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    Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif 13 [ Mus musculus (house mouse) ]

    Gene ID: 279028, updated on 25-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ADAMTS13 deficiency exacerbates neuroinflammation by targeting matrix metalloproteinase-9 in ischemic brain injury.

    ADAMTS13 deficiency exacerbates neuroinflammation by targeting matrix metalloproteinase-9 in ischemic brain injury.
    Jiang H, Hu J, He P, Wu Y, Li F, Chen Q.

    04/24/2024
    Regulation of von Willebrand factor by ADAMTS13 ameliorates lipopolysaccharide-induced lung injury in mice.

    Regulation of von Willebrand factor by ADAMTS13 ameliorates lipopolysaccharide-induced lung injury in mice.
    Onodera Y, Mitani S, Hosoda C, Takabayashi Y, Sakata A, Kawasaki R, Mori R, Ohshima C, Nishio K, Sugimoto M, Soejima K, Mackman N, Shima M, Tatsumi K.

    11/30/2023
    ADAMTS-13-regulated nuclear factor E2-related factor 2 signaling inhibits ferroptosis to ameliorate cisplatin-induced acute kidney injuy.

    ADAMTS-13-regulated nuclear factor E2-related factor 2 signaling inhibits ferroptosis to ameliorate cisplatin-induced acute kidney injuy.
    Meng X, Huang W, Mo W, Shu T, Yang H, Ning H., Free PMC Article

    02/19/2022
    Antibodies that conformationally activate ADAMTS13 allosterically enhance metalloprotease domain function.

    Antibodies that conformationally activate ADAMTS13 allosterically enhance metalloprotease domain function.
    Schelpe AS, Petri A, Roose E, Pareyn I, Deckmyn H, De Meyer SF, Crawley JTB, Vanhoorelbeke K., Free PMC Article

    06/19/2021
    Endothelial CD40 Mediates Microvascular von Willebrand Factor-Dependent Platelet Adhesion Inducing Inflammatory Venothrombosis in ADAMTS13 Knockout Mice.

    Endothelial CD40 Mediates Microvascular von Willebrand Factor-Dependent Platelet Adhesion Inducing Inflammatory Venothrombosis in ADAMTS13 Knockout Mice.
    Tahir S, Wagner AH, Dietzel S, Mannell H, Pircher J, Weckbach LT, Hecker M, Pohl U.

    12/26/2020
    These results support a synergistic effect of severe ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy in mice.

    Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy.
    Zheng L, Zhang D, Cao W, Song WC, Zheng XL., Free PMC Article

    02/1/2020
    ADAMTS13 knockout promotes the occurrence of early brain injury after experimental subarachnoid hemorrhage.

    Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage.
    Wan H, Wang Y, Ai J, Brathwaite S, Ni H, Macdonald RL, Hol EM, Meijers JCM, Vergouwen MDI., Free PMC Article

    09/21/2019
    ADAMTS13-vWF axis is partially involved in the pathophysiology of kidney ischemic reperfusion injury.

    ADAMTS13-von Willebrand factor axis is involved in the pathophysiology of kidney ischaemia-reperfusion injury.
    Kim MG, Lim SY, Ko YS, Lee HY, Jo SK, Cho WY.

    06/16/2018
    Adamts13 deficiency in obese mice promotes hepatic microthrombosis.

    ADAMTS13 deficiency promotes microthrombosis in a murine model of diet-induced liver steatosis.
    Geys L, Bauters D, Roose E, Tersteeg C, Vanhoorelbeke K, Hoylaerts MF, Lijnen RH, Scroyen I.

    03/3/2018
    ADAMTS13 retards progression of diabetic nephropathy, most likely by inhibiting VWF-dependent intrarenal thrombosis.

    ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in Mice.
    Dhanesha N, Doddapattar P, Chorawala MR, Nayak MK, Kokame K, Staber JM, Lentz SR, Chauhan AK., Free PMC Article

    07/15/2017
    administration of ADAMTS13 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA patency and consequently reduced cerebral infarct sizes

    ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice.
    Denorme F, Langhauser F, Desender L, Vandenbulcke A, Rottensteiner H, Plaimauer B, François O, Andersson T, Deckmyn H, Scheiflinger F, Kleinschnitz C, Vanhoorelbeke K, De Meyer SF.

    06/24/2017
    Sleeping beauty transposon-mediated gene therapy achieved sustained expression of transgene ADAMTS13 and long-term prophylaxis against congenital thrombotic thrombocytopenic purpura in Adamts13(-/-) mice.

    Long-Term Prevention of Congenital Thrombotic Thrombocytopenic Purpura in ADAMTS13 Knockout Mice by Sleeping Beauty Transposon-Mediated Gene Therapy.
    Verhenne S, Vandeputte N, Pareyn I, Izsvák Z, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K.

