| PELP1 and SRC kinase as important molecules in the estrogen-mediated pathway in human testis and epididymis. | PELP1 and SRC kinase as important molecules in the estrogen-mediated pathway in human testis and epididymis.
Skibińska I, Andrusiewicz M, Jendraszak M, Żbikowska A, Żaba C, Kotwicka M. | 06/23/2023 |
| Expression of estrogen receptors, PELP1, and SRC in human spermatozoa and their associations with semen quality. | Expression of estrogen receptors, PELP1, and SRC in human spermatozoa and their associations with semen quality.
Skibińska I, Andrusiewicz M, Jendraszak M, Żbikowska A, Jędrzejczak P, Kotwicka M., Free PMC Article | 02/28/2023 |
| PELP1 is overexpressed in lung cancer and promotes tumor cell malignancy and resistance to tyrosine kinase inhibitor drug. | PELP1 is overexpressed in lung cancer and promotes tumor cell malignancy and resistance to tyrosine kinase inhibitor drug.
Wang X, Yin W, Liang L. | 10/29/2022 |
| Interaction of transcription factor AP-2 gamma with proto-oncogene PELP1 promotes tumorigenesis by enhancing RET signaling. | Interaction of transcription factor AP-2 gamma with proto-oncogene PELP1 promotes tumorigenesis by enhancing RET signaling.
Liu J, Liu Z, Li M, Tang W, Pratap UP, Luo Y, Altwegg KA, Li X, Zou Y, Zhu H, Sareddy GR, Viswanadhapalli S, Vadlamudi RK., Free PMC Article | 01/15/2022 |
| Somatic mutations of cancer-related genes PELP1 and BDP1 in colorectal cancers. | Somatic mutations of cancer-related genes PELP1 and BDP1 in colorectal cancers.
Son HJ, Mo HY, Yoo NJ, Lee SH. | 01/15/2022 |
| Overexpression of PELP1 in Lung Adenocarcinoma Promoted E2 Induced Proliferation, Migration and Invasion of the Tumor Cells and Predicted a Worse Outcome of the Patients. | Overexpression of PELP1 in Lung Adenocarcinoma Promoted E(2) Induced Proliferation, Migration and Invasion of the Tumor Cells and Predicted a Worse Outcome of the Patients.
Zhang D, Dai J, Pan Y, Wang X, Qiao J, Sasano H, Zhao B, McNamara KM, Guan X, Liu L, Zhang Y, Chan MSM, Cao S, Liu M, Song S, Wang L., Free PMC Article | 12/25/2021 |
| PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER(+) breast cancer. | PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER(+) breast cancer.
Truong TH, Benner EA, Hagen KM, Temiz NA, Kerkvliet CP, Wang Y, Cortes-Sanchez E, Yang CH, Trousdell MC, Pengo T, Guillen KP, Welm BE, Dos Santos CO, Telang S, Lange CA, Ostrander JH., Free PMC Article | 12/25/2021 |
| PELP1 promotes the expression of RUNX2 via the ERK pathway during the osteogenic differentiation of human periodontal ligament stem cells. | PELP1 promotes the expression of RUNX2 via the ERK pathway during the osteogenic differentiation of human periodontal ligament stem cells.
Yan Y, Liu Y, Lu R. | 05/8/2021 |
| Estradiol-Induced MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERalpha-Positive Breast Cancer Cells. | Estradiol-Induced MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERα-Positive Breast Cancer Cells.
Pan Y, Wang X, Zhang Y, Qiao J, Sasano H, McNamara K, Zhao B, Zhang D, Fan Y, Liu L, Jia X, Liu M, Song S, Wang L., Free PMC Article | 10/3/2020 |
| Authors validated that PELP1 was significantly up-regulated in GC samples and cell lines. It was also demonstrated that the up-regulation of PELP1 was associated with several clinicopathologic features. | PELP1 is a novel oncogene in gastric tumorigenesis and negatively regulated by miR-15 family microRNAs.
Ma C, Miao C, Wang C, Song F, Luo M. | 03/28/2020 |
| Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC] | Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.
Fanis P, Gillemans N, Aghajanirefah A, Pourfarzad F, Demmers J, Esteghamat F, Vadlamudi RK, Grosveld F, Philipsen S, van Dijk TB., Free PMC Article | 02/28/2020 |
| Surveying the side chains with various alkyl groups led to the identification of a potent compound 14d that exhibited antiproliferative activity (IC50 value of 16 nM) on PCa cells. In addition, biochemical studies showed that 14d exerts its anticancer activity by inhibiting the AR-PELP1 interaction and AR transactivation. | A Structure-Activity Relationship Study of Bis-Benzamides as Inhibitors of Androgen Receptor-Coactivator Interaction.
Lee TK, Ravindranathan P, Sonavane R, Raj GV, Ahn JM., Free PMC Article | 01/4/2020 |
| The results of our study suggest that PEPL1 may be utilized as an indicator of sperm quality; thereby, PELP1 may be an additional biomarker useful in the evaluation of male infertility. | Increased expression of PELP1 in human sperm is correlated with decreased semen quality.
