| The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation. | The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation.
Kim H, Kang Y, Kim S, Park D, Heo SY, Yoo JS, Choi I, N MPA, Ahn JW, Yang JS, Bak N, Kim KK, Lee JY, Choi YK. | 10/1/2024 |
| MiR-107-3p Knockdown Alleviates Endothelial Injury in Sepsis via Kallikrein-Related Peptidase 5. | MiR-107-3p Knockdown Alleviates Endothelial Injury in Sepsis via Kallikrein-Related Peptidase 5.
Lin Y, Ma L, Dan H, Chen G, Dai J, Xu L, Liu Y. | 11/3/2023 |
| Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma. | Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.
Jackman JK, Stockwell A, Choy DF, Xie MM, Lu P, Jia G, Li H, Abbas AR, Bronson PG, Lin WY, Chiu CPC, Maun HR, Roose-Girma M, Tam L, Zhang J, Modrusan Z, Graham RR, Behrens TW, White SR, Naureckas T, Ober C, Ferreira M, Sedlacek R, Wu J, Lee WP, Lazarus RA, Koerber JT, Arron JR, Yaspan BL, Yi T. | 10/15/2022 |
| KLK5 is associated with the radioresistance, aggression, and progression of cervical cancer. | KLK5 is associated with the radioresistance, aggression, and progression of cervical cancer.
Zhou S, Liu S, Tian G, Zhao L, Wang H, Li Y, Shen Y, Han L. | 06/25/2022 |
| Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma. | Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma.
Abuduhadeer X, Xu X, Aihesan K, Yilihamu M, Zhao Y, Zhang W., Free PMC Article | 02/5/2022 |
| Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP. | Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.
Kang Y, Chen J, Li X, Luo M, Chen H, Cui B, Wang L, Lv D, Feng Y, Zhang P. | 01/15/2022 |
| Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition. | Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition.
Tian J, Wang V, Wang N, Khadang B, Boudreault J, Bakdounes K, Ali S, Lebrun JJ., Free PMC Article | 01/8/2022 |
| Kallikrein-related peptidase 5 contributes to the remodeling and repair of bronchial epithelium. | Kallikrein-related peptidase 5 contributes to the remodeling and repair of bronchial epithelium.
Lenga Ma Bonda W, Lavergne M, Vasseur V, Brisson L, Roger S, Legras A, Guillon A, Guyétant S, Hiemstra PS, Si-Tahar M, Iochmann S, Reverdiau P. | 10/23/2021 |
| Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer. | Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer.
Chang JS, Kim N, Kim JY, Do SI, Cho Y, Kim HS, Kim YB., Free PMC Article | 09/4/2021 |
| PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma. | PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.
Ma H, Hockla A, Mehner C, Coban M, Papo N, Radisky DC, Radisky ES., Free PMC Article | 10/24/2020 |
| The KLK5 mRNA expression may be useful for the differentiation of colorectal cancer (CRC) from colorectal adenoma and represents a potential unfavorable prognostic biomarker for CRC. | Uncovering the clinical impact of kallikrein-related peptidase 5 (KLK5) mRNA expression in the colorectal adenoma-carcinoma sequence.
Papachristopoulou G, Malachias A, Devetzi M, Kamouza E, Scorilas A, Xynopoulos D, Talieri M. | 04/4/2020 |
| The elevated expression of KLK5 mRNA is significantly related with shortened progression-free survival of patients afflicted with advanced high-grade serous ovarian cancer. | Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer.
Gong W, Liu Y, Seidl C, Diamandis EP, Kiechle M, Drecoll E, Kotzsch M, Magdolen V, Dorn J., Free PMC Article | 12/14/2019 |
| Using mouse Klk5 and Klk5-deficient mice, it demonstrated in vitro and in vivo that the mouse ortholog protease is not an IAV activating enzyme. | Kallikrein-related peptidase 5 and seasonal influenza viruses, limitations of the experimental models for activating proteases.
Magnen M, Elsässer BM, Zbodakova O, Kasparek P, Gueugnon F, Petit-Courty A, Sedlacek R, Goettig P, Courty Y. | 05/18/2019 |
| Nf-kappab activation is markedly enhanced in Klk5-/-, leading to increased resistance to apoptosis of mutated vaginal cells. Thus, KLK5 may represent a putative suppressor of vaginal cancer. | KLK5, a novel potential suppressor of vaginal carcinogenesis.
