| LTBP1 Gene Expression in the Cerebral Cortex and its Neuroprotective Mechanism in Mice with Postischemic Stroke Epilepsy. | LTBP1 Gene Expression in the Cerebral Cortex and its Neuroprotective Mechanism in Mice with Postischemic Stroke Epilepsy.
Liu B, Wang Y, He D, Han G, Wang H, Lin Y, Zhang T, Yi C, Li H. | 03/9/2023 |
| Fibulin-1c regulates transforming growth factor-beta activation in pulmonary tissue fibrosis. | Fibulin-1c regulates transforming growth factor-β activation in pulmonary tissue fibrosis.
Liu G, Cooley MA, Jarnicki AG, Borghuis T, Nair PM, Tjin G, Hsu AC, Haw TJ, Fricker M, Harrison CL, Jones B, Hansbro NG, Wark PA, Horvat JC, Argraves WS, Oliver BG, Knight DA, Burgess JK, Hansbro PM., Free PMC Article | 09/26/2020 |
| LTBP1 has a role in female reproduction | Latent TGF-β binding protein-1 deficiency decreases female fertility.
Dietzel E, Weiskirchen S, Floehr J, Horiguchi M, Todorovic V, Rifkin DB, Jahnen-Dechent W, Weiskirchen R. | 06/10/2017 |
| Data show the complete knockout of both isoforms of LTBP-1 leads to defective cardiovascular development and subsequent perinatal lethality supporting the idea that LTBP-1 is essential in the development of the great arteries and cardiac cushions. | Abrogation of both short and long forms of latent transforming growth factor-β binding protein-1 causes defective cardiovascular development and is perinatally lethal.
Horiguchi M, Todorovic V, Hadjiolova K, Weiskirchen R, Rifkin DB., Free PMC Article | 02/27/2016 |
| Ltbp1 functions in a mechanosensory capacity to establish and maintain mammary gland ductal luminal cell fate, support and detect ductal distension, trigger irreversible involution, and facilitate nipple sphincter function. | Ltbp1L is focally induced in embryonic mammary mesenchyme, demarcates the ductal luminal lineage and is upregulated during involution.
Chandramouli A, Simundza J, Pinderhughes A, Hiremath M, Droguett G, Frendewey D, Cowin P., Free PMC Article | 05/23/2015 |
| a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7. | Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network.
Nicklas D, Saiz L., Free PMC Article | 02/8/2014 |
| miR-133a mediates TGF-beta-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis. | miR-133a mediates TGF-β-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis.
Roderburg C, Luedde M, Vargas Cardenas D, Vucur M, Mollnow T, Zimmermann HW, Koch A, Hellerbrand C, Weiskirchen R, Frey N, Tacke F, Trautwein C, Luedde T. | 01/25/2014 |
| Induction of both Th17-producing cells and Tregs is caused preferentially by Tregs expressing the latent TGF-beta1/GARP complex on their cell surface rather than by secreted latent TGF-beta1. | Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation.
Edwards JP, Fujii H, Zhou AX, Creemers J, Unutmaz D, Shevach EM., Free PMC Article | 07/27/2013 |
| High transforming Growth Factor beta1 expression is associated with myelofibrosis. | Characterization of the TGF-β1 signaling abnormalities in the Gata1low mouse model of myelofibrosis.
Zingariello M, Martelli F, Ciaffoni F, Masiello F, Ghinassi B, D'Amore E, Massa M, Barosi G, Sancillo L, Li X, Goldberg JD, Rana RA, Migliaccio AR., Free PMC Article | 06/29/2013 |
| results suggest a role for VEGFA-driven tumour growth by TGF-beta signalling inhibition via paracrine mechanisms in vivo | Stromal interaction essential for vascular endothelial growth factor A-induced tumour growth via transforming growth factor-β signalling.
Weidenaar AC, ter Elst A, Kampen KR, Meeuwsen-de Boer TG, de Jonge HJ, Scherpen FJ, den Dunnen WF, Kamps WA, de Bont ES., Free PMC Article | 01/21/2012 |
| Study reports that master transcription factors also are responsible for directing the gene targets of TGF-beta signaling and thus determine the cell-type-specific effects of TGF-beta signaling. | Master transcription factors determine cell-type-specific responses to TGF-β signaling.
Mullen AC, Orlando DA, Newman JJ, Lovén J, Kumar RM, Bilodeau S, Reddy J, Guenther MG, DeKoter RP, Young RA., Free PMC Article | 12/24/2011 |
| requirement for TGF-beta signaling into T cells to achieve peripheral CD8 but not CD4 T-cell tolerance | LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L.
