| ENDOGENOUS beta 3 -ADRENERGIC RECEPTOR ACTIVATION ALLEVIATES SEPSIS-INDUCED CARDIOMYOCYTE APOPTOSIS VIA PI3K/AKT SIGNALING PATHWAY. | ENDOGENOUS β 3 -ADRENERGIC RECEPTOR ACTIVATION ALLEVIATES SEPSIS-INDUCED CARDIOMYOCYTE APOPTOSIS VIA PI3K/AKT SIGNALING PATHWAY.
Xing Y, Tian T, Zhang X, Yang D, Zhang C, Wang M, Wang Y, Luo T, Wang Z, Wang H, Li H. | 06/7/2024 |
| Blocking brown adipocyte beta3-adrenoceptor attenuates blood-spinal cord barrier impairment and chronic postsurgical pain in a rat model of preoperative stress. | Blocking brown adipocyte β(3)-adrenoceptor attenuates blood-spinal cord barrier impairment and chronic postsurgical pain in a rat model of preoperative stress.
Zhu J, Hou B, Rong H, Xu K, Jiang L, Yang S, Zhu H, Yang H, Jiao Y, Liu Y, Ni K, Ma Z. | 02/14/2024 |
| beta3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure. | β3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure.
Cannavo A, Jun S, Rengo G, Marzano F, Agrimi J, Liccardo D, Elia A, Keceli G, Altobelli GG, Marcucci L, Megighian A, Gao E, Feng N, Kammers K, Ferrara N, Finos L, Koch WJ, Paolocci N., Free PMC Article | 04/4/2023 |
| Present data can emphasize the important deleterious effect of beta3 -AR activation in cardiac remodeling under pathological condition, at least, through a cross-link between beta3 -AR activation, NO-signaling, and [Zn(2+) ]i pathways. | β(3) -adrenergic receptor activation plays an important role in the depressed myocardial contractility via both elevated levels of cellular free Zn(2+) and reactive nitrogen species.
Tuncay E, Olgar Y, Durak A, Degirmenci S, Bitirim CV, Turan B. | 05/30/2020 |
| Voluntary exercise induced opposite changes in the gene expression of beta3-adrenergic receptors in the white and in the brown adipose tissue. | Opposite Effects of Voluntary Physical Exercise on β3-Adrenergic Receptors in the White and Brown Adipose Tissue.
Balagova L, Graban J, Puhova A, Jezova D. | 05/30/2020 |
| In heart failure, the expression of cardiac beta3-adrenergic receptors (beta3-ARs) increases. However, the precise role of beta3-AR signaling within cardiomyocytes remains unclear. The beta3-AR activation in cardiomyocytes increases the expression of TGFbeta1 via the PKG/JNK/c-Jun pathway. | β(3)-adrenergic receptor activation induces TGFβ1 expression in cardiomyocytes via the PKG/JNK/c-Jun pathway.
Xu Z, Wu J, Xin J, Feng Y, Hu G, Shen J, Li M, Zhang Y, Xiao H, Wang L. | 12/1/2018 |
| Study demonstrates that MRI allows a precocious detection of the subtle myocardial dysfunction induced by beta1-adrenoreceptors-autoantibodies (beta1-aabs) and that beta3-adrenoreceptor stimulation blunts the development of beta1-aabs-induced dilated cardiomyopathy. | MRI Assessment of Cardiomyopathy Induced by β1-Adrenoreceptor Autoantibodies and Protection Through β3-Adrenoreceptor Overexpression.
Vanhoutte L, Guilbaud C, Martherus R, Bouzin C, Gallez B, Dessy C, Balligand JL, Moniotte S, Feron O., Free PMC Article | 11/10/2018 |
| Increasing beta3-AR stimulation may prevent the consequences of chronic NA exposure on Na(+)/K(+) pump and in vivo hemodynamics. beta3-AR agonism may thus represent a new therapeutic strategy for pharmacological modulation of hypertrophy under conditions of chronically enhanced sympathetic activity. | Role of the β(3)-adrenergic receptor subtype in catecholamine-induced myocardial remodeling.
Kayki Mutlu G, Arioglu Inan E, Karaomerlioglu I, Altan VM, Yersal N, Korkusuz P, Rocchetti M, Zaza A. | 11/3/2018 |
| After 16 h of lipopolysaccharide treatment, cultured neonatal cardiomyocytes showed a diminished Ca2+ transient amplitude associated with an increase in the beta3-AR level. | The Trend of β3-Adrenergic Receptor in the Development of Septic Myocardial Depression: A Lipopolysaccharide-Induced Rat Septic Shock Model.
Yang N, Shi XL, Zhang BL, Rong J, Zhang TN, Xu W, Liu CF., Free PMC Article | 10/6/2018 |
| role of beta2- and beta3-adrenoceptors in arterial stiffness in a state of hypertension | Role of β(2-) and β(3)-adrenoceptors in arterial stiffness in a state of hypertension.
Leblanc C, Tabrizchi R. | 08/11/2018 |
| Inhibition of cholinergic neurotransmission by beta3-adrenoceptors results from adenosine release via equilibrative nucleoside transporters and prejunctional A1-receptor stimulation in urinary bladder. | Inhibition of cholinergic neurotransmission by β(3)-adrenoceptors depends on adenosine release and A(1)-receptor activation in human and rat urinary bladders.
Silva I, Costa AF, Moreira S, Ferreirinha F, Magalhães-Cardoso MT, Calejo I, Silva-Ramos M, Correia-de-Sá P. | 09/23/2017 |
| The expression of beta3-adrenoceptor and muscarinic type 3 receptor immuno-reactivity in the major pelvic ganglion of the rat. | The expression of β3-adrenoceptor and muscarinic type 3 receptor immuno-reactivity in the major pelvic ganglion of the rat.
