| Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model. | Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model.
Chen B, Jin K, Dong J, Cheng S, Kong L, Hu S, Chen Z, Lu J., Free PMC Article | 10/23/2024 |
| A high-fat diet induced depression-like phenotype via hypocretin-HCRTR1 mediated inflammation activation. | A high-fat diet induced depression-like phenotype via hypocretin-HCRTR1 mediated inflammation activation.
Dong J, Zhang J, Cheng S, Qin B, Jin K, Chen B, Zhang Y, Lu J. | 09/9/2024 |
| The Role of Orexin-1 Receptors Within the Hippocampal CA1 Area in the Extinction and Reinstatement of Methamphetamine-Seeking Behaviors. | The Role of Orexin-1 Receptors Within the Hippocampal CA1 Area in the Extinction and Reinstatement of Methamphetamine-Seeking Behaviors.
Veisi A, Khaleghzadeh-Ahangar H, Fattahi M, Haghparast A. | 02/11/2023 |
| Blockade of the orexin 1-receptors and 'cocaine- and amphetamine-regulated transcript' in the nucleus accumbens shell alters impulse control in rats. | Blockade of the orexin 1-receptors and 'cocaine- and amphetamine-regulated transcript' in the nucleus accumbens shell alters impulse control in rats.
Schuller J, Koch M. | 01/14/2023 |
| Distinct roles for orexin-1 and orexin-2 receptors in the dentate gyrus of the hippocampus in the methamphetamine-seeking behavior in the rats. | Distinct roles for orexin-1 and orexin-2 receptors in the dentate gyrus of the hippocampus in the methamphetamine-seeking behavior in the rats.
Nazari-Serenjeh F, Azizbeigi R, Rashvand M, Mesgar S, Amirteymori H, Haghparast A. | 12/31/2022 |
| Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo. | Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo.
Zhang R, Li D, Mao H, Wei X, Xu M, Zhang S, Jiang Y, Wang C, Xin Q, Chen X, Li G, Ji B, Yan M, Cai X, Dong B, Randeva HS, Liu C, Chen J., Free PMC Article | 04/16/2022 |
| Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain. | Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain.
Zareie F, Ghalebandi S, Askari K, Mousavi Z, Haghparast A. | 03/26/2022 |
| Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway. | Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway.
Xu D, Kong T, Zhang S, Cheng B, Chen J, Wang C. | 01/22/2022 |
| [Increase in the level of orexin receptor 1 (OX1R) mRNA in the brain structures of rats prone to impulsivity in behavior].", trans "Povyshenie urovnia mRNK retseptora oreksina pervogo tipa (OX1R) v strukturakh golovnogo mozga u krys, sklonnykh k impul'sivnosti v povedenii. | [Increase in the level of orexin receptor 1 (OX1R) mRNA in the brain structures of rats prone to impulsivity in behavior].
Sekste EA, Lebedev AA, Bychkov ER, Airapetov MI, Gramota KE, Thyssen IY, Shabanov PD. | 11/22/2021 |
| Activation orexin 1 receptors in the ventrolateral periaqueductal gray matter attenuate nitroglycerin-induced migraine attacks and calcitonin gene related peptide up-regulation in trigeminal nucleus caudalis of rats. | Activation orexin 1 receptors in the ventrolateral periaqueductal gray matter attenuate nitroglycerin-induced migraine attacks and calcitonin gene related peptide up-regulation in trigeminal nucleus caudalis of rats.
Kooshki R, Abbasnejad M, Esmaeili-Mahani S, Raoof M, Sheibani V. | 08/14/2021 |
| Evaluation of the relationship between the gene expression level of orexin-1 receptor in the rat blood and prefrontal cortex, novelty-seeking, and proneness to methamphetamine dependence: A candidate biomarker. | Evaluation of the relationship between the gene expression level of orexin-1 receptor in the rat blood and prefrontal cortex, novelty-seeking, and proneness to methamphetamine dependence: A candidate biomarker.
Tavakkolifard M, Vousooghi N, Mahboubi S, Golab F, Ejtemaei Mehr S, Zarrindast MR. | 07/3/2021 |
| The orexin-1 receptor antagonist SB-334867 reduces motivation, but not inhibitory control, in a rat stop signal task. | The orexin-1 receptor antagonist SB-334867 reduces motivation, but not inhibitory control, in a rat stop signal task.
Wiskerke J, James MH, Aston-Jones G., Free PMC Article | 06/12/2021 |
| Investigating the role of the amygdala orexin receptor 1 in memory acquisition and extinction in a rat model of PTSD. | Investigating the role of the amygdala orexin receptor 1 in memory acquisition and extinction in a rat model of PTSD.
