| secretory PLA2s have important functions as genetic modifiers of inflammation and colon cancer. | Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.
Schewe M, Franken PF, Sacchetti A, Schmitt M, Joosten R, Böttcher R, van Royen ME, Jeammet L, Payré C, Scott PM, Webb NR, Gelb M, Cormier RT, Lambeau G, Fodde R. | 07/22/2017 |
| PLA2G10 releases omega-3 polyunsaturated fatty acids, suppresses colitis, and promotes sperm fertility. | Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility.
Murase R, Sato H, Yamamoto K, Ushida A, Nishito Y, Ikeda K, Kobayashi T, Yamamoto T, Taketomi Y, Murakami M., Free PMC Article | 08/6/2016 |
| Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2beta (iPLA2beta) and Group X Secreted Phospholipase A2 (sPLA2). | Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2β (iPLA2β) and Group X Secreted Phospholipase A2 (sPLA2).
Abi Nahed R, Martinez G, Escoffier J, Yassine S, Karaouzène T, Hograindleur JP, Turk J, Kokotos G, Ray PF, Bottari S, Lambeau G, Hennebicq S, Arnoult C., Free PMC Article | 06/28/2016 |
| GX sPLA2 negatively regulated pancreatic insulin secretion by augmenting COX-2-dependent PGE2 production. | Group X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism.
Shridas P, Zahoor L, Forrest KJ, Layne JD, Webb NR., Free PMC Article | 12/20/2014 |
| Mouse PLA2GX has a unique property of improving fertilization outcome among other secreted phospholipase A2 isoforms. | The effect of group X secreted phospholipase A2 on fertilization outcome is specific and not mimicked by other secreted phospholipases A2 or progesterone.
Abi Nahed R, Escoffier J, Revel C, Jeammet L, Payré C, Ray PF, Hennebicq S, Lambeau G, Arnoult C. | 10/11/2014 |
| Data indicate that experimental allergic bronchitis (EAB) in was associated with increased expression of sPLA2, specifically sPLA2gX, in the lungs. | Phospholipase A2 in experimental allergic bronchitis: a lesson from mouse and rat models.
Mruwat R, Yedgar S, Lavon I, Ariel A, Krimsky M, Shoseyov D., Free PMC Article | 08/30/2014 |
| Authors propose that activation of GX-sPLA2 during H1N1pdm infection is an early step of pulmonary inflammation and its inhibition increases adaptive immunity and improves survival. | Lack of group X secreted phospholipase A₂ increases survival following pandemic H1N1 influenza infection.
Kelvin AA, Degousee N, Banner D, Stefanski E, Leόn AJ, Angoulvant D, Paquette SG, Huang SS, Danesh A, Robbins CS, Noyan H, Husain M, Lambeau G, Gelb M, Kelvin DJ, Rubin BB., Free PMC Article | 06/7/2014 |
| Pla2G10 limits the development of atherosclerosis in LDL receptor-null mice. | Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice.
Ait-Oufella H, Herbin O, Lahoute C, Coatrieux C, Loyer X, Joffre J, Laurans L, Ramkhelawon B, Blanc-Brude O, Karabina S, Girard CA, Payré C, Yamamoto K, Binder CJ, Murakami M, Tedgui A, Lambeau G, Mallat Z. | 04/13/2013 |
| the use of a highly potent indole-based inhibitor of hGX-sPLA(2), RO061606 (which is ineffective against mGX-sPLA(2)), to assess the potential utility of GX-sPLA(2) blockade as a therapeutic intervention in asthma. | Blockade of human group X secreted phospholipase A2 (GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA2 inhibitor.
Henderson WR Jr, Oslund RC, Bollinger JG, Ye X, Tien YT, Xue J, Gelb MH., Free PMC Article | 05/12/2012 |
| sPLA(2)-X in neutrophils plays a pathogenic role in abdominal aortic aneurysms in a mouse model. | Group X secretory PLA2 in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice.
Watanabe K, Fujioka D, Saito Y, Nakamura T, Obata JE, Kawabata K, Watanabe Y, Mishina H, Tamaru S, Hanasaki K, Kugiyama K. | 02/18/2012 |
| sPLA2 plays a new role for fertilization by selecting a sperm subpopulation based on its effect on sperm motility. | Group X secreted phospholipase A₂ specifically decreases sperm motility in mice.
Escoffier J, Pierre VJ, Jemel I, Munch L, Boudhraa Z, Ray PF, De Waard M, Lambeau G, Arnoult C. | 10/15/2011 |
| Group X secretory phospholipase A2 promotes macrophage inflammatory responses by altering cellular cholesterol homeostasis and lipid raft content. | Group X secretory phospholipase A2 enhances TLR4 signaling in macrophages.
