| Inhibition of MEK Signaling Attenuates Cancer Stem Cell Activity in Anaplastic Thyroid Cancer. | Inhibition of MEK Signaling Attenuates Cancer Stem Cell Activity in Anaplastic Thyroid Cancer.
Kimura T, Doolittle WKL, Kruhlak M, Zhao L, Hwang E, Zhu X, Tang B, Wolcott KM, Cheng SY., | 04/16/2024 |
| The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task. | The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task.
Openshaw RL, Pratt JA, Morris BJ., Free PMC Article | 05/7/2022 |
| Dual Mkk4 and Mkk7 Gene Deletion in Adult Mouse Causes an Impairment of Hippocampal Immature Granule Cells. | Dual Mkk4 and Mkk7 Gene Deletion in Adult Mouse Causes an Impairment of Hippocampal Immature Granule Cells.
Castro-Torres RD, Olloquequi J, Etchetto M, Caruana P, Steele L, Leighton KM, Ureña J, Beas-Zarate C, Camins A, Verdaguer E, Auladell C., Free PMC Article | 10/23/2021 |
| Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice. | Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice.
Caliz AD, Yoo HJ, Vertii A, Dolan AC, Tournier C, Davis RJ, Keaney JF Jr, Kant S., Free PMC Article | 10/23/2021 |
| MKK7 deficiency in mature neurons impairs parental behavior in mice. | MKK7 deficiency in mature neurons impairs parental behavior in mice.
Shin T, Hiraoka Y, Yamasaki T, Marth JD, Penninger JM, Kanai-Azuma M, Tanaka K, Kofuji S, Nishina H., Free PMC Article | 07/10/2021 |
| Map2k7 Haploinsufficiency Induces Brain Imaging Endophenotypes and Behavioral Phenotypes Relevant to Schizophrenia. | Map2k7 Haploinsufficiency Induces Brain Imaging Endophenotypes and Behavioral Phenotypes Relevant to Schizophrenia.
Openshaw RL, Thomson DM, Thompson R, Penninger JM, Pratt JA, Morris BJ, Dawson N., Free PMC Article | 02/13/2021 |
| These results suggest that MKK4 and MKK7 may serve redundant and unique roles in molecular signaling important for retinal development and injury response following axonal insult. | Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death.
Syc-Mazurek SB, Rausch RL, Fernandes KA, Wilson MP, Libby RT., Free PMC Article | 12/14/2019 |
| we generated neuron-specific Mkk7 knockout mice (MKK7 cKO), which impaired constitutive activation of JNK in the nervous system. MKK7 cKO mice displayed impaired circadian behavioral rhythms and decreased locomotor activity. MKK7 cKO mice at 8 months showed motor dysfunctions such as weakness of hind-limb and gait abnormality in an age-dependent manner. | Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7.
Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H., Free PMC Article | 02/23/2019 |
| SENP3 potentiates lipopolysaccharide-induced TLR4 signaling via deSUMOylation of MKK7 leading to enhancement in JNK phosphorylation and the downstream events | DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages.
Lao Y, Yang K, Wang Z, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ETH, Yang J, Yi J., Free PMC Article | 01/12/2019 |
| High Map2k7 expression is associated with T-cell acute lymphoblastic leukemia. | Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway.
Shen Y, Park CS, Suppipat K, Mistretta TA, Puppi M, Horton TM, Rabin K, Gray NS, Meijerink JPP, Lacorazza HD. | 10/21/2017 |
| The loss of mkk4 and mkk7 locks damaged exocrine cells in a permanently de-differentiated state. | Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma.
Davies CC, Harvey E, McMahon RF, Finegan KG, Connor F, Davis RJ, Tuveson DA, Tournier C., Free PMC Article | 08/9/2014 |
| Arrestin-3 directly interacts with MKK7 and promotes JNK3alpha2 phosphorylation by both MKK4 and MKK7 in vitro as well as in intact cells. | JNK3 enzyme binding to arrestin-3 differentially affects the recruitment of upstream mitogen-activated protein (MAP) kinase kinases.
Zhan X, Kaoud TS, Kook S, Dalby KN, Gurevich VV., Free PMC Article | 12/7/2013 |
| MKK7 is specifically phosphorylated in the neurite shaft which triggers Map1b phosphorylation to regulate microtubule bundling leading to neurite elongation. | Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation.
