| identified cofilin rod, a pathological rod-like aggregation, formed in neurons of in vivo ischemic stroke animal model and induced neuronal impairment. | Brain ischemic insult induces cofilin rod formation leading to synaptic dysfunction in neurons.
Shu L, Chen B, Chen B, Xu H, Wang G, Huang Y, Zhao Y, Gong H, Jiang M, Chen L, Liu X, Wang Y., Free PMC Article | 06/20/2020 |
| Global inhibition of neddylation in developing neurons leads to cytoskeletal defects, altered actin dynamics and neurite growth impairments, whereas site-specific neddylation of cofilin 1 at K112 regulates neurite outgrowth, suggesting that cofilin 1 neddylation contributes to the regulation of neuronal actin organization. | Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics.
Vogl AM, Phu L, Becerra R, Giusti SA, Verschueren E, Hinkle TB, Bordenave MD, Adrian M, Heidersbach A, Yankilevich P, Stefani FD, Wurst W, Hoogenraad CC, Kirkpatrick DS, Refojo D, Sheng M. | 04/25/2020 |
| Actin depolymerizing factor (ADF)/cofilin controls actin turnover to sustain axon regeneration after spinal cord injury through its actin-severing activity. This pinpoints ADF/cofilin as a key regulator of axon growth competence, irrespective of developmental stage. | ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS.
Tedeschi A, Dupraz S, Curcio M, Laskowski CJ, Schaffran B, Flynn KC, Santos TE, Stern S, Hilton BJ, Larson MJE, Gurniak CB, Witke W, Bradke F., Free PMC Article | 03/28/2020 |
| CMIP inhibits cofilin1 activity and alters podocyte cytoskeleton organization at least through RhoA signaling in PAinduced podocyte injury | c‑Maf inducing protein inhibits cofilin‑1 activity and alters podocyte cytoskeleton organization.
Yu L, Ye J, Liu Q, Feng J, Gu X, Sun Q, Lu G. | 05/26/2018 |
| cofilin1 is involved in hypertensive nephropathy by modulating the nuclear translocation of NF-kappaB and the expression of its downstream inflammatory factors in renal tubular epithelial cells | Cofilin1 is involved in hypertension-induced renal damage via the regulation of NF-κB in renal tubular epithelial cells.
Wang QZ, Gao HQ, Liang Y, Zhang J, Wang J, Qiu J., Free PMC Article | 07/30/2016 |
| Cofilin1 regulates neocortical functional plasticity through the remodeling of dendritic spines within circuits that connect columns. | Cofilin1 controls transcolumnar plasticity in dendritic spines in adult barrel cortex.
Tsubota T, Okubo-Suzuki R, Ohashi Y, Tamura K, Ogata K, Yaguchi M, Matsuyama M, Inokuchi K, Miyashita Y., Free PMC Article | 01/16/2016 |
| Data indicate that RNAi-mediated silencing of cofilin induces dendritic spine shrinkage. | Activity-dependent dendritic spine shrinkage and growth involve downregulation of cofilin via distinct mechanisms.
Calabrese B, Saffin JM, Halpain S., Free PMC Article | 02/14/2015 |
| Prevention of the hypertrophic response to adenosine receptor agonists by adenosine receptor activation is mediated by prevention of RhoA stimulation and actin polymerization. | Prevention of RhoA activation and cofilin-mediated actin polymerization mediates the antihypertrophic effect of adenosine receptor agonists in angiotensin II- and endothelin-1-treated cardiomyocytes.
Zeidan A, Gan XT, Thomas A, Karmazyn M. | 07/5/2014 |
| Although ADF and cofilin-1 have many redundant functions, each of these proteins has functional differences that affect F-actin structures, cell adhesion and lamellipodial dynamics, all of which are important determinants of cell migration. | Non-overlapping activities of ADF and cofilin-1 during the migration of metastatic breast tumor cells.
Tahtamouni LH, Shaw AE, Hasan MH, Yasin SR, Bamburg JR., Free PMC Article | 06/21/2014 |
| For the first time, the dynamic cofilin rod formation pattern is demonstrated in detail under stress stimulation by time lapse imaging in cultured neurons. | Both NMDA and non-NMDA receptors mediate glutamate stimulation induced cofilin rod formation in cultured hippocampal neurons.
Chen B, Jiang M, Zhou M, Chen L, Liu X, Wang X, Wang Y. | 08/31/2013 |
| Active cofilin (unphosphorylated form) and inactive cofilin (phosphorylated form) are colocalized at the sexually dimorphic nucleus in the preoptic area, suggesting that actin dynamics occurs in the area. | Estrogen-induced cell signaling in the sexually dimorphic nucleus of the rat preoptic area: potential involvement of cofilin in actin dynamics for cell migration.
Wada-Kiyama Y, Suzuki C, Hamada T, Rai D, Kiyama R, Kaneda M, Sakuma Y. | 06/29/2013 |
| Data indicate that PKCalpha phosphorylates cofilin at Ser-23 and/or Ser-24 during degranulation. | Novel PKCα-mediated phosphorylation site(s) on cofilin and their potential role in terminating histamine release.
