| FBXL2 promotes E47 protein instability to inhibit breast cancer stemness and paclitaxel resistance. | FBXL2 promotes E47 protein instability to inhibit breast cancer stemness and paclitaxel resistance.
Li F, Niu M, Qin K, Guo R, Yi Y, Xu J, Li L, Xie S, Fu M, Wen N, Liao W, Xiao ZJ. | 02/4/2023 |
| FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth. | FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth.
Niu M, Xu J, Liu Y, Li Y, He T, Ding L, He Y, Yi Y, Li F, Guo R, Gao Y, Li R, Li L, Fu M, Hu Q, Luo Y, Zhang C, Qin K, Yi J, Yu S, Yang J, Chen H, Wang L, Li Z, Dong B, Qi S, Ouyang L, Zhang Y, Cao Y, Xiao ZJ., Free PMC Article | 11/6/2021 |
| Tumor Necrosis Factor Alpha Regulates Skeletal Myogenesis by Inhibiting SP1 Interaction with cis-Acting Regulatory Elements within the Fbxl2 Gene Promoter. | Tumor Necrosis Factor Alpha Regulates Skeletal Myogenesis by Inhibiting SP1 Interaction with cis-Acting Regulatory Elements within the Fbxl2 Gene Promoter.
O'Brien ME, Londino J, McGinnis M, Weathington N, Adair J, Suber T, Kagan V, Chen K, Zou C, Chen B, Bon J, Mallampalli RK., Free PMC Article | 08/29/2020 |
| The interaction with FBXL2 and ubiquitination of FOXM1 were reduced by elevated O-GlcNAcylation. Elevated O-GlcNAcylation contributes to cancer progression by suppressing FBXL2-mediated degradation of FOXM1. | O-GlcNAcylation-mediated degradation of FBXL2 stabilizes FOXM1 to induce cancer progression.
Ueda Y, Moriwaki K, Takeuchi T, Higuchi K, Asahi M. | 08/1/2020 |
| miR-346-5p promoted colorectal cancer cell growth in vitro and in vivo by targeting FBXL2 and activating the beta-catenin signaling. | MiR-346-5p promotes colorectal cancer cell proliferation in vitro and in vivo by targeting FBXL2 and activating the β-catenin signaling pathway.
Pan S, Wu W, Ren F, Li L, Li Y, Li W, Wang A, Liu D, Dong Y. | 02/15/2020 |
| PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth | PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth.
Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, Florens L, Washburn MP, Collazo-Lorduy A, Castillo-Martin M, Cordon-Cardo C, Sebti SM, Pinton P, Pagano M., Free PMC Article | 11/11/2017 |
| these results uncover a previous unknown network involving FBXL2 and FoxM1 in the regulation of gastric cancer growth. | F-box protein FBXL2 inhibits gastric cancer proliferation by ubiquitin-mediated degradation of forkhead box M1.
Li LQ, Pan D, Chen H, Zhang L, Xie WJ. | 08/6/2016 |
| FBXL2 recognizes Trp-73 within NALP3 for interaction and targets Lys-689 within NALP3 for ubiquitin ligation and degradation. | Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase.
Han S, Lear TB, Jerome JA, Rajbhandari S, Snavely CA, Gulick DL, Gibson KF, Zou C, Chen BB, Mallampalli RK., Free PMC Article | 10/17/2015 |
| FBXL2 mediates the ubiquitylation and degradation of p85beta on cell membranes. | FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade.
Kuchay S, Duan S, Schenkein E, Peschiaroli A, Saraf A, Florens L, Washburn MP, Pagano M., Free PMC Article | 06/29/2013 |
| These results suggested that the involvement of the reduction of FBL2 level is related to AD progression. | Neuronal expression of F-box and leucine-rich-repeat protein 2 decreases over Braak stages in the brains of Alzheimer's disease patients.
Watanabe T, von der Kammer H, Wang X, Shintani Y, Horiguchi T. | 03/2/2013 |
| FBXL2 is indispensible regulator of mitosis that serves as a tumor suppressor | F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest.
Chen BB, Glasser JR, Coon TA, Mallampalli RK., Free PMC Article | 09/1/2012 |
| FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. | F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation.
Chen BB, Glasser JR, Coon TA, Zou C, Miller HL, Fenton M, McDyer JF, Boyiadzis M, Mallampalli RK., Free PMC Article | 05/26/2012 |
| FBL2 is a novel and dual regulator of amyloid precursor protein (APP) metabolism through FBL2-dependent ubiquitination of APP. | FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis.
Watanabe T, Hikichi Y, Willuweit A, Shintani Y, Horiguchi T., Free PMC Article | 04/28/2012 |