| Genetic Variant in GRM1 Underlies Congenital Cerebellar Ataxia with No Obvious Intellectual Disability. | Genetic Variant in GRM1 Underlies Congenital Cerebellar Ataxia with No Obvious Intellectual Disability.
Protasova MS, Andreeva TV, Klyushnikov SA, Illarioshkin SN, Rogaev EI., Free PMC Article | 01/28/2023 |
| A Novel Nonsense Variant in GRM1 Causes Autosomal Recessive Spinocerebellar Ataxia 13 in a Consanguineous Pakistani Family. | A Novel Nonsense Variant in GRM1 Causes Autosomal Recessive Spinocerebellar Ataxia 13 in a Consanguineous Pakistani Family.
Yousaf H, Fatima A, Ali Z, Baig SM, Toft M, Iqbal Z., Free PMC Article | 10/22/2022 |
| The Emerging Key Role of the mGluR1-PKCgamma Signaling Pathway in the Pathogenesis of Spinocerebellar Ataxias: A Neurodevelopmental Viewpoint. | The Emerging Key Role of the mGluR1-PKCγ Signaling Pathway in the Pathogenesis of Spinocerebellar Ataxias: A Neurodevelopmental Viewpoint.
Wu QW, Kapfhammer JP., Free PMC Article | 09/3/2022 |
| Structural insights into the activation initiation of full-length mGlu1. | Structural insights into the activation initiation of full-length mGlu1.
Zhang J, Qu L, Wu L, Tang X, Luo F, Xu W, Xu Y, Liu ZJ, Hua T., Free PMC Article | 01/29/2022 |
| Brain (11) C-ITMM PET to longitudinally assess type 1 metabotropic glutamate receptor availability in Alzheimer's disease. | Brain (11) C-ITMM PET to longitudinally assess type 1 metabotropic glutamate receptor availability in Alzheimer's disease.
Ishibashi K, Miura Y, Wagatsuma K, Kameyama M, Ishii K. | 10/30/2021 |
| Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait. | Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait.
Shi G, Yin C, Fan Z, Xing L, Mostovoy Y, Kwok PY, Ashbrook LH, Krystal AD, Ptáček LJ, Fu YH. | 09/4/2021 |
| Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer. | Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer.
Bastiaansen AEM, Timmermans AM, Smid M, van Deurzen CHM, Hulsenboom ESP, Prager-van der Smissen WJC, Foekens R, Trapman-Jansen AMAC, Sillevis Smitt PAE, Luider TM, Martens JWM, vanDuijn MM., Free PMC Article | 05/8/2021 |
| This study provided the evidence that glutamate causes a dose-dependent increase in [Ca2+]i by activating mGluR1 and, at a larger extent, mGluR5. | Group 1 metabotropic glutamate receptors trigger glutamate-induced intracellular Ca(2+) signals and nitric oxide release in human brain microvascular endothelial cells.
Negri S, Faris P, Pellavio G, Botta L, Orgiu M, Forcaia G, Sancini G, Laforenza U, Moccia F., Free PMC Article | 06/20/2020 |
| we report the third pathogenic variant in GRM1 gene causing an autosomal-recessive form of cerebellar ataxia. Our observation not only emphasizes the central role of mGluR1-mediated signaling in cerebellar function but also provides valuable insights into the early clinical signs of recessive ataxia due to biallelic GRM1 pathogenic variants. | A novel truncating variant p.(Arg297*) in the GRM1 gene causing autosomal-recessive cerebellar ataxia with juvenile-onset.
Cabet S, Putoux A, Carneiro M, Labalme A, Sanlaville D, Guibaud L, Lesca G. | 02/15/2020 |
| TRPC6 regulates actin stress fiber formation and focal adhesions via the RhoA pathway in response to group I metabotropic glutamate receptor activation. | Group I metabotropic glutamate receptor activation induces TRPC6-dependent calcium influx and RhoA activation in cultured human kidney podocytes.
Wang Q, Wang D, Shibata S, Ji T, Zhang L, Zhang R, Yang H, Ma L, Jiao J. | 12/21/2019 |
| Our results suggest mGluR1 may serve as a novel endogenous regulator of inflammation in triple negative breast cancer. | Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer.
Sexton RE, Hachem AH, Assi AA, Bukhsh MA, Gorski DH, Speyer CL., Free PMC Article | 10/26/2019 |
| Fyn binds to mGluR1a at a consensus binding motif located in the intracellular C-terminus (CT) of mGluR1a in vitro. Active Fyn phosphorylates mGluR1a at a conserved tyrosine residue in the CT region. In cerebellar neurons and transfected HEK293T cells, Fyn-mediated tyrosine phosphorylation of mGluR1a is constitutively active and facilitates surface expression of mGluR1a and potentiates mGluR1a postreceptor signaling. | An Essential Role of Fyn in the Modulation of Metabotropic Glutamate Receptor 1 in Neurons.
