| Kv2.1 Channels Prevent Vasomotion and Safeguard Myogenic Reactivity in Rat Small Superior Cerebellar Arteries. | Kv2.1 Channels Prevent Vasomotion and Safeguard Myogenic Reactivity in Rat Small Superior Cerebellar Arteries.
Här K, Lysenko NN, Dimitrova D, Schlüter T, Zavaritskaya O, Kamkin AG, Mladenov M, Grisk O, Köhler R, Gagov H, Schubert R., Free PMC Article | 08/14/2023 |
| Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1. | Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1.
Dallas ML, Al-Owais MM, Hettiarachchi NT, Vandiver MS, Jarosz-Griffiths HH, Scragg JL, Boyle JP, Steele D, Peers C., Free PMC Article | 11/13/2021 |
| Tyrosine Phosphorylation of the Kv2.1 Channel Contributes to Injury in Brain Ischemia. | Tyrosine Phosphorylation of the K(v)2.1 Channel Contributes to Injury in Brain Ischemia.
Song MY, Hwang JY, Bae EJ, Kim S, Kang HM, Kim YJ, Park C, Park KS., Free PMC Article | 03/20/2021 |
| Site-specific contacts enable distinct modes of TRPV1 regulation by the potassium channel Kvbeta1 subunit. | Site-specific contacts enable distinct modes of TRPV1 regulation by the potassium channel Kvβ1 subunit.
Wang Y, Mo X, Ping C, Huang Q, Zhang H, Xie C, Zhong B, Li D, Yao J., Free PMC Article | 03/20/2021 |
| A molecular rheostat: Kv2.1 currents maintain or suppress repetitive firing in motoneurons. | A molecular rheostat: Kv2.1 currents maintain or suppress repetitive firing in motoneurons.
Romer SH, Deardorff AS, Fyffe REW. | 08/15/2020 |
| Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant. | Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant.
Yeh CY, Ye Z, Moutal A, Gaur S, Henton AM, Kouvaros S, Saloman JL, Hartnett-Scott KA, Tzounopoulos T, Khanna R, Aizenman E, Camacho CJ., Free PMC Article | 03/28/2020 |
| results suggest that Kv2.1 clusters exert a spatially discrete homeostatic braking mechanism on dopamine transporter by inducing a relative increase in inward-facing transporters | Clustered Kv2.1 decreases dopamine transporter activity and internalization.
Lebowitz JJ, Pino JA, Mackie PM, Lin M, Hurst C, Divita K, Collins AT, Koutzoumis DN, Torres GE, Khoshbouei H., Free PMC Article | 01/11/2020 |
| Enhanced Kv2.1 potassium whole-cell currents. | Molecular Neuroprotection Induced by Zinc-Dependent Expression of Hepatitis C-Derived Protein NS5A Targeting Kv2.1 Potassium Channels.
Justice JA, Manjooran DT, Yeh CY, Hartnett-Scott KA, Schulien AJ, Kosobucki GJ, Mammen S, Palladino MJ, Aizenman E., Free PMC Article | 10/12/2019 |
| Kv2.1 forms reservoir clusters on the beta-cell plasma membrane and binds Syn-3 via its C-terminal C1b domain, which recruits newcomer insulin secretory granules into this large reservoir. | K(v)2.1 clusters on β-cell plasma membrane act as reservoirs that replenish pools of newcomer insulin granule through their interaction with syntaxin-3.
Greitzer-Antes D, Xie L, Qin T, Xie H, Zhu D, Dolai S, Liang T, Kang F, Hardy AB, He Y, Kang Y, Gaisano HY., Free PMC Article | 02/2/2019 |
| up-regulation of the KV2.1 channel in renal artery myocytes may be involved in the compensatory mechanisms against decreased renal blood flow in salt-sensitive hypertension | Up-Regulation of the Voltage-Gated K(V)2.1 K(+) Channel in the Renal Arterial Myocytes of Dahl Salt-Sensitive Hypertensive Rats.
Ogiwara K, Ohya S, Suzuki Y, Yamamura H, Imaizumi Y. | 05/26/2018 |
| Trafficking of the Kv2.1 channel takes place in the somatodendritic plasma membrane and in the axon initial segment. | Trafficking of Kv2.1 Channels to the Axon Initial Segment by a Novel Nonconventional Secretory Pathway.
Jensen CS, Watanabe S, Stas JI, Klaphaak J, Yamane A, Schmitt N, Olesen SP, Trimmer JS, Rasmussen HB, Misonou H., Free PMC Article | 12/9/2017 |
| Data suggest that NMDAR plays key role in mediating effect of leptin to modulate function of insulin-secreting cells by promoting AMPK-dependent trafficking of KATP and Kv2.1 channels to plasma membrane. (NMDAR = N-methyl-D-aspartate receptor; AMPK = AMP-activated protein kinase; KATP = ATP-sensitive potassium channel; Kv2.1 = delayed-rectifier potassium channel 1) | NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic β-cells.
