| LINC00460 promotes neuroblastoma tumorigenesis and cisplatin resistance by targeting miR-149-5p/DLL1 axis and activating Notch pathway in vitro and in vivo. | LINC00460 promotes neuroblastoma tumorigenesis and cisplatin resistance by targeting miR-149-5p/DLL1 axis and activating Notch pathway in vitro and in vivo.
Xu Y, Qiu Z, Chen J, Huang L, Zhang J, Lin J. | 10/9/2024 |
| The phenotypic spectrum of terminal 6q deletions based on a large cohort derived from social media and literature: a prominent role for DLL1. | The phenotypic spectrum of terminal 6q deletions based on a large cohort derived from social media and literature: a prominent role for DLL1.
Engwerda A, Kerstjens-Frederikse WS, Corsten-Janssen N, Dijkhuizen T, van Ravenswaaij-Arts CMA., Free PMC Article | 03/24/2023 |
| Activation of NOTCH signaling via DLL1 is mediated by APE1-redox-dependent NF-kappaB activation in oesophageal adenocarcinoma. | Activation of NOTCH signaling via DLL1 is mediated by APE1-redox-dependent NF-κB activation in oesophageal adenocarcinoma.
Chen L, Lu H, Peng D, Cao LL, Ballout F, Srirmajayam K, Chen Z, Bhat A, Wang TC, Capobianco A, Que J, McDonald OG, Zaika A, Zhang S, El-Rifai W., Free PMC Article | 02/16/2023 |
| Association Between Soluble Notch Ligand Delta-like Ligand 1 and Bleeding Complications in Patients With Dengue Fever Infection. | Association Between Soluble Notch Ligand Delta-like Ligand 1 and Bleeding Complications in Patients With Dengue Fever Infection.
Hildebrand D, Nurjadi D, Hoan NX, Linh MTH, Sang VV, Bang MH, Pallerla SR, Kremsner PG, Heeg K, Song LH, Velavan TP. | 05/14/2022 |
| Terminal 6q deletions cause brain malformations, a phenotype mimicking heterozygous DLL1 pathogenic variants: A multicenter retrospective case series. | Terminal 6q deletions cause brain malformations, a phenotype mimicking heterozygous DLL1 pathogenic variants: A multicenter retrospective case series.
Lesieur-Sebellin M, Till M, Khau Van Kien P, Herve B, Bourgon N, Dupont C, Tabet AC, Barrois M, Coussement A, Loeuillet L, Mousty E, Ea V, El Assal A, Mary L, Jaillard S, Beneteau C, Le Vaillant C, Coutton C, Devillard F, Goumy C, Delabaere A, Redon S, Laurent Y, Lamouroux A, Massardier J, Turleau C, Sanlaville D, Cantagrel V, Sonigo P, Vialard F, Salomon LJ, Malan V. | 02/12/2022 |
| Association of DLL1 with type 1 diabetes in patients characterized by low polygenic risk score. | Association of DLL1 with type 1 diabetes in patients characterized by low polygenic risk score.
Qu J, Qu HQ, Bradfield JP, Glessner JT, Chang X, Tian L, March ME, Roizen JD, Sleiman PM, Hakonarson H. | 02/2/2021 |
| The potential mechanism of miR-130b on promotion of the invasion and metastasis of hepatocellular carcinoma by inhibiting Notch-Dll1. | The potential mechanism of miR-130b on promotion of the invasion and metastasis of hepatocellular carcinoma by inhibiting Notch-Dll1.
Ou C, Peng NF, Li H, Peng YC, Li LQ. | 12/12/2020 |
| DLL1 is a novel host-derived biomarker for the diagnosis of sepsis with a better performance compared to established ones, most likely due to its high robustness in non-infectious inflammatory responses. | Host-Derived Delta-Like Canonical Notch Ligand 1 as a Novel Diagnostic Biomarker for Bacterial Sepsis-Results From a Combinational Secondary Analysis.
Hildebrand D, Decker SO, Koch C, Schmitt FCF, Ruhrmann S, Schneck E, Sander M, Weigand MA, Brenner T, Heeg K, Uhle F., Free PMC Article | 07/11/2020 |
| Knockdown of DLL1 could promote the cardiomyocyte differentiation. | MIR148A family regulates cardiomyocyte differentiation of human embryonic stem cells by inhibiting the DLL1-mediated NOTCH signaling pathway.
Fang X, Miao S, Yu Y, Ding F, Han X, Wu H, Zhao ZA, Wang Y, Hu S, Lei W. | 06/27/2020 |
| DLL1 is a potent suppressor of pancreatic cancer metastasis. Understanding correlation between expression and function of DLL1 might contribute to our knowledge of the complicated mechanism of pancreatic cancer metastasis. | Silencing Delta-like 1 Expression Induces Migratory Features in Pancreatic Cancer Cells Through Stimulation of Src and p38 Signalling Pathway.
Lee J, Lee J, Kim DH, Kim JH. | 04/18/2020 |
| The dissimilar effects of DLL1 downregulation observed amongst MCF-7, BT474, and MDA-MB-231 cells is likely due to their distinctive genetic and biologic characteristics, suggesting that DLL1 contributes to breast cancer through various mechanisms | The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.
Sales-Dias J, Silva G, Lamy M, Ferreira A, Barbas A., Free PMC Article | 01/25/2020 |
| DLL1 locus was marginally associated with TgAb levels in females. | Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians.