Skibinska I, Andrusiewicz M, Soin M, Jendraszak M, Urbaniak P, Jedrzejczak P, Kotwicka M., Free PMC Article | 09/7/2019 |
| Data demonstrate that cytoplasmic PELP1 interacts with AIB1 to drive estrogen-independent events involved in regulation of breast cancer stem cell biology and disease progression. | Cancer Stem Cell Phenotypes in ER(+) Breast Cancer Models Are Promoted by PELP1/AIB1 Complexes.
Truong TH, Hu H, Temiz NA, Hagen KM, Girard BJ, Brady NJ, Schwertfeger KL, Lange CA, Ostrander JH., Free PMC Article | 08/3/2019 |
| Study shows that VPS11/18 inhibit the formation of the estrogen receptor alpha (ERalpha) membrane complex with c-Src by preventing its interaction with PELP1 through PELP1 ubiquitination. This impairs a feedforward stimulation between membrane and nuclear ERalpha molecules. | Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling.
Segala G, Bennesch MA, Ghahhari NM, Pandey DP, Echeverria PC, Karch F, Maeda RK, Picard D., Free PMC Article | 06/15/2019 |
| The data demonstrate that SUMO2 conjugation and SENP3-driven deSUMOylation of PELP1 is instrumental for ordered progression of ribosome maturation, and they provide molecular insight into the dynamics of ribosome maturation. | The AAA ATPase MDN1 Acts as a SUMO-Targeted Regulator in Mammalian Pre-ribosome Remodeling.
Raman N, Weir E, Müller S. | 09/2/2017 |
| High PELP1 expression is associated with inflammation and breast cancer. | Cytoplasmic Localization of Proline, Glutamic Acid, Leucine-rich Protein 1 (PELP1) Induces Breast Epithelial Cell Migration through Up-regulation of Inhibitor of κB Kinase ϵ and Inflammatory Cross-talk with Macrophages.
Girard BJ, Knutson TP, Kuker B, McDowell L, Schwertfeger KL, Ostrander JH., Free PMC Article | 06/3/2017 |
| three techniques for the first time demonstrated the presence of the PELP1 in paraspinal muscles of patients with idiopathic scoliosis. | Expression of Estrogen Receptor Coactivator Proline-, Glutamic Acid- and Leucine-Rich Protein 1 within Paraspinal Muscles in Adolescents with Idiopathic Scoliosis.
Skibinska I, Tomaszewski M, Andrusiewicz M, Urbaniak P, Czarnecka-Klos R, Shadi M, Kotwicki T, Kotwicka M., Free PMC Article | 08/13/2016 |
| PELP1 interacted with GR to activate Brk expression. | Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.
Regan Anderson TM, Ma SH, Raj GV, Cidlowski JA, Helle TM, Knutson TP, Krutilina RI, Seagroves TN, Lange CA., Free PMC Article | 07/30/2016 |
| we propose that PELP1/Ki-67 double high expression in tumors is an independent prognostic factor for predicting a poor outcome for patients with Triple-negative breast cancer | Prognostic significance of proline, glutamic acid, leucine rich protein 1 (PELP1) in triple-negative breast cancer: a retrospective study on 129 cases.
Zhang Y, Dai J, McNamara KM, Bai B, Shi M, Chan MS, Liu M, Sasano H, Wang X, Li X, Liu L, Ma Y, Cao S, Xing Y, Zhao B, Song Y, Wang L., Free PMC Article | 07/2/2016 |
| There is mounting evidence that PELP1 plays key roles in several biological processes and its deregulation leads to the development of cancers. | Minireview: Deciphering the Cellular Functions of PELP1.
Ravindranathan P, Lange CA, Raj GV., Free PMC Article | 06/28/2016 |
| There are significantly higher amounts of PELP1 transcript and protein in tumor tissues in patients with non-small cell lung cancer. | Increased expression of proline-, glutamic acid- and leucine-rich protein PELP1 in non-small cell lung cancer.
Słowikowski BK, Gałęcki B, Dyszkiewicz W, Jagodziński PP. | 05/7/2016 |
| The diffuse and strong nuclear immunoreactivity of PELP1 in most cases suggests that PELP1 may be a molecular target for the treatment of triple-negative breast carcinoma | Significantly increased PELP1 protein expression in primary and metastatic triple-negative breast carcinoma: comparison with GATA3 expression and PELP1's potential role in triple-negative breast carcinoma.
Dang DN, Raj G, Sarode V, Molberg KH, Vadlamudi RK, Peng Y. | 02/27/2016 |
| Results show that PELP1 is highly phosphorylated in triple negative breast cancer cells and interacts with mutated Tp53 and E2F1 to differentially regulates their target gene expression. | Novel role of PELP1 in regulating chemotherapy response in mutant p53-expressing triple negative breast cancer cells.
Krishnan SR, Nair BC, Sareddy GR, Roy SS, Natarajan M, Suzuki T, Peng Y, Raj G, Vadlamudi RK., Free PMC Article | 01/2/2016 |
| The PELP1 interacts with p53, functions as p53-coactivator and is required for optimal activation of p53 target genes under genomic stress. | Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response.
Nair BC, Krishnan SR, Sareddy GR, Mann M, Xu B, Natarajan M, Hasty P, Brann D, Tekmal RR, Vadlamudi RK., Free PMC Article | 04/25/2015 |