Jabłońska W, Bogucki J, Czuczwar SJ, Pluta R., Free PMC Article | 07/16/2016 |
| CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of BACE1. | CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase.
Singh AK, Pati U., Free PMC Article | 04/9/2016 |
| Although Jag1 shares a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1. | β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.
He W, Hu J, Xia Y, Yan R., Free PMC Article | 02/14/2015 |
| It is suggested that increased corticosterone levels associated to stress lead to increase BACE transcription both through epigenetic mechanisms and activation of JNK. | Mechanisms involved in BACE upregulation associated to stress.
Martisova E, Solas M, Gerenu G, Milagro FI, Campion J, Ramirez MJ. | 08/31/2013 |
| KCNE1 and KCNE2, auxiliary subunits of voltage-gated potassium channels, undergo sequential cleavage mediated by either alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 and PS/gamma-secretase in cells. | BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.
Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM, Kim DY., Free PMC Article | 08/3/2013 |
| the levels of BACE1 were increased in the cortex and hippocampus of congestive heart failure rats | BACE1 levels are elevated in congestive heart failure.
Nural-Guvener HF, Mutlu N, Gaballa MA. | 06/1/2013 |
| Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces beta-secretase (BACE1) levels and Abeta generation. | Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces β-secretase (BACE1) levels and Aβ generation.
Ding Y, Ko MH, Pehar M, Kotch F, Peters NR, Luo Y, Salamat SM, Puglielli L., Free PMC Article | 05/5/2012 |
| It is upregulated by AGEs/RAGE complex via NF-kappaB pathway activation. | AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation.
Guglielmotto M, Aragno M, Tamagno E, Vercellinatto I, Visentin S, Medana C, Catalano MG, Smith MA, Perry G, Danni O, Boccuzzi G, Tabaton M. | 03/17/2012 |