| Data suggest that Gnai1 subunit of GTP-binding protein catalyzes nucleotide exchange by selective perturbance of GDP-bound conformation of Gnai1 to metastable intermediate structural state and accelerates rate-limiting step of GDP release by surpassing kinetic barrier. | The nucleotide-free state of heterotrimeric G proteins α-subunit adopts a highly stable conformation.
Andhirka SK, Vignesh R, Aradhyam GK. | 09/30/2017 |
| Induction of Galphai1 structural heterogeneity by Ric-8A provides a mechanism for nucleotide release | Nanosecond Dynamics of Gαi1 Bound to Nucleotides or Ric-8A, a Gα Chaperone with GEF Activity.
Black LA, Thomas CJ, Nix GN, Terwilliger MC, Sprang SR, Ross JBA., Free PMC Article | 06/24/2017 |
| Molecular dynamics simulation of a myristoylated G protein subunit alpha i1 (Galphai1)-GTP complex suggests that the myristoyl-induced conformational changes of the switch II and alpha helical domains create new possibilities for protein-protein interactions. | Effect of N-Terminal Myristoylation on the Active Conformation of Gα(i1)-GTP.
van Keulen SC, Rothlisberger U. | 05/27/2017 |
| stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein expression levels mainly by triggering the Galphai/o signaling pathway. | The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules.
Simon K, Hennen S, Merten N, Blättermann S, Gillard M, Kostenis E, Gomeza J., Free PMC Article | 05/21/2016 |
| These results in part explain the mobility of Galphai1 protein upon reversible palmitoylation to meet one or another type of signaling protein partner. | G protein-membrane interactions I: Gαi1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization.
Álvarez R, López DJ, Casas J, Lladó V, Higuera M, Nagy T, Barceló M, Busquets X, Escribá PV. | 12/5/2015 |
| site-directed mutagenesis suggests that this interaction between Switch I and the phosphate binding loop is important for receptor-mediated nucleotide exchange in the wild-type Galphai1 subunit. | A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.
Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM., Free PMC Article | 06/7/2014 |
| Inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by G protein-coupled receptors. | Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors.
Vellano CP, Brown NE, Blumer JB, Hepler JR., Free PMC Article | 03/30/2013 |
| Data show complex formation between ERalpha, Galphai, and caveolin-1 in pituitary cells. | Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I.
Watson CS, Jeng YJ, Hu G, Wozniak A, Bulayeva N, Guptarak J., Free PMC Article | 08/18/2012 |
| The C-terminus of Galphai1 is shown to be a critical binding element for Ric-8A. | The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1.
Thomas CJ, Briknarová K, Hilmer JK, Movahed N, Bothner B, Sumida JP, Tall GG, Sprang SR., Free PMC Article | 12/24/2011 |
| N-methyl-D-aspartate (NMDA) receptor 2B and guanosine triphosphate (GTP)-binding protein G-alpha-i1) were affected by both thermogenesis-inducing conditions--ingestion of a high-fat diet and exposure to a cold environment. | Distinct subsets of hypothalamic genes are modulated by two different thermogenesis-inducing stimuli.
De Souza CT, Pereira-da-Silva M, Araujo EP, Morari J, Alvarez-Rojas F, Bordin S, Moreira-Filho DC, Carvalheira JB, Saad MJ, Velloso LA. | 12/9/2011 |
| Nucleobindin 1 is a calcium-regulated guanine nucleotide dissociation inhibitor of G{alpha}i1. | Nucleobindin 1 is a calcium-regulated guanine nucleotide dissociation inhibitor of G{alpha}i1.
Kapoor N, Gupta R, Menon ST, Folta-Stogniew E, Raleigh DP, Sakmar TP., Free PMC Article | 11/6/2010 |
| temporal relationship follows between a NO-induced decreased expression of NPR-C and G(i)alpha proteins | Nitric oxide attenuates the expression of natriuretic peptide receptor C and associated adenylyl cyclase signaling in aortic vascular smooth muscle cells: role of MAPK.
Arejian M, Li Y, Anand-Srivastava MB. | 01/21/2010 |
| Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP. | Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP.
Hilal-Dandan R, He H, Martin JL, Brunton LL, Dillmann WH., Free PMC Article | 01/21/2010 |
| Ric-8A has a role in catalyzing guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3 | Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3.
Thomas CJ, Tall GG, Adhikari A, Sprang SR., Free PMC Article | 01/21/2010 |
| These results suggest that C-ANP(4-23) decreases the enhanced oxidative stress in spontaneously hypertensive rats by attenuating the enhanced expression of Gialpha proteins and also the enhanced levels of NADPH oxidase. | Activation of natriuretic peptide receptor-C attenuates the enhanced oxidative stress in vascular smooth muscle cells from spontaneously hypertensive rats: implication of Gialpha protein.
Saha S, Li Y, Lappas G, Anand-Srivastava MB. | 01/21/2010 |
| Cyclic GMP modulates the expression of Gi protein and adenylyl cyclase signaling in vascular smooth muscle cells | Cyclic GMP modulates the expression of Gi protein and adenylyl cyclase signaling in vascular smooth muscle cells.
Bassil M, Anand-Srivastava MB. | 01/21/2010 |
| analysis of the subtype specificity for G{alpha}(i) required for G Protein activation without subunit dissociation | G Protein activation without subunit dissociation depends on a G{alpha}(i)-specific region.
Frank M, Thümer L, Lohse MJ, Bünemann M. | 01/21/2010 |
| PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching | PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching.
Martin NP, Whalen EJ, Zamah MA, Pierce KL, Lefkowitz RJ. | 01/21/2010 |