| Association between polymorphisms of Myf5, MSTN and CAST genes and fattening performance in Brown Swiss and Holstein cattle breeds. | Association between polymorphisms of Myf5, MSTN and CAST genes and fattening performance in Brown Swiss and Holstein cattle breeds.
Fadhil M, Zülkadir U. | 10/16/2021 |
| Most heifer reproductive traits were not significantly affected by CAST and CAPN1 markers that are widely used to improve beef tenderness by selection and breeders should not be concerned with how these markers affect reproduction and other heifer traits with the possible exception of CAPN1 effects on calving date. | μ-Calpain (CAPN1), calpastatin (CAST), and growth hormone receptor (GHR) genetic effects on Angus beef heifer performance traits and reproduction.
Tait RG Jr, Cushman RA, McNeel AK, Casas E, Smith TPL, Freetly HC, Bennett GL. | 09/29/2018 |
| The calpastatin gene (CAST), which is located on bovine chromosome 7 (BTAU7), is considered a strong functional candidate for meat tenderness in livestock species. | Effect of the g.98535683A>G SNP in the CAST gene on meat traits of Nellore beef cattle (Bos indicus) and their crosses with Bos taurus.
Enriquez-Valencia CE, Pereira GL, Malheiros JM, de Vasconcelos Silva JAII, Albuquerque LG, de Oliveira HN, Chardulo LAL, Curi RA. | 06/3/2017 |
| These results suggest an important role of genetics in meat color variation for cattle raised under the tropic conditions. | Association of single nucleotide polymorphisms in CAPN1, CAST and MB genes with meat color of Brahman and crossbreed cattle.
Castro S, Ríos M, Ortiz Y, Manrique C, Jiménez A, Ariza F. | 12/24/2016 |
| The suppression of calpastatin resulted in the increased expression of mu-calpain, caspases, and HSPs which in turn regulate apoptotic cell death. | Role of calpastatin in the regulation of mRNA expression of calpain, caspase, and heat shock protein systems in bovine muscle satellite cells.
Ba HV, Reddy BV, Hwang I. | 01/30/2016 |
| This work is supportive of the importance of CAPN1 and CAST for mean tenderness in beef. | CAPN1, CAST, and DGAT1 genetic effects on preweaning performance, carcass quality traits, and residual variance of tenderness in a beef cattle population selected for haplotype and allele equalization.
Tait RG Jr, Shackelford SD, Wheeler TL, King DA, Keele JW, Casas E, Smith TP, Bennett GL. | 10/24/2015 |
| bovine CAPN-CAST interaction were well reflected in the geometry between the pharmacophore features and its shape constraints identified using our modeled bovine CAPN1/CAST4 complex structures | Understanding the interaction determinants of CAPN1 inhibition by CAST4 from bovines using molecular modeling techniques.
Chai HH, Lim D, Jung E, Choi BH, Cho YM., Free PMC Article | 05/23/2015 |
| CAST binds and inhibits CAPN via its CAPN-inhibitor domains(CAST1-4) .CAST4 docks near the flexible active site of CAPN1, conformational changes at the interaction site after binding could be directly related to CAST4 inhibitory activity. | Homology modeling study of bovine μ-calpain inhibitor-binding domains.
Chai HH, Lim D, Lee SH, Chai HY, Jung E., Free PMC Article | 01/17/2015 |
| This work confirms the importance of CAPN1 and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR as a selection marker for beef quality. | μ-Calpain, calpastatin, and growth hormone receptor genetic effects on preweaning performance, carcass quality traits, and residual variance of tenderness in Angus cattle selected to increase minor haplotype and allele frequencies.
Tait RG Jr, Shackelford SD, Wheeler TL, King DA, Casas E, Thallman RM, Smith TP, Bennett GL. | 12/20/2014 |
| The association of single nucleotide polymorphisms in calpastatin with muscle tenderness was studied. | A post-transcriptional mechanism regulates calpastatin expression in bovine skeletal muscle.
Nattrass GS, Cafe LM, McIntyre BL, Gardner GE, McGilchrist P, Robinson DL, Wang YH, Pethick DW, Greenwood PL. | 12/20/2014 |
| three SNPs located at intron 5, exon 7 and and intron 12 were significantly associated with meat tenderness in the Parda de Montana breed | A new single nucleotide polymorphism in the calpastatin (CAST) gene associated with beef tenderness.
Calvo JH, Iguácel LP, Kirinus JK, Serrano M, Ripoll G, Casasús I, Joy M, Pérez-Velasco L, Sarto P, Albertí P, Blanco M. | 08/9/2014 |
| Association of polymorphisms in calpain 1, (mu/I) large subunit, calpastatin, and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle. | Association of polymorphisms in calpain 1, (mu/I) large subunit, calpastatin, and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle.