Sakuma M, Shirai Y, Yoshino K, Kuramasu M, Nakamura T, Yanagita T, Mizuno K, Hide I, Nakata Y, Saito N., Free PMC Article | 03/9/2013 |
| This study identifies cofilin1 and its upstream regulators, LIMK and SSH1, as end targets of a NRG1 signaling pathway | The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for Schwann cell myelination.
Sparrow N, Manetti ME, Bott M, Fabianac T, Petrilli A, Bates ML, Bunge MB, Lambert S, Fernandez-Valle C., Free PMC Article | 06/16/2012 |
| PGE(2)-dependent activation of cofilin-1 was mediated by the protein phosphatase activity of PTEN, with which it directly associated | PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi.
Serezani CH, Kane S, Medeiros AI, Cornett AM, Kim SH, Marques MM, Lee SP, Lewis C, Bourdonnay E, Ballinger MN, White ES, Peters-Golden M., Free PMC Article | 06/9/2012 |
| Cofilin-mediated Bax translocation is a key event in excitotoxic neuronal death as knock down of cofilin has a marked neuroprotective effect on NMDA-mediated neuronal death. | Cofilin activation mediates Bax translocation to mitochondria during excitotoxic neuronal death.
Posadas I, Pérez-Martínez FC, Guerra J, Sánchez-Verdú P, Ceña V. | 03/10/2012 |
| Linkage of estrogen communication to cofilin via LIM kinase provides functionality to age-sensitive pLIMK immunoreactivity that has been observed in vivo. | LIM kinase mediates estrogen action on the actin depolymerization factor Cofilin.
Yuen GS, McEwen BS, Akama KT., Free PMC Article | 01/21/2012 |
| It is not yet clear how citron-K signals to cofilin, though it may involve signaling through ROCK, LIM kinase or by directly modulating cofilin. | Citron kinase regulates axon growth through a pathway that converges on cofilin downstream of RhoA.
Ahmed Z, Douglas MR, Read ML, Berry M, Logan A. | 11/26/2011 |
| Leukotrienes target F-actin/cofilin-1 to enhance alveolar macrophage anti-fungal activity. | Leukotrienes target F-actin/cofilin-1 to enhance alveolar macrophage anti-fungal activity.
Morato-Marques M, Campos MR, Kane S, Rangel AP, Lewis C, Ballinger MN, Kim SH, Peters-Golden M, Jancar S, Serezani CH., Free PMC Article | 10/22/2011 |
| RhoC activity is spatially confined to areas surrounding invadopodia; it is controlled by "spatially distinct regulatory elements" that confine RhoC activation within this compartment. RhoC activation enhances cofilin phosphorylation outside invadopodia. | A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia.
Bravo-Cordero JJ, Oser M, Chen X, Eddy R, Hodgson L, Condeelis J., Free PMC Article | 08/27/2011 |
| Slit-2 triggered the activation of cofilin and the inhibition of RhoA, leading to the collapse of the leading front of olfactory ensheathing cells migration. | Slit-2 repels the migration of olfactory ensheathing cells by triggering Ca2+-dependent cofilin activation and RhoA inhibition.
Huang ZH, Wang Y, Su ZD, Geng JG, Chen YZ, Yuan XB, He C., Free PMC Article | 04/23/2011 |
| Arp2/3 and cofilin coordinate a dynamic cycle of actin branching and severing at the cell cortex, essential for insulin-mediated GLUT4 translocation in muscle cells. | Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells.
Chiu TT, Patel N, Shaw AE, Bamburg JR, Klip A., Free PMC Article | 03/19/2011 |
| LHR signaling via PKA activates a cofilin-regulated rearrangement of the actin cytoskeleton and active cofilin is required to initiate progesterone secretion by preovulatory granulosa cells. | Luteinizing hormone receptor-stimulated progesterone production by preovulatory granulosa cells requires protein kinase A-dependent activation/dephosphorylation of the actin dynamizing protein cofilin.
Karlsson AB, Maizels ET, Flynn MP, Jones JC, Shelden EA, Bamburg JR, Hunzicker-Dunn M., Free PMC Article | 01/1/2011 |
| Slingshot plays a pivotal role in AMPA receptor trafficking and synaptic transmission by controlling actin cytoskeleton via cofilin activation | Regulation of AMPA receptor channels and synaptic plasticity by cofilin phosphatase Slingshot in cortical neurons.
Yuen EY, Liu W, Kafri T, van Praag H, Yan Z., Free PMC Article | 10/23/2010 |
| There is a role for cofilin-actin rods in stress-induced disruption of cargo transport and synaptic function within hippocampal neurons. | Mapping cofilin-actin rods in stressed hippocampal slices and the role of cdc42 in amyloid-beta-induced rods.
Davis RC, Maloney MT, Minamide LS, Flynn KC, Stonebraker MA, Bamburg JR., Free PMC Article | 06/14/2010 |
| Coronin 2A and cofilin regulate a subset of focal-adhesion-turnover events. | Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway.
Marshall TW, Aloor HL, Bear JE., Free PMC Article | 01/21/2010 |