| Roles of Neuronal Protein Kinase Cepsilon on Endoplasmic Reticulum Stress and Autophagic Formation in Diabetic Neuropathy. | Roles of Neuronal Protein Kinase Cε on Endoplasmic Reticulum Stress and Autophagic Formation in Diabetic Neuropathy.
Kan YY, Chang YS, Liao WC, Chao TN, Hsieh YL., Free PMC Article | 05/7/2024 |
| PKCepsilon controls the fusion of secretory vesicles in mast cells in a phosphatidic acid-dependent mode. | PKCε controls the fusion of secretory vesicles in mast cells in a phosphatidic acid-dependent mode.
Serrano-López EM, López-Martínez D, Gómez-Fernández JC, Egea-Jiménez AL, Corbalán-García S. | 08/21/2021 |
| Ischemic Neuroprotectant PKCepsilon Restores Mitochondrial Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle after Ischemic Injury. | Ischemic Neuroprotectant PKCε Restores Mitochondrial Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle after Ischemic Injury.
Xu J, Khoury N, Jackson CW, Escobar I, Stegelmann SD, Dave KR, Perez-Pinzon MA., Free PMC Article | 07/31/2021 |
| Activated Protein Kinase C (PKC) Is Persistently Trafficked with Epidermal Growth Factor (EGF) Receptor. | Activated Protein Kinase C (PKC) Is Persistently Trafficked with Epidermal Growth Factor (EGF) Receptor.
Heckman CA, Biswas T, Dimick DM, Cayer ML., Free PMC Article | 06/19/2021 |
| PKCepsilon associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner. | PKCε associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner.
Zemel BM, Zhi L, Brown EV, Tymanskyj SR, Liang Q, Covarrubias M. | 06/19/2021 |
| Conjugated linoleic acid isomers impair insulin-induced Akt phosphorylation through activation of Pkce. | Isomers of conjugated linoleic acid induce insulin resistance through a mechanism involving activation of protein kinase Cε in liver cells.
Roura-Guiberna A, Hernandez-Aranda J, Ramirez-Flores CJ, Mondragon-Flores R, Garibay-Nieto N, Queipo-Garcia G, Laresgoiti-Servitje E, Soh JW, Olivares-Reyes JA. | 02/29/2020 |
| nPKCepsilon isoform is essential to positively regulate SNAP-25 phosphorylation on Ser-187. | nPKCε Mediates SNAP-25 Phosphorylation of Ser-187 in Basal Conditions and After Synaptic Activity at the Neuromuscular Junction.
Simó A, Cilleros-Mañé V, Just-Borràs L, Hurtado E, Nadal L, Tomàs M, Garcia N, Lanuza MA, Tomàs J. | 12/14/2019 |
| Serine 302 in cardiac myosin binding protein-C was identified as a PKCepsilon substrate that when phosphorylated contributed to the suppression of contraction and Ca(2+) transients by PKCepsilon following ET-1 stimulation. | Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes.
Smyrnias I, Goodwin N, Wachten D, Skogestad J, Aronsen JM, Robinson EL, Demydenko K, Segonds-Pichon A, Oxley D, Sadayappan S, Sipido K, Bootman MD, Roderick HL. | 06/22/2019 |
| profilin binds to activated PKCepsilon and facilitates PKCepsilon activation by accelerating ATP supply to PKCepsilon. | Profilin facilitates PKCε activation by accelerating ATP supply.
Nishizaki T. | 05/18/2019 |
| The present results suggested that the different cardiac hemodynamic overload could differentially activate a common signaling, PKCepsilon intermediate and thereby generate biological diversity. | Responses of PKCε to cardiac overloads on myocardial sympathetic innervation and NET expression.
Hu B, Zhang J, Wang J, He B, Wang D, Zhang W, Zhou X, Li H. | 10/6/2018 |
| Results suggest that PKCvarepsilon is required to generate Ca(2+) oscillations following mGluR5 activation, which support the regulation of astrocytic glutamate uptake. Reduced expression of astrocytic PKCvarepsilon could impair this neuroprotective process and participate in the progression of amyotrophic lateral sclerosis (ALS). | Constitutive downregulation protein kinase C epsilon in hSOD1(G93A) astrocytes influences mGluR5 signaling and the regulation of glutamate uptake.
Vergouts M, Doyen PJ, Peeters M, Opsomer R, Hermans E. | 09/1/2018 |
| Data suggest that ischemic preconditioning (IPC)-induced cardioprotection involves increased nitric oxide (NO)production, protein kinase C epsilon (PKC-epsilon) translocation, connexin43 (Cx43) phosphorylation, and chemical gap junction (GJ) uncoupling. | Nitric oxide, PKC-ε, and connexin43 are crucial for ischemic preconditioning-induced chemical gap junction uncoupling.
Rong B, Xie F, Sun T, Hao L, Lin MJ, Zhong JQ., Free PMC Article | 02/24/2018 |
| In hippocampal cultured slices, PKC epsilon activation decreased AMPAR current amplitudes in an arc- and GluR2-dependent manner. | Protein kinase C epsilon delays latency until anoxic depolarization through arc expression and GluR2 internalization.
