| There is an increase of Ucn2 mRNA levels in the adrenal medulla and spleen induced by immobilization stress. | Stressors affect urocortin 1 and urocortin 2 gene expression in rat spleen: The role of glucocorticoids.
Tillinger A, Padová A, Mravec B, Tomova A. | 06/20/2020 |
| Aldosterone and its receptors were expressed on tunica adventitia. Urotensin II promoted ALD protein secretion from cells in a dose and timedependent manner. | Urotensin II promotes aldosterone expression in rat aortic adventitial fibroblasts.
Li J, Zhang YG, Luo LM, Dong X, Ding WH, Dang SY., Free PMC Article | 07/28/2018 |
| These results suggest that urotensin II induces cardiomyocyte hypertrophy through the cAMP-dependent protein kinase A -mediated upregulation of phospholamban phosphorylation at Ser16, which provides a new experimental foundation for the prevention and/or treatment of cardiac hypertrophy. | Role of PKA in the process of neonatal cardiomyocyte hypertrophy induced by urotensin II.
Xu J, Han Q, Shi H, Liu W, Chu T, Li H. | 06/2/2018 |
| IRF3 expression and activation depend on the signal transduction of the the urotensin II/urotensin receptor (UII/UT) system, and play important roles in UII/UT-mediated immune inflammatory injury in the liver | IRF3 is an important molecule in the UII/UT system and mediates immune inflammatory injury in acute liver failure.
Liu LM, Tu WJ, Zhu T, Wang XT, Tan ZL, Zhong H, Gao DY, Liang DY., Free PMC Article | 02/17/2018 |
| This study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation | Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats.
Cadirci E, Halici Z, Yayla M, Toktay E, Bayir Y, Karakus E, Topcu A, Buyuk B, Albayrak A. | 12/2/2017 |
| results suggest that GRK5 may be involved in a UII-mediated hypertrophic response via activation of NF-kappaB and HDAC5 at least in part by ERK1/2 and GSK3alpha/beta-independent pathways. | A novel role of G protein-coupled receptor kinase 5 in urotensin II-stimulated cellular hypertrophy in H9c2(UT) cells.
Park CH, Lee JH, Lee MY, Lee JH, Lee BH, Oh KS. | 02/18/2017 |
| This study investigates the role and mode of action of urotensin II (U II) in the occurrence and progression of cardiac fibrosis in a pressureoverload rat model. | An investigation into the expression and mechanism of action of urotensin II in chronic pressure-overloaded rat hearts.
Liu W, Han Q, Liu Q, Liang G, Wang J, Liu C., Free PMC Article | 08/20/2016 |
| Urotensin II expression was increased significantly in brain from focal cerebral ischemia animals. | Expression of Urotensin II During Focal Cerebral Ischemic in Diabetic Rats.
Tian L, Li Y, Hua W, Jia Y, Zhou M, Gu Y, Qi J. | 07/2/2016 |
| The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-kappaB pathways in LPS-stimulated Kupffer cells. | The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-κB pathways in LPS-stimulated Kupffer cells.
Liu LM, Liang DY, Ye CG, Tu WJ, Zhu T., Free PMC Article | 03/19/2016 |
| MDA-MB-231 displayed a statistically significant higher sigma-2 receptor expression and also was the most sensitive cell line evaluated to SW IV-134 | The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer.
Makvandi M, Tilahun ED, Lieberman BP, Anderson RC, Zeng C, Xu K, Hou C, McDonald ES, Pryma DA, Mach RH., Free PMC Article | 03/19/2016 |
| Study demonstrated that UII and URP binding sites are totally overlapping and that these sites were functional in regions bordering the fourth ventricle; data support a role for UII/URP at the interface between brain parenchyma and cerebrospinal fluid | Concordant localization of functional urotensin II and urotensin II-related peptide binding sites in the rat brain: Atypical occurrence close to the fourth ventricle.
Bucharles C, Bizet P, Arthaud S, Arabo A, Leprince J, Lefranc B, Cartier D, Anouar Y, Lihrmann I. | 02/14/2015 |
| U-II increases cytosolic Ca(2+) concentration in cardiac vagal neurons of nucleus ambiguus via 2 pathways: Ca(2+) release from the ER via INSP3 receptor; and Ca(2+) influx through P/Q-type Ca(2+) channels. | Urotensin II promotes vagal-mediated bradycardia by activating cardiac-projecting parasympathetic neurons of nucleus ambiguus.
Brailoiu GC, Deliu E, Rabinowitz JE, Tilley DG, Koch WJ, Brailoiu E., Free PMC Article | 06/21/2014 |
| Urotensin-II can protect renal tubular cells from apoptosis through PGI2-mediated PPARA and Akt activation. | Urotensin II exerts antiapoptotic effect on NRK-52E cells through prostacyclin-mediated peroxisome proliferator-activated receptor alpha and Akt activation.
