| MKK6 deficiency promotes cardiac dysfunction through MKK3-p38gamma/delta-mTOR hyperactivation. | MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation.
Romero-Becerra R, Mora A, Manieri E, Nikolic I, Santamans AM, Montalvo-Romeral V, Cruz FM, Rodríguez E, León M, Leiva-Vega L, Sanz L, Bondía V, Filgueiras-Rama D, Jiménez-Borreguero LJ, Jalife J, Gonzalez-Teran B, Sabio G., Free PMC Article | 08/27/2022 |
| MicroRNA-370 carried by M2 macrophage-derived exosomes alleviates asthma progression through inhibiting the FGF1/MAPK/STAT1 axis. | MicroRNA-370 carried by M2 macrophage-derived exosomes alleviates asthma progression through inhibiting the FGF1/MAPK/STAT1 axis.
Li C, Deng C, Zhou T, Hu J, Dai B, Yi F, Tian N, Jiang L, Dong X, Zhu Q, Zhang S, Cui H, Cao L, Shang Y., Free PMC Article | 04/2/2022 |
| MEK6 Overexpression Exacerbates Fat Accumulation and Inflammatory Cytokines in High-Fat Diet-Induced Obesity. | MEK6 Overexpression Exacerbates Fat Accumulation and Inflammatory Cytokines in High-Fat Diet-Induced Obesity.
Lee S, Lee M., Free PMC Article | 01/22/2022 |
| Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis. | Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis.
Norheim F, Chella Krishnan K, Bjellaas T, Vergnes L, Pan C, Parks BW, Meng Y, Lang J, Ward JA, Reue K, Mehrabian M, Gundersen TE, Péterfy M, Dalen KT, Drevon CA, Hui ST, Lusis AJ, Seldin MM., Free PMC Article | 10/9/2021 |
| Elevated miR-10a-5p facilitates cell cycle and restrains adipogenic differentiation via targeting Map2k6 and Fasn, respectively. | Elevated miR-10a-5p facilitates cell cycle and restrains adipogenic differentiation via targeting Map2k6 and Fasn, respectively.
Wang X, Zhang H, Xu M, Shi X, Yang G, Sun S, Li X. | 06/5/2021 |
| Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling. | Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling.
Rahman SMT, Zhou W, Deiters A, Haugh JM., Free PMC Article | 01/9/2021 |
| Circ_016719 plays a critical role in neuron cell apoptosis induced by I/R via targeting miR-29c/Map2k6. | Circ_016719 plays a critical role in neuron cell apoptosis induced by I/R via targeting miR-29c/Map2k6.
Tang C, Ou J, Kou L, Deng J, Luo S. | 01/2/2021 |
| acts as a repressor of UCP1 expression, suggesting that its inhibition promotes adipose tissue browning and increases organismal energy expenditure | MKK6 controls T3-mediated browning of white adipose tissue.
Matesanz N, Bernardo E, Acín-Pérez R, Manieri E, Pérez-Sieira S, Hernández-Cosido L, Montalvo-Romeral V, Mora A, Rodríguez E, Leiva-Vega L, Lechuga-Vieco AV, Ruiz-Cabello J, Torres JL, Crespo-Ruiz M, Centeno F, Álvarez CV, Marcos M, Enríquez JA, Nogueiras R, Sabio G., Free PMC Article | 02/10/2018 |
| MAP2K6 functions in mouse testis determination, via positive effects on Sry, and a minor role for MAP2K3. | Genetic Analyses Reveal Functions for MAP2K3 and MAP2K6 in Mouse Testis Determination.
Warr N, Siggers P, Carré GA, Wells S, Greenfield A., Free PMC Article | 11/4/2017 |
| MKK3 and MKK6 differentially regulate bone loss due to estrogen withdrawal. MKK3 directly mediates osteoclastogenesis while MKK6 likely contributes to pro-inflammatory cytokine production that promotes osteoclast formation. | Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss.
