| PDGF Promotes Dermal Fibroblast Activation via a Novel Mechanism Mediated by Signaling Through MCHR1. | PDGF Promotes Dermal Fibroblast Activation via a Novel Mechanism Mediated by Signaling Through MCHR1.
Takamura N, Renaud L, da Silveira WA, Feghali-Bostwick C., Free PMC Article | 02/5/2022 |
| Melanin Concentrating Hormone Signaling Deficits in Schizophrenia: Association With Memory and Social Impairments and Abnormal Sensorimotor Gating. | Melanin Concentrating Hormone Signaling Deficits in Schizophrenia: Association With Memory and Social Impairments and Abnormal Sensorimotor Gating.
Vawter MP, Schulmann A, Alhassen L, Alhassen W, Hamzeh AR, Sakr J, Pauluk L, Yoshimura R, Wang X, Dai Q, Sanathara N, Civelli O, Alachkar A., Free PMC Article | 12/5/2020 |
| Polymorphisms in the MCHR1 gene are associated with differences in body composition and interact with physiologic and energy-related lifestyle factors. | Melanin-concentrating hormone receptor 1 polymorphisms are associated with components of energy balance in the Complex Diseases in the Newfoundland Population: Environment and Genetics (CODING) study.
Fontaine-Bisson B, Thorburn J, Gregory A, Zhang H, Sun G. | 04/19/2014 |
| results suggest that MCHR1 may influence schizophrenia susceptibility, in particular among men and patients responding to conventional (nonclozapine) treatment | The gene encoding the melanin-concentrating hormone receptor 1 is associated with schizophrenia in a Danish case-control sample.
Demontis D, Nyegaard M, Christensen JH, Severinsen J, Hedemand A, Hansen T, Werge T, Mors O, Børglum AD. | 06/23/2012 |
| SLC-1 protein human mutation demonstrated important genetic susceptibility of sporadic nonsyndromic hearing loss in China. | Microarray-based mutation detection of pediatric sporadic nonsyndromic hearing loss in China.
Qu C, Sun X, Shi Y, Gong A, Liang S, Zhao M, Chen Y, Liang F. | 05/26/2012 |
| DNA methylation at MCHR1 is allele-specific, age-dependent, body mass index-associated and affects transcription. | Allele-specific, age-dependent and BMI-associated DNA methylation of human MCHR1.
Stepanow S, Reichwald K, Huse K, Gausmann U, Nebel A, Rosenstiel P, Wabitsch M, Fischer-Posovszky P, Platzer M., Free PMC Article | 10/1/2011 |
| two loss-of-function mutants were identified in markedly underweight individuals, raising the possibility that a lean phenotype may be linked to deficient MCHR1 signaling | Two naturally occurring mutations in the type 1 melanin-concentrating hormone receptor abolish agonist-induced signaling.
Goldstein C, Schroeder JC, Fortin JP, Goss JM, Schaus SE, Beinborn M, Kopin AS., Free PMC Article | 02/5/2011 |
| MCHR1 expression level was 1.6 times higher in vitiligo uninvolved skin (P < 0.05) and 2.23 times lower in involved skin (P < 0.05), when compared to healthy control skin. | Analysis of the expression profile of CRH-POMC system genes in vitiligo skin biopsies.
Reimann E, Kingo K, Karelson M, Salum T, Aunin E, Reemann P, Abram K, Vasar E, Silm H, Kõks S. | 02/5/2011 |
| data suggest that RGS2 and RGS8 differentially associate with MCHR1 and may represent two distinct modes of signaling mechanisms in vivo | Functional interaction of regulator of G protein signaling-2 with melanin-concentrating hormone receptor 1.
Miyamoto-Matsubara M, Chung S, Saito Y. | 08/9/2010 |
| analysis of epitope specificity of MCHR1 antibodies | Mapping of melanin-concentrating hormone receptor 1 B cell epitopes predicts two major binding sites for vitiligo patient autoantibodies.
Gavalas NG, Gottumukkala RV, Gawkrodger DJ, Watson PF, Weetman AP, Kemp EH. | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.
Miller CL, Murakami P, Ruczinski I, Ross RG, Sinkus M, Sullivan B, Leonard S., Free PMC Article | 06/24/2009 |
| These data suggest that a functional interaction between MCHR1 and caveolin-1 in lipid rafts exists and provide a basis for further biochemical studies to understand the significance on MCH-mediated signal transduction events. | Caveolae as potential mediators of MCH-signaling pathways.
Cook LB, Delorme-Axford EB, Robinson K. | 01/21/2010 |
| Single nucleotide polymorphisms of MCHR1 did not have effects on metabolic variables in humans. | Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans.
Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Kuusisto J, Laakso M, Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Kuusisto J, Laakso M. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (6) articlesA large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group. A common variant in DRD3 receptor is associated with autism spectrum disorder.
de Krom M, Staal WG, Ophoff RA, Hendriks J, Buitelaar J, Franke B, de Jonge MV, Bolton P, Collier D, Curran S, van Engeland H, van Ree JM. Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans.
Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Kuusisto J, Laakso M, Rutanen J, Pihlajamäki J, Vänttinen M, Salmenniemi U, Ruotsalainen E, Kuulasmaa T, Kainulainen S, Kuusisto J, Laakso M. Association analyses suggest GPR24 as a shared susceptibility gene for bipolar affective disorder and schizophrenia.
Severinsen JE, Als TD, Binderup H, Kruse TA, Wang AG, Vang M, Muir WJ, Blackwood DH, Mors O, Børglum AD. Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity.
Bell CG, Meyre D, Samson C, Boyle C, Lecoeur C, Tauber M, Jouret B, Jaquet D, Levy-Marchal C, Charles MA, Weill J, Gibson F, Mein CA, Froguel P, Walley AJ, Bell CG, Meyre D, Samson C, Boyle C, Lecoeur C, Tauber M, Jouret B, Jaquet D, Levy-Marchal C, Charles MA, Weill J, Gibson F, Mein CA, Froguel P, Walley AJ. | 03/13/2008 |
| Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) | Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.
Gibson WT, Pissios P, Trombly DJ, Luan J, Keogh J, Wareham NJ, Maratos-Flier E, O'Rahilly S, Farooqi IS. | 03/13/2008 |
| Our results suggest that MIZIP might play an important role in mammalian cells by associating with tubulin and thus might provide a link between MCHR1 and tubulin functions. | MYND domain specific interaction of the melanin-concentrating hormone receptor 1 interacting zinc-finger protein with alpha- and beta-tubulin.
Francke F, Buck F, Bächner D. | 01/21/2010 |
| Association of MCHR1 alleles/haplotype detected might be related to juvenile-onset obesity, conditional on a particular genetic and/or environmental background. | Mutation analysis of the MCHR1 gene in human obesity.
Wermter AK, Reichwald K, Büch T, Geller F, Platzer C, Huse K, Hess C, Remschmidt H, Gudermann T, Preibisch G, Siegfried W, Goldschmidt HP, Li WD, Price RA, Biebermann H, Krude H, Vollmert C, Wichmann HE, Illig T, Sørensen TI, Astrup A, Larsen LH, Pedersen O, Eberlé D, Clément K, Blundell J, Wabitsch M, Schäfer H, Platzer M, Hinney A, Hebebrand J. | 01/21/2010 |
| Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail | Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail.
Murdoch H, Feng GJ, Bächner D, Ormiston L, White JH, Richter D, Milligan G. | 01/21/2010 |
| a single point mutation at position 255 (T255A), which is located at the junction of intracellular loop 3 and transmembrane domain 6, reduces the MCHR1 cell surface expression level to 20% of that observed for the wild-type receptor | A point mutation in the human melanin concentrating hormone receptor 1 reveals an important domain for cellular trafficking.
Fan J, Perry SJ, Gao Y, Schwarz DA, Maki RA. | 01/21/2010 |
| Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. | Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.
Bednarek MA, Tan C, Hreniuk DL, Palyha OC, MacNeil DJ, Van Der Ploeg LH, Howard AD, Feighner SD. | 01/21/2010 |
| study suggests that severe forms of obesity with early onset may be associated with single nucleotide polymorphisms in melanin-concentrating hormone receptor 1 (MCHR1) | Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity.
Bell CG, Meyre D, Samson C, Boyle C, Lecoeur C, Tauber M, Jouret B, Jaquet D, Levy-Marchal C, Charles MA, Weill J, Gibson F, Mein CA, Froguel P, Walley AJ, Bell CG, Meyre D, Samson C, Boyle C, Lecoeur C, Tauber M, Jouret B, Jaquet D, Levy-Marchal C, Charles MA, Weill J, Gibson F, Mein CA, Froguel P, Walley AJ. | 01/21/2010 |
| MCHR1 receptor expression on most cell types can trigger, in the presence of MCH, cAMP synthesis and calcium mobilization in peripheral blood mononuclear cells (PBMCs). Moreover, MCH treatment decreases the CD3-stimulated PBMC proliferation in vitro. | Human immune cells express ppMCH mRNA and functional MCHR1 receptor.
Verlaet M, Adamantidis A, Coumans B, Chanas G, Zorzi W, Heinen E, Grisar T, Lakaye B. | 01/21/2010 |
| MCHR1 is expressed and functional in human skin | Melanin-concentrating hormone and its receptor are expressed and functional in human skin.
Hoogduijn MJ, Ancans J, Suzuki I, Estdale S, Thody AJ. | 01/21/2010 |
| MCH1 and MCH2 receptors were investigated and are different from those in SVK14 cells. | SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor.
Audinot V, Lahaye C, Suply T, Rovère-Jovène C, Rodriguez M, Nicolas JP, Beauverger P, Cardinaud B, Galizzi JP, Fauchère JL, Nahon JL, Boutin JA. | 01/21/2010 |
| study demonstrates a complex interaction between melanin concentrating hormone receptor 1 and Gs protein-coupled signaling pathways | Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways.
Pissios P, Trombly DJ, Tzameli I, Maratos-Flier E. | 01/21/2010 |