| AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis. | AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.
Liao R, Chen X, Cao Q, Bai L, Ma C, Dai Z, Dong C., Free PMC Article | 05/14/2024 |
| AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth. | AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth.
Sari IN, Yang YG, Wijaya YT, Jun N, Lee S, Kim KS, Bajaj J, Oehler VG, Kim SH, Choi SY, Park SH, Kim DW, Reya T, Han J, Kwon HY. | 07/31/2021 |
| Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers. | Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers.
Xu L, You X, Cao Q, Huang M, Hong LL, Chen XL, Lei L, Ling ZQ, Chen Y. | 09/5/2020 |
| Three SNPs (RUNX3 rs7553295 G > T, AMD1 rs1279590 G > A and MSRA rs73534533 C > A) were replicated in the validation dataset, and their meta-analysis showed an adjusted hazards ratio [HR] of 0.82 [95% confidence interval (CI) =0.75-0.89] and pmeta = 2.86 x 10(-6) , 0.81 (0.73-0.91) and pmeta = 4.63 x 10(-4) , and 0.77 (0.68-0.89) and pmeta = 2.07 x 10(-4) , respectively). | Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients.
Chen K, Liu H, Liu Z, Luo S, Patz EF Jr, Moorman PG, Su L, Shen S, Christiani DC, Wei Q., Free PMC Article | 12/14/2019 |
| this study shows that AMD1 promotes cell migration in epidermal wound healimg | Polyamine Regulator AMD1 Promotes Cell Migration in Epidermal Wound Healing.
Lim HK, Rahim AB, Leo VI, Das S, Lim TC, Uemura T, Igarashi K, Common J, Vardy LA. | 09/14/2019 |
| AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation | AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation.
Yordanova MM, Loughran G, Zhdanov AV, Mariotti M, Kiniry SJ, O'Connor PBF, Andreev DE, Tzani I, Saffert P, Michel AM, Gladyshev VN, Papkovsky DB, Atkins JF, Baranov PV. | 06/16/2018 |
| AMD1 is upregulated in human prostate cancer with activated mTORC1 | mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.
Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A., Free PMC Article | 11/18/2017 |
| AMD1 gene variants previously found to associate among Indian children did not associate with risk of obesity or obesity-related quantitative measures among Caucasian children and juvenile men from Denmark. | Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: a case-control study.
Hollensted M, Ahluwalia TS, Have CT, Grarup N, Fonvig CE, Nielsen TR, Trier C, Paternoster L, Pedersen O, Holm JC, Sørensen TI, Hansen T., Free PMC Article | 04/30/2016 |
| (AMD1)-mediated mRNA processing and cell adhesion activated & inhibited transition mechanisms | Adenosylmethionine decarboxylase 1 (AMD1)-mediated mRNA processing and cell adhesion activated & inhibited transition mechanisms by different comparisons between chimpanzee and human left hemisphere.
Wang L, Huang J, Jiang M, Diao H, Zhou H, Li X, Chen Q, Jiang Z, Feng H. | 09/5/2015 |
| Gene expression studies have identified altered expression of AMD1 in suicide completers with a history of mood disorders. | Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide.
Gross JA, Fiori LM, Labonté B, Lopez JP, Turecki G., Free PMC Article | 08/31/2013 |
| This study demomistrated that H3K4me3 modification plays an important role in up regulation of AMD1 in prefrontal cortex. | Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide.
Fiori LM, Gross JA, Turecki G. | 12/29/2012 |
| Genetic variant of AMD1 is associated with obesity. | Genetic variant of AMD1 is associated with obesity in urban Indian children.
Tabassum R, Jaiswal A, Chauhan G, Dwivedi OP, Ghosh S, Marwaha RK, Tandon N, Bharadwaj D., Free PMC Article | 08/25/2012 |
| Overexpression of S-adenosylmethionine decarboxylase in rodent fibroblasts led to aggressive transformants. | Chaotic neovascularization induced by aggressive fibrosarcoma cells overexpressing S-adenosylmethionine decarboxylase.