    06/24/2017
    Results also suggest that Toxoplasma gondii-mediated apoptosis might play a pivotal role and a different type of role in the mechanism of neurodegeneration and neuropathology in the process of toxoplasma encephalitis. Furthermore, expression of ADAMTS-13 might give an idea of the progress and is critical for diagnosis of this disease.

    Increased expressions of ADAMTS-13 and apoptosis contribute to neuropathology during Toxoplasma gondii encephalitis in mice.
    Dincel GC, Atmaca HT.

    02/4/2017
    Letter: deficiency of ADAMTS13 results in increased formation of venous thrombosis in mice.

    Influence of ADAMTS13 deficiency on venous thrombosis in mice.
    Tashima Y, Banno F, Akiyama M, Miyata T.

    04/9/2016
    ADAMTS13 substrate specificity

    Probing ADAMTS13 substrate specificity using phage display.
    Desch KC, Kretz C, Yee A, Gildersleeve R, Metzger K, Agrawal N, Cheng J, Ginsburg D., Free PMC Article

    04/2/2016
    Data indicate that the p.D187H mutation impairs ADAMTS13 activity and secretion and may contribute to thrombotic thrombocytopenic purpura.

    The novel ADAMTS13-p.D187H mutation impairs ADAMTS13 activity and secretion and contributes to thrombotic thrombocytopenic purpura in mice.
    De Cock E, Hermans C, De Raeymaecker J, De Ceunynck K, De Maeyer B, Vandeputte N, Vandenbulcke A, Deckmyn H, Rottensteiner H, De Maeyer M, De Meyer SF, Vanhoorelbeke K.

    11/21/2015
    Data show that metalloendopeptidase ADAMTS13 does not directly promote development of adipose tissue.

    ADAMTS13 deficiency in mice does not affect adipose tissue development.
    Geys L, Scroyen I, Roose E, Vanhoorelbeke K, Lijnen HR.

    10/3/2015
    findings provide further evidence on the pathophysiological role for the ADAMTS13/VWF axis in atherosclerosis

    ADAMTS13 modulates atherosclerotic plaque progression in mice via a VWF-dependent mechanism.
    Gandhi C, Ahmad A, Wilson KM, Chauhan AK.

    11/22/2014
    Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner.

    Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner.
    Bao J, Xiao J, Mao Y, Zheng XL., Free PMC Article

    03/22/2014
    Three novel mutations in a homozygous state were identified in these patients: c.1308G>C, c.428T>C (p.Ile143Thr) and c.1709A>G (p.Tyr570Cys)

    Congenital thrombotic thrombocytopenic purpura with novel mutations in three unrelated Turkish children.
    Metin A, Unal S, Gümrük F, Palla R, Cairo A, Underwood M, Gurgey A.

    03/15/2014
    The results indicate that the microvascular process induced by ADAMTS13 deficiency triggers complement activation on platelets and the endothelium, which may contribute to formation of thrombotic microangiopathy.

    Complement activation associated with ADAMTS13 deficiency in human and murine thrombotic microangiopathy.
    Tati R, Kristoffersson AC, Ståhl AL, Rebetz J, Wang L, Licht C, Motto D, Karpman D., Free PMC Article

    11/16/2013
    model of acute myocardial infarction in ADAMTS13 gene deleted (Adamts13 -/-) mice

    ADAMTS13 safeguards the myocardium in a mouse model of acute myocardial infarction.
    Doi M, Matsui H, Takeda H, Saito Y, Takeda M, Matsunari Y, Nishio K, Shima M, Banno F, Akiyama M, Kokame K, Miyata T, Sugimoto M.

    05/18/2013
    We hypothesize that ADAMTS13 protects brain from ischemia-reperfusion injury by regulating von Willebrand factor -dependent inflammation as well as microvascular plugging

    ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion injury.
    Fujioka M, Nakano T, Hayakawa K, Irie K, Akitake Y, Sakamoto Y, Mishima K, Muroi C, Yonekawa Y, Banno F, Kokame K, Miyata T, Nishio K, Okuchi K, Iwasaki K, Fujiwara M, Siesjö BK.

    04/20/2013
    Cyclophilin B activity regulated secretion and activity of ADAMTS13.

    Cyclosporin A impairs the secretion and activity of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat).
    Hershko K, Simhadri VL, Blaisdell A, Hunt RC, Newell J, Tseng SC, Hershko AY, Choi JW, Sauna ZE, Wu A, Bram RJ, Komar AA, Kimchi-Sarfaty C., Free PMC Article

    03/30/2013
    Adamts13(-/-) mice developed larger myocardial infarctions than wild-type control mice.

    Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice.
    De Meyer SF, Savchenko AS, Haas MS, Schatzberg D, Carroll MC, Schiviz A, Dietrich B, Rottensteiner H, Scheiflinger F, Wagner DD., Free PMC Article

    02/16/2013
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