| Synaptotagmin-1 is a bidirectional Ca(2+) sensor for neuronal endocytosis. | Synaptotagmin-1 is a bidirectional Ca(2+) sensor for neuronal endocytosis.
Chen Y, Hu S, Wu X, Xie Z, Wang Y, Wang B, Li X, Pei Y, Gu Y, Huang K, Huo J, Wei A, Bi C, Lu Z, Song Q, Xu H, Kang X, Shao S, Long J, Liu J, Zhou Z, Huang R, Chai Z, Wang C., Free PMC Article | 05/14/2022 |
| Synaptotagmin-1-, Munc18-1-, and Munc13-1-dependent liposome fusion with a few neuronal SNAREs. | Synaptotagmin-1-, Munc18-1-, and Munc13-1-dependent liposome fusion with a few neuronal SNAREs.
Stepien KP, Rizo J., Free PMC Article | 06/12/2021 |
| Downregulation of Synaptotagmin 1 in the Prelimbic Cortex Drives Alcohol-Associated Behaviors in Rats. | Downregulation of Synaptotagmin 1 in the Prelimbic Cortex Drives Alcohol-Associated Behaviors in Rats.
Barbier E, Barchiesi R, Domi A, Chanthongdee K, Domi E, Augier G, Augier E, Xu L, Adermark L, Heilig M. | 05/1/2021 |
| Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis. | Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis.
Ramakrishnan S, Bera M, Coleman J, Rothman JE, Krishnakumar SS., Free PMC Article | 03/20/2021 |
| Conserved arginine residues in synaptotagmin 1 regulate fusion pore expansion through membrane contact. | Conserved arginine residues in synaptotagmin 1 regulate fusion pore expansion through membrane contact.
Nyenhuis SB, Karandikar N, Kiessling V, Kreutzberger AJB, Thapa A, Liang B, Tamm LK, Cafiso DS., Free PMC Article | 02/27/2021 |
| Ca(2+)-dependent release of synaptotagmin-1 from the SNARE complex on phosphatidylinositol 4,5-bisphosphate-containing membranes. | Ca(2+)-dependent release of synaptotagmin-1 from the SNARE complex on phosphatidylinositol 4,5-bisphosphate-containing membranes.
Voleti R, Jaczynska K, Rizo J., Free PMC Article | 02/27/2021 |
| Synaptotagmin 1 Is Involved in Neuropathic Pain and Electroacupuncture-Mediated Analgesic Effect. | Synaptotagmin 1 Is Involved in Neuropathic Pain and Electroacupuncture-Mediated Analgesic Effect.
Wan J, Nan S, Liu J, Ding M, Zhu H, Suo C, Wang Z, Hu M, Wang D, Ding Y., Free PMC Article | 11/21/2020 |
| Phosphatidylinositol 4,5 Bisphosphate Controls the cis and trans Interactions of Synaptotagmin 1. | Phosphatidylinositol 4,5 Bisphosphate Controls the cis and trans Interactions of Synaptotagmin 1.
Nyenhuis SB, Thapa A, Cafiso DS., Free PMC Article | 09/12/2020 |
| During assembly of synaptic vesicle (SV) fusion pores, the major Ca2+ sensor for SV exocytosis, synaptotagmin 1(syt1), directly regulates the occurrence, size, and dynamics of fusion pores by promoting SNARE zippering into a functionally committed state. Syt1-PIP2 interactions stabilize fusion pores and Ca2+-syt1 commits trans-SNARE complexes. | Resolving kinetic intermediates during the regulated assembly and disassembly of fusion pores.
Das D, Bao H, Courtney KC, Wu L, Chapman ER., Free PMC Article | 04/11/2020 |
| a point mutation on synaptotagmin, located outside of the BoNT/B-binding segment, inhibited GT1b binding and blocked GT1b-induced potentiation of BoNT/B binding to synaptotagmin-expressing cells. | Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B.
Flores A, Ramirez-Franco J, Desplantes R, Debreux K, Ferracci G, Wernert F, Blanchard MP, Maulet Y, Youssouf F, Sangiardi M, Iborra C, Popoff MR, Seagar M, Fantini J, Lévêque C, El Far O., Free PMC Article | 03/28/2020 |
| Study shows that neonatal anesthesia impairs synapsin 1 and synaptotagmin 1, two key regulators of synaptic vesicle docking and fusion. | Neonatal anesthesia impairs synapsin 1 and synaptotagmin 1, two key regulators of synaptic vesicle docking and fusion.
Atluri N, Ferrarese B, Osuru HP, Sica R, Keller C, Zuo Z, Lunardi N., Free PMC Article | 12/7/2019 |
| Cation (Mg(2+)/Ca(2+)) dependent membrane interaction is a key determinant of the dual clamp/activator function of Synaptotagmin-1. | Structural basis for the clamping and Ca(2+) activation of SNARE-mediated fusion by synaptotagmin.
Grushin K, Wang J, Coleman J, Rothman JE, Sindelar CV, Krishnakumar SS., Free PMC Article | 06/29/2019 |
| The expression of p-65 is up-regulated in dorsal root ganglion following surgical incision compared to control groups. | Membrane protein Nav1.7 contributes to the persistent post-surgical pain regulated by p-p65 in dorsal root ganglion (DRG) of SMIR rats model.
