| KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea. | KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea.
Redford KE, Rognant S, Jepps TA, Abbott GW., Free PMC Article | 09/4/2021 |
| Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root ganglion neurons in the streptozotocin rat model of painful diabetic neuropathy. | Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root ganglion neurons in the streptozotocin rat model of painful diabetic neuropathy.
Djouhri L, Zeidan A, Abd El-Aleem SA. | 05/1/2021 |
| KCNQ5-selective activation is a defining molecular mechanistic signature of genetically diverse traditional botanical hypotensives. | KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines.
Manville RW, van der Horst J, Redford KE, Katz BB, Jepps TA, Abbott GW., Free PMC Article | 03/28/2020 |
| Downregulated pulmonary expression of KCNQ5 in rat nitrofen-induced congenital diaphragmatic hernia lungs suggests that this potassium channel may play an important role in the development of pulmonary hypertension in this model. KCNQ1 and KCNQ4 expression was not altered. | Downregulation of KCNQ5 expression in the rat pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia.
Zimmer J, Takahashi T, Hofmann AD, Puri P. | 12/2/2017 |
| The high expression and function of Kv7 channels in the left coronary artery and their down-regulation by diabetes critically determine the sensitivity to key regulators of coronary tone. | Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia.
Morales-Cano D, Moreno L, Barreira B, Pandolfi R, Chamorro V, Jimenez R, Villamor E, Duarte J, Perez-Vizcaino F, Cogolludo A. | 02/13/2016 |
| These results show that peripheral activity from auditory nerve afferents is necessary to maintain the subcellular distribution of KCNQ5 in synaptic endings of the auditory brainstem. | Loss of auditory activity modifies the location of potassium channel KCNQ5 in auditory brainstem neurons.
Caminos E, Garcia-Pino E, Juiz JM., Free PMC Article | 10/31/2015 |
| Data indicate that the voltage-gated K(+) channel subfamily member, Kcnq5, mRNA was a target for miR-190. | MicroRNA-190 regulates hypoxic pulmonary vasoconstriction by targeting a voltage-gated K⁺ channel in arterial smooth muscle cells.
Li SS, Ran YJ, Zhang DD, Li SZ, Zhu D. | 12/20/2014 |
| Kv7.1/Kv7.5 form heterotetrameric channels increasing the diversity of structures which fine-tune blood vessel reactivity. The lipid raft localization of Kv7.1/Kv7.5 heteromers provides efficient spatial and temporal regulation of smooth muscle function. | Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology.
Oliveras A, Roura-Ferrer M, Solé L, de la Cruz A, Prieto A, Etxebarria A, Manils J, Morales-Cano D, Condom E, Soler C, Cogolludo A, Valenzuela C, Villarroel A, Comes N, Felipe A. | 08/30/2014 |
| In cerebral arteries, Kv7.4 and Kv7.5 proteins exist predominantly as a functional heterotetramer, which regulates intrinsic myogenicity and vasodilation attributed to CGRP. | Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity.
Chadha PS, Jepps TA, Carr G, Stott JB, Zhu HL, Cole WC, Greenwood IA. | 05/24/2014 |
| Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels. | Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.
Brueggemann LI, Mackie AR, Cribbs LL, Freda J, Tripathi A, Majetschak M, Byron KL., Free PMC Article | 03/29/2014 |
| Findings show that K(V)7/KCNQ channels were functionally expressed in primary cultured OLCs and might play an important role in OPCs functioning in physiological or pathological conditions. | K(V)7/KCNQ channels are functionally expressed in oligodendrocyte progenitor cells.
Wang W, Gao XF, Xiao L, Xiang ZH, He C., Free PMC Article | 12/31/2011 |
| KCNQ5 channels control resting properties and release probability of a synapse. | KCNQ5 channels control resting properties and release probability of a synapse.
Huang H, Trussell LO., Free PMC Article | 09/3/2011 |
| KCNQ5 potassium channel participates in the myogenic control of cerebral artery diameter. | Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter.
Zhong XZ, Harhun MI, Olesen SP, Ohya S, Moffatt JD, Cole WC, Greenwood IA., Free PMC Article | 06/25/2011 |
| These findings suggest that synaptic targeting of KCNQ5 in brainstem auditory neurons occurs around the time of hearing onset, regardless of auditory nerve activity. However, long-term synaptic localization after hearing onset depends on peripheral input. | KCNQ5 reaches synaptic endings in the auditory brainstem at hearing onset and targeting maintenance is activity-dependent.
Garcia-Pino E, Caminos E, Juiz JM. | 06/14/2010 |
| These results suggest that suppression of KCNQ5 currents alone is sufficient to excite A7r5 cells, but Arg(8)]-vasopressin-induced activation of TRPC6 contributes to the stimulation of Ca(2+) spiking. | Opposite regulation of KCNQ5 and TRPC6 channels contributes to vasopressin-stimulated calcium spiking responses in A7r5 vascular smooth muscle cells.
Mani BK, Brueggemann LI, Cribbs LL, Byron KL., Free PMC Article | 01/21/2010 |
| among the allowed assembly conformations are KCNQ3/4 and KCNQ4/5 heteromers. | Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.
Bal M, Zhang J, Zaika O, Hernandez CC, Shapiro MS., Free PMC Article | 01/21/2010 |
| KCNQ2, KCNQ3 and KCNQ5 channels provide a hyperpolarizing influence to offset the previously described depolarizing influence of the HCN channels in baroreceptor neurons and their terminals. | The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats.
Wladyka CL, Feng B, Glazebrook PA, Schild JH, Kunze DL., Free PMC Article | 01/21/2010 |
| These results indicate that the cell cycle-dependent expression of Kv7.5 is involved in skeletal muscle cell proliferation. | Skeletal muscle Kv7 (KCNQ) channels in myoblast differentiation and proliferation.
Roura-Ferrer M, Solé L, Martínez-Mármol R, Villalonga N, Felipe A. | 01/21/2010 |
| CaM acts as a mediator in the Ca2+-dependent modulation of KCNQ channels. | The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels.
Yus-Najera E, Santana-Castro I, Villarroel A. | 01/21/2010 |
| -2 is potentially an important regulator of M-current activity in the nervous system and voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination | Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2.
Ekberg J, Schuetz F, Boase NA, Conroy SJ, Manning J, Kumar S, Poronnik P, Adams DJ. | 01/21/2010 |
| Stimulation of Ca(2+) spiking by physiological concentrations of argipressin involves protein kinase C-dependent inhibition of KCNQ5 channels | Vasopressin stimulates action potential firing by protein kinase C-dependent inhibition of KCNQ5 in A7r5 rat aortic smooth muscle cells.
Brueggemann LI, Moran CJ, Barakat JA, Yeh JZ, Cribbs LL, Byron KL., Free PMC Article | 01/21/2010 |
| Single-cell PCR of dissociated hippocampal pyramidal neurons gave detectable signals for KCNQ2, KCNQ3 and KCNQ5. | Molecular correlates of the M-current in cultured rat hippocampal neurons.
Shah M, Mistry M, Marsh SJ, Brown DA, Delmas P., Free PMC Article | 01/21/2010 |