| ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-kappaB signaling pathway. | ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.
Huang W, Tang H, Liu Y, Li W, Shimu AS, Li B, Zhu C. | 07/27/2023 |
| Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression. | Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression.
Irmer B, Efing J, Reitnauer LE, Angenendt A, Heinrichs S, Schubert A, Schulz M, Binder C, Tio J, Hansen U, Geyer C, Gerwing M, Bleckmann A, Menck K., Free PMC Article | 07/17/2023 |
| Ror1 promotes PPARalpha-mediated fatty acid metabolism in astrocytes. | Ror1 promotes PPARα-mediated fatty acid metabolism in astrocytes.
Tanaka Y, Minami Y, Endo M. | 04/6/2023 |
| The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation. | The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation.
Chavkin NW, Sano S, Wang Y, Oshima K, Ogawa H, Horitani K, Sano M, MacLauchlan S, Nelson A, Setia K, Vippa T, Watanabe Y, Saucerman JJ, Hirschi KK, Gokce N, Walsh K., Free PMC Article | 11/6/2021 |
| Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1alpha regulator. | Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator.
Isomura H, Taguchi A, Kajino T, Asai N, Nakatochi M, Kato S, Suzuki K, Yanagisawa K, Suzuki M, Fujishita T, Yamaguchi T, Takahashi M, Takahashi T., Free PMC Article | 04/13/2021 |
| WNT5a-ROR Signaling Is Essential for Alveologenesis. | WNT5a-ROR Signaling Is Essential for Alveologenesis.
Li C, Smith SM, Peinado N, Gao F, Li W, Lee MK, Zhou B, Bellusci S, Pryhuber GS, Ho HH, Borok Z, Minoo P., Free PMC Article | 02/13/2021 |
| ROR1 is expressed in hepatocellular carcinoma and contributes to disease development. | ROR1 Expression and Its Functional Significance in Hepatocellular Carcinoma Cells.
Cetin M, Odabas G, Douglas LR, Duriez PJ, Balcik-Ercin P, Yalim-Camci I, Sayan AE, Yagci T., Free PMC Article | 12/7/2019 |
| ROR1 was one of the most significantly regulated receptor tyrosine kinases in the ischemic heart and may be a potential target for the treatment of ischemic heart injury. | Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target.
Heliste J, Jokilammi A, Paatero I, Chakroborty D, Stark C, Savunen T, Laaksonen M, Elenius K., Free PMC Article | 06/1/2019 |
| ROR1 is a targeted gene of Twist. Twist/ROR1 signaling is critical for invasion and metastasis in breast cancer. | Twist promotes tumor metastasis in basal-like breast cancer by transcriptionally upregulating ROR1.
Cao J, Wang X, Dai T, Wu Y, Zhang M, Cao R, Zhang R, Wang G, Jiang R, Zhou BP, Shi J, Kang T., Free PMC Article | 05/18/2019 |
| Ror1 genetically interacts with Wnt9a. Ror1hyp/hyp;Wnt9a-/- double mutants displayed a secondary palate cleft phenotype and shorter long bones. | Genetic interactions between Ror2 and Wnt9a, Ror1 and Wnt9a and Ror2 and Ror1: Phenotypic analysis of the limb skeleton and palate in compound mutants.
Weissenböck M, Latham R, Nishita M, Wolff LI, Ho HH, Minami Y, Hartmann C., Free PMC Article | 05/18/2019 |
| Ror1 has a critical role in regulating SC proliferation during skeletal muscle regeneration | The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle.
Kamizaki K, Doi R, Hayashi M, Saji T, Kanagawa M, Toda T, Fukada SI, Ho HH, Greenberg ME, Endo M, Minami Y., Free PMC Article | 10/14/2017 |
| Ror1 is crucial for spiral ganglion neurons to innervate auditory hair cells. Impairment of ROR1 function largely affects development of the inner ear and hearing in humans and mice. | ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice.
Diaz-Horta O, Abad C, Sennaroglu L, Foster J 2nd, DeSmidt A, Bademci G, Tokgoz-Yilmaz S, Duman D, Cengiz FB, Grati M, Fitoz S, Liu XZ, Farooq A, Imtiaz F, Currall BB, Morton CC, Nishita M, Minami Y, Lu Z, Walz K, Tekin M., Free PMC Article | 12/24/2016 |
| Although Ror1-mutant mice show no apparent defects in ureteric bud (UB) formation, Ror1; Ror2-double-mutant mice exhibit either defects in UB outgrowth and branching morphogenesis, associated with the loss of the MM from the UB domain, or ectopic formation of the UB. | Essential role of Wnt5a-Ror1/Ror2 signaling in metanephric mesenchyme and ureteric bud formation.
Qi X, Okinaka Y, Nishita M, Minami Y. | 12/17/2016 |
| Wnt5a-Ror1 and Wnt5a-Ror2 signaling pathways regulated neurogenesis in the developing neocortex. | Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex.
Endo M, Doi R, Nishita M, Minami Y. | 01/26/2013 |
| results identify resistin as a potential inhibitory ligand for the receptor ROR1 and demonstrate, for the first time, that ROR1 plays an important role in adipogenesis and glucose homeostasis in 3T3-L1 cells | Mouse resistin modulates adipogenesis and glucose uptake in 3T3-L1 preadipocytes through the ROR1 receptor.
Sánchez-Solana B, Laborda J, Baladrón V., Free PMC Article | 07/7/2012 |
| These findings suggest that Wnt5a-Ror-Dishevelled signaling constitutes a core noncanonical Wnt pathway that is conserved through evolution and is crucial during embryonic development. | Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis.
Ho HY, Susman MW, Bikoff JB, Ryu YK, Jonas AM, Hu L, Kuruvilla R, Greenberg ME., Free PMC Article | 05/12/2012 |
| loss of the orphan receptor Ror1 results in a variety of phenotypic defects within the skeletal and urogenital systems | Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded.
Lyashenko N, Weissenböck M, Sharir A, Erben RG, Minami Y, Hartmann C. | 11/27/2010 |
| these data suggest that Ror1 and Ror2 proteins play a key role in Wnt-5a-activated signaling pathways leading to synapse formation in the mammalian CNS | Ror1-Ror2 complexes modulate synapse formation in hippocampal neurons.
Paganoni S, Bernstein J, Ferreira A., Free PMC Article | 03/15/2010 |
| Expression and subcellular localization of Ror tyrosine kinase receptors are developmentally regulated in cultured hippocampal neurons. | Expression and subcellular localization of Ror tyrosine kinase receptors are developmentally regulated in cultured hippocampal neurons.
Paganoni S, Ferreira A. | 01/21/2010 |
| The ROR1 protein suppression using antisense oligonucleotides or RNA interference (RNAi), neurons extended shorter and less branched minor processes when compared to those in control cells. | Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2.
Paganoni S, Ferreira A., Free PMC Article | 01/21/2010 |