Cohan CH, Stradecki-Cohan HM, Morris-Blanco KC, Khoury N, Koronowski KB, Youbi M, Wright CB, Perez-Pinzon MA., Free PMC Article | 12/23/2017 |
| adenosine-induced translocation of PKCepsilon to mitochondria is mediated by a caveolin-3-dependent mechanism and this process is age-related, possibly in part, through regulation of HSP90 and TOM70 expression | Regulation of protein kinase C-epsilon and its age-dependence.
Kang C, Qin J, Osei W, Hu K. | 06/10/2017 |
| PKCepsilon is a direct target of miR-101b. | MicroRNA-101b attenuates cardiomyocyte hypertrophy by inhibiting protein kinase C epsilon signaling.
Lee JS, Yang DK, Park JH, Kim JO, Park WJ, Cho C, Kim DH. | 05/27/2017 |
| These results indicate that PKC promotes synaptogenesis by activating PSD-95 phosphorylation directly through JNK1 and calcium/calmodulin-dependent kinase II and also by inducing expression of PSD-95 and synaptophysin. | Protein Kinase Cϵ (PKCϵ) Promotes Synaptogenesis through Membrane Accumulation of the Postsynaptic Density Protein PSD-95.
Sen A, Hongpaisan J, Wang D, Nelson TJ, Alkon DL., Free PMC Article | 05/6/2017 |
| Therefore, the results of the present study suggest that U83836E has a potent protective effect against MIRI in rat models through the direct antioxidative stress mechanisms and the activation of PKC signaling. | Lazaroid U83836E protects the heart against ischemia reperfusion injury via inhibition of oxidative stress and activation of PKC.
Lai LN, Zhang XJ, Zhang XY, Song LH, Guo CH, Lei JW, Song XL. | 02/18/2017 |
| after inflammation, an Epac-PKC dependent increase in F-actin in dorsal root ganglion neurons enhances the membrane expression of P2X3Rs to bring about sensitization of P2X3Rs and abnormal pain behaviors. | EXPRESS: F-actin links Epac-PKC signaling to purinergic P2X3 receptors sensitization in dorsal root ganglia following inflammation.
Gu Y, Wang C, Li G, Huang LY., Free PMC Article | 12/31/2016 |
| Hypoxic preconditioning promotes the translocation of protein kinase C epsilon binding with caveolin-3 at cell membrane, not at mitochondrial one, in rat heart. | Hypoxic preconditioning promotes the translocation of protein kinase C ε binding with caveolin-3 at cell membrane not mitochondrial in rat heart.
Yu H, Yang Z, Pan S, Yang Y, Tian J, Wang L, Sun W., Free PMC Article | 09/17/2016 |
| Data indicate that the beneficial effects of pre- (IP) and postconditioning (IPC) were annulled when protein kinase C (PKC) was inhibited with Che. | Cyclosporine-A mimicked the ischemic pre- and postconditioning-mediated cardioprotection in hypertensive rats: Role of PKCε.
González Arbeláez LF, Ciocci Pardo A, Fantinelli JC, Mosca SM. | 09/10/2016 |
| with strain there was significant PKCepsilon translocation to the Z-disc and co-localization with CapZbeta1 or alpha-actinin, which was quantified on confocal images. | Cyclic mechanical strain of myocytes modifies CapZβ1 post translationally via PKCε.
Lin YH, Swanson ER, Li J, Mkrtschjan MA, Russell B., Free PMC Article | 09/10/2016 |
| these results point to the importance of nPKCepsilon isoform in the control of acetylcholine release in the neuromuscular junction. | The novel protein kinase C epsilon isoform modulates acetylcholine release in the rat neuromuscular junction.
Obis T, Hurtado E, Nadal L, Tomàs M, Priego M, Simon A, Garcia N, Santafe MM, Lanuza MA, Tomàs J., Free PMC Article | 07/16/2016 |
| The experiments suggest that in the SHR but not the WKY aorta, alpha1 -adrenoceptor activation desensitizes TP receptors through activation of PKC-epsilon. | α1 -Adrenoceptor activation of PKC-ε causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats.
Zhao Y, Vanhoutte PM, Leung SW., Free PMC Article | 05/21/2016 |
| The results also demonstrate that synaptic activity-induced muscle contraction promotes changes in presynaptic nPKCepsilon through the brain-derived neurotrophic factor (BDNF)-mediated tyrosine kinase receptor B (TrkB) signaling. | The novel protein kinase C epsilon isoform at the adult neuromuscular synapse: location, regulation by synaptic activity-dependent muscle contraction through TrkB signaling and coupling to ACh release.
Obis T, Besalduch N, Hurtado E, Nadal L, Santafe MM, Garcia N, Tomàs M, Priego M, Lanuza MA, Tomàs J., Free PMC Article | 01/23/2016 |
| Results suggest a sexually dimorphic response of lactotroph cells to the proliferative effects of EGF, with the PKCepsilon/ERK1/2 Pit-1 pathway being involved in this action. | Epidermal growth factor induces a sexually dimorphic proliferative response of lactotroph cells through protein kinase C-ERK1/2-Pit-1 in vitro.
De Paul AL, Gutiérrez S, Sabatino ME, Mukdsi JH, Palmeri CM, Soaje M, Petiti JP, Torres AI. | 11/7/2015 |