| Cdk8 and Hira mutations trigger X chromosome elimination in naive female hybrid mouse embryonic stem cells. | Cdk8 and Hira mutations trigger X chromosome elimination in naive female hybrid mouse embryonic stem cells.
Halter K, Chen J, Priklopil T, Monfort A, Wutz A., Free PMC Article | 10/21/2024 |
| Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems. | Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems.
Li J, Bai Y, Liu Y, Song Z, Yang Y, Zhao Y. | 10/11/2023 |
| CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium. | CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.
Prieto S, Dubra G, Camasses A, Aznar AB, Begon-Pescia C, Simboeck E, Pirot N, Gerbe F, Angevin L, Jay P, Krasinska L, Fisher D., Free PMC Article | 02/15/2023 |
| The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis. | The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis.
Yamada T, Fukasawa K, Horie T, Kadota T, Lyu J, Tokumura K, Ochiai S, Iwahashi S, Suzuki A, Park G, Ueda R, Yamamoto M, Kitao T, Shirahase H, Ochi H, Sato S, Iezaki T, Hinoi E., Free PMC Article | 07/23/2022 |
| MiR-382-5p suppresses M1 macrophage polarization and inflammatory response in response to bronchopulmonary dysplasia through targeting CDK8: Involving inhibition of STAT1 pathway. | MiR-382-5p suppresses M1 macrophage polarization and inflammatory response in response to bronchopulmonary dysplasia through targeting CDK8: Involving inhibition of STAT1 pathway.
Lv Y, Li Y, Wang J, Li M, Zhang W, Zhang H, Shen Y, Li C, Du Y, Jiang L. | 01/22/2022 |
| Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development. | Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.
Postlmayr A, Dumeau CE, Wutz A., Free PMC Article | 02/13/2021 |
| MiR-297 alleviates LPS-induced A549 cell and mice lung injury via targeting cyclin dependent kinase 8. | MiR-297 alleviates LPS-induced A549 cell and mice lung injury via targeting cyclin dependent kinase 8.
Xi X, Yao Y, Liu N, Li P. | 11/28/2020 |
| CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic beta Cells. | CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells.
Xue J, Scotti E, Stoffel M. | 09/19/2020 |
| FBXL19 and CDK-Mediator support long-range interactions between silent gene promoters that rely on FBXL19 for their induction during differentiation and gene regulatory elements. | CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions.
Feldmann A, Dimitrova E, Kenney A, Lastuvkova A, Klose RJ., Free PMC Article | 05/23/2020 |
| Both genetic and pharmacological inhibition of CDK8 and its homologous twin kinase CDK19 leads to abrogation of BMP4-induced EMT. | Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer.
Serrao A, Jenkins LM, Chumanevich AA, Horst B, Liang J, Gatza ML, Lee NY, Roninson IB, Broude EV, Mythreye K., Free PMC Article | 03/2/2019 |
| we have shown CDK8 does not influence NK cell development and proliferation, but instead suppresses NK-cell antitumor activity in vivo. | NK Cell-Specific CDK8 Deletion Enhances Antitumor Responses.
Witalisz-Siepracka A, Gotthardt D, Prchal-Murphy M, Didara Z, Menzl I, Prinz D, Edlinger L, Putz EM, Sexl V. | 02/23/2019 |
| these observations suggest that Zyxin promotes colon cancer tumorigenesis in a mitotic-phosphorylation-dependent manner and through CDK8-mediated YAP activation. | Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation.
Zhou J, Zeng Y, Cui L, Chen X, Stauffer S, Wang Z, Yu F, Lele SM, Talmon GA, Black AR, Chen Y, Dong J., Free PMC Article | 09/22/2018 |
| identification of the Mediator-associated kinase CDK8, and its paralog CDK19, as negative regulators of IL-10 production during innate immune activation | Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
Johannessen L, Sundberg TB, O'Connell DJ, Kolde R, Berstler J, Billings KJ, Khor B, Seashore-Ludlow B, Fassl A, Russell CN, Latorre IJ, Jiang B, Graham DB, Perez JR, Sicinski P, Phillips AJ, Schreiber SL, Gray NS, Shamji AF, Xavier RJ., Free PMC Article | 10/14/2017 |
| our findings uncover a tumour suppressor function for CDK8 in vivo and suggest that the role of CDK8 activity in driving oncogenesis is context-specific. | Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis.