Pampalakis G, Zingkou E, Sotiropoulou G. | 05/18/2019 |
| Study provides mechanistic insights into the molecular interaction between KLK5 and DPP4 as well as CD4+ T cell derived KLK5 mediated enzymatic cleavage of DPP4 from cell surface. Study uncovers a hitherto unknown cellular source and mechanism behind enhanced plasma DPP4 activity in T2DM. | KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes.
Nargis T, Kumar K, Ghosh AR, Sharma A, Rudra D, Sen D, Chakrabarti S, Mukhopadhyay S, Ganguly D, Chakrabarti P., Free PMC Article | 01/19/2019 |
| persistently upregulated KLK5 resulted in atopic dermatitis-like skin architecture and secretion of atopic dermatitis-related cytokines from keratinocytes in a PAR2 independent manner | Persistent kallikrein 5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity.
Zhu Y, Underwood J, Macmillan D, Shariff L, O'Shaughnessy R, Harper JI, Pickard C, Friedmann PS, Healy E, Di WL. | 11/25/2017 |
| It may be considered that circulating kallikrein 5 is down-regulated in chronic spontaneous urticaria patients, however its potential role and the possible underlying mechanism are unknown. | Decreased plasma kallikrein 5 concentrations in patients with chronic spontaneous urticaria.
Grzanka A, Damasiewicz-Bodzek A, Szumska M, Kasperska-Zajac A. | 08/19/2017 |
| Thus, these findings point to the involvement of KLK5 in the proteolytic activation and spread of seasonal influenza viruses in humans. | Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs.
Magnen M, Gueugnon F, Guillon A, Baranek T, Thibault VC, Petit-Courty A, de Veer SJ, Harris J, Humbles AA, Si-Tahar M, Courty Y., Free PMC Article | 08/12/2017 |
| The results of the present study indicated that the mRNA and protein expression levels of KLK5 were significantly upregulated in CRC tissues and sera, and were associated with an advanced tumor stage. | Upregulation of kallikrein‑related peptidase 5 is associated with the malignant behavior of colorectal cancer.
Wu Y, Chen Y, Li Q, Gong Y, Liu X, Bi L, Hu C. | 04/8/2017 |
| the expression level of hK5 in tumor stromal cells is a promising biomarker for poor prognosis in TNBC. | Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer: tissue expression analysis and relationship with disease course.
Yang F, Li JY, Yin QN, Yang K, Dong SN, Bai LJ, Liu P, Tong XW. | 06/11/2016 |
| This report demonstrates that concurrent loss of KLK5 and KLK7 associates with a poor clinical outcome in Oral Squamous-Cell Carcinoma and could therefore serve as prognostic marker in this disease. | The Co-Expression of Kallikrein 5 and Kallikrein 7 Associates with Poor Survival in Non-HPV Oral Squamous-Cell Carcinoma.
Leusink FK, van Diest PJ, Frank MH, Broekhuizen R, Braunius W, van Hooff SR, Willems SM, Koole R. | 05/14/2016 |
| Low KLK5 expression is associated with breast cancer. | The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway.
Pampalakis G, Obasuyi O, Papadodima O, Chatziioannou A, Zoumpourlis V, Sotiropoulou G., Free PMC Article | 02/21/2015 |
| KLK5 is an important contributor to the Netherton syndrome proteolytic cascade. | Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome.
Furio L, de Veer S, Jaillet M, Briot A, Robin A, Deraison C, Hovnanian A., Free PMC Article | 05/10/2014 |
| Data indicate that the KLK5 SNP rs268908 was associated with an increased risk of prostate cancer. | Common variation in Kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness.
Lose F, Batra J, O'Mara T, Fahey P, Marquart L, Eeles RA, Easton DF, Al Olama AA, Kote-Jarai Z, Guy M, Muir K, Lophatananon A, Rahman AA, Neal DE, Hamdy FC, Donovan JL, Chambers S, Gardiner RA, Aitken JF, Yaxley J, Alexander K, Clements JA, Spurdle AB, Kedda MA, Australian Prostate Cancer BioResource. | 01/25/2014 |
| Kallikrein 5 and kallikrein 12 cleave human influenza hemagglutinins and activate thrombolytic zymogens. | Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12.
Hamilton BS, Whittaker GR., Free PMC Article | 08/31/2013 |