| GAK and PRKCD are positive regulators of PRKN-independent mitophagy. | GAK and PRKCD are positive regulators of PRKN-independent mitophagy.
Munson MJ, Mathai BJ, Ng MYW, Trachsel-Moncho L, de la Ballina LR, Schultz SW, Aman Y, Lystad AH, Singh S, Singh S, Wesche J, Fang EF, Simonsen A., Free PMC Article | 11/22/2021 |
| Mutation Analysis of DNAJC Family for Early-Onset Parkinson's Disease in a Chinese Cohort. | Mutation Analysis of DNAJC Family for Early-Onset Parkinson's Disease in a Chinese Cohort.
Li C, Ou R, Chen Y, Gu X, Wei Q, Cao B, Zhang L, Hou Y, Liu K, Chen X, Song W, Zhao B, Wu Y, Shang H. | 06/26/2021 |
| Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury. | Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury.
Tian X, Inoue K, Zhang Y, Wang Y, Sperati CJ, Pedigo CE, Zhao T, Yan M, Groener M, Moledina DG, Ebenezer K, Li W, Zhang Z, Liebermann DA, Greene L, Greer P, Parikh CR, Ishibe S., Free PMC Article | 06/12/2021 |
| Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic. | Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic.
He K, Song E, Upadhyayula S, Dang S, Gaudin R, Skillern W, Bu K, Capraro BR, Rapoport I, Kusters I, Ma M, Kirchhausen T., Free PMC Article | 10/24/2020 |
| These findings indicate that the abnormal mitoses seen after silencing OIP5-AS1 were caused by an untimely rise in GAK levels and suggest that OIP5-AS1 suppresses cell proliferation at least in part by reducing GAK levels. | LncRNA OIP5-AS1/cyrano suppresses GAK expression to control mitosis.
Kim J, Noh JH, Lee SK, Munk R, Sharov A, Lehrmann E, Zhang Y, Wang W, Abdelmohsen K, Gorospe M., Free PMC Article | 04/28/2018 |
| that the multiple single nucleotide polymorphisms of GAK synergistically participate in the pathogenesis of sporadic Parkinson's disease through multiple pathways. | The Potential Mutation of GAK Gene in the Typical Sporadic Parkinson's Disease from the Han Population of Chinese Mainland.
Zhang J, Zeng H, Zhu L, Deng L, Fang X, Deng X, Liang H, Tang C, Cao X, Lu Y, Li J, Ren X, Zuo W, Zhang X, Xu R. | 12/30/2017 |
| We have demonstrated that siRNA-mediated GAK silencing causes marked cell cycle disruption resulting in a raised sub-G1 alongside decreased G1 and G2/M cell cycle phases. Dual FBXW7-GAK inhibition increases multipolar mitoses | RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.
Dolly SO, Gurden MD, Drosopoulos K, Clarke P, de Bono J, Kaye S, Workman P, Linardopoulos S., Free PMC Article | 10/7/2017 |
| GAK gene expression is increased in Parkinson disease | The 4p16.3 Parkinson Disease Risk Locus Is Associated with GAK Expression and Genes Involved with the Synaptic Vesicle Membrane.
Nagle MW, Latourelle JC, Labadorf A, Dumitriu A, Hadzi TC, Beach TG, Myers RH., Free PMC Article | 08/26/2017 |
| These results suggest that the c-Src_GAK_MCM axis plays an important role in cell cycle progression through control of the DNA replication licensing system. | GAK is phosphorylated by c-Src and translocated from the centrosome to chromatin at the end of telophase.
Fukushima K, Wang M, Naito Y, Uchihashi T, Kato Y, Mukai S, Yabuta N, Nojima H., Free PMC Article | 06/24/2017 |
| We filtered four OSCC genes including SERPINB9, SERPINE2, GAK, and HSP90B1 through the gene global prioritization score (P < 0.005). | Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma.
Sun W, Lv W, Lv H, Zhang R, Jiang Y. | 02/4/2017 |
| This meta-analysis suggests that GAK rs1564282 C/T polymorphism is associated with increased susceptibility to Parkinson's disease--{REVIEW} | Quantitative assessment of the association between GAK rs1564282 C/T polymorphism and the risk of Parkinson's disease.
Ma ZG, He F, Xu J. | 04/23/2016 |
| Data indicated that GBA and TMEM175/GAK significantly alter age at onset in PD. | Impact of Parkinson's disease risk loci on age at onset.
Lill CM, Hansen J, Olsen JH, Binder H, Ritz B, Bertram L. | 04/9/2016 |
| AAK1 and GAK are critical regulators of HCV entry that function in part by activating EGFR, AP2M1, and NUMB, and as the molecular targets underlying the antiviral effect of sunitinib and erlotinib, respectively. | AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.