Feltrin D, Fusco L, Witte H, Moretti F, Martin K, Letzelter M, Fluri E, Scheiffele P, Pertz O., Free PMC Article | 05/25/2013 |
| Data indicate that mitogen activated protein kinase kinase 7 (MKK7) plays a critical regulatory role in the c-Jun N-terminal kinase pathway in a murine model of rheumatoid arthritis. | Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-terminal kinase pathway.
Lee SI, Boyle DL, Berdeja A, Firestein GS., Free PMC Article | 12/22/2012 |
| a novel function for the stress kinase MKK7 as a regulator of the circadian clock in mammalian cells at steady state. | Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock.
Uchida Y, Osaki T, Yamasaki T, Shimomura T, Hata S, Horikawa K, Shibata S, Todo T, Hirayama J, Nishina H., Free PMC Article | 05/5/2012 |
| Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation. | Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.
Wang J, Chen L, Ko CI, Zhang L, Puga A, Xia Y., Free PMC Article | 03/17/2012 |
| MKK4/7 and JNK1/2 played regulatory role in cytoskeleton reorganization during vaccinia virus infection. | A vaccinia virus-driven interplay between the MKK4/7-JNK1/2 pathway and cytoskeleton reorganization.
Pereira AC, Leite FG, Brasil BS, Soares-Martins JA, Torres AA, Pimenta PF, Souto-Padrón T, Traktman P, Ferreira PC, Kroon EG, Bonjardim CA., Free PMC Article | 02/18/2012 |
| This study demonistrated that Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. | Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.
Yamasaki T, Kawasaki H, Arakawa S, Shimizu K, Shimizu S, Reiner O, Okano H, Nishina S, Azuma N, Penninger JM, Katada T, Nishina H., Free PMC Article | 01/14/2012 |
| The results reveal an essential role of MKK7 in cardiomyocytes for protecting the heart from hypertrophic insults thereby preventing the transition to heart failure. | Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload.
Liu W, Zi M, Chi H, Jin J, Prehar S, Neyses L, Cartwright EJ, Flavell RA, Davis RJ, Wang X. | 06/25/2011 |
| These results suggest that HSP70 expression is up-regulated by SEK1 and down-regulated by MKK7 through distinct MAPK isoforms in mouse embryonic stem cells treated with cadmium chloride. | Differential regulation of HSP70 expression by the JNK kinases SEK1 and MKK7 in mouse embryonic stem cells treated with cadmium.
Nishitai G, Matsuoka M. | 01/21/2010 |
| The role of NF-kappaB and c-jun N-terminal kinase (JNK) activation in RANKL-induced osteoclast differentiation was investigated using an adenovirus vector carrying the dominant negative 1kappaB kinase 2 gene or dominant negative MKK7 gene. | Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand.
Yamamoto A, Miyazaki T, Kadono Y, Takayanagi H, Miura T, Nishina H, Katada T, Wakabayashi K, Oda H, Nakamura K, Tanaka S. | 01/21/2010 |
| Genetic inactivation of the stress signalling kinase, MKK7, a direct activator of JNKs in mice, results in embryonic lethality and impaired proliferation of hepatocytes. | MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.
Wada T, Joza N, Cheng HY, Sasaki T, Kozieradzki I, Bachmaier K, Katada T, Schreiber M, Wagner EF, Nishina H, Penninger JM. | 01/21/2010 |
| Changes in MKK7 gene expression between subspecies of Mus musculus are most likely affected by positive selection. | A change of expression in the conserved signaling gene MKK7 is associated with a selective sweep in the western house mouse Mus musculus domesticus.
Harr B, Voolstra C, Heinen TJ, Baines JF, Rottscheidt R, Ihle S, Müller W, Bonhomme F, Tautz D. | 01/21/2010 |
| Differential employment of MKK4 and MKK7 by scaffold proteins Axin, Dvl, and Epstein-Barr virus latent membrane protein-1 (LMP-1) in mediating JNK activation was examined. | Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins.
Zou H, Li Q, Lin SC, Wu Z, Han J, Ye Z. | 01/21/2010 |
| A noncanonical function of Map2k5 and Map3k2 domain is decribed for coordinating erk5 kinase and map2k7 signaling. | Noncanonical function of MEKK2 and MEK5 PB1 domains for coordinated extracellular signal-regulated kinase 5 and c-Jun N-terminal kinase signaling.
Nakamura K, Johnson GL., Free PMC Article | 01/21/2010 |