Shridas P, Bailey WM, Talbott KR, Oslund RC, Gelb MH, Webb NR., Free PMC Article | 09/3/2011 |
| the spatiotemporal expression of sPLA(2)-X in hair follicles, the presence of skin-specific machinery leading to sPLA(2)-X activation, a functional link of sPLA(2)-X with hair follicle homeostasis. | Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin.
Yamamoto K, Taketomi Y, Isogai Y, Miki Y, Sato H, Masuda S, Nishito Y, Morioka K, Ishimoto Y, Suzuki N, Yokota Y, Hanasaki K, Ishikawa Y, Ishii T, Kobayashi T, Fukami K, Ikeda K, Nakanishi H, Taguchi R, Murakami M., Free PMC Article | 06/4/2011 |
| Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function. | Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.
Sato H, Isogai Y, Masuda S, Taketomi Y, Miki Y, Kamei D, Hara S, Kobayashi T, Ishikawa Y, Ishii T, Ikeda K, Taguchi R, Ishimoto Y, Suzuki N, Yokota Y, Hanasaki K, Suzuki-Yamamoto T, Yamamoto K, Murakami M., Free PMC Article | 06/4/2011 |
| GX sPLA(2) promotes Ang II-induced pathological responses leading to abdominal aortic aneurysm formation | Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice.
Zack M, Boyanovsky BB, Shridas P, Bailey W, Forrest K, Howatt DA, Gelb MH, de Beer FC, Daugherty A, Webb NR., Free PMC Article | 05/21/2011 |
| hydrolytic products generated by GX sPLA(2) negatively regulate adipogenesis, possibly by suppressing LXR activation | Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models.
Li X, Shridas P, Forrest K, Bailey W, Webb NR., Free PMC Article | 01/1/2011 |
| The overexpression of GX sPLA(2) significantly reduced ABCA1 and ABCG1 expression in J774 macrophage-like cells, whereas GX sPLA(2) deficiency in peritoneal macrophages was associated with enhanced expression. | Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages.
Shridas P, Bailey WM, Gizard F, Oslund RC, Gelb MH, Bruemmer D, Webb NR., Free PMC Article | 10/23/2010 |
| Data show that GX sPLA(2) is expressed in mouse adrenal glands and functions to negatively regulate corticosteroid synthesis, most likely by negatively regulating StAR expression. | Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands.
Shridas P, Bailey WM, Boyanovsky BB, Oslund RC, Gelb MH, Webb NR., Free PMC Article | 08/30/2010 |
| Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice | Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice.
Escoffier J, Jemel I, Tanemoto A, Taketomi Y, Payre C, Coatrieux C, Sato H, Yamamoto K, Masuda S, Pernet-Gallay K, Pierre V, Hara S, Murakami M, De Waard M, Lambeau G, Arnoult C., Free PMC Article | 05/31/2010 |
| Enhanced protein expression in mammalian cells using engineered SUMO fusions: example of secreted PLA2-X. | Enhanced protein expression in mammalian cells using engineered SUMO fusions: secreted phospholipase A2.
Peroutka RJ, Elshourbagy N, Piech T, Butt TR., Free PMC Article | 01/21/2010 |
| secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology | Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology.
Curfs DM, Ghesquiere SA, Vergouwe MN, van der Made I, Gijbels MJ, Greaves DR, Verbeek JS, Hofker MH, de Winther MP. | 01/21/2010 |
| Myocardial ischemia/reperfusion injury was attenuated in sPLA(2)-X(-/-) mice partly through the suppression of neutrophil cytotoxic activities | Reduction in myocardial ischemia/reperfusion injury in group X secretory phospholipase A2-deficient mice.
Fujioka D, Saito Y, Kobayashi T, Yano T, Tezuka H, Ishimoto Y, Suzuki N, Yokota Y, Nakamura T, Obata JE, Kanazawa M, Kawabata K, Hanasaki K, Kugiyama K. | 01/21/2010 |
| direct attention to group X-secreted phospholipase A2 as a novel therapeutic target for asthma | Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model.
Henderson WR Jr, Chi EY, Bollinger JG, Tien YT, Ye X, Castelli L, Rubtsov YP, Singer AG, Chiang GK, Nevalainen T, Rudensky AY, Gelb MH., Free PMC Article | 01/21/2010 |
| sPLA2-X induces potent arachidonic acid release without activation of cytosolic phospholipase A2 alpha. | Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2 alpha.
Saiga A, Uozumi N, Ono T, Seno K, Ishimoto Y, Arita H, Shimizu T, Hanasaki K. | 01/21/2010 |
| group X secreted phospholipase A2 is expressed in neural cells and has neuritogenic action | Neuronal expression and neuritogenic action of group X secreted phospholipase A2.
Masuda S, Murakami M, Takanezawa Y, Aoki J, Arai H, Ishikawa Y, Ishii T, Arioka M, Kudo I. | 01/21/2010 |