Eastham J, Stephenson C, Korstanje K, Gillespie JI. | 03/26/2016 |
| sympathetic denervation-induced MSC mobilization in rat mandibular distraction osteogenesis is associated with inhibition of MSC migration and osteogenic differentiation by NE/adrb3 | Sympathetic denervation-induced MSC mobilization in distraction osteogenesis associates with inhibition of MSC migration and osteogenesis by norepinephrine/adrb3.
Du Z, Wang L, Zhao Y, Cao J, Wang T, Liu P, Zhang Y, Yang X, Cheng X, Liu B, Lei D., Free PMC Article | 11/14/2015 |
| It can be concluded that BRL 37344 has an anti-oxidant protective effect in rats with RE. | The preventive effect of β3 adrenoceptor stimulation against experimentally induced reflux esophagitis.
Malek HA, Shalaby A. | 06/20/2015 |
| The upregulation of beta3-adrenoreceptor (AR) and endothelial nitric oxide synthase proteins following heart failure were also attenuated by matrine. | Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3‑adrenoreceptor/endothelial nitric oxide synthase pathway.
Yu J, Yang S, Wang X, Gan R. | 06/20/2015 |
| ADRB3 partially mediates the development of COMT-dependent pain by increasing production of nitric oxide and proinflammatory cytokines. | β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines.
Hartung JE, Ciszek BP, Nackley AG., Free PMC Article | 02/14/2015 |
| results demonstrate that the activation of beta3-adrenoceptors inhibits neurogenic contractions ofboth rat and human urinary bladder. | Modulation of nerve-evoked contractions by β3-adrenoceptor agonism in human and rat isolated urinary bladder.
Rouget C, Rekik M, Camparo P, Botto H, Rischmann P, Lluel P, Palea S, Westfall TD. | 01/12/2015 |
| beta3-Adrenoreceptor stimulation with BRL-37344 was associated with an increase in LA diameter and a decrease in LA function in chronic heart failure | Effect of β3-adrenergic receptor on atrial L-type Ca(2+) current in rats with chronic heart failure.
Li B, Zhao Q, Wang LX, Deng CY, Zeng F, Wu TG, Jiang ZF, Xu DL. | 12/20/2014 |
| Data suggest that adrb3 is involved in regulation of pancreatic islet blood flow; hyperlipidemia (triglycerides and free fatty acids) is associated with vagus nerve-dependent increase in pancreatic/islet blood flow and up-regulation of insulin secretion. | Blood lipids affect rat islet blood flow regulation through β₃-adrenoceptors.
Lai E, Pettersson U, Verdugo AD, Carlsson PO, Bodin B, Källskog Ö, Persson AE, Sandberg M, Jansson L. | 12/20/2014 |
| Adrb-mediated vasodilatation in aorta is driven by endothelial Adrb2 and Adrb3, but also by Adrb2 present in smooth muscle cells, and is coupled to the NO/cGMP pathway | Different β-adrenoceptor subtypes coupling to cAMP or NO/cGMP pathways: implications in the relaxant response of rat conductance and resistance vessels.
Flacco N, Segura V, Perez-Aso M, Estrada S, Seller JF, Jiménez-Altayó F, Noguera MA, D'Ocon P, Vila E, Ivorra MD., Free PMC Article | 10/11/2014 |
| A set of miRNAs is differently expressed in the aorta of high salt treated rats with miR-320 increased and miR-26b and -21 decreased, through beta1 and beta3-adrenoreceptor pathways. | Modulation of microRNAs in hypertension-induced arterial remodeling through the β1 and β3-adrenoreceptor pathways.
Ling S, Nanhwan M, Qian J, Kodakandla M, Castillo AC, Thomas B, Liu H, Ye Y. | 06/28/2014 |
| this study has demonstrated that the rats which experienced early postnatal maternal separation show enhanced PHB levels in white adipose tissue, attenuated b3-AR levels, and unchanged UCP-1 levels in brown adipose tissue. | Early postnatal maternal separation causes alterations in the expression of β3-adrenergic receptor in rat adipose tissue suggesting long-term influence on obesity.
Miki T, Liu JQ, Ohta K, Suzuki S, Kusaka T, Warita K, Yokoyama T, Jamal M, Ueki M, Yakura T, Tamai M, Sumitani K, Hosomi N, Takeuchi Y. | 04/26/2014 |
| The level of beta3-adrenergic receptor mRNA expression is associated with the atrial mass index in rats with chronic heart failure. | Upregulation of β3-adrenergic receptor expression in the atrium of rats with chronic heart failure.
Zhao Q, Zeng F, Liu JB, He Y, Li B, Jiang ZF, Wu TG, Wang LX. | 10/26/2013 |
| Following immobilization stress, T cells were more vulnerable than B cells to stress due to increased beta-, beta- and betaadrenoceptors in spleen. | Acute stress differently modulates β1, β2 and β3 adrenoceptors in T cells, but not in B cells, from the rat spleen.
Laukova M, Vargovic P, Csaderova L, Chovanova L, Vlcek M, Imrich R, Krizanova O, Kvetnansky R. | 07/28/2012 |
| These results suggest that beta3-adrenoceptors play crucial roles in vasodilator responses to adrenaline of retinal arterioles but have minor or no effect on noradrenaline-induced responses | Role of β3-adrenoceptors in regulation of retinal vascular tone in rats.
Mori A, Nakahara T, Sakamoto K, Ishii K. | 03/31/2012 |