| ATF3/EGR1 regulates myocardial ischemia/reperfusion injury induced autophagy and inflammation in cardiomyocytes. | ATF3/EGR1 regulates myocardial ischemia/reperfusion injury induced autophagy and inflammation in cardiomyocytes.
Li L, Fu G, Liu C, Liu Y. | 04/29/2024 |
| MicroRNA-124 conducts neuroprotective effect via inhibiting AK4/ATF3 after subarachnoid hemorrhage. | MicroRNA-124 conducts neuroprotective effect via inhibiting AK4/ATF3 after subarachnoid hemorrhage.
Jiang W, Jia Q, Ma H, Han S, Bi S, Zhu K, Chen L, Liang G. | 01/17/2024 |
| Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by regulating FUS-mediated ATF3 mRNA stability in epilepsy. | Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by regulating FUS-mediated ATF3 mRNA stability in epilepsy.
Kang Q, Zhang J, Xie C, Fang S, Chai W. | 01/3/2024 |
| ATF3 Regulates Osteogenic Function by Mediating Osteoblast Ferroptosis in Type 2 Diabetic Osteoporosis. | ATF3 Regulates Osteogenic Function by Mediating Osteoblast Ferroptosis in Type 2 Diabetic Osteoporosis.
Zhao Y, Du Y, Gao Y, Xu Z, Zhao D, Yang M., Free PMC Article | 11/19/2022 |
| Protective role of activating transcription factor 3 against neuronal damage in rats with cerebral ischemia. | Protective role of activating transcription factor 3 against neuronal damage in rats with cerebral ischemia.
Ma N, Li G, Fu X., Free PMC Article | 04/30/2022 |
| Data suggest that heat stress enhances ovarian levels of Hsp70 and affects Erk1/2 and Atf3 phosphorylation levels, but not c-Akt activation/phosphorylation, in pseudo-pregnant rats during luteal regression induced by cloprostenol, a prostaglandin F2alpha analog. (Hsp70 = heat shock 70 kDa protein; Erk = extracellular signal-regulated kinase; Atf3 = activating transcription factor-3; c-Akt = proto-oncogene protein c-Akt) | Temporal regulation of extracellular signal-regulated kinase 1/2 phosphorylation, heat shock protein 70 and activating transcription factor 3 during prostaglandin F-induced luteal regression in pseudopregnant rats following heat stress.
Bai WJ, Jin PJ, Kuang MQ, Wei QW, Shi FX, Davis JS, Mao DG. | 07/14/2018 |
| ATF3 was highly expressed in the livers of ZDF rats. Insulin resistance and hepatic steatosis were associated with increased ATF3 expression and decreased fatty acid oxidation via mitochondrial dysfunction and were attenuated by in vivo ATF3 silencing. Knockdown of ATF3 also ameliorated glucose intolerance, impaired insulin action, and inflammatory responses in ZDF rats. | Activating transcription factor 3 is a target molecule linking hepatic steatosis to impaired glucose homeostasis.
Kim JY, Park KJ, Hwang JY, Kim GH, Lee D, Lee YJ, Song EH, Yoo MG, Kim BJ, Suh YH, Roh GS, Gao B, Kim W, Kim WH. | 05/12/2018 |
| sublytic C5b-9-induced activation of Egr-1/p300-ATF3/Gadd45 axis plays a critical role in glomerular mesangial cells apoptosis in Thy-1N rats. | Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation.
He F, Zhou M, Yu T, Zhao D, Zhang J, Qiu W, Lu Y, Liu Y, Wang L, Wang Y. | 09/30/2017 |
| The cellular injury/stress response induced in sensory neurons by tissue damage and indicated by ATF3 expression is positioned to contribute to pain which can occur after tissue damage. | Cutaneous tissue damage induces long-lasting nociceptive sensitization and regulation of cellular stress- and nerve injury-associated genes in sensory neurons.
Rau KK, Hill CE, Harrison BJ, Venkat G, Koenig HM, Cook SB, Rabchevsky AG, Taylor BK, Hai T, Petruska JC., Free PMC Article | 05/6/2017 |
| Heme oxygenase-1/signal transducer and activator of transcription 3 signaling plays a critical role in propofol-mediated amelioration of hyperglycemia-induced cardiomyocyte hypertrophy and apoptosis. | Propofol ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction via heme oxygenase-1/signal transducer and activator of transcription 3 signaling pathway in rats.
Xu J, Li H, Irwin MG, Xia ZY, Mao X, Lei S, Wong GT, Hung V, Cheung CW, Fang X, Clanachan AS, Xia Z. | 04/16/2016 |
| satellite glial cells (SGCs) play an important role in articular inflammation, with 7 days of disease being a critical time-point in the arthritis model, and suggest that ATF3 might be involved in SGCs' reactive changes such as activation. | Satellite glial cells surrounding primary afferent neurons are activated and proliferate during monoarthritis in rats: is there a role for ATF3?
Nascimento DS, Castro-Lopes JM, Moreira Neto FL., Free PMC Article | 12/26/2015 |
| this is the first study to provide evidence for temporal relationships between MAPK activation and ATF3 expression during PGF-induced luteal regression in the rat. | Prostaglandin F2α induces expression of activating transcription factor 3 (ATF3) and activates MAPK signaling in the rat corpus luteum.
