| MiR-20 promotes cartilage repair in knee osteoarthritis rats via BMP2/Smad1 signaling pathway. | MiR-20 promotes cartilage repair in knee osteoarthritis rats via BMP2/Smad1 signaling pathway.
Zheng Z, Wang D, Zhang W, Yu H, Zhang Y, Feng T, Zhong X. | 01/5/2024 |
| MiR-145 expression is downregulated during decidualization in the rat uterus. MiR-145 downregulated Smad1 which suppresses Smad1/5/8, Wnt-4, MMP-9, Cox-2, and VEGF. | MicroRNA-145 targets Smad1 in endometrial stromal cells and regulates decidualization in rat.
Sirohi VK, Gupta K, Kapoor R, Dwivedi A. | 06/27/2020 |
| findings demonstrate that KGF-1 promotes fibroblast contraction and accelerates wound contraction via the TGF-beta1/Smad signaling pathway in a double-paracrine manner. | KGF-1 accelerates wound contraction through the TGF-β1/Smad signaling pathway in a double-paracrine manner.
Peng Y, Wu S, Tang Q, Li S, Peng C., Free PMC Article | 12/14/2019 |
| miR2033p inhibits osteogenesis in jaw bones of diabetic rats by targeting Smad1 to inhibit the BMP/Smad pathway. | miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1.
Tang Y, Zheng L, Zhou J, Chen Y, Yang L, Deng F, Hu Y., Free PMC Article | 08/4/2018 |
| exposure to hyperoxia altered the balance between TGF-beta-ALK1-Smad1/5 and TGF-beta-ALK5-Smad2/3 pathways in pulmonary endothelial cells, which may ultimately lead to the development of BPD. | Alteration of TGF-β-ALK-Smad signaling in hyperoxia-induced bronchopulmonary dysplasia model of newborn rats.
Jin M, Lee J, Lee KY, Jin Z, Pak JH, Kim HS. | 12/2/2017 |
| Actin cytoskeleton depolymerization inhibites BMP2 signaling via blocking of Smad by dephosphorylated CNN1 in osteoblast cells under simulated microgravity. | Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity.
Xu H, Wu F, Zhang H, Yang C, Li K, Wang H, Yang H, Liu Y, Ding B, Tan Y, Yuan M, Li Y, Dai Z. | 08/12/2017 |
| Cpd 861 markedly upregulated the gene expression of BMP7 and Smad5, as well as the protein expression of BMP7 and Smad1/5. In addition, p-Smad1/5/8 protein expression was markedly increased by Cpd 861 in the liver fibrosis model. | Attenuation of liver fibrosis by herbal compound 861 via upregulation of BMP-7/Smad signaling in the bile duct ligation model rat.
Hou F, Liu R, Liu X, Cui L, Wen Y, Yan S, Yin C. | 02/25/2017 |
| BMP2 promoted the expression of nNOS in primary myenteric neurons and induced phosphorylation of Smad1 in slow transit constipation. | Bone morphogenetic protein 2 regulates the differentiation of nitrergic enteric neurons by modulating Smad1 signaling in slow transit constipation.
Liu X, Liu S, Xu Y, Liu X, Sun D., Free PMC Article | 08/13/2016 |
| Taken together, these results indicated that FSTL1 protects the SNP-induced injury in cardiac H9c2 cells through, at least in part, the activation of Akt and inhibition of Smad1/5/9 signaling. | Follistatin-like 1 protects cardiomyoblasts from injury induced by sodium nitroprusside through modulating Akt and Smad1/5/9 signaling.
Chen W, Xia J, Hu P, Zhou F, Chen Y, Wu J, Lei W, Shen Z. | 05/28/2016 |
| Smad1 as a novel binding protein of KSHV latency-associated nuclear antigen (LANA). LANA interacted with and sustained BMP-activated p-Smad1 in the nucleus and enhanced its loading on the Id promoters. | Oncogenic herpesvirus KSHV Hijacks BMP-Smad1-Id signaling to promote tumorigenesis.
Liang D, Hu H, Li S, Dong J, Wang X, Wang Y, He L, He Z, Gao Y, Gao SJ, Lan K., Free PMC Article | 11/7/2015 |
| results demonstrate that overexpression of Runx2, Dlx5 or c-Src stimulates BSP transcription, and suggest that Runx2, Dlx5 and c-Src might be crucial transcriptional regulators of mineralization and bone formation | Osteogenic transcription factors and proto-oncogene regulate bone sialoprotein gene transcription.
Takai H, Mezawa M, Choe J, Nakayama Y, Ogata Y. | 09/26/2015 |
| Investigations into expression and interaction of Smad1 and p97/VCP in postnatal testis and epididymis support roles in spermatogenesis. | Interaction between Smad1 and p97/VCP in rat testis and epididymis during the postnatal development.
Cayli S, Erdemir F, Ocakli S, Ungor B, Kesici H, Yener T, Aslan H. | 06/30/2012 |
| SMAD1, 5, and 8 transcripts are localized to trigeminal ganglia axons and these mRNAs are selectively translated in response to BDNF. | Intra-axonal translation of SMAD1/5/8 mediates retrograde regulation of trigeminal ganglia subtype specification.
