| Podocalyxin molecular characteristics and endometrial expression: high conservation between humans and macaques but divergence in micedagger. | Podocalyxin molecular characteristics and endometrial expression: high conservation between humans and macaques but divergence in mice†.
Thach B, Samarajeewa N, Li Y, Heng S, Tsai T, Pangestu M, Catt S, Nie G. | 06/25/2022 |
| Distinct Functional Requirements for Podocalyxin in Immature and Mature Podocytes Reveal Mechanisms of Human Kidney Disease. | Distinct Functional Requirements for Podocalyxin in Immature and Mature Podocytes Reveal Mechanisms of Human Kidney Disease.
Refaeli I, Hughes MR, Wong AK, Bissonnette MLZ, Roskelley CD, Wayne Vogl A, Barbour SJ, Freedman BS, McNagny KM., Free PMC Article | 11/28/2020 |
| The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin and ezrin in podocytes was associated with the stability of the PC/ezrin complex. | The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex.
Yuan YP, Zhao H, Peng LQ, Li ZF, Liu S, Yuan CY, Mwamunyi MJ, Pearce D, Yao LJ., Free PMC Article | 12/14/2019 |
| Podocalyxin-like protein 1 is a relevant marker for human c-kit(pos) cardiac stem cells.( | Podocalyxin-like protein 1 is a relevant marker for human c-kit(pos) cardiac stem cells.
Moscoso I, Tejados N, Barreiro O, Sepúlveda P, Izarra A, Calvo E, Dorronsoro A, Salcedo JM, Sádaba R, Díez-Juan A, Trigueros C, Bernad A. | 11/26/2017 |
| Podxl-KO led to heightened G-CSF activation of Rap1a(GTP), and Rap1a(GTP) inhibition attenuated Podxl-KO neutrophil migration. Studies have revealed novel roles for Podxl as an important modulator of neutrophil and monocyte formation and of Rap1a activation during stress hematopoiesis. | Novel roles for podocalyxin in regulating stress myelopoiesis, Rap1a, and neutrophil migration.
Li P, Karaczyn AA, McGlauflin R, Favreau-Lessard AJ, Jachimowicz E, Vary CP, Xu K, Wojchowski DM, Sathyanarayana P., Free PMC Article | 09/30/2017 |
| Podxl-overexpression in neural stem/progenitor cells leads to an up-regulation of Annexin A2. | High Podocalyxin levels promote cell viability partially through up-regulation of Annexin A2.
San IV, Prost G, Williams JA, Moss SE, Nuber UA. | 05/27/2017 |
| when endogenous podocalyxin was removed from highly metastatic 4T1 mammary tumor cells there was a decrease in collective invasion . Podocalyxin is a tumor cell-intrinsic regulator of experimental collective tumor cell invasion and tumor budding. | The cell surface mucin podocalyxin regulates collective breast tumor budding.
Graves ML, Cipollone JA, Austin P, Bell EM, Nielsen JS, Gilks CB, McNagny KM, Roskelley CD., Free PMC Article | 10/8/2016 |
| Podocalyxin has a role in glioblastoma multiforme cell invasion and proliferation via beta-catenin signaling | Podocalyxin promotes glioblastoma multiforme cell invasion and proliferation via β-catenin signaling.
Liu Y, Yang L, Liu B, Jiang YG., Free PMC Article | 01/16/2016 |
| Loss of podocalyxin from the lung vasculature results in changes to the lung structure and function including increased lung volume when inflated under constant pressure (25 cm H2O) and changes to the matrix composition. | Podocalyxin regulates murine lung vascular permeability by altering endothelial cell adhesion.
Debruin EJ, Hughes MR, Sina C, Lu A, Cait J, Jian Z, Lopez M, Lo B, Abraham T, McNagny KM., Free PMC Article | 07/4/2015 |
| CTGF is an important mediator of high glucose-induced podocyte damage and decreases the protein level of podocalyxin by the ERK1/2 pathway. | [Connective tissue growth factor mediates high glucose-induced down-regulation of podocalyxin expression in mouse podocytes].
Zhang J, Li PH, Yang L, DU QS, Guo TT, Tang X. | 03/9/2013 |
| platelet Podxl is involved in the control of hemostasis acting as a platelet co-stimulator, likely due to its pro-adhesive properties | Diminished thrombogenic responses by deletion of the Podocalyxin Gene in mouse megakaryocytes.
Pericacho M, Alonso-Martín S, Larrucea S, González-Manchón C, Fernández D, Sánchez I, Ayuso MS, Parrilla R., Free PMC Article | 02/18/2012 |
| Full-length recombinant murine podocalyxin recruits NHERF-1 to the apical domain. Ectopic expression in human & canine epithelial cells leads to microvilli formation on an apical domain extending laterally to the junctional complexes. | The CD34-related molecule podocalyxin is a potent inducer of microvillus formation.
Nielsen JS, Graves ML, Chelliah S, Vogl AW, Roskelley CD, McNagny KM., Free PMC Article | 05/10/2011 |
| Podocalyxin plays multiple roles in neural development | Podocalyxin is a novel polysialylated neural adhesion protein with multiple roles in neural development and synapse formation.
Vitureira N, Andrés R, Pérez-Martínez E, Martínez A, Bribián A, Blasi J, Chelliah S, López-Doménech G, De Castro F, Burgaya F, McNagny K, Soriano E., Free PMC Article | 11/6/2010 |
| PODXL may act as a costimulator of agonists in the activation of platelets and formation of a stable thrombus. | Overexpression of podocalyxin in megakaryocytes and platelets decreases the bleeding time and enhances the agonist-induced aggregation of platelets.
Alonso-Martin S, Nowakowski A, Larrucea S, Fernández D, Vilar-Egea M, Ayuso MS, Parrilla R. | 09/27/2010 |
| Data show that in podocalyxin-deficient mice, the thickness of the main carotid artery is significantly increased, and there is an increased number of choroidal capillaries lining the ventricular spaces. | Ventricular enlargement associated with the panneural ablation of the podocalyxin gene.
Nowakowski A, Alonso-Martín S, González-Manchón C, Larrucea S, Fernández D, Vilar M, Cerdán S, Ayuso MS, Parrilla R. | 05/3/2010 |
| Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery. | Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery.
Maltby S, Hughes MR, Zbytnuik L, Paulson RF, McNagny KM. | 01/21/2010 |
| PODXL(hi)/CD49f(hi) MSCs were less prone to produce lethal pulmonary emboli | The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice.
Lee RH, Seo MJ, Pulin AA, Gregory CA, Ylostalo J, Prockop DJ., Free PMC Article | 01/21/2010 |
| In mice expressing an Erythropoietin receptor allele, compromised erythropoietin-induced podocalyxin expression correlated with enucleated red cells in bone marrow. | Erythropoietin modulation of podocalyxin and a proposed erythroblast niche.
Sathyanarayana P, Menon MP, Bogacheva O, Bogachev O, Niss K, Kapelle WS, Houde E, Fang J, Wojchowski DM., Free PMC Article | 01/21/2010 |
| Podocalyxin mRNA was widely expressed at least from E14, the first age we studied, and expression remained high until adulthood | Pattern of expression of the podocalyxin gene in the mouse brain during development.
Vitureira N, McNagny K, Soriano E, Burgaya F. | 01/21/2010 |
| Podocalyxin is required for normal kidney function | Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin.
Doyonnas R, Kershaw DB, Duhme C, Merkens H, Chelliah S, Graf T, McNagny KM., Free PMC Article | 04/6/2007 |