| Circadian rhythm disruption upregulating Per1 in mandibular condylar chondrocytes mediating temporomandibular joint osteoarthritis via GSK3beta/beta-CATENIN pathway. | Circadian rhythm disruption upregulating Per1 in mandibular condylar chondrocytes mediating temporomandibular joint osteoarthritis via GSK3β/β-CATENIN pathway.
Wei J, Wang Y, Tu S, Zhang S, Feng Y, Hou Y, Ai H, Chen Z., Free PMC Article | 08/13/2024 |
| Clock gene Per1 regulates rat temporomandibular osteoarthritis through NF-kappaB pathway: an in vitro and in vivo study. | Clock gene Per1 regulates rat temporomandibular osteoarthritis through NF-κB pathway: an in vitro and in vivo study.
Wei JM, Tu SQ, Wang YX, Zhang S, Feng Y, Ai H, Chen Z., Free PMC Article | 11/3/2023 |
| Pers reverse angiotensin II -induced vascular smooth muscle cell proliferation by targeting cyclin E expression via inhibition of the MAPK signaling pathway. | Pers reverse angiotensin II -induced vascular smooth muscle cell proliferation by targeting cyclin E expression via inhibition of the MAPK signaling pathway.
Jin W, Tian Y, Ding Y, Zhou D, Li L, Yuan M, Wu Y, Ye M, Luan J, Yang K. | 08/25/2023 |
| rs2253820 Variant Controls Blood Pressure Dip After Stroke by Increasing CLOCK-BMAL1 Expression. | rs2253820 Variant Controls Blood Pressure Dip After Stroke by Increasing CLOCK-BMAL1 Expression.
He M, Li L, Li J, Chen S, Shi H. | 06/29/2023 |
| The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats. | The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats.
Costello HM, Juffre A, Cheng KY, Bratanatawira P, Crislip GR, Zietara A, Spires DR, Staruschenko A, Douma LG, Gumz ML., Free PMC Article | 03/6/2023 |
| Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats. | Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats.
Zietara A, Spires DR, Juffre A, Costello HM, Crislip GR, Douma LG, Levchenko V, Dissanayake LV, Klemens CA, Nikolaienko O, Geurts AM, Gumz ML, Staruschenko A., Free PMC Article | 11/26/2022 |
| This study demonstrated that optimal auditory conditioned fear extinction learning is reliant on the presence of normal per1 gene expression in the vmPFC as well as the presence of both circadian and training-associated elevations of glucocorticoid hormone | Coordination between Prefrontal Cortex Clock Gene Expression and Corticosterone Contributes to Enhanced Conditioned Fear Extinction Recall.
Woodruff ER, Chun LE, Hinds LR, Varra NM, Tirado D, Morton SJ, McClung CA, Spencer RL., Free PMC Article | 03/23/2019 |
| Restraint stress increased Per1 mRNA in the hypothalamic paraventricular nucleus and prefrontal cortex of both sexes. | Adrenal-dependent and -independent stress-induced Per1 mRNA in hypothalamic paraventricular nucleus and prefrontal cortex of male and female rats.
Chun LE, Christensen J, Woodruff ER, Morton SJ, Hinds LR, Spencer RL. | 01/5/2019 |
| Sequential and tandem ChIP analyses showed that, after forced swim (FS) stress , MRs and GRs bind concomitantly to the same GRE sites within Fkbp5 and Per1 but not Sgk1 Thus, after stress, MRs and GRs seem to bind to GREs as homo- and/or heterodimers in a gene-dependent manner. MR binding to GREs at baseline seems to be restricted, whereas after stress, GR binding may facilitate cobinding of MR | Acute stress enhances heterodimerization and binding of corticosteroid receptors at glucocorticoid target genes in the hippocampus.
Mifsud KR, Reul JM., Free PMC Article | 02/10/2018 |
| Report altered expression pattern of clock genes, Per1, Per2 and Bmal1, in sub-oscillators of the rat brain and in the liver in rat model of depression. | Altered Expression Pattern of Clock Genes in a Rat Model of Depression.
Christiansen SL, Bouzinova EV, Fahrenkrug J, Wiborg O., Free PMC Article | 01/13/2018 |
| Study demonstrates that transcriptional activation of Per1 and Per2 via E-box enhancer sequences is necessary for the temporally specific phase shifts induced by melatonin at circadian time 10. These findings support a link between melatonin-induced signal transduction pathways activating necessary Per1 and Per2 transcription and clock resetting in the suprachiasmatic nucleus by melatonin at dusk. | Melatonin Signal Transduction Pathways Require E-Box-Mediated Transcription of Per1 and Per2 to Reset the SCN Clock at Dusk.
Kandalepas PC, Mitchell JW, Gillette MU., Free PMC Article | 07/22/2017 |
| Results show that exposure to constant light by up-regulation of Per2 and dopamine D1 receptor in the striatum and prefrontal cortex and up-regulation of Per1 in the striatum and the possible involvement of melatonin makes animals vulnerable to morphine preference and addiction | Effect of circadian rhythm disturbance on morphine preference and addiction in male rats: Involvement of period genes and dopamine D1 receptor.