Ji SJ, Jaffrey SR., Free PMC Article | 06/23/2012 |
| downregulation of Smad1/Wif1 gene expression may contribute to pulmonary hypoplasia in the nitrofen CDH model by retardation of lung development during saccular stage. | Smad1 and WIF1 genes are downregulated during saccular stage of lung development in the nitrofen rat model.
Fujiwara N, Doi T, Gosemann JH, Kutasy B, Friedmacher F, Puri P. | 06/16/2012 |
| Diabetes is associated with abnormal bone morphogenetic protein (BMP)/MAD homolog Smad signaling expression in the myenteric ganglia that affects homeostasis of the enteric plexus. | Neuronal loss and abnormal BMP/Smad signaling in the myenteric plexus of diabetic rats.
Honoré SM, Zelarayan LC, Genta SB, Sánchez SS. | 06/9/2012 |
| Smad1 and Smad2 were identified as the key mediators of IL-13-dependent Connective tissue growth factor expression | IL-13 induces connective tissue growth factor in rat hepatic stellate cells via TGF-β-independent Smad signaling.
Liu Y, Meyer C, Müller A, Herweck F, Li Q, Müllenbach R, Mertens PR, Dooley S, Weng HL. | 10/22/2011 |
| biomechanical stimulation of osteoblasts activates SMAD 1/5/8 in the BMP signaling pathway through BMPR1 and may enhance osteogenesis by upregulating SMAD-dependent osteogenic genes | Biomechanical forces exert anabolic effects on osteoblasts by activation of SMAD 1/5/8 through type 1 BMP receptor.
Rath B, Nam J, Deschner J, Schaumburger J, Tingart M, Grässel S, Grifka J, Agarwal S., Free PMC Article | 09/10/2011 |
| CRMP2 suppression by BMP2, BMP4, SMAD1 and SMAD4 gradient signaling controls multiple stages of neuronal development | The suppression of CRMP2 expression by bone morphogenetic protein (BMP)-SMAD gradient signaling controls multiple stages of neuronal development.
Sun Y, Fei T, Yang T, Zhang F, Chen YG, Li H, Xu Z., Free PMC Article | 01/15/2011 |
| Prostacyclin analogues inhibited smooth muscle cell proliferation and prevented progression of pulmonary hypertension while enhancing Smad1/5 phosphorylation and Id1 gene expression. | Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.
Yang J, Li X, Al-Lamki RS, Southwood M, Zhao J, Lever AM, Grimminger F, Schermuly RT, Morrell NW. | 08/30/2010 |
| findings show phosphorylated Smad2 & Smad3 were upregulated in the hippocampus of streptozotocin-induced diabetic rats; data indicate Smad signalling is enhanced in hippocampal astrocytes of diabetic rats | Increased expression of phosphorylated Smad2 and Smad3 in the hippocampus of streptozotocin-induced diabetic rats.
Bao Y, Jiang L, Shi YQ, Zou JJ, Zhao Y, Liu ZM. | 05/10/2010 |
| Smad1 is a critical responsible molecule for developing glomerulosclerosis in rat diabetic nephropathy; angiotensin II (AngII)-Src-Smad1 signaling pathway has played a key role for development of diabetic nephropathy | The current clinical problems for early phase of diabetic nephropathy and approach for pathogenesis of diabetic nephropathy.
Doi T, Mima A, Matsubara T, Tominaga T, Arai H, Abe H. | 01/21/2010 |
| Increase of urinary Smad1 in the early stages of diabetes is correlated with later development of glomerulosclerosis in two rodent models. | Urinary Smad1 is a novel marker to predict later onset of mesangial matrix expansion in diabetic nephropathy.
Mima A, Arai H, Matsubara T, Abe H, Nagai K, Tamura Y, Torikoshi K, Araki M, Kanamori H, Takahashi T, Tominaga T, Matsuura M, Iehara N, Fukatsu A, Kita T, Doi T. | 01/21/2010 |
| Vascular remodeling in the monocrotaline model is associated with alterations in BMP receptors and persistent endothelial Smad 1 signaling. | Smad signaling in the rat model of monocrotaline pulmonary hypertension.
Ramos MF, Lamé MW, Segall HJ, Wilson DW. | 01/21/2010 |
| intron 1 of the follistatin gene has a critical role in mediating Smad-dependent effects of activin and regulating the expression level of this gene | A Smad-binding element in intron 1 participates in activin-dependent regulation of the follistatin gene.
Blount AL, Vaughan JM, Vale WW, Bilezikjian LM. | 01/21/2010 |
| Rat Smad1 promoter was cloned and characterized in hepatocyte and HSC cell line (CFSC-8B cells) at different culture conditions. | Cloning and promoter activity of rat Smad1 5'-flanking region in rat hepatic stellate cells.
Sun Y, Fan J, Shen H, Li P, Cattini P, Gong Y. | 01/21/2010 |