| rs110343126 associated with fertility in hot-humid climate | Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate.
Leyva-Corona JC, Reyna-Granados JR, Zamorano-Algandar R, Sanchez-Castro MA, Thomas MG, Enns RM, Speidel SE, Medrano JF, Rincon G, Luna-Nevarez P. | 03/30/2019 |
| A total of 1169 cows of 4 pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. 3 combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among the breeds studied, as opposed to individuals carrying the worst CC/AA combination. | Polymorphism in exon 2 encoding the putative ligand binding pocket of the bovine insulin-like growth factor 1 receptor affects milk traits in four different cattle breeds.
Szewczuk M. | 02/18/2017 |
| study determined IGFR1 and PAPP-A expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A secretion as a modulator of IGF1 in cattle with COD | Involvement of PAPP-A and IGFR1 in Cystic Ovarian Disease in Cattle.
Rodríguez FM, Colombero M, Amweg AN, Huber E, Gareis NC, Salvetti NR, Ortega HH, Rey F. | 05/21/2016 |
| Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection. | Effects in cattle of genetic variation within the IGF1R gene on the superovulation performance and pregnancy rates after embryo transfer.
Yang WC, Yang LG, Riaz H, Tang KQ, Chen L, Li SJ. | 09/6/2014 |
| two SNPs in the coding region of the insulin-like growth factor 1 receptor gene may have a role in growth of Angus cattle | Association of two SNPs in the coding region of the insulin-like growth factor 1 receptor (IGF1R) gene with growth-related traits in Angus cattle.
Szewczuk M, Zych S, Wójcik J, Czerniawska-Piątkowska E., Free PMC Article | 01/18/2014 |
| insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization | Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization.
Siddals KW, Allen J, Sinha S, Canfield AE, Kalra PA, Gibson JM., Free PMC Article | 07/16/2011 |
| The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed. | Association between IGF-IR, m-calpain and UCP-3 gene polymorphisms and growth traits in Nanyang cattle.
Zhang R, Li X. | 05/28/2011 |
| Data describes the long-term changes to skeletal muscle growth and IGF1, 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine. | Protein intake during gestation affects postnatal bovine skeletal muscle growth and relative expression of IGF1, IGF1R, IGF2 and IGF2R.
Micke GC, Sullivan TM, McMillen IC, Gentili S, Perry VE. | 04/30/2011 |
| Results do not support the premise that increased apoptosis associated with high levels of IGF1 is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos. | Increased apoptosis in bovine blastocysts exposed to high levels of IGF1 is not associated with downregulation of the IGF1 receptor.
Velazquez MA, Hermann D, Kues WA, Niemann H. | 03/26/2011 |
| IGF-I down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells. | Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3beta and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylation.
Nemoto T, Satoh S, Maruta T, Kanai T, Yoshikawa N, Miyazaki S, Yanagita T, Wada A. | 07/26/2010 |
| IGF-1 and IGF-1r gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds. | IGF-1 and IGF-1r gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds.
Akis I, Oztabak K, Gonulalp I, Mengi A, Un C. | 07/19/2010 |
| Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells. | Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
Kamanga-Sollo E, White ME, Hathaway MR, Chung KY, Johnson BJ, Dayton WR. | 01/21/2010 |
| Treatment with IGF1R antibodies reduced the stimulatory effect of IGF2 and IGF1 on estradiol production and cell proliferation. | Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptor.
Spicer LJ, Aad PY. | 01/21/2010 |
| study to assess the mRNA expression of IGF-I, IGF-II, IGF-IR and IGF-IIR in bovine oocytes and different stages of preimplantation embryos | Expression of IGF receptors and its ligands in bovine oocytes and preimplantation embryos.
Wang LM, Feng HL, Ma YZh, Cang M, Li HJ, Yan Zh, Zhou P, Wen JX, Bou S, Liu DJ. | 01/21/2010 |
| Data conclude that insulin and IGF-I receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state. | Insulin and insulin-like growth factor-I receptors differentially mediate insulin-stimulated adhesion molecule production by endothelial cells.
Li G, Barrett EJ, Ko SH, Cao W, Liu Z., Free PMC Article | 01/21/2010 |
| delivery of insulin-like growth factor-1 (IGF-1, delivered at concentrations of 0, 10, 50, and 100 ng/mL) affects the endogenous expression of IGF-1, its receptor (IGF-1R), and a well known IGF-1 binding protein (IGFBP-3) by articular chondrocytes | Effects of exogenous IGF-1 delivery on the early expression of IGF-1 signaling molecules by alginate embedded chondrocytes.
Yoon DM, Fisher JP. | 01/21/2010 |
| For Day 25 conceptuses, there was higher expression of IGF-I mRNA for nuclear transfer and in vitro production embryonic tissues than for in vivo embryonic tissues. | Insulin-like growth factor (IGF) family genes are aberrantly expressed in bovine conceptuses produced in vitro or by nuclear transfer.
Moore K, Kramer JM, Rodriguez-Sallaberry CJ, Yelich JV, Drost M. | 01/21/2010 |
| granulosa cell clustering is accompanied by marked increases in FSHr, IGF-1r, and p450 arom expression, and precedes induction and subsequent peak E2 production | Temporal relationships between FSH receptor, type 1 insulin-like growth factor receptor, and aromatase expression during FSH-induced differentiation of bovine granulosa cells maintained in serum-free culture.
Marsters P, Kendall NR, Campbell BK. | 01/21/2010 |