Salehabadi S, Abrari K, Elahdadi Salmani M, Nasiri M, Lashkarbolouki T. | 05/22/2021 |
| The Effect of Orexin Receptor Antagonism on Quinpirole-Induced Compulsive-Like Checking Behavior in Rats. | The Effect of Orexin Receptor Antagonism on Quinpirole-Induced Compulsive-Like Checking Behavior in Rats.
Abounoori M, Maddah MM, Akbari E, Houshmand G, Ardeshiri MR. | 02/20/2021 |
| Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation. | Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation.
García-Brito S, Aldavert-Vera L, Huguet G, Kádár E, Segura-Torres P. | 01/23/2021 |
| The rostral ventromedial medulla orexin 1 receptors and extracellular signal-regulated kinase in hippocampus are involved in modulation of anxiety behavior induced by dental pulp nociception in adult male rats. | The rostral ventromedial medulla orexin 1 receptors and extracellular signal-regulated kinase in hippocampus are involved in modulation of anxiety behavior induced by dental pulp nociception in adult male rats.
Shahsavari F, Abbasnejad M, Raoof M, Esmaeili-Mahani S. | 10/31/2020 |
| Downregulation of Orexin Receptor in Hypothalamic Paraventricular Nucleus Decreases Blood Pressure in Obese Zucker Rats. | Downregulation of Orexin Receptor in Hypothalamic Paraventricular Nucleus Decreases Blood Pressure in Obese Zucker Rats.
Zhou JJ, Ma HJ, Shao J, Wei Y, Zhang X, Zhang Y, Li DP., Free PMC Article | 10/24/2020 |
| Study shows that hippocampal orexin receptor (OXRs) blocking prevented the stress induced social learning and memory deficits. Study identifies hippocampal OXRs as potential candidates capable of preventing acute stress-induced impairments of social novelty and anxiety behavior. | Hippocampal orexin receptor blocking prevented the stress induced social learning and memory deficits.
Bahramzadeh Zoeram S, Elahdadi Salmani M, Lashkarbolouki T, Goudarzi I. | 11/30/2019 |
| Orexin-A, via OX1R, potentiates the suppressive effect of naloxone on GABAergic IPSCs of LC neurons. | Decrease of inhibitory synaptic currents of locus coeruleus neurons via orexin type 1 receptors in the context of naloxone-induced morphine withdrawal.
Davoudi M, Azizi H, Mirnajafi-Zadeh J, Semnanian S., Free PMC Article | 06/1/2019 |
| Age-related decrease in OX1R expression is associated with delayed emergence from isoflurane anaesthesia in aged rats | Orexin-1 receptor is involved in ageing-related delayed emergence from general anaesthesia in rats.
Ran M, Wang Z, Yang H, Zhang L, Li W, Yang Q, Dong H. | 01/19/2019 |
| In the diet-induced obesity (DIO) and diet-induced obesity resistance (DR) rat model, mRNA expression of OX-1R and mu-opioid receptors were increased in the basomedial amygdala. | Activation of orexin-1 receptors in the amygdala enhances feeding in the diet-induced obesity rats: Blockade with μ-opioid antagonist.
Wang M, Sun X, Guo F, Luan X, Wang C, Xu L. | 01/19/2019 |
| findings suggest that OX1rs in the CA1 region of the hippocampus are involved in the expression of morphine CPP. | Role of orexin-1 receptors in the dorsal hippocampus (CA1 region) in expression and extinction of the morphine-induced conditioned place preference in the rats.
Farahimanesh S, Karimi S, Haghparast A. | 12/29/2018 |
| Results showed that the blockade of Ox1r and Ox2r in the nucleus accumbens (NAc) attenuated the effect of food deprivation (FD) on morphine reinstatement; however, they were more effective in FD condition. Findings indicate that the NAc is a brain area within which orexin has a fundamental role in the effect of stress on morphine-induced reinstatement and the effect of food deprivation- on the reinstatement of morphine. | Role of the orexin receptors within the nucleus accumbens in the drug priming-induced reinstatement of morphine seeking in the food deprived rats.
Sahafzadeh M, Karimi-Haghighi S, Mousavi Z, Haghparast A. | 09/1/2018 |
| Results suggest that both orexin-1 and -2 receptors in the nucleus accumbens are involved in the development of morphine-induced conditioned place preference. It seems that orexin-1 receptors in this region are more effective in development of drug seeking behaviors in the rats. | Role of intra-accumbal orexin receptors in the acquisition of morphine-induced conditioned place preference in the rats.
Alizamini MM, Farzinpour Z, Ezzatpanah S, Haghparast A. | 06/16/2018 |
| Study suggests that orexins, via activation of both orexin receptor type 1 and orexin receptor type 2, play a significant role in the expression of NMDA-dependent long-term depression, thereby contributing to the spinal modulation of pain transmission. | Orexin receptors mediate long-term depression of excitatory synaptic transmission in the spinal cord dorsal horn.
Park KB, Weon H. | 06/16/2018 |