Garmabi B, Vousooghi N, Vosough M, Yoonessi A, Bakhtazad A, Zarrindast MR. | 12/17/2016 |
| real-time monitoring of Per1 and Per2 transcription in the suprachiasmatic nucleus of freely moving rats; Per1-luc and Per2-luc rhythms peaked in the middle and late subjective day, respectively | Real-Time Recording of Circadian Per1 and Per2 Expression in the Suprachiasmatic Nucleus of Freely Moving Rats.
Yamaguchi Y, Okada K, Mizuno T, Ota T, Yamada H, Doi M, Kobayashi M, Tei H, Shigeyoshi Y, Okamura H. | 10/29/2016 |
| Data show that corticosterone (CORT) status modulates core clock genes Per1, Per2, and Bmal1 mRNA diurnal expression in the prefrontal cortex (PFC) but not in the suprachiasmatic nucleus (SCN). | Diurnal Corticosterone Presence and Phase Modulate Clock Gene Expression in the Male Rat Prefrontal Cortex.
Woodruff ER, Chun LE, Hinds LR, Spencer RL., Free PMC Article | 08/20/2016 |
| Data show there were 3 distinct gene expression profiles of circadian rhythm signaling proteins Per1, Per2, and Bmal1 across the brain. regions. | Variations in Phase and Amplitude of Rhythmic Clock Gene Expression across Prefrontal Cortex, Hippocampus, Amygdala, and Hypothalamic Paraventricular and Suprachiasmatic Nuclei of Male and Female Rats.
Chun LE, Woodruff ER, Morton S, Hinds LR, Spencer RL., Free PMC Article | 06/28/2016 |
| Results suggest that Per1 and Per2 expression may increase the efficacy of radiotherapy against glioma by promoting apoptosis. | Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo.
Zhanfeng N, Yanhui L, Zhou F, Shaocai H, Guangxing L, Hechun X., Free PMC Article | 03/19/2016 |
| Data show that Bmal1 and Per1 expression also varied along the day, but only in females. | Gender associated circadian oscillations of the clock genes in rat choroid plexus.
Quintela T, Sousa C, Patriarca FM, Gonçalves I, Santos CR. | 01/30/2016 |
| Our observations point to a novel role for PER1 as a key player in the interface between stress and circadian rhythms. | Stress-induced changes in the expression of the clock protein PERIOD1 in the rat limbic forebrain and hypothalamus: role of stress type, time of day, and predictability.
Al-Safadi S, Al-Safadi A, Branchaud M, Rutherford S, Dayanandan A, Robinson B, Amir S., Free PMC Article | 12/19/2015 |
| each layer of the retina in the Per1-Luc rat harbors a self-sustained oscillator whose period is significantly longer ( approximately 26 hours) than in whole-retina explants ( approximately 22.9 hours), indicating that the period is correlated with the degree of coupling | Circadian organization of the rodent retina involves strongly coupled, layer-specific oscillators.
Jaeger C, Sandu C, Malan A, Mellac K, Hicks D, Felder-Schmittbuhl MP. | 06/27/2015 |
| We investigated the effect of aging on daily rhythms of various clock genes such as rPer1, rPer2, rCry1, rCry2 and rBmal1 in the SCN of male Wistar rats. | Differential role of melatonin in restoration of age-induced alterations in daily rhythms of expression of various clock genes in suprachiasmatic nucleus of male Wistar rats.
Mattam U, Jagota A. | 01/3/2015 |
| Per1 knockdown induces CCL2 and IL-6 transcription. Overexpression of PER1 decreases the production of CCL2 and IL-6, and the phosphorylation of p38, JNK and IkappaBalpha in cultured spinal astrocytes. | Clock gene Per1 regulates the production of CCL2 and interleukin-6 through p38, JNK1 and NF-κB activation in spinal astrocytes.
Sugimoto T, Morioka N, Zhang FF, Sato K, Abe H, Hisaoka-Nakashima K, Nakata Y. | 12/20/2014 |
| Findings link the initiation of clock gene Per1 rhythms in the rat ovary to the luteinising hormone receptor and suggest a functional link to androgen and progesterone production. | Expression of the clock genes Per1 and Bmal1 during follicle development in the rat ovary. Effects of gonadotropin stimulation and hypophysectomy.
Gräs S, Georg B, Jørgensen HL, Fahrenkrug J. | 08/10/2013 |
| The present data indicate that there is a close relationship between the expression pattern of Per1 and that of melatonin synthesis during the development of postnatal rats. | The expression of Per1 and Aa-nat genes in the pineal gland of postnatal rats.
Wongchitrat P, Govitrapong P, Phansuwan-Pujito P. | 06/22/2013 |
| DHT exposure in pubertal rats led to a significant decline in internal circadian organization, characterized by disruption of the phase distribution of per1-luc expression and synchrony among peripheral oscillators. | Excess androgen during puberty disrupts circadian organization in female rats.
Sellix MT, Murphy ZC, Menaker M., Free PMC Article | 05/11/2013 |
| the oxytocin- and retinol-dependent increase of the PER1 expression and the subsequent change of ratio of efficiency of oxytocin and GABA at the prenatal stage of formation of the circadian clock-mechanism of the rat embryo anterior hypothalamus. | [Effect of retinol on interaction of the protein period1, oxytocin, and GABA at the prenatal period of formation of the circadian clock-mechanism in rats].
Chernysheva MP, Romanova IV, Mikhrina AL. | 12/8/2012 |