| CHD5 inhibits metastasis of neuroblastoma. | CHD5 inhibits metastasis of neuroblastoma.
Laut AK, Dorneburg C, Fürstberger A, Barth TFE, Kestler HA, Debatin KM, Beltinger C., Free PMC Article | 08/29/2024 |
| CHD5 gene variant predicts leptomeningeal metastasis after surgical resection of brain metastases of breast cancer. | CHD5 gene variant predicts leptomeningeal metastasis after surgical resection of brain metastases of breast cancer.
Otani R, Sadato D, Yamada R, Yajima H, Kawamura S, Shimizu S, Tanaka S, Takayanagi S, Takami H, Yamaguchi T. | 08/4/2023 |
| CHD5 gene (rs9434741) might be a genetic risk factor for infertility in non-obstructive azoospermia and severe oligozoospermia. | CHD5 gene (rs9434741) might be a genetic risk factor for infertility in non-obstructive azoospermia and severe oligozoospermia.
Naeimi N, Mohseni Kouchesfehani H, Heidari Z, Mahmoudzadeh-Sagheb H, Movahed S. | 12/10/2022 |
| Pan-Cancer Analysis Identifies CHD5 as a Potential Biomarker for Glioma. | Pan-Cancer Analysis Identifies CHD5 as a Potential Biomarker for Glioma.
Xu L, Shao F, Luo T, Li Q, Tan D, Tan Y., Free PMC Article | 08/27/2022 |
| mRNA expression and epigenetic-based role of chromodomain helicase DNA-binding 5 in hepatocellular carcinoma. | mRNA expression and epigenetic-based role of chromodomain helicase DNA-binding 5 in hepatocellular carcinoma.
Heidari Z, Asemi-Rad A, Moudi B, Mahmoudzadeh-Sagheb H., Free PMC Article | 07/16/2022 |
| Missense and truncating variants in CHD5 in a dominant neurodevelopmental disorder with intellectual disability, behavioral disturbances, and epilepsy. | Missense and truncating variants in CHD5 in a dominant neurodevelopmental disorder with intellectual disability, behavioral disturbances, and epilepsy.
Parenti I, Lehalle D, Nava C, Torti E, Leitão E, Person R, Mizuguchi T, Matsumoto N, Kato M, Nakamura K, de Man SA, Cope H, Shashi V, Undiagnosed Diseases Network, Friedman J, Joset P, Steindl K, Rauch A, Muffels I, van Hasselt PM, Petit F, Smol T, Le Guyader G, Bilan F, Sorlin A, Vitobello A, Philippe C, van de Laar IMBH, van Slegtenhorst MA, Campeau PM, Au PYB, Nakashima M, Saitsu H, Yamamoto T, Nomura Y, Louie RJ, Lyons MJ, Dobson A, Plomp AS, Motazacker MM, Kaiser FJ, Timberlake AT, Fuchs SA, Depienne C, Mignot C., Free PMC Article | 08/21/2021 |
| Chromodomain Helicase DNA-Binding Protein 5 Inhibits Renal Cell Carcinoma Tumorigenesis by Activation of the p53 and RB Pathways. | Chromodomain Helicase DNA-Binding Protein 5 Inhibits Renal Cell Carcinoma Tumorigenesis by Activation of the p53 and RB Pathways.
Huang S, Yan Q, Xiong S, Peng Y, Zhao R, Liu C., Free PMC Article | 05/15/2021 |
| SLC16A1-AS1 enhances radiosensitivity and represses cell proliferation and invasion by regulating the miR-301b-3p/CHD5 axis in hepatocellular carcinoma. | SLC16A1-AS1 enhances radiosensitivity and represses cell proliferation and invasion by regulating the miR-301b-3p/CHD5 axis in hepatocellular carcinoma.
Pei S, Chen Z, Tan H, Fan L, Zhang B, Zhao C. | 11/21/2020 |
| Our results suggest that the rare CHD5 gene haplotype and alcohol intake contribute to the risk of hepatocellular carcinoma | A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk.
Xiao Q, Chen L, Luo H, Li H, Kong Q, Jiao F, Pang S, Zhang M, Lan F, Fan W, Luo H, Tao T, Zhu X., Free PMC Article | 02/9/2019 |
| CHD5 was identified as a direct target of miR-454. CHD5 was downregulated in GC tissues/cell lines and the expresssion of CHD5 inversely correlated with the level of miR-454 in GC tissues. Taken together, these observations indicate that HDAC3 is associated with GC cell growth via the miR-454-mediated targeting of CHD5. | Histone deacetylase 3 is associated with gastric cancer cell growth via the miR-454-mediated targeting of CHD5.
Xu G, Zhu H, Zhang M, Xu J., Free PMC Article | 07/28/2018 |
| Data show that chromodomain helicase DNA binding protein 5 (CHD5) acted as a functional tumor suppressor and was frequently silenced by promoter CpG methylation in renal cell carcinoma (RCC). | The epigenetic modifier CHD5 functions as a novel tumor suppressor for renal cell carcinoma and is predominantly inactivated by promoter CpG methylation.