Guo N, Meng C, Bai W, Wei Q, Shi F, Davis JS, Mao D. | 11/21/2015 |
| our data demonstrate that a cell-autonomous program consisting of a stress-induced Atf3-gelsolin cascade affects the change in dendritic spine morphology in models of tuberous sclerosis complex | The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex.
Nie D, Chen Z, Ebrahimi-Fakhari D, Di Nardo A, Julich K, Robson VK, Cheng YC, Woolf CJ, Heiman M, Sahin M., Free PMC Article | 10/17/2015 |
| Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis. | Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis.
Pu H, Wang X, Su L, Ma C, Zhang Y, Zhang L, Chen X, Li X, Wang H, Liu X, Zhang J., Free PMC Article | 10/3/2015 |
| ATF3 activation caused induction of modulators of the inflammatory response NF-kappaB and Nkx-2.5, as well as attenuation of pro-fibrotic and pro-inflammatory proteins IL-6 and PAI-1. | Characterization of the regulatory mechanisms of activating transcription factor 3 by hypertrophic stimuli in rat cardiomyocytes.
Koivisto E, Jurado Acosta A, Moilanen AM, Tokola H, Aro J, Pennanen H, Säkkinen H, Kaikkonen L, Ruskoaho H, Rysä J., Free PMC Article | 05/30/2015 |
| ATF3 is a novel nuclear marker for migrating ependymal stem cells in the spinal cord. | ATF3 is a novel nuclear marker for migrating ependymal stem cells in the rat spinal cord.
Mladinic M, Bianchetti E, Dekanic A, Mazzone GL, Nistri A. | 01/10/2015 |
| Atf3-silencing reversed ethanol-mediated Gck down-regulation and beta-cell dysfunction, followed by the amelioration of impaired glucose tolerance and insulin resistance. | Chronic ethanol consumption inhibits glucokinase transcriptional activity by Atf3 and triggers metabolic syndrome in vivo.
Kim JY, Hwang JY, Lee DY, Song EH, Park KJ, Kim GH, Jeong EA, Lee YJ, Go MJ, Kim DJ, Lee SS, Kim BJ, Song J, Roh GS, Gao B, Kim WH., Free PMC Article | 12/20/2014 |
| ATF3 may play as a counteracting regulator of AMPK and thus promote beta-cell dysfunction and the development of type-2 diabetes and could be a potential therapeutic target in treating type-2 diabetes. | In vivo activating transcription factor 3 silencing ameliorates the AMPK compensatory effects for ER stress-mediated β-cell dysfunction during the progression of type-2 diabetes.
Kim JY, Park KJ, Kim GH, Jeong EA, Lee DY, Lee SS, Kim DJ, Roh GS, Song J, Ki SH, Kim WH. | 12/6/2014 |
| Epithelium-derived exosomal ATF3 RNA attenuates ischemia-reperfusion induced kidney injury by inhibiting MCP-1 gene transcription. | Exosomal ATF3 RNA attenuates pro-inflammatory gene MCP-1 transcription in renal ischemia-reperfusion.
Chen HH, Lai PF, Lan YF, Cheng CF, Zhong WB, Lin YF, Chen TW, Lin H. | 07/26/2014 |
| Expression of ATF3 in uninjured dorsal root ganglion neurons may contribute to pain following brachial plexus avulsion injury. | Expression of activating transcription factor 3 (ATF3) in uninjured dorsal root ganglion neurons in a lower trunk avulsion pain model in rats.
Matsuura Y, Ohtori S, Iwakura N, Suzuki T, Kuniyoshi K, Takahashi K., Free PMC Article | 05/31/2014 |
| Penetrating ballistic-like brain injury alone significantly increased ATF3 in microglia/macrophages, NKCs, astrocytes, and neurons. NNZ-2566 further increased this. PBBI decreased Atf3 levels in T cells but this was reversed by NNZ-2566. | Mechanism of action for NNZ-2566 anti-inflammatory effects following PBBI involves upregulation of immunomodulator ATF3.
Cartagena CM, Phillips KL, Williams GL, Konopko M, Tortella FC, Dave JR, Schmid KE. | 04/19/2014 |
| Psychological stress following restraint induces the endoplasmic reticulum stress gene, ATF3. | Psychological stress, cocaine and natural reward each induce endoplasmic reticulum stress genes in rat brain.
Pavlovsky AA, Boehning D, Li D, Zhang Y, Fan X, Green TA., Free PMC Article | 03/1/2014 |
| Diabetic BB rats display an increased activation of ATF 3 and also a rise in apoptotic caspase 3 expression in Schwann cells. | Expression of activating transcription factor 3 (ATF 3) and caspase 3 in Schwann cells and axonal outgrowth after sciatic nerve repair in diabetic BB rats.
Stenberg L, Kanje M, Dolezal K, Dahlin LB. | 02/9/2013 |
| Loss of Atf3 causes abnormal cardiomyocyte growth, presumably resulting from the dysregulation of target genes. | Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target.
Giraldo A, Barrett OP, Tindall MJ, Fuller SJ, Amirak E, Bhattacharya BS, Sugden PH, Clerk A., Free PMC Article | 07/14/2012 |
| ATF3 plays an important role in caspase-dependent neuronal apoptotic signal transduction pathways caused by focal cerebral ischemia and reperfusion injury. | Role of activating transcription factor 3 in ischemic penumbra region following transient middle cerebral artery occlusion and reperfusion injury.
Song DY, Oh KM, Yu HN, Park CR, Woo RS, Jung SS, Baik TK. | 05/19/2012 |