| HIF-1alpha is a "brake" in JNK-mediated activation of amyloid protein precursor and hyperphosphorylation of tau induced by T-2 toxin in BV2 cells. | HIF-1α is a "brake" in JNK-mediated activation of amyloid protein precursor and hyperphosphorylation of tau induced by T-2 toxin in BV2 cells.
Zhao Y, Valis M, Wang X, Nepovimova E, Wu Q, Kuca K. | 04/26/2024 |
| Knockdown of BUB1B Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer by Regulating the JNK/c-Jun Signaling Pathway. | Knockdown of BUB1B Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer by Regulating the JNK/c-Jun Signaling Pathway.
Zeng Q, Zhang S, He L, Fu Q, Liao L, Chen L, Ding X. | 04/17/2024 |
| Axonal injury mediated by neuronal p75NTR/TRAF6/JNK pathway contributes to cognitive impairment after repetitive mTBI. | Axonal injury mediated by neuronal p75NTR/TRAF6/JNK pathway contributes to cognitive impairment after repetitive mTBI.
Liu G, He M, Wu C, Lv P, Sun H, Wang H, Xin X, Liao H. | 01/4/2024 |
| Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK. | Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK.
Xu Y, Xu H, Ling T, Cui Y, Zhang J, Mu X, Zhou D, Zhao T, Li Y, Su Z, You Q. | 12/5/2023 |
| Physical exercise elicits UPR[mt] in the skeletal muscle: The role of c-Jun N-terminal kinase. | Physical exercise elicits UPR(mt) in the skeletal muscle: The role of c-Jun N-terminal kinase.
Gaspar RS, Katashima CK, Crisol BM, Carneiro FS, Sampaio I, Silveira LDR, Silva ASRD, Cintra DE, Pauli JR, Ropelle ER., Free PMC Article | 11/30/2023 |
| MicroRNA miR-181d-5p regulates the MAPK signaling pathway by targeting mitogen-activated protein kinase 8 (MAPK8) to improve lupus nephritis. | MicroRNA miR-181d-5p regulates the MAPK signaling pathway by targeting mitogen-activated protein kinase 8 (MAPK8) to improve lupus nephritis.
Chai F, Peng H, Qin L, Liu C, Zeng Y, Wang R, Xu G, Wang R, Wei G, Huang H, Lan Y, Chen W, Wang C. | 11/21/2023 |
| Endoplasmic reticulum chaperone GRP78 participates in fluoride-induced autophagy in LS8 cells by regulating the IRE1-TRAF2-JNK pathway. | Endoplasmic reticulum chaperone GRP78 participates in fluoride-induced autophagy in LS8 cells by regulating the IRE1-TRAF2-JNK pathway.
Zhao L, Wang L, Wang H, Xi T, Liu S, Li Y, Ruan J, Huang Y. | 06/23/2023 |
| JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy. | JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.
Sun K, Hou L, Guo Z, Wang G, Guo J, Xu J, Zhang X, Guo F. | 05/23/2023 |
| Transmembrane p24 trafficking protein 10 (TMED10) inhibits mitochondrial damage and protects neurons in ischemic stroke via the c-Jun N-terminal kinase (JNK) signaling pathway. | Transmembrane p24 trafficking protein 10 (TMED10) inhibits mitochondrial damage and protects neurons in ischemic stroke via the c-Jun N-terminal kinase (JNK) signaling pathway.
Li Q, Liu X, Xing R, Sui R., Free PMC Article | 05/19/2023 |
| c-Jun N-terminal kinase 1 (JNK1) phosphorylates OTX2 transcription factor that regulates early retinal development. | c-Jun N-terminal kinase 1 (JNK1) phosphorylates OTX2 transcription factor that regulates early retinal development.
An MJ, Lee HM, Kim CH, Shin GS, Jo AR, Kim JY, Kim MJ, Kim J, Park J, Hwangbo Y, Kim J, Kim JW. | 03/24/2023 |
| JNK1-Dependent Phosphorylation of GAP-43 Serine 142 is a Novel Molecular Marker for Axonal Growth. | JNK1-Dependent Phosphorylation of GAP-43 Serine 142 is a Novel Molecular Marker for Axonal Growth.
Okada M, Kawagoe Y, Takasugi T, Nozumi M, Ito Y, Fukusumi H, Kanemura Y, Fujii Y, Igarashi M. | 09/24/2022 |
| Role of JNK in the Regulation of Xenobiotic Metabolizing Function of Hepatocytes. | Role of JNK in the Regulation of Xenobiotic Metabolizing Function of Hepatocytes.
Bryushinina OS, Zyuz'kova YG, Yanovskaya EA, Abdrashitova NY, Frelikh GA, Lakeev AP, Tsuran DV, Udut VV, Zyuz'kov GN. | 04/2/2022 |
| Role of JNK and p53 in Implementation of Functions of Various Types of Regeneration-Competent Cells of the Nervous Tissue. | Role of JNK and p53 in Implementation of Functions of Various Types of Regeneration-Competent Cells of the Nervous Tissue.