Boyle DL, Hammaker D, Edgar M, Zaiss MM, Teufel S, David JP, Schett G, Firestein GS., Free PMC Article | 09/13/2014 |
| Activation of distinct p38MAPK isoforms is regulated by the selective and synchronized action of two kinases, MKK3 and MKK6, in response to cell stress. | Differential activation of p38MAPK isoforms by MKK6 and MKK3.
Remy G, Risco AM, Iñesta-Vaquera FA, González-Terán B, Sabio G, Davis RJ, Cuenda A. | 03/1/2010 |
| MKK6 appears mainly to facilitate p38 and MK2 colocalization in the nucleus rather than to phosphorylate p38. | Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression.
Yoshizawa T, Hammaker D, Boyle DL, Corr M, Flavell R, Davis R, Schett G, Firestein GS., Free PMC Article | 01/21/2010 |
| MKK6-p38 and insulin growth factor 1 (IGF1)-induced PI3K/AKT pathways converge on the chromatin of muscle genes to target distinct components of the muscle transcriptosome. | Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation.
Serra C, Palacios D, Mozzetta C, Forcales SV, Morantte I, Ripani M, Jones DR, Du K, Jhala US, Simone C, Puri PL., Free PMC Article | 01/21/2010 |
| These results suggest that p38 MAPK signaling plays a critical role in the survival of osteoclasts in inflammatory diseases. | MKK6-p38 MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts.
Yamashita T, Kobayashi Y, Mizoguchi T, Yamaki M, Miura T, Tanaka S, Udagawa N, Takahashi N. | 01/21/2010 |
| MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity. | MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity.
Harraz MM, Park A, Abbott D, Zhou W, Zhang Y, Engelhardt JF., Free PMC Article | 01/21/2010 |
| All these results suggest that DGK may play a role in glucose transport in the skeletal muscle cells through modulating a MKK3/6-p38 signaling pathway. | A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells.
Takahashi N, Nagamine M, Tanno S, Motomura W, Kohgo Y, Okumura T. | 01/21/2010 |
| increased activity of Sox9 accounts at least in part for the phenotype caused by constitutive activation of MKK6 in chondrocytes | Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation.
Zhang R, Murakami S, Coustry F, Wang Y, de Crombrugghe B., Free PMC Article | 01/21/2010 |
| p38alpha can negatively regulate the stability of the MKK6 mRNA and thus control the steady-state concentration of one of its upstream activators | Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase.
Ambrosino C, Mace G, Galban S, Fritsch C, Vintersten K, Black E, Gorospe M, Nebreda AR., Free PMC Article | 01/21/2010 |
| MKK6 is one of three different protein kinases which activate p38 MAPK in vitro. | Mechanism of p38 MAP kinase activation in vivo.
Brancho D, Tanaka N, Jaeschke A, Ventura JJ, Kelkar N, Tanaka Y, Kyuuma M, Takeshita T, Flavell RA, Davis RJ., Free PMC Article | 01/21/2010 |
| Involvement of MKK6 in apoptotic cell death in thymocytes. | Involvement of MKK6 in TCRalphabeta(int)CD69lo: a target population for apoptotic cell death in thymocytes.
Suzuki H, Wu J, Hossain K, Ohhata T, Du J, Akhand AA, Hayakawa A, Kimura H, Hagiwara M, Nakashima I. | 01/21/2010 |
| MKK6 is downreglated in peripheral CD4(+)T cells | Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis.
Tanaka N, Kamanaka M, Enslen H, Dong C, Wysk M, Davis RJ, Flavell RA., Free PMC Article | 01/21/2010 |
| MKK3 and MKK6 are rapidly activated during engagement of the Type I IFN receptor and play important roles in Type I IFN signaling and the generation of IFN responses | Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons.
Li Y, Batra S, Sassano A, Majchrzak B, Levy DE, Gaestel M, Fish EN, Davis RJ, Platanias LC. | 01/21/2010 |
| These results indicate that TAK1 and MKK6 constitute the p38 signalling pathway to participate to Oc differentiation by RANKL through p65 phosphorylation and NFATc1 induction. | Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL.
Huang H, Ryu J, Ha J, Chang EJ, Kim HJ, Kim HM, Kitamura T, Lee ZH, Kim HH. | 01/21/2010 |