| Serotonin enhances depolarizing spontaneous fluctuations, excitability, and ongoing activity in isolated rat DRG neurons via 5-HT4 receptors and cAMP-dependent mechanisms. | Serotonin enhances depolarizing spontaneous fluctuations, excitability, and ongoing activity in isolated rat DRG neurons via 5-HT(4) receptors and cAMP-dependent mechanisms.
Lopez ER, Carbajal AG, Tian JB, Bavencoffe A, Zhu MX, Dessauer CW, Walters ET., Free PMC Article | 10/23/2021 |
| Hypertension exhibits 5-HT4 receptor as a modulator of sympathetic neurotransmission in the rat mesenteric vasculature. | Hypertension exhibits 5-HT(4) receptor as a modulator of sympathetic neurotransmission in the rat mesenteric vasculature.
García-Pedraza JÁ, García-Domingo M, Gómez-Roso M, Ruiz-Remolina L, Rodríguez-Barbero A, Martín ML, Morán A. | 09/19/2020 |
| findings suggested that unilateral lesions of the Substantia Nigra induced working memory impairment and up-regulation of 5-HT4 receptors in the Lateral Habenula. Activation and blockade of LHb 5-HT4 receptors improved working memory, that were related to the change of monoamines levels. | Activation and blockade of serotonin(4) receptors in the lateral habenula improve working memory in unilateral 6-hydroxydopamine-lesioned Parkinson's rats.
Guo Y, Zhang L, Zhang J, Du CX, Lv SX, Wang T, Wang HS, Xie W, Liu J. | 12/21/2019 |
| Results indicate that visceral nociceptive transmission through the caudal medulla is negatively modulated by descending serotonin type 4 receptor dependent mechanisms. | The 5-HT(4) receptor-mediated inhibition of visceral nociceptive neurons in the rat caudal ventrolateral medulla.
Lyubashina OA, Sivachenko IB. | 05/5/2018 |
| Results support a specific role for 5-HT4-receptors in fine-tuning of the dynamic capacity of hippocampal synapses to express synaptic plasticity. | The 5-hydroxytryptamine4 receptor enables differentiation of informational content and encoding in the hippocampus.
Twarkowski H, Hagena H, Manahan-Vaughan D., Free PMC Article | 01/13/2018 |
| Study suggests a novel role for the 5-HT4 receptor in facilitation of dendrite formation in which intracellular signaling of PKA and the BDNF-TrkB system may be involved. | Roles of the serotonin 5-HT4 receptor in dendrite formation of the rat hippocampal neurons in vitro.
Kozono N, Ohtani A, Shiga T. | 08/12/2017 |
| 5-HT4 receptor regulating insulin secretion and acting as a potential drug target in diabetes treatment | Activation of islet 5-HT4 receptor regulates glycemic control through promoting insulin secretion.
Chen H, Hong F, Chen Y, Li J, Yao YS, Zhang Y, Zheng LF, Zhu JX. | 03/25/2017 |
| Data suggest a strong interaction between 5-HT4 and CB1 receptors within the nucleus accumbens shell | Effect of nucleus accumbens shell 5-HT4 receptors on the impairment of ACPA-induced emotional memory consolidation in male Wistar rats.
Khodayar E, Oryan S, Nasehi M, Zarrindast MR. | 09/24/2016 |
| Increased p11 expression by BDNF and imipramine unraveled a 5-HT4R-mediated modulation of cardiac Ca(2+) handling | p11 modulates calcium handling through 5-HT₄R pathway in rat ventricular cardiomyocytes.
Meschin P, Demion M, Cazorla O, Finan A, Thireau J, Richard S, Lacampagne A. | 09/24/2016 |
| A novel apical 5-HT4 -mediated bicarbonate secretory pathway and an nitric oxide-dependent inhibitory mechanism are present in the proximal colon | Luminal 5-HT stimulates colonic bicarbonate secretion in rats.
Kaji I, Akiba Y, Said H, Narimatsu K, Kaunitz JD., Free PMC Article | 07/16/2016 |
| Results indicate that 5-HT4 receptors are not synthesized by cholinergic cells, and thus would be absent from cholinergic terminals. Several non-cholinergic cell populations in the basal forebrain and its target express these receptors. | Serotonin 5-HT4 receptors and forebrain cholinergic system: receptor expression in identified cell populations.
Peñas-Cazorla R, Vilaró MT. | 06/28/2016 |
| Anhedonia, not despair or a decline in exploratory interest, may be associated with upregulation of Let-7a and downregulation of Htr4 expression in the hippocampus; hippocampal Htr4 level may be regulated by Let-7a in rats | Anhedonia was associated with the dysregulation of hippocampal HTR4 and microRNA Let-7a in rats.
Bai M, Zhu XZ, Zhang Y, Zhang S, Zhang L, Xue L, Zhong M, Zhang X. | 12/20/2014 |
| We conclude that the 5-HT4(a)-receptor may play a more prominent role in the modulation of motor cortico-ponto-cerebellar, cortico-spinal, rubro-spinal, vestibulo-spinal and cortico-nuclear tracts during juvenile development. | Distribution of serotonin 4(a) receptors in the juvenile rat brain and spinal cord.