Ribeca C, Bonfatti V, Cecchinato A, Albera A, Maretto F, Gallo L, Carnier P. | 08/31/2013 |
| Single nucleotide polymorphisms in the CAST gene are associated with meat quality traits in Yanbian cattle of China. | Association of CAST gene polymorphisms with carcass and meat quality traits in Yanbian cattle of China.
Li YX, Jin HG, Yan CG, Seo KS, Zhang LC, Ren CY, Jin X. | 06/22/2013 |
| The CAST28 genotypes showing allele frequencies of C (0.429) and T (0.571) were significantly associated with calpastatin activity and Warner-Bratzler Shear Force in beef. | Effects of genetic variants for the calpastatin gene on calpastatin activity and meat tenderness in Hanwoo (Korean cattle).
Chung H, Davis M. | 04/21/2012 |
| Gene expression of CAST was affected by polymorphism in cattle | Polymorphism and parent-of-origin effects on gene expression of CAST, leptin and DGAT1 in cattle.
Niciura SC, Ibelli AM, Gouveia GV, Gromboni JG, Rocha MI, de Souza MM, de Mello SS, Regitano LC. | 03/3/2012 |
| The association of polymorphisms in calpastatin and mu-calpain genes with meat tenderness in 3 French beef breeds is reported. | Effects of polymorphisms in the calpastatin and μ-calpain genes on meat tenderness in 3 French beef breeds.
Allais S, Journaux L, Levéziel H, Payet-Duprat N, Raynaud P, Hocquette JF, Lepetit J, Rousset S, Denoyelle C, Bernard-Capel C, Renand G. | 08/13/2011 |
| characteristic properties of ER membrane m-calpain (MCp), calpastatins and lumen m-calpain (LCp) and a brief comparative study between MCp and LCp | Characteristic properties of endoplasmic reticulum membrane m-calpain, calpastatin and lumen m-calpain: a comparative study between membrane and lumen m-calpains.
Samanta K, Kar P, Chakraborti T, Shaikh S, Chakraborti S. | 10/23/2010 |
| Single-nucleotide polymorphisms (SNPs) in the calpain (CAPN) and calpastatin (CAST) genes, described from Bos primigenius taurus, were examined to see if they were polymorphic in Nellore cattle. | Association of SNPs on CAPN1 and CAST genes with tenderness in Nellore cattle.
Pinto LF, Ferraz JB, Meirelles FV, Eler JP, Rezende FM, Carvalho ME, Almeida HB, Silva RC. | 10/23/2010 |
| These findings suggest that high molecular weight calmodulin-binding protein (HMWCaMBP) is the homolog of calpastatin and may be a CaM-binding form of calpastatin. | Cardiac high molecular weight calmodulin-binding protein is homologous to calpastatin I and calpastatin II.
Singh N, Shrivastav A, Olson D, Lakshmikuttyamma A, Ross A, Parr T, Bardsley RG, Sharma RK. | 01/21/2010 |
| The genetic variants in the bovine CAST gene can be analyzed with RFLP method and was studied in 375 bulls of six breeds, including Hereford, Aberdeen-angus, Simmental, Charolaise, Limousine and Polish Black-and-White (BW; Fresian) breeds. | A novel polymorphisms in intron 12 of the bovine calpastatin gene.
Juszczuk-Kubiak E, Wyszyńska-Koko J, Wicińska K, Rosochacki S. | 01/21/2010 |
| These studies indicate that an association between mu-calpain and calpastatin occurs in the inner membrane towards the inter membrane space of the mitochondria. | Submitochondrial localization of associated mu-calpain and calpastatin.
Kar P, Chakraborti T, Samanta K, Chakraborti S. | 01/21/2010 |
| The CAST SNP allele C was associated with increased muscle tenderness across days of postmortem aging. | Association of a single nucleotide polymorphism in the calpastatin gene with carcass and meat quality traits of beef cattle.
Schenkel FS, Miller SP, Jiang Z, Mandell IB, Ye X, Li H, Wilton JW. | 01/21/2010 |
| Molecular association between mu-calpain and calpastatin in the mitochondria indicating that calpastatin could play an important role in preventing uncontrolled activity of mu-calpain. | Identification of calpastatin and mu-calpain and studies of their association in pulmonary smooth muscle mitochondria.
Kar P, Chakraborti T, Roy S, Choudhury R, Chakraborti S. | 01/21/2010 |
| results indicate a change in skeletal muscle calpain/calpastatin proteolytic system during protein repletion following depletion with diets of less than 15% crude protein during early to peak lactation in dairy cows | Short commuunication: Effect of dietary protein depletion and repletion on skeletal muscle calpastatin during early lactation.
Cummins KA, Lonergan SM, Huff-Lonergan E. | 01/21/2010 |
| Two polymorphisms within the CAST gene are associated with pregnancy rate and productive life in dairy cattle. | Significant association of the calpastatin gene with fertility and longevity in dairy cattle.
Garcia MD, Michal JJ, Gaskins CT, Reeves JJ, Ott TL, Liu Y, Jiang Z. | 01/21/2010 |