| miR-124 mediates the effects of gut microbial dysbiosis on brain function in chronic stressed mice. | miR-124 mediates the effects of gut microbial dysbiosis on brain function in chronic stressed mice.
Chen H, Ouyang W, Cui X, Ma X, Hu S, Qing W, Tong J. | 11/4/2024 |
| Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating neuronal apoptosis in chronic cerebral ischemia. | Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating neuronal apoptosis in chronic cerebral ischemia.
Yang J, Liu X, Zhao Y, Dong W, Xue Y, Ruan X, Wang P, Liu L, E T, Song J, Cui Z, Liu Y. | 12/5/2023 |
| Role of miR-124-3p in regulatory mechanisms of Gpm6a expression in the hippocampus of chronically stressed rats. | Role of miR-124-3p in regulatory mechanisms of Gpm6a expression in the hippocampus of chronically stressed rats.
Alzuri SE, Rosas NM, Hlavacova N, Jezova D, Fuchsova B. | 05/30/2023 |
| miR-124-3p sabotages lncRNA MALAT1 stability to repress chondrocyte pyroptosis and relieve cartilage injury in osteoarthritis. | miR-124-3p sabotages lncRNA MALAT1 stability to repress chondrocyte pyroptosis and relieve cartilage injury in osteoarthritis.
Rozi R, Zhou Y, Rong K, Chen P., Free PMC Article | 10/22/2022 |
| Microglia-Derived Small Extracellular Vesicles Reduce Glioma Growth by Modifying Tumor Cell Metabolism and Enhancing Glutamate Clearance through miR-124. | Microglia-Derived Small Extracellular Vesicles Reduce Glioma Growth by Modifying Tumor Cell Metabolism and Enhancing Glutamate Clearance through miR-124.
Serpe C, Monaco L, Relucenti M, Iovino L, Familiari P, Scavizzi F, Raspa M, Familiari G, Civiero L, D'Agnano I, Limatola C, Catalano M., Free PMC Article | 11/13/2021 |
| These results show that antagonizing let-7 and increasing levels of miR-25 and miR-124 using miRNA mimics is useful in reprogramming Muller glial cells to retinal neurons in vitro and could help in stimulating regeneration in this system. | MicroRNAs miR-25, let-7 and miR-124 regulate the neurogenic potential of Müller glia in mice.
Wohl SG, Hooper MJ, Reh TA., Free PMC Article | 07/18/2020 |
| Synchronizing the expression of miR-124, miR-128, and miR-137 in a gene therapy approach displays significant anticancer synergism, abrogates this epigenesis-mediated, multi-protein tumor survival mechanism and results in a 5-fold increase in survival when combined with chemotherapy in murine glioblastoma models. | The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma.
Bhaskaran V, Nowicki MO, Idriss M, Jimenez MA, Lugli G, Hayes JL, Mahmoud AB, Zane RE, Passaro C, Ligon KL, Haas-Kogan D, Bronisz A, Godlewski J, Lawler SE, Chiocca EA, Peruzzi P., Free PMC Article | 02/16/2019 |
| Knockdown of miR-124 exerts cardioprotection via preventing apoptosis and ameliorating mitochondrial dysfunction following MI by targeting STAT3. | Inhibition of MicroRNA-124 Reduces Cardiomyocyte Apoptosis Following Myocardial Infarction via Targeting STAT3.
He F, Liu H, Guo J, Yang D, Yu Y, Yu J, Yan X, Hu J, Du Z. | 12/22/2018 |
| Rap2a is a common target of both miR-9 and miR-124. miR-9 and miR-124 together, but neither miRNA alone, strongly suppressed Rap2a, thereby promoting neuronal differentiation of neural stem cells and dendritic branching of differentiated neurons. | miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3β pathway by targeting Rap2a.
Xue Q, Yu C, Wang Y, Liu L, Zhang K, Fang C, Liu F, Bian G, Song B, Yang A, Ju G, Wang J., Free PMC Article | 04/14/2018 |
| OSBP may be a target and downstream effector of miR-124 for regulating neurite outgrowth and elongation. | MicroRNA124 Regulated Neurite Elongation by Targeting OSBP.
Gu X, Li A, Liu S, Lin L, Xu S, Zhang P, Li S, Li X, Tian B, Zhu X, Wang X. | 01/27/2018 |
| RNCR3 has an atheroprotective role in atherosclerosis. | Role of long non-coding RNA-RNCR3 in atherosclerosis-related vascular dysfunction.