Li Z, Li Y, Cao J, Han X, Cai W, Zang W, Xu J, Zhang W., Free PMC Article | 07/14/2018 |
| Study showed postsynaptic localization of synaptotagmin 1, at concentrations moderately lower than, but comparable to presynaptic concentrations. It is present in significant concentrations at the postsynaptic density, pointing to the likelihood of insertion of glutamate receptors directly into the synaptic plasma membrane. Synaptotagmin 1 is reduced in postsynaptic spines after eight weeks of kainite-induced epilepsy. | The calcium sensor synaptotagmin 1 is expressed and regulated in hippocampal postsynaptic spines.
Hussain S, Egbenya DL, Lai YC, Dosa ZJ, Sørensen JB, Anderson AE, Davanger S. | 06/9/2018 |
| This work has shed new light on the molecular mechanism for Rab3 and synaptotamin regulation of neurotransmitter release. | Rab3A Inhibition of Ca(2+) -Dependent Dopamine Release From PC12 Cells Involves Interaction With Synaptotagmin I.
Dai Z, Tang X, Chen J, Tang X, Wang X. | 01/6/2018 |
| The authors show that synaptotagmin-1 (from Rattus norvegicus and expressed in Escherichia coli) binds to phosphatidylinositol 4,5-diphosphate via a polybasic lysine patch in the C2B domain, which may promote the priming or docking of synaptic vesicles. | PtdInsP(2) and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium.
Pérez-Lara Á, Thapa A, Nyenhuis SB, Nyenhuis DA, Halder P, Tietzel M, Tittmann K, Cafiso DS, Jahn R., Free PMC Article | 12/2/2017 |
| In this study, the authors show that the C2B domain of Syt1 interacts simultaneously with acidic membranes and SNARE complexes via the top Ca(2+)-binding loops, the side polybasic patch, and the bottom face in response to Ca(2+). | Synaptotagmin-1 C2B domain interacts simultaneously with SNAREs and membranes to promote membrane fusion.
Wang S, Li Y, Ma C., Free PMC Article | 11/18/2017 |
| Data suggest that GTP-binding protein beta/gamma (Gb/g) heterodimers interact specifically with lipid-embedded neuronal t-SNARE proteins syntaxin 1A and SNAP-25B (synaptosomal-associated protein 25B); this binding is competitive with synaptotagmin 1 for binding sites on the t-SNARE proteins; Gb/g inhibits Ca2+/synaptotagmin 1-dependent membrane fusion. | Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes.
Zurawski Z, Page B, Chicka MC, Brindley RL, Wells CA, Preininger AM, Hyde K, Gilbert JA, Cruz-Rodriguez O, Currie KPM, Chapman ER, Alford S, Hamm HE., Free PMC Article | 08/12/2017 |
| After single synaptic vesicle fusion, syt1 acted as an essential determinant of synaptic vesicle endocytosis time course by delaying the kinetics of vesicle retrieval in response to increasing Ca(2+) levels. | Synaptotagmin-1- and Synaptotagmin-7-Dependent Fusion Mechanisms Target Synaptic Vesicles to Kinetically Distinct Endocytic Pathways.
Li YC, Chanaday NL, Xu W, Kavalali ET., Free PMC Article | 07/29/2017 |
| Rab3A-binding site on C2A domain of synaptotagmin I | Localization of Rab3A-binding site on C2A domain of synaptotagmin I to reveal its regulatory mechanism.
Tang X, Xie C, Wang Y, Wang X. | 04/22/2017 |
| Substitution of 4 Syt1 residues, YHRD, at C2 domain interface, disrupted interaction between tandem C2 domains, altered intrinsic affinity of Syt1 for Ca(2+), and shifted Ca(2+) dependency for binding to membranes and driving membrane fusion. YHRD mutant yielded reductions in synaptic transmission in neurons. Thus physical interactions between tandem C2 domains of syt1 contribute to excitation-secretion coupling. | Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1.
Evans CS, He Z, Bai H, Lou X, Jeggle P, Sutton RB, Edwardson JM, Chapman ER., Free PMC Article | 01/14/2017 |
| Study indicates that the accumulation of Synaptotagmin1 may play an important role in axon/dendrite differentiation | Presynaptic protein Synaptotagmin1 regulates the neuronal polarity and axon differentiation in cultured hippocampal neurons.
Inoue Y, Kamikubo Y, Ezure H, Ito J, Kato Y, Moriyama H, Otsuka N., Free PMC Article | 09/3/2016 |
| different structural states of syt underlie the control of distinct forms of synaptic transmission. | Different states of synaptotagmin regulate evoked versus spontaneous release.
Bai H, Xue R, Bao H, Zhang L, Yethiraj A, Cui Q, Chapman ER., Free PMC Article | 08/13/2016 |
| The interaction of Dvl1 with Syt-1, which is regulated by Wnts, modulates neurotransmitter release. | Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
Ciani L, Marzo A, Boyle K, Stamatakou E, Lopes DM, Anane D, McLeod F, Rosso SB, Gibb A, Salinas PC., Free PMC Article | 05/7/2016 |
| Syt-1 regulates endogenous APP-CTF and Abeta levels in PC12 cells. Syt-1 knockdown reduces APP-CTF, sAPPbeta and Abeta levels. Secreted sAPPbeta levels were significantly reduced in PC12 cells lacking Syt-1 expression. | Synaptotagmins interact with APP and promote Aβ generation.
Gautam V, D'Avanzo C, Berezovska O, Tanzi RE, Kovacs DM., Free PMC Article | 03/26/2016 |