Matana A, Popović M, Boutin T, Torlak V, Brdar D, Gunjača I, Kolčić I, Boraska Perica V, Punda A, Polašek O, Hayward C, Barbalić M, Zemunik T. | 01/4/2020 |
| This study reveals NFIA as a pro-endocrine factor in the pancreas, acting to repress Mib1, inhibit Dll1 endocytosis and thus promote escape from Notch activation. | Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA.
Scavuzzo MA, Chmielowiec J, Yang D, Wamble K, Chaboub LS, Duraine L, Tepe B, Glasgow SM, Arenkiel BR, Brou C, Deneen B, Borowiak M. | 12/7/2019 |
| It has been demonstrated that DLL1-dependent Notch signaling and GM-CSF cooperate to promote human dendritic cell differentiation. | Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity.
Balan S, Arnold-Schrauf C, Abbas A, Couespel N, Savoret J, Imperatore F, Villani AC, Vu Manh TP, Bhardwaj N, Dalod M., Free PMC Article | 11/30/2019 |
| CSF DLL1, VDBP and fetuin exhibited fair diagnostic performance for TBM diagnosis | Delta-like 1 protein, vitamin D binding protein and fetuin for detection of Mycobacterium tuberculosis meningitis.
Bahr NC, Halupnick R, Linder G, Kiggundu R, Nabeta HW, Williams DA, Musubire AK, Morawski BM, Sreevatsan S, Meya DB, Rhein J, Boulware DR., Free PMC Article | 07/27/2019 |
| DLL1-mediated Notch signaling promotes luminal breast cancer | Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer.
Kumar S, Srivastav RK, Wilkes DW, Ross T, Kim S, Kowalski J, Chatla S, Zhang Q, Nayak A, Guha M, Fuchs SY, Thomas C, Chakrabarti R., Free PMC Article | 05/4/2019 |
| This study produced recombinant DLL1-DE3, a novel soluble form of DLL1 protein, which contains the DSL domain and EGF1-3 repeats critical for Notch pathway activation. Cellular assays revealed recombinant DLL1-DE3 was biologically active as it increased expression of Notch-dependent genes in inducible pluripotent and breast cancer cells. | Production and characterization of a novel Delta-like 1 functional unit as a tool for Notch pathway activation and generation of a specific antibody.
Ferreira A, Lamy M, Margarida Rocha M, Silva G, Bandeiras TM, Barbas A. | 03/2/2019 |
| Abnormal DLL1 methylation and expression observed in early gastric lesions and in gastric cancers may be relevant to the pathogenesis of gastric cancer. | Inverse Correlation between Methylation and Expression of the Delta-like Ligand 1 Gene in Gastric Cancer.
Shen CH, Tung SY, Tseng MJ, Leu YW. | 12/1/2018 |
| This study suggested that miR-34a-5p, DLL1 and the ATF2/ATF3/ATF4 signaling pathway-associated genes are the potential diagnostic and/or therapeutic targets for an effective chemotherapy of osteosarcoma. | MiR-34a-5p promotes multi-chemoresistance of osteosarcoma through down-regulation of the DLL1 gene.
Pu Y, Zhao F, Wang H, Cai S., Free PMC Article | 11/10/2018 |
| miR-34a contributes to chondrocyte death, causing Osteoarthritis progression through DLL1 and modulation of the PI3K/AKT pathway. | MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway.
Zhang W, Hsu P, Zhong B, Guo S, Zhang C, Wang Y, Luo C, Zhan Y, Zhang C. | 09/15/2018 |
| Circulating levels of DLL1 and POSN were higher in patients with severe dilated cardiomyopathy and correlated with the degree of diastolic dysfunction. | The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy.
Norum HM, Broch K, Michelsen AE, Lunde IG, Lekva T, Abraityte A, Dahl CP, Fiane AE, Andreassen AK, Christensen G, Aakhus S, Aukrust P, Gullestad L, Ueland T. | 07/21/2018 |
| Soluble DLL1 was significantly increased in uterine lavage samples of infertile women compared with fertile women in the secretory phase of the menstrual cycle. | Soluble Delta-like ligand 1 alters human endometrial epithelial cell adhesive capacity.
Van Sinderen M, Oyanedel J, Menkhorst E, Cuman C, Rainczuk K, Winship A, Salamonsen L, Edgell T, Dimitriadis E. | 07/14/2018 |
| Neuroblastoma cells were transfected with miRNA-34 family members, and the effect of miRNAs transfection on DLL1 mRNA expression levels, on cell differentiation, proliferation and apoptosis was measured | Notch ligand Delta-like 1 as a novel molecular target in childhood neuroblastoma.
Bettinsoli P, Ferrari-Toninelli G, Bonini SA, Prandelli C, Memo M., Free PMC Article | 03/10/2018 |
| Highly methylated domains containing a putative fetal brain enhancer near DLL1 was found to reach genome-wide significance and was validated for significantly higher methylation in autism spectrum disorders children than in controls. | Placental methylome analysis from a prospective autism study.
Schroeder DI, Schmidt RJ, Crary-Dooley FK, Walker CK, Ozonoff S, Tancredi DJ, Hertz-Picciotto I, LaSalle JM., Free PMC Article | 10/28/2017 |
| The DLK1 inhibited the odontoblastic differentiation of hDPSCs, which maybe through ERK signalling pathway. | The effect of delta-like 1 homologue on the proliferation and odontoblastic differentiation in human dental pulp stem cells.
Qi S, Yan Y, Wen Y, Li J, Wang J, Chen F, Tang X, Shang G, Xu Y, Wang R., Free PMC Article | 10/7/2017 |