Paasinen-Sohns A, Kääriäinen E, Yin M, Järvinen K, Nummela P, Hölttä E. | 05/21/2011 |
| Decreased AMD1 is associated with prostate cancer. | Assessing prostate cancer growth with mRNA of spermine metabolic enzymes.
Kaul D, Wu CL, Adkins CB, Jordan KW, Defeo EM, Habbel P, Peterson RT, McDougal WS, Pohl U, Cheng LL. | 12/11/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.
Levine AJ, Figueiredo JC, Lee W, Conti DV, Kennedy K, Duggan DJ, Poynter JN, Campbell PT, Newcomb P, Martinez ME, Hopper JL, Le Marchand L, Baron JA, Limburg PJ, Ulrich CM, Haile RW., Free PMC Article | 09/15/2010 |
| determined crystal structures cocrystallized with 5'-deoxy-5'-dimethylthioadenosine and 5'-deoxy-5'-(N-dimethyl)amino-8-methyladenosine. The crystal structures revealed cation-pi interaction between the ligand and aromatic side chains of Phe7 and Phe223 | Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase.
Bale S, Brooks W, Hanes JW, Mahesan AM, Guida WC, Ealick SE., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesPlasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes.
Reynolds R, Hartnett ME, Atkinson JP, Giclas PC, Rosner B, Seddon JM. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).
Franke B, Vermeulen SH, Steegers-Theunissen RP, Coenen MJ, Schijvenaars MM, Scheffer H, den Heijer M, Blom HJ. | 03/25/2009 |
| Binding of putrescine to wild type dimeric ADOMETDC protein is cooperative; putrescine activates the enzyme through electrostatic effects and acts as a switch to correctly orient key catalytic residues. | Structural basis for putrescine activation of human S-adenosylmethionine decarboxylase.
Bale S, Lopez MM, Makhatadze GI, Fang Q, Pegg AE, Ealick SE., Free PMC Article | 01/21/2010 |
| Antisense RNA specifically inhibited the expression of ODC and AdoMetDC and the synthesis of polyamine, while it induced p21 expression, resulting in cell growth arrest in the G1 phase in prostate cancer cells | Effects of antisense RNA targeting of ODC and AdoMetDC on the synthesis of polyamine synthesis and cell growth in prostate cancer cells using a prostatic androgen-dependent promoter in adenovirus.
Li W, Liu X, Wang W, Sun H, Hu Y, Lei H, Liu G, Gao Y. | 01/21/2010 |
| AdoMetDC is ubiquitinated and degraded by the 26 S proteasome | S-adenosylmethionine decarboxylase degradation by the 26 S proteasome is accelerated by substrate-mediated transamination.
Yerlikaya A, Stanley BA. | 01/21/2010 |
| For such cells, gamma-radiation and cisplatin, which are direct DNA-damaging agents, were very effective for promoting cell death. | S-Adenosylmethionine decarboxylase partially regulates cell growth of HL-60 cells by controlling the intracellular ROS level: Early senescence and sensitization to gamma-radiation.
Kim JS, Kim TL, Kim KC, Choe C, Chung HW, Cho EW, Kim IG. | 01/21/2010 |
| schizophrenia and bipolar disorder patients, the increase of S-adenosyl methionine is associated with an overexpression of DNA methyltransferase-1 mRNA in Brodmann's area 9 GABAergic neurons. | S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis.
Guidotti A, Ruzicka W, Grayson DR, Veldic M, Pinna G, Davis JM, Costa E. | 01/21/2010 |
| The adhesion-dependent expression of SAM-DC and ODC contributes to extracellular matrix-dependent salivary gland cell differentiation. | HSG cells differentiated by culture on extracellular matrix involves induction of S-adenosylmethione decarboxylase and ornithine decarboxylase.
Lam K, Zhang L, Bewick M, Lafrenie RM. | 01/21/2010 |