Du Z, Li L, Huang X, Jin J, Huang S, Zhang Q, Tao Q., Free PMC Article | 12/9/2017 |
| CHD5 may act as a tumor suppressor gene in NSCLC. | CHD5 is a potential tumor suppressor in non small cell lung cancer (NSCLC).
Baykara O, Tansarikaya M, Bulut P, Demirkaya A, Buyru N. | 06/10/2017 |
| Authors identified the CHD5 as a direct target of miR-454. CHD5 was downregulated in HCC tissues and cell lines and the expression level of CHD5 was inversely correlated with the expression of miR-454 in HCC tissues. | miR-454 functions as an oncogene by inhibiting CHD5 in hepatocellular carcinoma.
Yu L, Gong X, Sun L, Yao H, Lu B, Zhu L., Free PMC Article | 12/17/2016 |
| Data show a mutual suppression regulation between chromodomain helicase DNA binding protein 5 (CHD5) and enhancer of zeste homolog 2 (EZH2, which may provide new insights into their potential therapeutic significance for hepatocellular carcinoma (HCC). | Mutual regulation between CHD5 and EZH2 in hepatocellular carcinoma.
Xie CR, Li Z, Sun HG, Wang FQ, Sun Y, Zhao WX, Zhang S, Zhao WX, Wang XM, Yin ZY., Free PMC Article | 10/1/2016 |
| CHD5 methylation of rectal cancer has a great effect in influencing its clinical and pathological features. | Influence of colorectal cancer tumor suppressor gene CHD5 methylation on its clinical and pathological characteristics.
Liu JB, Zhou QB, Xu JZ, Wang GX, Yuan WT. | 03/5/2016 |
| Study shows that CHD5 is a Nucleosome remodeling and deacetylase complex-associated transcriptional repressor and identifies WEE1 as one of the CHD5-regulated genes that may link CHD5 to tumor suppression. | The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.
Quan J, Adelmant G, Marto JA, Look AT, Yusufzai T., Free PMC Article | 06/27/2015 |
| Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer. | Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer.
Hall WA, Petrova AV, Colbert LE, Hardy CW, Fisher SB, Saka B, Shelton JW, Warren MD, Pantazides BG, Gandhi K, Kowalski J, Kooby DA, El-Rayes BF, Staley CA 3rd, Volkan Adsay N, Curran WJ, Landry JC, Maithel SK, Yu DS. | 05/2/2015 |
| CHD5 is a potential tumour suppressor gene epigenetically silenced in hepatocellular carcinoma. | CHD5 a tumour suppressor is epigenetically silenced in hepatocellular carcinoma.
Zhao R, Wang N, Huang H, Ma W, Yan Q. | 02/28/2015 |
| The tumor suppressor chromodomain helicase DNA-binding protein 5 (CHD5) remodels nucleosomes by unwrapping. | The tumor suppressor chromodomain helicase DNA-binding protein 5 (CHD5) remodels nucleosomes by unwrapping.
Quan J, Yusufzai T., Free PMC Article | 02/14/2015 |
| repression of CHD5 gene expression in human leukemia is mediated in part by DNA methylation of its promoter. | Silencing of CHD5 gene by promoter methylation in leukemia.
Zhao R, Meng F, Wang N, Ma W, Yan Q., Free PMC Article | 09/20/2014 |
| CHD5 activity is regulated by DNA methylation and repressive histone modifications. CHD5 likely acts as a tumor-suppressor gene in early colorectal carcinogenesis. | Epigenetic silencing of CHD5, a novel tumor-suppressor gene, occurs in early colorectal cancer stages.
Fatemi M, Paul TA, Brodeur GM, Shokrani B, Brim H, Ashktorab H., Free PMC Article | 03/1/2014 |
| CHD5 might act as a tumor suppressor in glioma | Downregulation of chromatin remodeling factor CHD5 is associated with a poor prognosis in human glioma.
Wang L, He S, Tu Y, Ji P, Zong J, Zhang J, Feng F, Zhao J, Gao G, Zhang Y. | 01/18/2014 |
| These findings provide insights into the regulatory role of CHD5 during neurogenesis and suggest how inactivation of this candidate tumor suppressor might contribute to neuroblastoma. | CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression.
Egan CM, Nyman U, Skotte J, Streubel G, Turner S, O'Connell DJ, Rraklli V, Dolan MJ, Chadderton N, Hansen K, Farrar GJ, Helin K, Holmberg J, Bracken AP. | 11/2/2013 |
| Decreased expression of chromodomain helicase DNA-binding protein 5 is associated with primary gallbladder carcinoma | Decreased expression of chromodomain helicase DNA-binding protein 5 is an unfavorable prognostic marker in patients with primary gallbladder carcinoma.
Du X, Wu T, Lu J, Zang L, Song N, Yang T, Zhao H, Wang S. | 08/31/2013 |
| CHD% protein mediates the p53-dependent senescence program triggered by decreased JMJD2A levels. | JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5.
Mallette FA, Richard S. | 05/11/2013 |