McCleland ML, Soukup TM, Liu SD, Esensten JH, de Sousa e Melo F, Yaylaoglu M, Warming S, Roose-Girma M, Firestein R. | 05/28/2016 |
| The Skp2-mH2A1-CDK8 axis has a critical role in breast cancer development via dysregulation of the G2/M transition, polyploidy, cell growth dysregulation, and loss of tumor suppression. | Skp2-macroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis.
Xu D, Li CF, Zhang X, Gong Z, Chan CH, Lee SW, Jin G, Rezaeian AH, Han F, Wang J, Yang WL, Feng ZZ, Chen W, Wu CY, Wang YJ, Chow LP, Zhu XF, Zeng YX, Lin HK., Free PMC Article | 03/26/2016 |
| our results suggest that mTORC1 activation in NAFLD and insulin resistance results in down-regulation of the CDK8-CycC complex and elevation of lipogenic protein expression. | mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).
Feng D, Youn DY, Zhao X, Gao Y, Quinn WJ 3rd, Xiaoli AM, Sun Y, Birnbaum MJ, Pessin JE, Yang F., Free PMC Article | 02/27/2016 |
| Constitutive phosphorylation of S727 depends on cyclin-dependent kinase 8 (CDK8). | CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance.
Putz EM, Gotthardt D, Hoermann G, Csiszar A, Wirth S, Berger A, Straka E, Rigler D, Wallner B, Jamieson AM, Pickl WF, Zebedin-Brandl EM, Müller M, Decker T, Sexl V., Free PMC Article | 06/7/2014 |
| CDK8 is a key regulator of STAT1 and antiviral responses. | CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response.
Bancerek J, Poss ZC, Steinparzer I, Sedlyarov V, Pfaffenwimmer T, Mikulic I, Dölken L, Strobl B, Müller M, Taatjes DJ, Kovarik P., Free PMC Article | 04/13/2013 |
| Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities | Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.
Porter DC, Farmaki E, Altilia S, Schools GP, West DK, Chen M, Chang BD, Puzyrev AT, Lim CU, Rokow-Kittell R, Friedhoff LT, Papavassiliou AG, Kalurupalle S, Hurteau G, Shi J, Baran PS, Gyorffy B, Wentland MP, Broude EV, Kiaris H, Roninson IB., Free PMC Article | 11/3/2012 |
| This study illustrates a new gene-repressive mechanism of RIP140 that can affect the transcription machinery by directly interacting with CDK8. | Gene repressive activity of RIP140 through direct interaction with CDK8.
Persaud SD, Huang WH, Park SW, Wei LN., Free PMC Article | 01/28/2012 |
| knockdown of CDK8 in cells depleted of mH2A suppresses the proliferative advantage induced by mH2A loss | The histone variant macroH2A suppresses melanoma progression through regulation of CDK8.
Kapoor A, Goldberg MS, Cumberland LK, Ratnakumar K, Segura MF, Emanuel PO, Menendez S, Vardabasso C, Leroy G, Vidal CI, Polsky D, Osman I, Garcia BA, Hernando E, Bernstein E., Free PMC Article | 01/8/2011 |
| As receptor-activated Smads form transcriptional complexes, they are phosphorylated at an interdomain linker region by CDK8 and CDK9, which are components of transcriptional mediator and elongation complexes. | Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.
Alarcón C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, Barlas A, Miller AN, Manova-Todorova K, Macias MJ, Sapkota G, Pan D, Massagué J., Free PMC Article | 01/21/2010 |
| Results suggest that transcriptional repression of genes critical for early-cell-fate determination underlies the requirement of Cdk8 in embryogenesis. | Cdk8 is essential for preimplantation mouse development.
Westerling T, Kuuluvainen E, Mäkelä TP., Free PMC Article | 01/21/2010 |