Lucas CL, Workman CJ, Beyaz S, LoCascio S, Zhao G, Vignali DA, Sykes M., Free PMC Article | 08/13/2011 |
| Ltbp1L is a major regulator of Tgf-beta activity during valvulogenesis since its absence results in a perturbed Tgf-beta pathway that causes all Ltbp1L(-/-) valvular defects. | Long form of latent TGF-β binding protein 1 (Ltbp1L) regulates cardiac valve development.
Todorovic V, Finnegan E, Freyer L, Zilberberg L, Ota M, Rifkin DB., Free PMC Article | 05/14/2011 |
| Shows that Latent Tgfbeta Binding protein 1 (LTBP1), which is a key extracellular modulator of Tgfbeta ligand bioavailability, is coexpressed with Tgfbetas in the early limb bud. | Tgfbeta2 and 3 are coexpressed with their extracellular regulator Ltbp1 in the early limb bud and modulate mesodermal outgrowth and BMP signaling in chicken embryos.
Lorda-Diez CI, Montero JA, Garcia-Porrero JA, Hurle JM., Free PMC Article | 08/16/2010 |
| When TGF-beta activity would inhibit further maturation and mineralization, LTBP-1 containing large latent TGF-beta1 complexes that accumulate into the ECM and represent targets for osteoclast mediated release and activation of TGF-beta in bone tissue. | Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells.
Koli K, Ryynänen MJ, Keski-Oja J. | 01/21/2010 |
| Data suggest that association of latent TGF-beta binding protein (LTBP) with the latent TGF-beta complex is important for proper TGF-beta1 function. | Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors.
Yoshinaga K, Obata H, Jurukovski V, Mazzieri R, Chen Y, Zilberberg L, Huso D, Melamed J, Prijatelj P, Todorovic V, Dabovic B, Rifkin DB., Free PMC Article | 01/21/2010 |
| Blocking Tgfb-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. | Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS, Flavell RA., Free PMC Article | 01/21/2010 |
| AhR regulates Ltbp-1 transcription by a mechanism involving recruitment of co-activators such as CREB1 and co-repressors such as HDAC2 to the Ltbp-1 promoter. | Recruitment of CREB1 and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its constitutive expression in a dioxin receptor-dependent manner.
Gomez-Duran A, Ballestar E, Carvajal-Gonzalez JM, Marlowe JL, Puga A, Esteller M, Fernandez-Salguero PM., Free PMC Article | 01/21/2010 |
| LTBP-1 has essential functions in the control of TGF-beta activation | Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailability.
Drews F, Knöbel S, Moser M, Muhlack KG, Mohren S, Stoll C, Bosio A, Gressner AM, Weiskirchen R. | 01/21/2010 |
| Data show that the lack of Ltbp1L in the extracellular matrix of the septating cardiac outflow tract and associated vessels results in altered gene expression and function of cardiac neural crest cells and decreased Tgf-beta activity in the OFT. | Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling.
Todorovic V, Frendewey D, Gutstein DE, Chen Y, Freyer L, Finnegan E, Liu F, Murphy A, Valenzuela D, Yancopoulos G, Rifkin DB, Todorovic V, Frendewey D, Gutstein DE, Chen Y, Freyer L, Finnegan E, Liu F, Murphy A, Valenzuela D, Yancopoulos G, Rifkin DB. | 01/21/2010 |
| The long form of LTBP1 (LTBP-1L) is essential for proper heart development. | Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling.
Todorovic V, Frendewey D, Gutstein DE, Chen Y, Freyer L, Finnegan E, Liu F, Murphy A, Valenzuela D, Yancopoulos G, Rifkin DB, Todorovic V, Frendewey D, Gutstein DE, Chen Y, Freyer L, Finnegan E, Liu F, Murphy A, Valenzuela D, Yancopoulos G, Rifkin DB. | 11/16/2007 |
| integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1 requires fibronectin | Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1.
Fontana L, Chen Y, Prijatelj P, Sakai T, Fässler R, Sakai LY, Rifkin DB. | 01/21/2010 |
| fibronectin has a role in LTBP1 assembly in the ECM and in regulation of TGF beta via LTBP1 interactions | Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1.
Dallas SL, Sivakumar P, Jones CJ, Chen Q, Peters DM, Mosher DF, Humphries MJ, Kielty CM. | 01/21/2010 |
| IGFBP-3 can bind to LTBP-1 and provide a potential mechanism whereby IGFBP-3 can interact with the TGF-beta system | Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1.
Gui Y, Murphy LJ. | 01/21/2010 |
| Cleavage of LTBP1 by BMP1 is involved in TGFbeta1 activation. | BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein.
Ge G, Greenspan DS., Free PMC Article | 01/21/2010 |