| Expression of TSP50, SERCA2 and IL-8 in Colorectal Adenoma and Carcinoma: Correlation to Clinicopathological Factors. | Expression of TSP50, SERCA2 and IL-8 in Colorectal Adenoma and Carcinoma: Correlation to Clinicopathological Factors.
Youssef HMK, Radi DA, Abd El-Azeem MA., Free PMC Article | 02/12/2022 |
| TSP50 promotes the Warburg effect and hepatocyte proliferation via regulating PKM2 acetylation. | TSP50 promotes the Warburg effect and hepatocyte proliferation via regulating PKM2 acetylation.
Gao F, Zhang X, Wang S, Zheng L, Sun Y, Wang G, Song Z, Bao Y., Free PMC Article | 10/16/2021 |
| miR-4709-3p Inhibits Cell Proliferation by Downregulating TSP50 Expression in Breast Cancer Cells. | miR-4709-3p Inhibits Cell Proliferation by Downregulating TSP50 Expression in Breast Cancer Cells.
Wang Y, Xu S, Wang S, Song Z, Zheng L, Wang G, Sun Y, Bao Y. | 07/31/2021 |
| TSP50 promotes hepatocyte proliferation and tumour formation by activating glucose-6-phosphate dehydrogenase (G6PD). | TSP50 promotes hepatocyte proliferation and tumour formation by activating glucose-6-phosphate dehydrogenase (G6PD).
Zhang X, Gao F, Ai H, Wang S, Song Z, Zheng L, Wang G, Sun Y, Bao Y., Free PMC Article | 04/17/2021 |
| TSP50 promotes the proliferation, migration and invasion of gastric cancer cells involving NF-kappaB dependent EMT activation. Targeting TSP50 may provide a novel therapeutic strategy for the management of gastric cancer | Testes-specific protease 50 (TSP50) promotes invasion and metastasis by inducing EMT in gastric cancer.
Cao QH, Liu F, Li CZ, Liu N, Shu M, Lin Y, Ding L, Xue L., Free PMC Article | 08/11/2018 |
| human epidermal growth factor receptor 2 (HER-2) levels, were correlated well with TSP50/p-Samd2/3 and TSP50/p27 expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer | Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling.
Song ZB, Wu P, Ni JS, Liu T, Fan C, Bao YL, Wu Y, Sun LG, Yu CL, Huang YX, Li YX. | 11/4/2017 |
| In patients with Colon cancer, the expression of TSP50 gene was associated with a poor prognosis. | [Cancer-testis genes in colon cancer].
Hilal NR, Novikov DV, Novikov VV, Karaulov AV. | 09/2/2017 |
| TSP50 plays a significant role in NSCLC cell proliferation and may act as a novel oncogene in the development and progression of NSCLC. | Lentivirus-mediated knockdown of TSP50 suppresses the growth of non-small cell lung cancer cells via G0/G1 phase arrest.
Qiao WL, Hu HY, Shi BW, Zang LJ, Jin W, Lin Q. | 03/4/2017 |
| Results suggest that 7P3A, which consists of 70 % 25-methoxyl-dammarane-3beta, 12beta, 20-triol and 30 % artemisinin, exhibits anti-cancer effects, in part, through downregulation of testes-specific protease 50 (TSP50) expression. | 25-methoxyl-dammarane-3β, 12β, 20-triol and artemisinin synergistically inhibit MDA-MB-231 cell proliferation through downregulation of testes-specific protease 50 (TSP50) expression.
Wang D, Zhao Y, Wang Y, Rong Y, Qin H, Bao Y, Song Z, Yu C, Sun L, Li Y. | 02/18/2017 |
| Results show that TSP50 is up-regulated in laryngocarcinoma tumour tissues and its down-regulation inhibits cell proliferation, reduces cell migration and induces cell apoptosis of laryngocarcinoma in NF-KB mediated pathway. | Down-regulation of testes-specific protease 50 induces apoptosis in human laryngocarcinoma HEp2 cells in a NF-κB-mediated pathway.
Liu YL, Sun YN. | 01/16/2016 |
| we found that some breast cancer diagnosis-associated features such as tumor size, tumor grade, estrogen receptors (ER) and progesterone receptors (PR) levels, were correlated well with TSP50/p65 and TSP50/MMP9 expression status | Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression.
Song ZB, Ni JS, Wu P, Bao YL, Liu T, Li M, Fan C, Zhang WJ, Sun LG, Huang YX, Li YX., Free PMC Article | 12/5/2015 |
| TSP50's threonine protease activity is crucial for its effects on tumor formation. | TSP50 depends on its threonine protease activity and its interactions with TNF-α-induced NF-κB for its role in human cervical tumorigenesis.
Yuan J, Wu C, Huang M, Zhou J, Ben W, Zhang G. | 10/10/2015 |
| The mutations in the catalytic triad of TSP50 could significantly depressed TSP50-mediated cell proliferation and tumor formation. | The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation.
Song ZB, Liu B, Li YY, Wu P, Bao YL, Huang YX, Wu Y, Sun LG, Yu CL, Sun Y, Zheng LH, Li YX. | 09/5/2015 |
| High TSP50 expression is associated with laryngocarcinoma. | Depression of testes-specific protease 50 (TSP50) inhibits cell proliferation and induces apoptosis in laryngocarcinoma.
Zhang X. | 04/18/2015 |
| the importance of threonine 310, the most critical protease catalytic site in TSP50, to TSP50-induced cell proliferation and tumor formation | The threonine protease activity of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation.
Li YY, Bao YL, Song ZB, Sun LG, Wu P, Zhang Y, Fan C, Huang YX, Wu Y, Yu CL, Sun Y, Zheng LH, Wang GN, Li YX., Free PMC Article | 09/15/2012 |
| TSP50 is a potential effective indicator of poor survival for colorectal carcinoma patients, especially for those with early-stage tumors. | High expression of testes-specific protease 50 is associated with poor prognosis in colorectal carcinoma.
Zheng L, Xie G, Duan G, Yan X, Li Q., Free PMC Article | 11/12/2011 |
| Results strongly suggest that bFGF mediates TSP50 downregulation by ERK1/2 activation, leading to the phosphorylation of Sp1 in this process. | Basic FGF downregulates TSP50 expression via the ERK/Sp1 pathway.
Wang M, Bao YL, Wu Y, Yu CL, Meng XY, Huang YX, Sun Y, Zheng LH, Li YX. | 02/26/2011 |
| These findings suggested that DNA methylation might regulate the TSP50 and mTSP50 gene expressions in different types of tissues and spermatic cells. | Differential methylation of TSP50 and mTSP50 genes in different types of human tissues and mouse spermatic cells.
Huang Y, Wang Y, Wang M, Sun B, Li Y, Bao Y, Tian K, Xu H. | 01/21/2010 |
| Overexpression of Sp1 and C/EBPbeta transcriptional factors upregulated the activities of the TSP50 promoter. | Identification and characterization of the human testes-specific protease 50 gene promoter.
Wang M, Bao YL, Wu Y, Yu CL, Meng X, Xu HP, Li YX. | 01/21/2010 |
| TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells. | TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells.
Shan J, Yuan L, Xiao Q, Chiorazzi N, Budman D, Teichberg S, Xu HP. | 01/21/2010 |
| TSP50 was largely downregulated in all testicular germ cell tumors. It may function in mammalian spermatogenesis. Its linear catalytic structure is similar to many serine proteases, except for a Thr-for-Ser residual catalytic site substitution. | Localization and expression of TSP50 protein in human and rodent testes.
Xu HP, Yuan L, Shan J, Feng H. | 01/21/2010 |