Neveu G, Ziv-Av A, Barouch-Bentov R, Berkerman E, Mulholland J, Einav S., Free PMC Article | 05/30/2015 |
| The effects of rs11248051 and rs1564282 variants of GAK, and the rs3129882 variant of HLA-DRA, were investigated in Parkinson's disease patients. | Reaffirmation of GAK, but not HLA-DRA, as a Parkinson's disease susceptibility gene in a Taiwanese population.
Lin CH, Chen ML, Tai YC, Yu CY, Wu RM. | 10/25/2014 |
| GAK apo structure reveals a dimeric inactive state of the catalytic domain mediated by an unusual activation segment interaction. | Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.
Chaikuad A, Keates T, Vincke C, Kaufholz M, Zenn M, Zimmermann B, Gutiérrez C, Zhang RG, Hatzos-Skintges C, Joachimiak A, Muyldermans S, Herberg FW, Knapp S, Müller S., Free PMC Article | 05/10/2014 |
| Cyclin-G-associated kinase is a binding partners of LRRK2, a candidate genes for risk for sporadic Parkinson disease, and part of a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system. | Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Beilina A, Rudenko IN, Kaganovich A, Civiero L, Chau H, Kalia SK, Kalia LV, Lobbestael E, Chia R, Ndukwe K, Ding J, Nalls MA, International Parkinson’s Disease Genomics Consortium, North American Brain Expression Consortium, Olszewski M, Hauser DN, Kumaran R, Lozano AM, Baekelandt V, Greene LE, Taymans JM, Greggio E, Cookson MR., Free PMC Article | 04/19/2014 |
| Dominant negative mutants of IRAK4 and GAK show strong apoptotic effects in A498 cells under anoxia. | A kinome-wide siRNA screen identifies multiple roles for protein kinases in hypoxic stress adaptation, including roles for IRAK4 and GAK in protection against apoptosis in VHL-/- renal carcinoma cells, despite activation of the NF-κB pathway.
Pan J, Zhang J, Hill A, Lapan P, Berasi S, Bates B, Miller C, Haney S. | 02/15/2014 |
| neither the CT, TT genotypes nor the minor allele T of single nucleotide polymorphism rs1564282 were associated with Parkinson's disease among the subjects from Taiwan and Singapore. | Genetic variations of GAK in two Chinese Parkinson's disease populations: a case-control study.
Tseng WE, Chen CM, Chen YC, Yi Z, Tan EK, Wu YR., Free PMC Article | 02/8/2014 |
| rs11248060 significantly increasThis study found that the minor alleles of GAK rpopulationss1564282 and DGKQ e the risk of PD in Han Chinese . | GAK rs1564282 and DGKQ rs11248060 increase the risk for Parkinson's disease in a Chinese population.
Chen YP, Song W, Huang R, Chen K, Zhao B, Li J, Yang Y, Shang HF. | 01/11/2014 |
| GAK as a regulator of dephosphorylation events under the control of the PP2A B'gamma subunit. | Cyclin G-associated kinase regulates protein phosphatase 2A by phosphorylation of its B'γ subunit.
Naito Y, Shimizu H, Kasama T, Sato J, Tabara H, Okamoto A, Yabuta N, Nojima H. | 09/15/2012 |
| study demonstrated that the rs1564282 variant in GAK (PARK17) increases the risk of Parkinson's disease in Han Chinese patients from mainland China | GWAS-linked GAK locus in Parkinson's disease in Han Chinese and meta-analysis.
Li NN, Chang XL, Mao XY, Zhang JH, Zhao DM, Tan EK, Peng R. | 08/25/2012 |
| cyclin G associated kinase is associated with Parkinson disease risk and suggest that cyclin G associated kinase and alpha-synuclein interact in a pathway involved in disease pathogenesis | Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study.
Dumitriu A, Pacheco CD, Wilk JB, Strathearn KE, Latourelle JC, Goldwurm S, Pezzoli G, Rochet JC, Lindquist S, Myers RH., Free PMC Article | 07/23/2011 |
| GAK is a new candidate for investigation in future studies. | Replication of GWAS associations for GAK and MAPT in Parkinson's disease.
Rhodes SL, Sinsheimer JS, Bordelon Y, Bronstein JM, Ritz B, Rhodes SL, Sinsheimer JS, Bordelon Y, Bronstein JM, Ritz B., Free PMC Articles: PMC3074465, PMC3074465 | 04/9/2011 |
| Osteosarcoma cell proliferation and survival are dependent on GAK. | Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking.
Susa M, Choy E, Liu X, Schwab J, Hornicek FJ, Mankin H, Duan Z. | 04/2/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Replication of GWAS associations for GAK and MAPT in Parkinson's disease.
Rhodes SL, Sinsheimer JS, Bordelon Y, Bronstein JM, Ritz B, Rhodes SL, Sinsheimer JS, Bordelon Y, Bronstein JM, Ritz B., Free PMC Articles: PMC3074465, PMC3074465 | 12/5/2010 |