Zyuz'kov GN, Zhdanov VV, Miroshnichenko LA, Polyakova TY, Simanina EV, Stavrova LA, Danilets MG, Agafonov VI, Chaikovskii AV. | 01/8/2022 |
| A non-translational role of threonyl-tRNA synthetase in regulating JNK signaling during myogenic differentiation. | A non-translational role of threonyl-tRNA synthetase in regulating JNK signaling during myogenic differentiation.
Dai C, Reyes-Ordoñez A, You JS, Chen J., Free PMC Article | 10/30/2021 |
| c-Jun N-terminal kinase 1 (JNK1) modulates oligodendrocyte progenitor cell architecture, proliferation and myelination. | c-Jun N-terminal kinase 1 (JNK1) modulates oligodendrocyte progenitor cell architecture, proliferation and myelination.
Lorenzati M, Boda E, Parolisi R, Bonato M, Borsello T, Herdegen T, Buffo A, Vercelli A., Free PMC Article | 10/23/2021 |
| JNK1 Signaling Downstream of the EGFR Pathway Contributes to Aldara((R))-Induced Skin Inflammation. | JNK1 Signaling Downstream of the EGFR Pathway Contributes to Aldara(®)-Induced Skin Inflammation.
Le A, Azouz A, Thomas S, Istaces N, Nguyen M, Goriely S., Free PMC Article | 06/26/2021 |
| JUN Amino-Terminal Kinase 1 Signaling in the Proximal Tubule Causes Cell Death and Acute Renal Failure in Rat and Mouse Models of Renal Ischemia/Reperfusion Injury. | JUN Amino-Terminal Kinase 1 Signaling in the Proximal Tubule Causes Cell Death and Acute Renal Failure in Rat and Mouse Models of Renal Ischemia/Reperfusion Injury.
Grynberg K, Ozols E, Mulley WR, Davis RJ, Flavell RA, Nikolic-Paterson DJ, Ma FY. | 05/22/2021 |
| Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue. | Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue.
Henrie H, Bakhos-Douaihy D, Cantaloube I, Pilon A, Talantikite M, Stoppin-Mellet V, Baillet A, Poüs C, Benoit B., Free PMC Article | 03/20/2021 |
| Both JNK1 and JNK2 Are Indispensable for Sensitized Extracellular Matrix Mineralization in IKKbeta-Deficient Osteoblasts. | Both JNK1 and JNK2 Are Indispensable for Sensitized Extracellular Matrix Mineralization in IKKβ-Deficient Osteoblasts.
Hao Q, Liu Z, Lu L, Zhang L, Zuo L., Free PMC Article | 02/6/2021 |
| Deletion of JNK Enhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice. | Deletion of JNK Enhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice.
Loeser RF, Kelley KL, Armstrong A, Collins JA, Diekman BO, Carlson CS., Free PMC Article | 01/9/2021 |
| Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice. | Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice.
Liao C, Cai B, Feng Y, Chen J, Wu Y, Zhuang J, Liu Z, Wu Y., Free PMC Article | 12/26/2020 |
| The IL-33-induced p38-/JNK1/2-TNFalpha axis is antagonized by activation of beta-adrenergic-receptors in dendritic cells. | The IL-33-induced p38-/JNK1/2-TNFα axis is antagonized by activation of β-adrenergic-receptors in dendritic cells.
Helbig C, Weber F, Andreas N, Herdegen T, Gaestel M, Kamradt T, Drube S., Free PMC Article | 12/5/2020 |
| JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma. | JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma.
Manieri E, Folgueira C, Rodríguez ME, Leiva-Vega L, Esteban-Lafuente L, Chen C, Cubero FJ, Barrett T, Cavanagh-Kyros J, Seruggia D, Rosell A, Sanchez-Cabo F, Gómez MJ, Monte MJ, G Marin JJ, Davis RJ, Mora A, Sabio G., Free PMC Article | 09/26/2020 |
| ORMDL3 knockdown in the lungs alleviates airway inflammation and airway remodeling in asthmatic mice via JNK1/JNK2-MMP-9 pathway. | ORMDL3 knockdown in the lungs alleviates airway inflammation and airway remodeling in asthmatic mice via JNK1/2-MMP-9 pathway.
Wang H, Liu Y, Shi J, Cheng Z. | 07/11/2020 |
| these results indicate that CrkII negatively regulates osteoblast differentiation and function through JNK phosphorylation. Given that CrkII acts as a negative and positive regulator of osteoblast and osteoclast differentiation, respectively, the regulation of CrkII expression in bone cells may help to develop new strategies to enhance bone formation and inhibit bone resorption. | Adaptor protein CrkII negatively regulates osteoblast differentiation and function through JNK phosphorylation.
Kim JH, Kim K, Kim I, Seong S, Nam KI, Kim KK, Kim N., Free PMC Article | 06/27/2020 |