Jin DZ, Mao LM, Wang JQ., Free PMC Article | 09/22/2018 |
| Age-dependent increase in metabotropic glutamate receptor type 1 availability in several brain regions may exist predominantly in males. | Age and gender effects of (11)C-ITMM binding to metabotropic glutamate receptor type 1 in healthy human participants.
Sakata M, Toyohara J, Ishibashi K, Wagatsuma K, Ishii K, Zhang MR, Ishiwata K. | 12/2/2017 |
| Missense Mutation in GRM1 gene is associated with Spinocerebellar Ataxia Type 44. | Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44.
Watson LM, Bamber E, Schnekenberg RP, Williams J, Bettencourt C, Lickiss J, Jayawant S, Fawcett K, Clokie S, Wallis Y, Clouston P, Sims D, Houlden H, Becker EBE, Németh AH., Free PMC Article | 10/28/2017 |
| our findings suggest that pharmacological manipulation of mglur1 should be explored as an exciting new approach for the treatment of a variety of human cerebellar ataxias. | Are Type 1 metabotropic glutamate receptors a viable therapeutic target for the treatment of cerebellar ataxia?
Power EM, English NA, Empson RM., Free PMC Article | 09/2/2017 |
| a missense variant was found in GRM1 gene, while in the second family, a frameshift alteration was identified in TRMT1, both of which were found to co-segregate with the intellectual disability. | The Role of a Novel TRMT1 Gene Mutation and Rare GRM1 Gene Defect in Intellectual Disability in Two Azeri Families.
Davarniya B, Hu H, Kahrizi K, Musante L, Fattahi Z, Hosseini M, Maqsoud F, Farajollahi R, Wienker TF, Ropers HH, Najmabadi H., Free PMC Article | 05/21/2016 |
| It has the intrinsic ability to form a heteromeric complex with adenosine A1 receptor and mutually modulate signaling. | Complex formation and functional interaction between adenosine A1 receptor and type-1 metabotropic glutamate receptor.
Kamikubo Y, Tabata T, Sakairi H, Hashimoto Y, Sakurai T. | 05/14/2016 |
| These data demonstrate that the approaches commonly used to study mGlu1 receptor function and signaling in other systems may be inappropriate for studying mGlu1 receptor-mediated melanoma cell viability. | Atypical signaling of metabotropic glutamate receptor 1 in human melanoma cells.
Gelb T, Pshenichkin S, Hathaway HA, Grajkowska E, Dalley CB, Wolfe BB, Wroblewski JT. | 02/13/2016 |
| Our results are likely relevant to human breast cancer, highlighting a putative role of mGluR1 in the pathophysiology of breast cancer and the potential of mGluR1 as a novel therapeutic target. | Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells.
Teh JL, Shah R, La Cava S, Dolfi SC, Mehta MS, Kongara S, Price S, Ganesan S, Reuhl KR, Hirshfield KM, Karantza V, Chen S., Free PMC Article | 01/30/2016 |
| elevated glutamate secretion and mGluR1 expression play a role in Kaposi's sarcoma associated herpesvirus induced cell proliferation | Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation.
Valiya Veettil M, Dutta D, Bottero V, Bandyopadhyay C, Gjyshi O, Sharma-Walia N, Dutta S, Chandran B., Free PMC Article | 12/5/2015 |
| alpha-actinin-4 is a novel group 1 mGluR-interacting partner that orchestrates spine dynamics and morphogenesis in neurons. | Actinin-4 Governs Dendritic Spine Dynamics and Promotes Their Remodeling by Metabotropic Glutamate Receptors.
Kalinowska M, Chávez AE, Lutzu S, Castillo PE, Bukauskas FF, Francesconi A., Free PMC Article | 10/3/2015 |
| Deleterious GRM1 mutations are associated with schizophrenia. | Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics.
Cho HP, Garcia-Barrantes PM, Brogan JT, Hopkins CR, Niswender CM, Rodriguez AL, Venable DF, Morrison RD, Bubser M, Daniels JS, Jones CK, Conn PJ, Lindsley CW., Free PMC Article | 07/25/2015 |
| These novel mutations may contribute to the disease by alterations in GRM1 gene splicing, receptor activation, and post-receptor downstream signaling. | Identification of novel GRM1 mutations and single nucleotide polymorphisms in prostate cancer cell lines and tissues.
Ali S, Shourideh M, Koochekpour S., Free PMC Article | 04/18/2015 |
| Results suggest a role for mGluR1 in breast cancer as a pro-angiogenic factor as well as a mediator of tumor progression. | Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer.
Speyer CL, Hachem AH, Assi AA, Johnson JS, DeVries JA, Gorski DH., Free PMC Article | 01/3/2015 |
| In mice expressing mutant beta-III spectrin, mGluR1 localization is altered at Purkinje cell dendritic spines. | Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.
Armbrust KR, Wang X, Hathorn TJ, Cramer SW, Chen G, Zu T, Kangas T, Zink AN, Öz G, Ebner TJ, Ranum LP., Free PMC Article | 09/27/2014 |