| Decreased expression of Chrna4 by METTL3-mediated m6A modification participates in BPA-induced spatial memory deficit. | Decreased expression of Chrna4 by METTL3-mediated m6A modification participates in BPA-induced spatial memory deficit.
Li D, Huang C, Liu Z, Ai S, Wang HL. | 10/11/2023 |
| Hippocampal asymmetry and regional dispersal of nAChRs alpha4 and alpha7 subtypes in the adult rat. | Hippocampal asymmetry and regional dispersal of nAChRs alpha4 and alpha7 subtypes in the adult rat.
Baradaran R, Anbarkeh FR, Delavar A, Khorasgani EM, Rahimian N, Abbasi Y, Jaberi N. | 02/26/2022 |
| Pathogenesis and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy with S284L-mutant alpha4 subunit of nicotinic ACh receptor. | Pathogenesis and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy with S284L-mutant α4 subunit of nicotinic ACh receptor.
Fukuyama K, Fukuzawa M, Shiroyama T, Okada M., Free PMC Article | 07/10/2021 |
| Lovastatin Differentially Regulates alpha7 and alpha4 Neuronal Nicotinic Acetylcholine Receptor Levels in Rat Hippocampal Neurons. | Lovastatin Differentially Regulates α7 and α4 Neuronal Nicotinic Acetylcholine Receptor Levels in Rat Hippocampal Neurons.
Borroni V, Kamerbeek C, Pediconi MF, Barrantes FJ., Free PMC Article | 03/28/2021 |
| the mechanism of interaction between [Upsilon4E]GID and the agonist binding pockets of the alpha4beta2 and the halpha7 receptors, and to estimate their relative binding affinities, was investigated. | Molecular simulation study of the unbinding of α-conotoxin [ϒ4E]GID at the α7 and α4β2 neuronal nicotinic acetylcholine receptors.
Suresh A, Hung A. | 02/3/2018 |
| findings indicate that alterations in expression of the alpha4beta2 subtype of nAChR may be involved in the molecular mechanism(s) underlying the cognitive deficit associated with vascular dementia | Inhibited Expression of α(4)β(2) Nicotinic Acetylcholine Receptor in Blood Leukocytes of Chinese Patients with Vascular Dementia and in Blood Leukocytes as Well as the Hippocampus of Brain from Ischemic Rats.
Xiao Y, Zhao L, Kuang SX, Guan ZZ. | 02/25/2017 |
| These results demonstrate that nicotine modulates gamma oscillations via a7 and a4b2 nAChR as well as NMDA activation, suggesting that nAChR activation may have a therapeutic role for the clinical disorder such as schizophrenia | The modulation of nicotinic acetylcholine receptors on the neuronal network oscillations in rat hippocampal CA3 area.
Wang Y, Wang Z, Wang J, Wang Y, Henderson Z, Wang X, Zhang X, Song J, Lu C., Free PMC Article | 03/26/2016 |
| maternal stress alters the development of hippocampal alpha4 beta2 (alpha4beta2 *) and alpha7 (alpha7 *) nicotinic receptor levels in adult offspring. | The effects of prenatal stress on alpha4 beta2 and alpha7 hippocampal nicotinic acetylcholine receptor levels in adult offspring.
Schulz KM, Andrud KM, Burke MB, Pearson JN, Kreisler AD, Stevens KE, Leonard S, Adams CE., Free PMC Article | 05/17/2014 |
| Data indicate that compounds showed favorable subtype selectivity for beta2*-nAChRs over beta4*-nAChRs. | Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II.
Zhang HK, Yu LF, Eaton JB, Whiteaker P, Onajole OK, Hanania T, Brunner D, Lukas RJ, Kozikowski AP., Free PMC Article | 03/15/2014 |
| Artificial food colors and additives led to a decrease in the expressions of nAChR alpha4 subunits in male rats. | Effects of maternally exposed coloring food additives on receptor expressions related to learning and memory in rats.
Ceyhan BM, Gultekin F, Doguc DK, Kulac E. | 01/11/2014 |
| Data suggest that alpha4 beta2 nicotinic receptors (Chrna4; Chrnb2) are involved in tolerance to DOPA exhibited as drug-induced dyskinesias in late stages of Parkinson's disease. | α4β2 Nicotinic receptors play a role in the nAChR-mediated decline in L-dopa-induced dyskinesias in parkinsonian rats.
Quik M, Campos C, Bordia T, Strachan JP, Zhang J, McIntosh JM, Letchworth S, Jordan K., Free PMC Article | 01/11/2014 |
| The azabicyclic alcohol was found to compete with MTSEA between residues 6' & 13' in a state-dependent manner, but the reactive probe only bonded with 13' in the open state, suggesting that the 13' position is the dominant binding site. | Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors.
