| Exploring the parity paradox: Differential effects on neuroplasticity and inflammation by APOEe4 genotype at middle age. | Exploring the parity paradox: Differential effects on neuroplasticity and inflammation by APOEe4 genotype at middle age.
Lee BH, Cevizci M, Lieblich SE, Ibrahim M, Wen Y, Eid RS, Lamers Y, Duarte-Guterman P, Galea LAM. | 08/29/2024 |
| The role of ApoE in fatty acid transport from neurons to astrocytes under ischemia/hypoxia conditions. | The role of ApoE in fatty acid transport from neurons to astrocytes under ischemia/hypoxia conditions.
Chen H, Zhao S, Jian Q, Yan Y, Wang S, Zhang X, Ji Y. | 04/3/2024 |
| Apolipoprotein E-depletion accelerates arterial fat deposition in the spontaneously hypertensive rat. | Apolipoprotein E-depletion accelerates arterial fat deposition in the spontaneously hypertensive rat.
Matsuo H, Kawakami K, Ohara H, Kaneko T, Mashimo T, Yamada T, Nabika T., Free PMC Article | 03/21/2024 |
| Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-kappaB Signaling Pathway. | Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-κB Signaling Pathway.
Jiang C, Chen Z, Wang X, Zhang Y, Guo X, Fan H, Huang D, He Y, Tang X, Ai Y, Liu Y, Yang H, Hao D., Free PMC Article | 11/1/2023 |
| Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats. | Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats.
Nguyen TD, Watanabe A, Burleigh S, Ghaffarzadegan T, Kanklai J, Prykhodko O, Hållenius FF, Nyman M., Free PMC Article | 10/1/2022 |
| ApoE4 attenuates cortical neuronal activity in young behaving apoE4 rats. | ApoE4 attenuates cortical neuronal activity in young behaving apoE4 rats.
Har-Paz I, Arieli E, Moran A. | 01/22/2022 |
| Cdc42 Facilitates Axonogenesis by Enhancing Microtubule Stabilization in Primary Hippocampal Neurons. | Cdc42 Facilitates Axonogenesis by Enhancing Microtubule Stabilization in Primary Hippocampal Neurons.
Li A, Zhu HM, Chen Y, Yan F, Liu ZY, Li ZL, Dong WR, Zhang L, Wang HH. | 01/15/2022 |
| Astrocytic expression of the Alzheimer's disease risk allele, ApoEepsilon4, potentiates neuronal tau pathology in multiple preclinical models. | Astrocytic expression of the Alzheimer's disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models.
Jablonski AM, Warren L, Usenovic M, Zhou H, Sugam J, Parmentier-Batteur S, Voleti B., Free PMC Article | 11/13/2021 |
| Apolipoprotein E4 Is Associated with Right Ventricular Dysfunction in Dilated Cardiomyopathy-An Animal and In-Human Comparative Study. | Apolipoprotein E4 Is Associated with Right Ventricular Dysfunction in Dilated Cardiomyopathy-An Animal and In-Human Comparative Study.
Diaconu R, Schaaps N, Afify M, Boor P, Cornelissen A, Florescu RA, Simsekyilmaz S, El-Khoury T, Schumacher D, Ioana M, Streata I, Militaru C, Donoiu I, Vogt F, Liehn EA., Free PMC Article | 10/30/2021 |
| The inhibition of HDAC6 activity was also demonstrated to reduce brain injury induced by APOE4 and Abeta140 coaggregation in model rats. | Inhibition of HDAC6 expression decreases brain injury induced by APOE4 and Aβ co‑aggregation in rats.
Ding Y, Kang A, Tang Q, Zhao Y. | 02/8/2020 |
| Data demonstrated that mechanical injury of neurons stimulated oligodendrocytes to secrete apoE. The injured neurons could absorb secreted apoE. The expression of apoE contributed to the activation of p38 MAPK, which facilitated neuron repair. | The absorption of apolipoprotein E by damaged neurons facilitates neuronal repair.
Chen M, Xie M, Peng C, Long S. | 09/14/2019 |
| Deficiency of either Ldlr or Apoe genes induced hyperlipidemia, which promoted endothelial inflammation and led to typical atherosclerosis in rats on normal or Western diets. | Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats.
Zhao Y, Yang Y, Xing R, Cui X, Xiao Y, Xie L, You P, Wang T, Zeng L, Peng W, Li D, Chen H, Liu M. | 06/1/2019 |
| After isolation and during maintenance in culture, adherent rat islets reduce expression of key beta-cell transcription factors necessary for beta-cell function and that soluble pancreatic decellularized matrix can enhance beta-cell gene expression. Study identified APOE as an extracellular protein that significantly increased the expression of key beta-cell genes, mediated at least in part through the JAK/STAT signali... | Apolipoprotein E is a pancreatic extracellular factor that maintains mature β-cell gene expression.