Suwa B, Bock N, Preusse S, Rothenberger A, Manzke T. | 11/8/2014 |
| Activation of 5-HT4 receptors facilitates expression of long-term depression at hippocampal output synapses in acute rat brain slices. | 5-HT4-receptors modulate induction of long-term depression but not potentiation at hippocampal output synapses in acute rat brain slices.
Wawra M, Fidzinski P, Heinemann U, Mody I, Behr J., Free PMC Article | 10/4/2014 |
| the 5-HT(4) receptor is a representative of a foetal cardiac gene program, functional in late foetal development and reactivated in heart failure. | The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure.
Brattelid T, Qvigstad E, Moltzau LR, Bekkevold SV, Sandnes DL, Birkeland JA, Skomedal T, Osnes JB, Sjaastad I, Levy FO., Free PMC Article | 03/9/2013 |
| Mucosal 5-HT(4) receptor activation can mediate the prokinetic and antinociceptive actions of 5-HT(4)R agonists. | Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.
Hoffman JM, Tyler K, MacEachern SJ, Balemba OB, Johnson AC, Brooks EM, Zhao H, Swain GM, Moses PL, Galligan JJ, Sharkey KA, Greenwood-Van Meerveld B, Mawe GM., Free PMC Article | 06/2/2012 |
| beta(1)-AR and 5-HT(4) receptor signalling are subject to opposite regulatory control by cGMP generated by soluble guanylyl cyclase in failing hearts. | Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle.
Afzal F, Qvigstad E, Aronsen JM, Moltzau LR, Sjaastad I, Skomedal T, Osnes JB, Levy FO., Free PMC Article | 03/31/2012 |
| Up-regulation of 5-HT3 and 5-HT4 receptors expression in the mucosal/submucosal layer is involved to restore the delayed transit after the parasympathetic denervation in rats. | The role of 5-HT3 and 5-HT4 receptors in the adaptive mechanism of colonic transit following the parasympathetic denervation in rats.
Tong W, Kamiyama Y, Ridolfi TJ, Zietlow A, Zheng J, Kosinski L, Ludwig K, Takahashi T., Free PMC Article | 01/7/2012 |
| Selective activation of 5-HT(4) receptors improved memory performance in an olfactory associative discrimination task in aged rats | Enhancement of reference memory in aged rats by specific activation of 5-HT(4) receptors using an olfactory associative discrimination task.
Marchetti E, Jacquet M, Escoffier G, Miglioratti M, Dumuis A, Bockaert J, Roman FS. | 11/19/2011 |
| Study revealed that 5-HT4b, 5-HT2A and 5-HT2B coexisted in auricular myocytes of newborn rat, that 5-HT4 activation reduced cAMP concentration, ICaL and intercellular coupling whereas 5-HT2A or 5-HT2B activation conversely enhanced GJIC. | 5-HT4 and 5-HT2 receptors antagonistically influence gap junctional coupling between rat auricular myocytes.
Derangeon M, Bozon V, Defamie N, Peineau N, Bourmeyster N, Sarrouilhe D, Argibay JA, Hervé JC. | 05/3/2010 |
| 5-HT4 receptor-mediated positive inotropic responses in failing rat ventricle were cAMPdependent. | 5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles.
Afzal F, Andressen KW, Mørk HK, Aronsen JM, Sjaastad I, Dahl CP, Skomedal T, Levy FO, Osnes JB, Qvigstad E., Free PMC Article | 01/21/2010 |
| complete recovery of associative learning performance in the lesioned rats by 5-HT4 receptor agonists | Complete recovery of olfactory associative learning by activation of 5-HT4 receptors after dentate granule cell damage in rats.
Marchetti E, Jacquet M, Jeltsch H, Migliorati M, Nivet E, Cassel JC, Roman FS. | 01/21/2010 |
| Serotonin 4a receptors were found predominantly in the neuropilat late embryonic (E18-E20) stages. At birth, expression was predominantly somatic. | Developmental changes of serotonin 4(a) receptor expression in the rat pre-Bötzinger complex.
Manzke T, Preusse S, Hülsmann S, Richter DW. | 01/21/2010 |
| Functional 5-HT(2A) and 5-HT(4) receptors are differentially induced in LV hypertrophy and failure. | Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle.
Brattelid T, Qvigstad E, Birkeland JA, Swift F, Bekkevold SV, Krobert KA, Sejersted OM, Skomedal T, Osnes JB, Levy FO, Sjaastad I. | 01/21/2010 |
| Positive inotropic response of failing heart to 5-HT(4) stimulation results from increased L-type Ca2+ current/sarcoplamic reticulum Ca(2+) content. | Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes.
Birkeland JA, Swift F, Tovsrud N, Enger U, Lunde PK, Qvigstad E, Levy FO, Sejersted OM, Sjaastad I. | 01/21/2010 |