Quek GX, Lin D, Halliday JI, Absalom N, Ambrus JI, Thompson AJ, Lochner M, Lummis SC, McLeod MD, Chebib M., Free PMC Article | 08/31/2013 |
| Data indicate that functional alpha4/beta2 nicotinic acetylcholine receptors (alpha4beta2 nAChR) plays a role in proliferation and differentiation fate into a neuronal lineage in neural progenitors of developing neocortex. | Promoted neuronal differentiation after activation of alpha4/beta2 nicotinic acetylcholine receptors in undifferentiated neural progenitors.
Takarada T, Nakamichi N, Kitajima S, Fukumori R, Nakazato R, Le NQ, Kim YH, Fujikawa K, Kou M, Yoneda Y., Free PMC Article | 04/6/2013 |
| nAChR alpha4 subtype contributes to the cholinergic nicotinic regulation of catecholamine signaling in the carotid body system. | Functional expression of the α7 and α4-containing nicotinic acetylcholine receptors on the neonatal rat carotid body.
Meza RC, Ortiz FC, Bravo E, Iturriaga-Vásquez P, Eugenín JL, Varas R. | 10/20/2012 |
| Our results identify a novel palmitoylation site on cysteine 273 in the M1-M2 loop of the alpha4 nAChR and determine that cysteines in both intracellular loops are regulatory factors in total and cell surface protein expression of the alpha4beta2 nAChR. | A highly conserved cytoplasmic cysteine residue in the α4 nicotinic acetylcholine receptor is palmitoylated and regulates protein expression.
Amici SA, McKay SB, Wells GB, Robson JI, Nasir M, Ponath G, Anand R., Free PMC Article | 09/15/2012 |
| The number of functional alpha4beta2 heteromeric neuronal nicotinic receptors is decreased in the brains of rats with severe renal failure. | Selective down-regulation of α4β2 neuronal nicotinic acetylcholine receptors in the brain of uremic rats with cognitive impairment.
Ballesta JJ, del Pozo C, Castelló-Banyuls J, Faura CC. | 08/11/2012 |
| The effect of Abeta (at different concentrations) on the neurotransmitter release stimulated by the activation of pre-synaptic cholinergic nicotinic receptors (nAChRs, alpha4beta2 and alpha7 subtypes), is reported. | Dual effect of beta-amyloid on α7 and α4β2 nicotinic receptors controlling the release of glutamate, aspartate and GABA in rat hippocampus.
Mura E, Zappettini S, Preda S, Biundo F, Lanni C, Grilli M, Cavallero A, Olivero G, Salamone A, Govoni S, Marchi M., Free PMC Article | 06/2/2012 |
| determined the site specificity for Mor potentiation by studying differences in modulation between alpha3beta2 and alpha4beta2 receptors | Specificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiation.
Cesa LC, Higgins CA, Sando SR, Kuo DW, Levandoski MM., Free PMC Article | 05/5/2012 |
| Nicotine-induced upregulation of the nAChR alpha4beta2 receptor demonstrates that at least two different kinetic mechanisms underlie multiple processes occurring at different rates in rat cortical neurons in real time. | Nicotine-induced upregulation of native neuronal nicotinic receptors is caused by multiple mechanisms.
Govind AP, Walsh H, Green WN., Free PMC Article | 03/31/2012 |
| the lower alpha4beta2 nAChR number in spontaneously hypertensive rat compared with WKY may be a consequence of dysfunctional post-transcriptional regulation of nAChRs | Decreased α4β2 nicotinic receptor number in the absence of mRNA changes suggests post-transcriptional regulation in the spontaneously hypertensive rat model of ADHD.
Wigestrand MB, Mineur YS, Heath CJ, Fonnum F, Picciotto MR, Walaas SI., Free PMC Article | 11/5/2011 |
| Changes in density and affinity of this hippocampal receptor after alcohol drinking. | Ethanol consumption produces changes in behavior and on hippocampal alpha7 and alpha4beta2 nicotinic receptors.
Robles N, Sabriá J. | 10/4/2011 |
| Our study shows for the first time that rat hippocampal synaptosomes possess a7 and a4b2 nAChR subtypes, which can enhance the release of endogenous GLU and ASP via two distinct mechanisms of action | Pre-synaptic nicotinic receptors evoke endogenous glutamate and aspartate release from hippocampal synaptosomes by way of distinct coupling mechanisms.
Zappettini S, Grilli M, Salamone A, Fedele E, Marchi M., Free PMC Article | 02/26/2011 |
| central alpha4beta2 nicotinic acetylcholine receptors that enable a provoking effect of endogenous acetylcholine play a critical role in impulsive action | Endogenous acetylcholine modulates impulsive action via alpha4beta2 nicotinic acetylcholine receptors in rats.
Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M. | 02/5/2011 |
| Data show that a hydrogen bond is functionally significant in the alpha4beta2 neuronal nAChR. | Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH.
Blum AP, Lester HA, Dougherty DA., Free PMC Article | 10/4/2010 |
| Suggest a critical role for alpha4beta2 nAChRs in the infralimbic cortex in mediating the effects of nicotine on impulsive-like actions. | Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex.
Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M. | 07/12/2010 |