Mahmoud AI, Galdos FX, Dinan KA, Jedrychowski MP, Davis JC, Vujic A, Rachmin I, Shigley C, Pancoast JR, Lee S, Hollister-Lock J, MacGillivray CM, Gygi SP, Melton DA, Weir GC, Lee RT., Free PMC Article | 03/23/2019 |
| Infusion of AngII did not lead to the formation of dissecting abdominal aortic aneurysms or atherosclerosis in ApoE-knockout rats. | Angiotensin II Infusion Does Not Cause Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Rats.
Phillips EH, Chang MS, Gorman S, Qureshi HJ, Ejendal KFK, Kinzer-Ursem TL, Blaize AN, Goergen CJ., Free PMC Article | 06/23/2018 |
| Results demonstrated that apolipoprotein E4 (ApoE4)exerted direct neurotoxicity and enhanced the neurotoxicity of Abeta1-40 on spatial cognitive function and hippocampal long term potentiation. This may partly elucidate the mechanism by which APOE4 allele exerted negative effects as a major genetic risk factor for developing Alzheimer's disease. | Co-injection of Aβ1-40 and ApoE4 impaired spatial memory and hippocampal long-term potentiation in rats.
Wu M, He Y, Zhang J, Yang J, Qi J. | 11/11/2017 |
| renal denervation improves aortic distensibility and attenuated endothelial dysfunction in ApoE(-/-)-rats. | Modulation of the sympathetic nervous system by renal denervation prevents reduction of aortic distensibility in atherosclerosis prone ApoE-deficient rats.
Hohl M, Linz D, Fries P, Müller A, Stroeder J, Urban D, Speer T, Geisel J, Hummel B, Laufs U, Schirmer SH, Böhm M, Mahfoud F., Free PMC Article | 10/21/2017 |
| The expression of ApoE and S-100 correlated with the progression of focal cerebral contusion. | ApoE and S-100 expression and its significance in the brain tissue of rats with focal contusion.
Wang ZL, Chai RF, Yang WS, Liu Y, Qin H, Wu H, Zhu XF, Wang YX, Dangmurenjiafu G. | 10/29/2016 |
| Apolipoprotein E-deficient rats develop atherosclerotic plaques in partially ligated carotid arteries. | Apolipoprotein E-deficient rats develop atherosclerotic plaques in partially ligated carotid arteries.
Wei S, Zhang Y, Su L, He K, Wang Q, Zhang Y, Yang D, Yang Y, Ma S. | 09/17/2016 |
| rats treated with KD (EXP2) showed a significant down-regulated expression of ZnT-3, MT-3, ApoE, clusterin, and ACAT-1 in hippocampus | Neurobehavioral Deficits in a Rat Model of Recurrent Neonatal Seizures Are Prevented by a Ketogenic Diet and Correlate with Hippocampal Zinc/Lipid Transporter Signals.
Tian T, Ni H, Sun BL. | 06/4/2016 |
| Findings suggest that endogenous apoE generates lower density HDL to produce more lipidated HDL using previously synthesized cholesterol through the interaction with ABCA1 in caveolin-1-rich domain of astrocytes | Astrocyte׳s endogenous apoE generates HDL-like lipoproteins using previously synthesized cholesterol through interaction with ABCA1.
Ito J, Nagayasu Y, Miura Y, Yokoyama S, Michikawa M. | 01/31/2015 |
| Although rat apolipoprotein E sequence resembles apoE4, an isoform of apoE3, rat apoE displays the biophysical behavior of apoE3. | Biochemical and biophysical characterization of recombinant rat apolipoprotein E: similarities to human apolipoprotein E3.
Tran TN, Kim SH, Gallo C, Amaya M, Kyees J, Narayanaswami V., Free PMC Article | 02/16/2013 |
| A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma | A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma.
Hayashi H, Eguchi Y, Fukuchi-Nakaishi Y, Takeya M, Nakagata N, Tanaka K, Vance JE, Tanihara H., Free PMC Article | 10/20/2012 |
| Lower expression of MMP-2 and MMP-9 is associated with the increased expression of apoE in the glomerulus | Less gelatinases is associated with apolipoprotein E accumulation in glomerulosclerosis rats.
Zhou TB, Qin YH, Lei FY, Su LN, Zhao YJ, Huang WF. | 04/21/2012 |
| ApoE-containing astrocyte lipoproteins exhibit the most robust interactions with Abeta. | Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift.
LaDu MJ, Munson GW, Jungbauer L, Getz GS, Reardon CA, Tai LM, Yu C., Free PMC Article | 04/14/2012 |
| Apolipoproteins E3 exerts neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures. | Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures.
Kosacka J, Gericke M, Nowicki M, Kacza J, Borlak J, Spanel-Borowski K. | 12/14/2011 |