Shan K, Jiang Q, Wang XQ, Wang YN, Yang H, Yao MD, Liu C, Li XM, Yao J, Liu B, Zhang YY, J Y, Yan B., Free PMC Article | 10/14/2017 |
| miR-124, targeting USP2 and USP14, negatively regulates LPS-induced TNF-alpha production in mouse macrophages, suggesting miR-124 as a new therapeutic target in inflammation-related diseases | MicroRNA-124 negatively regulates LPS-induced TNF-α production in mouse macrophages by decreasing protein stability.
Sun Y, Qin Z, Li Q, Wan JJ, Cheng MH, Wang PY, Su DF, Yu JG, Liu X., Free PMC Article | 08/5/2017 |
| RNCR3 reduces cell migration and tube formation in vitro. RNCR3 regulates endothelial cell function through RNCR3/KLF2/miR-185-5p regulatory network | RNCR3: A regulator of diabetes mellitus-related retinal microvascular dysfunction.
Shan K, Li CP, Liu C, Liu X, Yan B. | 06/10/2017 |
| PPARg-induced miR-124 inhibits the production of pro-inflammatory cytokines in severe sepsis. | Activation of PPARγ inhibits pro-inflammatory cytokines production by upregulation of miR-124 in vitro and in vivo.
Wang D, Shi L, Xin W, Xu J, Xu J, Li Q, Xu Z, Wang J, Wang G, Yao W, He B, Yang Y, Hu M. | 06/3/2017 |
| miR-124 contributes to the establishment of specific neuronal features in developing sympathoadrenal cells. | MiR-124 is differentially expressed in derivatives of the sympathoadrenal cell lineage and promotes neurite elongation in chromaffin cells.
Shtukmaster S, Narasimhan P, El Faitwri T, Stubbusch J, Ernsberger U, Rohrer H, Unsicker K, Huber K. | 05/20/2017 |
| miR124 plays a role in the neuronal differentiation of inner ear neural stem cells. | miR-124 promotes the neuronal differentiation of mouse inner ear neural stem cells.
Jiang D, Du J, Zhang X, Zhou W, Zong L, Dong C, Chen K, Chen Y, Chen X, Jiang H., Free PMC Article | 03/18/2017 |
| The expression of miR-124 decreased over time in the Pb-exposed animals and was significantly less than the levels exhibited by the control animals at PND700 | Early-Life Exposure to Lead (Pb) Alters the Expression of microRNA that Target Proteins Associated with Alzheimer's Disease.
Masoud AM, Bihaqi SW, Machan JT, Zawia NH, Renehan WE. | 12/31/2016 |
| miR-124, -128, and -137 act synergistically to regulate Sp1 expression. | miR-124, -128, and -137 Orchestrate Neural Differentiation by Acting on Overlapping Gene Sets Containing a Highly Connected Transcription Factor Network.
Santos MC, Tegge AN, Correa BR, Mahesula S, Kohnke LQ, Qiao M, Ferreira MA, Kokovay E, Penalva LO. | 12/17/2016 |
| MicroRNA-124 regulates cell specification in the cochlea through modulation of Sfrp4 and Sfrp5. | MicroRNA-124 Regulates Cell Specification in the Cochlea through Modulation of Sfrp4/5.
Huyghe A, Van den Ackerveken P, Sacheli R, Prévot PP, Thelen N, Renauld J, Thiry M, Delacroix L, Nguyen L, Malgrange B. | 07/16/2016 |
| MicroRNA-124 and microRNA-137 cooperatively control caspase-3 activity through BCL2L13 in hippocampal neural stem cells. | MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells.
Schouten M, Fratantoni SA, Hubens CJ, Piersma SR, Pham TV, Bielefeld P, Voskuyl RA, Lucassen PJ, Jimenez CR, Fitzsimons CP., Free PMC Article | 05/28/2016 |
| shows that the miR-124 promoted the differentiation of neuronal cells from bone marrow mesenchymal stem cells | MiR-124 promotes bone marrow mesenchymal stem cells differentiation into neurogenic cells for accelerating recovery in the spinal cord injury.
Zhao Y, Jiang H, Liu XW, Xiang LB, Zhou DP, Chen JT. | 04/9/2016 |
| PAX6 downregulates miR-124 expression to promote cell migration during embryonic stem cell differentiation | PAX6 downregulates miR-124 expression to promote cell migration during embryonic stem cell differentiation.
Fang J, Zhang T, Liu Y, Li Y, Zhou S, Song D, Zhao Y, Feng R, Zhang X, Li L, Wen J., Free PMC Article | 11/21/2015 |
| miR-124 plays an important role in the proliferation of mouse embryonic stem cells by promoting Cdk4 and cyclin D1 expression through directly inhibiting Fmr1 expression | Computational identification and experimental validation of microRNAs binding to the fragile X syndrome gene Fmr1.
Gong X, Wang Y, Zeng J, Li S, Luo Y. | 11/14/2015 |