| Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide adenine dinucleotide cofactors. | Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide adenine dinucleotide cofactors.
Abshire ET, Hughes KL, Diao R, Pearce S, Gopalakrishna S, Trievel RC, Rorbach J, Freddolino PL, Goldstrohm AC., Free PMC Article | 04/3/2021 |
| Measuring NOCTURNIN expression levels in human peripheral blood lymphocytes can improve investigations on the relationship between changes in circadian rhythm and metabolic disorders. Shift workers show higher NOCTURNIN levels than daytime worker | NOCTURNIN Gene Diurnal Variation in Healthy Volunteers and Expression Levels in Shift Workers.
Bracci M, Copertaro A, Ciarapica V, Barbaresi M, Esposito S, Albanesi A, Valentino M, Ledda C, Rapisarda V, Santarelli L., Free PMC Article | 01/25/2020 |
| Study present a 2.7-A crystal structure of the catalytic domain of human NOCT. Our structure shows that NOCT has a close overall similarity to CCR4 deadenylase family members, PDE12 and CNOT6L, and to a DNA repair enzyme TDP2. All the key catalytic residues present in PDE12, CNOT6L and TDP2 are conserved in NOCT and have the same conformations. | Crystal Structure of Human Nocturnin Catalytic Domain.
Estrella MA, Du J, Korennykh A., Free PMC Article | 11/30/2019 |
| NOCT is an exoribonuclease that can degrade mRNAs to inhibit protein expression | The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.
Abshire ET, Chasseur J, Bohn JA, Del Rizzo PA, Freddolino PL, Goldstrohm AC, Trievel RC., Free PMC Article | 08/3/2019 |
| This review seeks to integrate these new discoveries into our understanding of Nocturnin's regulatory functions and highlight the important remaining unanswered questions surrounding its regulation, biochemical activities, protein partners, and target mRNAs. | Regulatory roles of vertebrate Nocturnin: insights and remaining mysteries.
Hughes KL, Abshire ET, Goldstrohm AC., Free PMC Article | 01/12/2019 |
| results highlight the clinical significance of PARN and NOC on the survival in SCC diagnosed patients. | Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression.
Maragozidis P, Papanastasi E, Scutelnic D, Totomi A, Kokkori I, Zarogiannis SG, Kerenidi T, Gourgoulianis KI, Balatsos NA., Free PMC Article | 07/16/2016 |
| Three tag SNPs (rs938836, rs17050680, rs3805213) in the CCRN4L are significant correlation with genotype and allele frequency in lung cancer. | Association between CLOCK, PER3 and CCRN4L with non‑small cell lung cancer in Brazilian patients.
Couto P, Miranda D, Vieira R, Vilhena A, De Marco L, Bastos-Rodrigues L. | 01/17/2015 |
| Genetic variation in the NOC gene is associated with body mass index in Chinese subjects. | Genetic variation in the NOC gene is associated with body mass index in Chinese subjects.
Chang YC, Chiu YF, Liu PH, Hee SW, Chang TJ, Jiang YD, Lee WJ, Lee PC, Kao HY, Hwang JJ, Chuang LM., Free PMC Article | 05/3/2014 |
| Ccr4d functions as an anti-proliferating protein through the induction of cell cycle arrest via a p21-dependent and p53-independent pathway and suggest that Ccr4d might have an important role in carcinogenesis. | RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway.
Yi X, Hong M, Gui B, Chen Z, Li L, Xie G, Liang J, Wang X, Shang Y., Free PMC Article | 08/25/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| The transcription of human nocturnin gene displayed circadian oscillations in Huh7 cells (a human hepatoma cell line) and was regulated by CLOCK/BMAL1 heterodimer via the E-box of nocturnin promoter. | CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter.
Li R, Yue J, Zhang Y, Zhou L, Hao W, Yuan J, Qiang B, Ding JM, Peng X, Cao JM. | 01/21/2010 |
| A human lung cancer cell line SBC-5 that efficiently metastasized to bone when intravenously injected into SCID mice was found to express CCR4. | RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4.
Nakamura ES, Koizumi K, Kobayashi M, Saitoh Y, Arita Y, Nakayama T, Sakurai H, Yoshie O, Saiki I. | 01/21/2010 |