| Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity. | Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity.
Lin YH, Schmidt W, Fritz KS, Jeong MY, Cammarato A, Foster DB, Biesiadecki BJ, McKinsey TA, Woulfe KC., Free PMC Article | 01/23/2021 |
| regular aerobic exercise appeared to have antioxidant effects in the muscle that reduced TNNI1 slow carbonylation and promoted Ca(2+) /calmodulin-dependent protein kinase IIalpha and TNNI1 expression for skeletal muscle contraction regulation | Regular aerobic exercise-ameliorated troponin I carbonylation to mitigate aged rat soleus muscle functional recession.
Liu W, Kuang H, Xia Y, Pope ZC, Wang Z, Tang C, Yin D. | 07/25/2020 |
| Troponin I interaction with calcium and Troponin C in cardiac muscle | The concerted movement of the switch region of Troponin I in cardiac muscle thin filaments as tracked by conventional and pulsed (DEER) EPR.
Potluri PR, Chamoun J, Cooke JA, Badr M, Guse JA, Rayes R, Cordina NM, McCamey D, Fajer PG, Brown LJ. | 04/7/2018 |
| these results suggest that cTnI(R146G) and cTnI(R21C) blunt PKA modulation of activation and relaxation kinetics by prohibiting cardiac-specific N-terminal interaction with the cTnI inhibitory peptide. | Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation.
Cheng Y, Rao V, Tu AY, Lindert S, Wang D, Oxenford L, McCulloch AD, McCammon JA, Regnier M., Free PMC Article | 03/12/2016 |
| These findings suggest that altered TnI function, due to changes in the distribution of phosphorylated sites, is an early contributor to reduced contractility of the heart. | Reduced force production during low blood flow to the heart correlates with altered troponin I phosphorylation.
Christopher B, Pizarro GO, Nicholson B, Yuen S, Hoit BD, Ogut O., Free PMC Article | 01/21/2010 |
| observed higher relative level of natural antisense RNA in neonatal cardiac fibroblasts compared to neonatal cardiomyocytes, pointing to a cell type-specific expression of sense and antisense RNA | Cell type-specific expression of endogenous cardiac Troponin I antisense RNA in the neonatal rat heart.
Voigtsberger S, Bartsch H, Baumann G, Luther HP. | 01/21/2010 |
| The negative inotropic effect of HIV gp120 is mediated by a novel signaling pathway that begins with binding to a cardiac myocyte CXCR4 receptor, followed by phosphorylation of both p38 MAP kinase and Troponin I. | CXCR4 receptor antagonist blocks cardiac myocyte p38 MAP kinase phosphorylation by HIV gp120.
Yuan Y, Kan H, Fang Q, Chen F, Finkel MS. | 01/21/2010 |
| Study identifies tyrosine phosphorylation as a novel protein kinase Cdelta (PKCdelta) activation mechanism that modifies PKCdelta-dependent phosphorylation of cardiac troponin I. | Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I.
Sumandea MP, Rybin VO, Hinken AC, Wang C, Kobayashi T, Harleton E, Sievert G, Balke CW, Feinmark SJ, Solaro RJ, Steinberg SF., Free PMC Article | 01/21/2010 |
| This study highlights cellular contractile defects by cardiomyopathy mutant cTnIs that are allele and species dependent. | Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin I mutants.
Davis J, Wen H, Edwards T, Metzger JM., Free PMC Article | 01/21/2010 |
| The goal here was to identify domain clusters and residues that confer troponin I isoform-specific myofilament Ca2+ and pH sensitivities of contraction. | Single amino acid substitutions define isoform-specific effects of troponin I on myofilament Ca2+ and pH sensitivity.
Westfall MV, Metzger JM., Free PMC Article | 01/21/2010 |
| troponin I phosphorylation has a role in protein kinase C-mediated enhanced contractile performance of myocytes | Role of troponin I phosphorylation in protein kinase C-mediated enhanced contractile performance of rat myocytes.
Westfall MV, Borton AR. | 01/21/2010 |
| A novel role is described for cardiac TnI PKA phosphorylation in the rate-dependent enhancement of systolic & diastolic function in vivo & afterload sensitivity of relaxation. This has implications for cardiac failure. | Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites.
Takimoto E, Soergel DG, Janssen PM, Stull LB, Kass DA, Murphy AM. | 01/21/2010 |
| MuRF1 functions as a ubiquitin ligase to catalyze ubiquitylation of troponin I through a RING finger-dependent mechanism | Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I.
Kedar V, McDonough H, Arya R, Li HH, Rockman HA, Patterson C., Free PMC Article | 01/21/2010 |
| TnI-isoform and titin-isoform switching and corresponding functional changes during heart development are not initiated by birth but are genetically programmed | Developmental changes in passive stiffness and myofilament Ca2+ sensitivity due to titin and troponin-I isoform switching are not critically triggered by birth.
Krüger M, Kohl T, Linke WA. | 01/21/2010 |