Wu Y, Fortin DA, Cochrane VA, Chen PC, Shyng SL., Free PMC Article | 09/30/2017 |
| The experiments presented here demonstrate that the cell death-specific role of Kv2.1 can be uniquely modulated to provide neuroprotection in an animal model of acute ischemic stroke. We thus reveal a novel therapeutic strategy for neurological disorders that are accompanied by Kv2.1-facilitated forms of cell death. | Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke.
Yeh CY, Bulas AM, Moutal A, Saloman JL, Hartnett KA, Anderson CT, Tzounopoulos T, Sun D, Khanna R, Aizenman E., Free PMC Article | 08/26/2017 |
| Taken together, these results suggest that HIV-1 gp120 induces hippocampal neuron apoptosis by enhancement of the Ik, which might be associated with increased Kv2.1 expression via the p38 MAPK pathway. | Target of HIV-1 Envelope Glycoprotein gp120-Induced Hippocampal Neuron Damage: Role of Voltage-Gated K(+) Channel Kv2.1.
Zhu Q, Song X, Zhou J, Wang Y, Xia J, Qian W, Zhu J, Gao R, Wang J, Xiao H., Free PMC Article | 08/13/2016 |
| Structural evidence shows that two distinct domains form the C-terminal part within the Kv2.1 ion channel. | Domain structure and conformational changes in rat KV2.1 ion channel.
Grizel A, Popinako A, Kasimova MA, Stevens L, Karlova M, Moisenovich MM, Sokolova OS. | 06/27/2015 |
| modifications in Kv2.1 are dependent on the activation of the chemokine co-receptors CCR5 and CXCR4 | Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.
Shepherd AJ, Loo L, Mohapatra DP., Free PMC Article | 06/21/2014 |
| From histological assessment illustrates that the Kv2.1 and Kv.2 subunits are widely expressed in a mixture of DRG neurons and appear enriched in the myelinated neuron population. | Kv2 dysfunction after peripheral axotomy enhances sensory neuron responsiveness to sustained input.
Tsantoulas C, Zhu L, Yip P, Grist J, Michael GJ, McMahon SB., Free PMC Article | 02/22/2014 |
| Convergent Ca2+ and Zn2+ signaling regulates apoptotic Kv2.1 K+ currents. | Convergent Ca2+ and Zn2+ signaling regulates apoptotic Kv2.1 K+ currents.
McCord MC, Aizenman E., Free PMC Article | 11/30/2013 |
| distinct modifications in Kv2.1 in response to short- and long-term CXCR4-mediated signaling could provide a basis for neuroprotection or apoptosis in neuropathologies. | Distinct modifications in Kv2.1 channel via chemokine receptor CXCR4 regulate neuronal survival-death dynamics.
Shepherd AJ, Loo L, Gupte RP, Mickle AD, Mohapatra DP., Free PMC Article | 04/13/2013 |
| The present data provide evidence that the transcriptional regulation of Kcnv2 and Kv2.1 is a way through which the retinal clock system drives the functional adaptation of visual function to the marked daily changes in environmental lighting conditions. | The retinal clock drives the expression of Kcnv2, a channel essential for visual function and cone survival.
Hölter P, Kunst S, Wolloscheck T, Kelleher DK, Sticht C, Wolfrum U, Spessert R. | 01/12/2013 |
| the molecular determinants of Kv2.1 localization and modulation are distinct regions of the channel that function independently. | The C-terminus of neuronal Kv2.1 channels is required for channel localization and targeting but not for NMDA-receptor-mediated regulation of channel function.
Baver SB, O'Connell KM., Free PMC Article | 11/24/2012 |
| Direct interaction between syntaxin 1A and the Kv2.1 C-terminus is required for efficient insulin exocytosis and glucose-stimulated insulin secretion. | The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.
Dai XQ, Manning Fox JE, Chikvashvili D, Casimir M, Plummer G, Hajmrle C, Spigelman AF, Kin T, Singer-Lahat D, Kang Y, Shapiro AM, Gaisano HY, Lotan I, Macdonald PE. | 09/1/2012 |
| BKCa and KV channels limit conducted vasomotor responses in rat mesenteric terminal arterioles. | BKCa and KV channels limit conducted vasomotor responses in rat mesenteric terminal arterioles.
Hald BO, Jacobsen JC, Braunstein TH, Inoue R, Ito Y, Sørensen PG, Holstein-Rathlou NH, Jensen LJ. | 06/16/2012 |
| The elevation of membrane cholesterol enhances susceptibility of cerebellar granule neurons to apoptotic stimuli via cyclic AMP/PKA/CREB-dependent up-regulation of Kv2.1. | Cholesterol enhances neuron susceptibility to apoptotic stimuli via cAMP/PKA/CREB-dependent up-regulation of Kv2.1.
Zhou MH, Yang G, Jiao S, Hu CL, Mei YA. | 03/10/2012 |
| TGF-beta1 upregulates Kv2.1 channel expression and I(K) currents and thereby promotes cerebellar granule neuron maturation | TGF-β1 enhances Kv2.1 potassium channel protein expression and promotes maturation of cerebellar granule neurons.
Zhuang JL, Wang CY, Zhou MH, Duan KZ, Mei YA. | 12/10/2011 |