Hsu YH, Chen TH, Chen YC, Cheng CY, Sue YM, Chen JR, Chen CH. | 05/3/2014 |
| Hypoxia in cardiomyocytes increases UII and collagen I expression through the induction of AngII, ROS, and the JNK pathway causing cardiomyocyte hypertrophy and fibrosis. | Angiotensin II and the JNK pathway mediate urotensin II expression in response to hypoxia in rat cardiomyocytes.
Chiu CZ, Wang BW, Shyu KG. | 04/5/2014 |
| Urotensin II increased aortic adventitial fibroblast expression of the 5-LO mRNA/protein by NF-kappaB activation through p38 MAPK and ERK pathways. | Urotensin II promotes the production of LTC4 in rat aortic adventitial fibroblasts through NF-κB-5-LO pathway by p38 MAPK and ERK activations.
Dong X, Ye X, Song N, Zhao J, Di B, Peng F, Tang C, Ding W. | 03/8/2014 |
| study suggests that UII could induce collagen synthesis and secretion through upregulation of TGF-beta1 expression and secretion in VSMCs, and that TGF-beta1/Smad2/3 signaling might be one of the important pathways by which UII is involved in vascular fibrosis | Urotensin II-induced collagen synthesis in cultured smooth muscle cells from rat aortic media and a possible involvement of transforming growth factor-β1/Smad2/3 signaling pathway.
Zhao J, Ding W, Song N, Dong X, Di B, Peng F, Tang C. | 09/21/2013 |
| The current study provides new evidence that Urotensin II (UII) is involved in the TGF-beta mediated mitogenic effect on ASMCs. UII, at least partially, uses ERK pathway to render such effect. | Urotensin upregulates transforming growth factor-β1 expression of asthma airway through ERK-dependent pathway.
Zhang WX, Liang YF, Wang XM, Nie Y, Chong L, Lin L, Chen C, Li CC. | 09/22/2012 |
| U-II and URP can differentially modulate nuclear UT functions such as gene expression, and both ligands can reach the internal cellular space through a receptor-independent mechanism | Biochemical and pharmacological characterization of nuclear urotensin-II binding sites in rat heart.
Doan ND, Nguyen TT, Létourneau M, Turcotte K, Fournier A, Chatenet D., Free PMC Article | 08/11/2012 |
| The two hypertrophic peptides urotensin II and urocortin stimulate the expression of myostatin. | Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes.
Gruson D, Ginion A, Lause P, Ketelslegers JM, Thissen JP, Bertrand L. | 06/23/2012 |
| The expression of U II and Uts2R in right ventricle arteries and right ventricle myocytes increases significantly during the formation of pulmonary hypertension and right ventricle hypertrophy in rats chronically exposed to hypoxia-hypercapnia. | [Expression of Urotensin II and its receptor on right ventricle in rats of pulmonary hypertension].
Huang H, Gong YS, Fan XF, Hu LG, Luo JF, Wu XM. | 06/2/2012 |
| Transforming growth factor-beta1 involved in urotensin II-induced phenotypic differentiation of adventitial fibroblasts from rat aorta. | Transforming growth factor-β1 involved in urotensin II-induced phenotypic differentiation of adventitial fibroblasts from rat aorta.
Zhang YG, Hu YC, Mao YY, Wei RH, Bao SL, Wu LB, Kuang ZJ. | 04/28/2012 |
| In diethylnitrosamine-induced precancerous liver lesions, the UII/UT system was up-regulated, which may contribute to the pathogenesis of liver cancer through a PKC- or ERK1/2-dependent pro-mitogenic pathway in an autocrine/paracrine manner. | Elevated expression of urotensin II and its receptor in diethylnitrosamine-mediated precancerous lesions in rat liver.
Wang H, Dong K, Xue X, Feng P, Wang X. | 05/7/2011 |
| UII infusion elevates portal pressure and induces hepatic fibrosis in normal rats. | Urotensin II modulates hepatic fibrosis and portal hemodynamic alterations in rats.
Kemp W, Kompa A, Phrommintikul A, Herath C, Zhiyuan J, Angus P, McLean C, Roberts S, Krum H. | 10/30/2010 |
| In the arcuate and paraventricular nuclei, where expression is high and moderate, U-II produces a pressor/tachycardic response in the former and a weaker response in the latter | A rat brain atlas of urotensin-II receptor expression and a review of central urotensin-II effects.
Hunt BD, Ng LL, Lambert DG. | 09/27/2010 |
| The expression of urotensin 2 is increased in airways of rat asthmatic models and of patients with asthma. | [The role of urotensin II in airway remodeling of asthma].
Cheng DY, Fan LL, Yi XF. | 09/13/2010 |