| PRG4 mitigates hemorrhagic shock-induced cardiac injury by inhibiting mitochondrial dysregulation, oxidative stress and NLRP3-mediated pyroptosis. | PRG4 mitigates hemorrhagic shock-induced cardiac injury by inhibiting mitochondrial dysregulation, oxidative stress and NLRP3-mediated pyroptosis.
Zhou W, Wang N, Dong S, Huan Z, Sui L, Ge X. | 08/5/2024 |
| Immunohistochemical evaluation of autotaxin and lubricin in mild osteoarthritic rat model performing moderate physical activity. | Immunohistochemical evaluation of autotaxin and lubricin in mild osteoarthritic rat model performing moderate physical activity.
Ravalli S, Roggio F, Magrì B, Lauretta G, Broggi G, Caltabiano R, Vecchio GM, Magro G, Loreto C, Castorina A, Musumeci G. | 08/20/2022 |
| Proteoglycan 4 (lubricin) is a highly sialylated glycoprotein associated with cardiac valve damage in animal models of infective endocarditis. | Proteoglycan 4 (lubricin) is a highly sialylated glycoprotein associated with cardiac valve damage in animal models of infective endocarditis.
Solakyildirim K, Li Y, Bayer AS, Sullam PM, Xiong YQ, Lebrilla CB, Bensing BA., Free PMC Article | 03/19/2022 |
| Effects of in vivo cyclic compressive loading on the distribution of local Col2 and superficial lubricin in rat knee cartilage. | Effects of in vivo cyclic compressive loading on the distribution of local Col2 and superficial lubricin in rat knee cartilage.
Ji X, Ito A, Nakahata A, Nishitani K, Kuroki H, Aoyama T. | 05/8/2021 |
| sinusoidal electromagnetic fields exposure can promote lubricin synthesis of rat chondrocytes. | Effects of electromagnetic fields on the metabolism of lubricin of rat chondrocytes.
Wang W, Li W, Song M, Wei S, Liu C, Yang Y, Wu H. | 09/12/2018 |
| Data suggest that moderate physical activity and normal mechanical joint loading in elderly rats improve tribology and lubricative properties of articular cartilage, promoting lubricin synthesis and its elevation in synovial fluid. | Physical activity ameliorates cartilage degeneration in a rat model of aging: a study on lubricin expression.
Musumeci G, Castrogiovanni P, Trovato FM, Imbesi R, Giunta S, Szychlinska MA, Loreto C, Castorina S, Mobasheri A. | 09/12/2018 |
| The objective of this study was to characterize and quantify the effect of ESWT on lubricin expression in tendons and septa in a rat model.[Lubricin] | Extracorporeal shockwave-induced expression of lubricin in tendons and septa.
Zhang D, Kearney CJ, Cheriyan T, Schmid TM, Spector M. | 09/12/2018 |
| Results showed that protein and mRNA levels of lubricin increased in normal cartilage but decreased in osteoarthritic cartilage. | Co-Expression and Co-Localization of Cartilage Glycoproteins CHI3L1 and Lubricin in Osteoarthritic Cartilage: Morphological, Immunohistochemical and Gene Expression Profiles.
Szychlinska MA, Trovato FM, Di Rosa M, Malaguarnera L, Puzzo L, Leonardi R, Castrogiovanni P, Musumeci G., Free PMC Article | 12/17/2016 |
| Cartilage derived from MSCs expressed lubricin protein both in vitro and in vivo | Cartilage Derived from Bone Marrow Mesenchymal Stem Cells Expresses Lubricin In Vitro and In Vivo.
Nakagawa Y, Muneta T, Otabe K, Ozeki N, Mizuno M, Udo M, Saito R, Yanagisawa K, Ichinose S, Koga H, Tsuji K, Sekiya I., Free PMC Article | 07/30/2016 |
| Data indicate a marked intensity-specific effect of running on the immunolocalisation and gene expression of lubricin (proteoglycan 4) in cartilage. | Intensity-dependent effect of treadmill running on lubricin metabolism of rat articular cartilage.
Ni GX, Lei L, Zhou YZ., Free PMC Article | 05/16/2015 |
| mechanical stimulation in the articular cartilage could induce the expression of lubricin, which is capable of inhibiting caspase-3 activity, preventing chondrocyte death. | The effects of physical activity on apoptosis and lubricin expression in articular cartilage in rats with glucocorticoid-induced osteoporosis.
Musumeci G, Loreto C, Leonardi R, Castorina S, Giunta S, Carnazza ML, Trovato FM, Pichler K, Weinberg AM. | 09/22/2014 |
| PRG4 is induced in skeletal muscle-derived mesenchymal stem cells following TGF-beta1 and BMP-7 application. | Induction of superficial zone protein (SZP)/lubricin/PRG 4 in muscle-derived mesenchymal stem/progenitor cells by transforming growth factor-β1 and bone morphogenetic protein-7.
Andrades JA, Motaung SC, Jiménez-Palomo P, Claros S, López-Puerta JM, Becerra J, Schmid TM, Reddi AH., Free PMC Article | 05/25/2013 |
| lubricin was down-regulated, on both sides of the periodontal ligament during tooth movement, in a time-dependent fashion, being at any time more expressed on the tension side | Immunolocalization of lubricin in the rat periodontal ligament during experimental tooth movement.
Leonardi R, Loreto C, Talic N, Caltabiano R, Musumeci G. | 11/3/2012 |
| Blocking TNFalpha resulted in a chondroprotective effect, exemplified by increased lubricin deposition on articular cartilage and a decrease in sGAG release from articular cartilage in an animal model of posttraumatic arthritis. | The impact of anterior cruciate ligament injury on lubricin metabolism and the effect of inhibiting tumor necrosis factor alpha on chondroprotection in an animal model.
Elsaid KA, Machan JT, Waller K, Fleming BC, Jay GD., Free PMC Article | 12/15/2011 |
| PRG4 is synthesized and secreted by condylar cartilage chondrocytes and its expression is differentially regulated by IL-1alpha and TGF-beta1. | Differential regulation of proteoglycan-4 expression by IL-1α and TGF-β1 in rat condylar chondrocytes.
Cheng J, Wang Y, Wang Z, Yang M, Wu Y. | 02/26/2011 |